Positions

Overview

  • Irshad H. Chaudry was born on May 2, 1945. He received a B.S. as well as M.S. with honors from Sind University, and a Ph.D. from Monash University, Australia. After his postdoctoral training at Toronto University, Canada, he was an appointed as an Instructor and subsequently as an Assistant Professor at the Jewish Hospital and Washington University School of Medicine. He then moved to Yale University as an Associate Professor and subsequently became a Professor. He moved to Michigan State University in 1986 as Professor and Director of Research and in 1996 became the Director of the Center for Surgical Research at Brown University. In 2000, he became the Director of the Center for Surgical Research at the University of Alabama at Birmingham. His has over 600 publications to his credit and is a recipient of the NIH MERIT award.

    Current research interests include determining the mechanisms responsible for cellular and subcellular alterations following soft tissue trauma, bone fracture, hemorrhage and sepsis. Additionally, the use of novel, readily available, FDA approved inexpensive therapeutic agents to attenuate such alterations in patients following trauma is planned. Other areas include evaluation of: (1) gender dimorphism and the mechanisms responsible for producing cardiovascular and hepatocellular dysfunction and immunological alterations following trauma-hemorrhage; (2) trauma-induced changes in the hypothalamus-pituitary-adrenal axis; (3) apoptosis of immune cells; and (4) wound healing. Specific research interests include determining the mechanism of regulation of estradiol levels by hypothalamic/pituitary factors, adrenals and steroidogenic enzyme activity and how differences in estradiol levels or the estradiol: androgen ratio due to the estrus cycle, ovariectomy, and age affect immune responses after trauma. Studies of T lymphocytes, macrophages and Kupffer cell functions using molecular biological techniques are being conducted to determine why low estradiol fails to maintain immune functions in aged females after trauma. The use of estradiol, Raloxifene, prolactin, metoclopramide, or flutamide to restore immune/cardiovascular functions following trauma should yield novel information and provide an innovative approach for improving the host responses and reducing mortality from sepsis following trauma in postmenopausal and in surgically ovariectomized patients with low estrogen activity. Additional interests encompass the mechanisms by which androgen depletion/androgen antagonists improve cardiac performance and other organ functions after trauma. These studies also examine whether androgen depletion/androgen antagonists affect the adrenals and modify the response of the heart, liver and vascular smooth muscle to catecholamines. The hemodynamic parameters and organ functions being measured include blood flow, circulating blood volume, cardiac output, left ventricular performance, vascular reactivity, liver, gut, adrenal and pulmonary functions. The integration of cardiac function with other organ functions and detailed mechanistic studies at the cellular and subcellular levels using physiological, pharmacological and molecular biology techniques to identify targets for novel treatment modalities using sex steroid antagonists/agonists or hormones should provide new information for the improved treatment of trauma victims with major blood loss and for decreasing the susceptibility to sepsis following trauma.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy EndpointsShock.  51:33-43. 2019
    2019 Premise for Standardized Sepsis ModelsShock.  51:4-9. 2019
    2018 Gender differences in trauma, shock and sepsisMilitary Medical Research.  5. 2018
    2018 Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (Infection, (2018), 46, 5, (687-691), 10.1007/s15010-018-1183-8)Infection.  46:745-747. 2018
    2018 Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsisInfection.  46:687-691. 2018
    2018 Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.Intensive Care Medicine Experimental.  6:26. 2018
    2018 Minimum quality threshold in pre-clinical sepsis studies (mqtipss): An international expert consensus initiative for improvement of animal modeling in sepsisShock.  50:377-380. 2018
    2017 Treatment of traumatic brain injury with 17α-ethinylestradiol-3-sulfate in a rat modelJournal of Neurosurgery.  127:23-31. 2017
    2017 Hepatoprotective effects of corilagin following hemorrhagic shock are through Akt-dependent pathwayShock.  47:346-351. 2017
    2016 The Role and Use of Estrogens Following TraumaShock.  46:4-11. 2016
