Positions

Overview

  • Irshad H. Chaudry was born on May 2, 1945. He received a B.S. as well as M.S. with honors from Sind University, and a Ph.D. from Monash University, Australia. After his postdoctoral training at Toronto University, Canada, he was an appointed as an Instructor and subsequently as an Assistant Professor at the Jewish Hospital and Washington University School of Medicine. He then moved to Yale University as an Associate Professor and subsequently became a Professor. He moved to Michigan State University in 1986 as Professor and Director of Research and in 1996 became the Director of the Center for Surgical Research at Brown University. In 2000, he became the Director of the Center for Surgical Research at the University of Alabama at Birmingham. His has over 600 publications to his credit and is a recipient of the NIH MERIT award.

    Current research interests include determining the mechanisms responsible for cellular and subcellular alterations following soft tissue trauma, bone fracture, hemorrhage and sepsis. Additionally, the use of novel, readily available, FDA approved inexpensive therapeutic agents to attenuate such alterations in patients following trauma is planned. Other areas include evaluation of: (1) gender dimorphism and the mechanisms responsible for producing cardiovascular and hepatocellular dysfunction and immunological alterations following trauma-hemorrhage; (2) trauma-induced changes in the hypothalamus-pituitary-adrenal axis; (3) apoptosis of immune cells; and (4) wound healing. Specific research interests include determining the mechanism of regulation of estradiol levels by hypothalamic/pituitary factors, adrenals and steroidogenic enzyme activity and how differences in estradiol levels or the estradiol: androgen ratio due to the estrus cycle, ovariectomy, and age affect immune responses after trauma. Studies of T lymphocytes, macrophages and Kupffer cell functions using molecular biological techniques are being conducted to determine why low estradiol fails to maintain immune functions in aged females after trauma. The use of estradiol, Raloxifene, prolactin, metoclopramide, or flutamide to restore immune/cardiovascular functions following trauma should yield novel information and provide an innovative approach for improving the host responses and reducing mortality from sepsis following trauma in postmenopausal and in surgically ovariectomized patients with low estrogen activity. Additional interests encompass the mechanisms by which androgen depletion/androgen antagonists improve cardiac performance and other organ functions after trauma. These studies also examine whether androgen depletion/androgen antagonists affect the adrenals and modify the response of the heart, liver and vascular smooth muscle to catecholamines. The hemodynamic parameters and organ functions being measured include blood flow, circulating blood volume, cardiac output, left ventricular performance, vascular reactivity, liver, gut, adrenal and pulmonary functions. The integration of cardiac function with other organ functions and detailed mechanistic studies at the cellular and subcellular levels using physiological, pharmacological and molecular biology techniques to identify targets for novel treatment modalities using sex steroid antagonists/agonists or hormones should provide new information for the improved treatment of trauma victims with major blood loss and for decreasing the susceptibility to sepsis following trauma.
  • Research Overview

  • trauma, hemorrhage, sepsis, gender dimorphism, immune functions, cardiovascular functions
  • Principal Investigator On

  • Increasing Survival Rate Following Hemorrhagic Shock and Traumatic Brain Injury in Austere Environments  awarded by THE MIND RESEARCH NETWORK 2018 - 2020
  • Part B - Surviving Blood Loss: First in Human Studies to Assess Safety and Physiological Effects of Synthetic Ethinyl Estradiol-3-Sulfate (EE·3·SO4) in Healthy Subjects, Both Euvolemic and Following 10-20% Iatrogenic Blood Loss  awarded by DOD - Department of Defense 2015 - 2018
  • Treatment of Traumatic Brain Injury (TBI) with Hormonal and Pharmacological Support--Preclinical Validation Using Diffuse and Mechanical TBI Animal Models  awarded by DOD - ARMY MEDICAL RESEARCH AND MATERIAL COMMAND 2008 - 2016
  • Maintenance of Organ Function Following Injury  awarded by National Institute of General Medical Sciences/NIH/DHHS 2009 - 2014
  • Development of a Controlled Hemorrhage Model in Mature, Miniature Pigs for Multi-Center Applications and Trial of Novel Field Expedient Treatment  awarded by Texas A&M University 2012 - 2013
  • Immunological Aspects of Hemorrhage  awarded by National Institute of General Medical Sciences/NIH/DHHS 2007 - 2013
  • Evaluation of Premarin in a Rat Model of Mild and Severe Hemorrhage  awarded by Defense Advanced Research Projects Agency 2010 - 2012
  • Trauma and Inflammation Research Training  awarded by National Institute of General Medical Sciences/NIH/DHHS 2006 - 2012
  • Role of Zinc in Estrogen-Mediated Salutary Effects on Cardiovascular Functions Following Trauma-Hemorrhage  awarded by American Heart Association (Southeast Affiliate) 2009 - 2011
  • Private Grant  awarded by AKEBIA THERAPEUTICS, INC. 2010 - 2011
  • Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, 1969
  • Full Name

  • Irshad Chaudry