Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff.Journal of Virology.  92. 2018
2018 Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode.Journal of Virology2018
2017 Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge.Journal of Virology.  92. 2017
2017 β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.Journal of Virology2017
2017 Aspicilia goettweigensis (Megasporaceae, lichenized Ascomycetes) – a poorly known and overlooked species in Europe and RussiaNordic Journal of Botany.  35:595-601. 2017
2017 Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly.Journal of Virology.  91. 2017
2017 A chikungunya fever vaccine utilizing an insect-specific virus platform.Nature Medicine.  23:192-199. 2017
2016 New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.PLoS Pathogens.  12:e1005810. 2016
2016 The extensive geographical range of several species of Teloschistaceae: Evidence from RussiaLichenologist.  48:171-189. 2016
2016 Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode.Virology.  487:230-241. 2016
2015 The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly.Journal of Virology.  90:2008-2020. 2015
2015 IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.PLoS Pathogens.  11:e1004863. 2015
2015 Long-term Socioeconomic Challenges for Russia and Demand for New TechnologyForesight and STI Governance (Foresight-Russia till No. 3/2015).  9:6-17. 2015
2015 Long-term Socioeconomic Challenges for Russia and Demand for New TechnologyФорсайт.  9:6-17. 2015
2015 Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection.PLoS Neglected Tropical Diseases.  9:e0004119. 2015
2015 Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.Journal of Virology.  89:71-82. 2015
2014 Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs.Proceedings of the National Academy of Sciences.  111:10708-10713. 2014
2014 Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.Journal of Virology.  88:2116-2130. 2014
2013 The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains.Journal of Virology.  87:12003-12019. 2013
2013 Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.Journal of Virology.  87:7569-7584. 2013
2013 Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.Journal of Virology.  87:4202-4213. 2013
2013 A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.Vaccine.  31:1464-1470. 2013
2013 Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes.Journal of Virology.  87:1997-2010. 2013
2013 Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation.Journal of Virology.  87:2023-2035. 2013
2013 IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety.PLoS Neglected Tropical Diseases.  7:e2197. 2013
2012 New PARP gene with an anti-alphavirus function.Journal of Virology.  86:8147-8160. 2012
2012 Early events in alphavirus replication determine the outcome of infection.Journal of Virology.  86:5055-5066. 2012
2011 Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response.Journal of Virology.  85:9249-9252. 2011
2011 A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion.Journal of Virology.  85:8105-8115. 2011
2011 Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.Journal of Virology.  85:8022-8036. 2011
2011 Characterization of the RepliVax platform for replication-defective flavivirus vaccines.Vaccine.  29:5184-5194. 2011
2011 Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism.PLoS Pathogens.  7:e1002142. 2011
2011 Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.Journal of Virology.  85:4363-4376. 2011
2010 Functional Sindbis virus replicative complexes are formed at the plasma membrane.Journal of Virology.  84:11679-11695. 2010
2010 Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein.Journal of Virology.  84:10004-10015. 2010
2010 Efficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever viruses.Virology.  400:8-17. 2010
2010 Infection, dissemination, and transmission of a West Nile virus green fluorescent protein infectious clone by Culex pipiens quinquefasciatus mosquitoes.Vector-Borne and Zoonotic Diseases.  10:267-274. 2010
2009 Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription.Journal of Virology.  83:9031-9044. 2009
2009 Structural and functional elements of the promoter encoded by the 5' untranslated region of the Venezuelan equine encephalitis virus genome.Journal of Virology.  83:8327-8339. 2009
2009 Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.Vaccine.  27:4309-4319. 2009
2009 The 5'UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins.Virology.  387:211-221. 2009
2008 Different types of nsP3-containing protein complexes in Sindbis virus-infected cells.Journal of Virology.  82:10088-10101. 2008
2008 Chimeric alphavirus vaccine candidates for chikungunya.Vaccine.  26:5030-5039. 2008
2008 IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells.Virology.  377:160-169. 2008
2008 A new role for ns polyprotein cleavage in Sindbis virus replication.Journal of Virology.  82:6218-6231. 2008
2008 Identification of mutated cyclization sequences that permit efficient replication of West Nile virus genomes: use in safer propagation of a novel vaccine candidate.Journal of Virology.  82:6942-6951. 2008
2008 Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence.Journal of Virology.  82:4920-4930. 2008
2008 Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in Mammalian but not in mosquito cells.Journal of Virology.  82:4028-4041. 2008
2008 Experimental infection of Aedes sollicitans and Aedes taeniorhynchus with two chimeric Sindbis/Eastern equine encephalitis virus vaccine candidates.American Journal of Tropical Medicine and Hygiene.  78:93-97. 2008
2008 Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses.Advances in Virus Research.  72:77-126. 2008
2007 Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription.Journal of Virology.  81:13552-13565. 2007
2007 Production of pseudoinfectious yellow fever virus with a two-component genome.Journal of Virology.  81:11737-11748. 2007
2007 Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection.Virology.  367:307-323. 2007
2007 Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice.Vaccine.  25:7573-7581. 2007
2007 Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins.Virology.  366:212-225. 2007
2007 Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells.Virology.  362:475-487. 2007
2007 Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning.Journal of Virology.  81:5046-5057. 2007
2007 Recombinant alphaviruses are safe and useful serological diagnostic tools.American Journal of Tropical Medicine and Hygiene.  76:774-781. 2007
2007 The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff.Journal of Virology.  81:2472-2484. 2007
2006 Production and characterization of vaccines based on flaviviruses defective in replication.Virology.  351:432-443. 2006
2006 Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines.Virology.  351:196-209. 2006
2006 Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription.Journal of Virology.  80:5686-5696. 2006
2006 Formation of nsP3-specific protein complexes during Sindbis virus replication.Journal of Virology.  80:4122-4134. 2006
2006 Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.Journal of Virology.  80:2784-2796. 2006
2006 The efficient packaging of Venezuelan equine encephalitis virus-specific RNAs into viral particles is determined by nsP1-3 synthesis.Virology.  344:315-327. 2006
2005 Inhibition of transcription and translation in Sindbis virus-infected cells.Journal of Virology.  79:9397-9409. 2005
2005 Noncytopathic replication of Venezuelan equine encephalitis virus and eastern equine encephalitis virus replicons in Mammalian cells.Journal of Virology.  79:7597-7608. 2005
2005 Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication.Journal of Virology.  79:3231-3242. 2005
2005 Venezuelan equine encephalitis virus in the guinea pig model: evidence for epizootic virulence determinants outside the E2 envelope glycoprotein gene.American Journal of Tropical Medicine and Hygiene.  72:330-338. 2005
2005 Sindbis virus with a tricomponent genome.Journal of Virology.  79:637-643. 2005
2004 Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein.Journal of Gene Medicine.  6:1082-1091. 2004
2004 PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection.Journal of Virology.  78:8455-8467. 2004
2004 Changes of the secondary structure of the 5' end of the Sindbis virus genome inhibit virus growth in mosquito cells and lead to accumulation of adaptive mutations.Journal of Virology.  78:4953-4964. 2004
2004 Analysis of the 3' cis-acting elements of rubella virus by using replicons expressing a puromycin resistance gene.Journal of Virology.  78:2553-2561. 2004
2004 Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus.Journal of Virology.  78:2414-2425. 2004
2004 Persistent infection and suppression of host response by alphaviruses.Archives of Virology -Supplement-.  139-147. 2004
2004 Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication.Journal of Virology.  78:61-75. 2004
2003 Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.Journal of Virology.  77:9278-9286. 2003
2002 Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection.Journal of Virology.  76:11254-11264. 2002
2001 Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.RNA.  7:1638-1651. 2001
2001 Efficient translation initiation is required for replication of bovine viral diarrhea virus subgenomic replicons.Journal of Virology.  75:4226-4238. 2001
2000 Infection of human dendritic cells by a sindbis virus replicon vector is determined by a single amino acid substitution in the E2 glycoprotein.Journal of Virology.  74:11849-11857. 2000
1999 Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells.Journal of Virology.  73:3854-3865. 1999
1999 Stable alphavirus packaging cell lines for Sindbis virus and Semliki Forest virus-derived vectors.Proceedings of the National Academy of Sciences.  96:4598-4603. 1999
1999 Construction of recombinant sindbis-based expression vectors for the study of HCV genes and their products.Methods in Molecular Medicine.  19:565-574. 1999
1998 cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5' nontranslated region chimeras.RNA.  4:1418-1435. 1998
1998 Noncytopathic Sindbis virus RNA vectors for heterologous gene expression.Proceedings of the National Academy of Sciences.  95:12989-12994. 1998
1997 Sindbis virus replicons and Sindbis virus: assembly of chimeras and of particles deficient in virus RNA.Journal of Virology.  71:2819-2829. 1997
1997 Packaging signals in alphaviruses.Journal of Virology.  71:248-258. 1997
1996 Alphavirus-based expression vectors: strategies and applications.Proceedings of the National Academy of Sciences.  93:11371-11377. 1996
1996 [Preparation and study of recombinant strains of Venezuelan equine encephalomyelitis virus expressing the PreS2-S gene of the hepatitis B virus].Voprosy virusologii.  41:100-104. 1996
1996 Translation of Sindbis virus mRNA: analysis of sequences downstream of the initiating AUG codon that enhance translation.Journal of Virology.  70:1182-1190. 1996
1996 Construction and investigation of recombinant strains of Venezuelan equine encephalomyelitis virus expressing preS2-S gene of hepatitis B virusVoprosy virusologii.  41:104. 1996
1995 [Study of the structure-function organization of the variola virus genome. IV. Sequencing and analysis of the nucleotide sequence of the right terminus of the India-1967 strain genome].Molecular Biology.  29:772-789. 1995
1994 Translation of Sindbis virus mRNA: effects of sequences downstream of the initiating codon.Journal of Virology.  68:8111-8117. 1994
1994 Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells.Journal of Virology.  68:1721-1727. 1994
1994 [Structure-activity organization of the variola virus genome. III. Sequencing and analysis of the nucleotide sequence of the conserved region of HindIII-F, -N-, and -A-fragments of the India 1967 strain genome].Molecular Biology.  28:392-406. 1994
1994 A cell line that expresses a reporter gene in response to infection by Sindbis virus: a prototype for detection of positive strand RNA viruses.Virology.  198:381-384. 1994
1994 Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection.Archives of Virology.  139:173-181. 1994
1993 Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs.Journal of Virology.  67:6439-6446. 1993
1993 [Recombinant equine Venezuelan encephalomyelitis virus, expressing HBsAg].Доклады Академии Наук / Doklady Biological Sciences.  332:789-791. 1993
1993 [The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus].Voprosy virusologii.  38:222-226. 1993
1993 Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragments.Virus Research.  27:25-35. 1993
1992 [Study of the structural-functional organization of the natural variola virus genome. I. Cloning HindIII- and XhoI-fragments of viral DNA and sequencing HindIII -M, -L, -I fragments].Molecular Biology.  26:1099-1115. 1992
1992 [Effect of mutations in genes of Venezuelan equine encephalomyelitis virus structural proteins on its attenuation].Доклады Академии Наук / Doklady Biological Sciences.  326:1078-1082. 1992
1992 [Obtaining infectious Venezuelan equine encephalomyelitis virus based on a full length DNA copy of its genome].Доклады Академии Наук / Doklady Biological Sciences.  327:160-164. 1992
1992 [Study of the prospects for creating vector systems based on the alpha-virus genome].Доклады Академии Наук / Doklady Biological Sciences.  326:738-741. 1992
1991 [Comparison of the amino acid sequence of structural proteins from attenuated and pathogenic strains of the Venezuelan equine encephalomyelitis virus].Doklady Akademii nauk SSSR.  318:1488-1491. 1991
1991 [Variants of the Venezuelan equine encephalomyelitis virus resistant to the neutralizing action of monoclonal antibodies].Doklady Akademii nauk SSSR.  320:1485-1488. 1991
1990 [A comparison of the primary structures of the 26S RNA in variants of the eastern equine encephalomyelitis virus].Doklady Akademii nauk SSSR.  313:216-219. 1990
1989 [Primary structure of the avian influenza virus A/FVP/Weybridge hemagglutinin gene].Molekuliarnaia genetika, mikrobiologiia i virusologiia.  26-34. 1989

Education And Training

  • Bachelor's Level Degree in Biology / Biological Sciences, Novosibirsk State University
  • Doctor of Philosophy in Molecular Biology, Institution Not Available in List
  • Master's Level Degree in Biology / Biological Sciences, Novosibirsk State University
  • Full Name

  • Ilya Frolov
  • Blazerid

  • ivfrolov