    2015 Hepatoprotective effect of casodex after trauma hemorrhage in a rodent modelShock.  43:470-474. 2015
    2015 Morbidity and survival probability in burn patients in modern burn careCritical Care Medicine.  43:808-815. 2015
    2015 17a-ethynylestradiol-3-sulfate treatment of severe blood loss in ratsJournal of Surgical Research.  193:355-360. 2015
    2015 Expression of ConcernShock.  43:620. 2015
    2015 Inflammatory response to traumatic injury: Clinical and animal researches in inflammationMediators of Inflammation.  2015. 2015
    2015 Potential therapeutic targets for sepsis in womenExpert Opinion on Therapeutic Targets.  19:1531-1543. 2015
    2015 Salutary Effects of Estrogen Sulfate for Traumatic Brain InjuryJournal of Neurotrauma.  32:1210-1216. 2015
    2015 The ERRor of our ways: Estrogen-related receptors are about energy, not hormones, and are potential new targets for trauma and shockShock.  44:3-15. 2015
    2014 Abandon the mouse research ship? Not just yet!Shock.  41:463-475. 2014
    2014 Efficacy of 17α-ethynylestradiol-3-sulfate for severe hemorrhage in minipigs in the absence of fluid resuscitationJournal of Trauma and Acute Care Surgery.  76:1409-1416. 2014
    2014 Gender differences in sepsis: Cardiovascular and immunological aspectsVirulence.  5:12-19. 2014
    2014 Gender-specific effects on immune response and cardiac function after trauma hemorrhage and sepsisViszeralmedizin.  30:91-96. 2014
    2014 Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat modelMolecular Medicine.  20:10-16. 2014
    2014 Sex- and diagnosis-dependent differences in mortality and admission cytokine levels among patients admitted for intensive careCritical Care Medicine.  42:1110-1120. 2014
    2014 The august krogh principle: Seeking unity in diversity: ReplyShock.  42:480-481. 2014
    2013 17β-estradiol confers protection after traumatic brain injury in the rat and involves activation of G protein-coupled estrogen receptor 1Journal of Neurotrauma.  30:1531-1541. 2013
    2013 Trauma-associated human neutrophil alterations revealed by comparative proteomics profilingPROTEOMICS - Clinical Applications.  7:571-583. 2013
    2013 Role of Akt/HO-1 pathway in estrogen-mediated attenuation of trauma-hemorrhage-induced lung injuryJournal of Surgical Research.  182:319-325. 2013
    2013 Tranexamic acid and trauma: Current status and knowledge gaps with recommended research prioritiesShock.  39:121-126. 2013
    2013 Hepatic gene expression patterns following trauma-hemorrhage: Effect of posttreatment with estrogenShock.  39:77-82. 2013
    2012 The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 1: Central nervous system, lung, and heartJournal of Anesthesia.  26:883-891. 2012
    2012 The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 2: Liver, intestine, spleen, and kidneyJournal of Anesthesia.  26:892-899. 2012
    2012 Does gender influence outcomes in critically ill patients?Critical Care.  16. 2012
    2012 Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1Molecular Medicine.  18:209-214. 2012
    2011 Influence of aging and hemorrhage injury on Sirt1 expression: Possible role of myc-Sirt1 regulation in mitochondrial functionBBA - Molecular Basis of Disease.  1812:1446-1451. 2011
    2011 Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and punctureSurgical Infections.  12:283-289. 2011
    2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injuryMolecular Medicine.  17:542-549. 2011
    2011 Lidocaine suppresses mouse Peyer's Patch T cell functions and induces bacterial translocationSurgery.  149:106-113. 2011
    2011 Role of PPARγ in the salutary effects of 17β-estradiol on kupffer cell cytokine production following trauma-hemorrhageJournal of Cellular Physiology.  226:205-211. 2011
    2011 The mitoscriptome in aging and diseaseAging and Disease.  2:174-180. 2011
    2010 Erratum: The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhageJournal of Cellular Physiology.  225:915-915. 2010
    2010 Erratum: The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage (Annals of Surgery (2007) 245:6 (971-7))Annals of Surgery.  252:894. 2010
    2010 Single photon emission computed tomography demonstrated efficacy of 17β-estradiol therapy in male rats after trauma-hemorrhage and extended hypotensionJournal of Trauma.  69:1266-1273. 2010
    2010 Salutary effects of 17β-estradiol on Peyer's patch T cell functions following trauma-hemorrhageCytokine.  51:166-172. 2010
    2010 Corrigendum to "Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage" [J. Mol. Cell. Cardiol. 42 (2007) 620-630] (DOI:10.1016/j.yjmcc.2006.12.004)Journal of Molecular and Cellular Cardiology.  48:429-430. 2010
    2010 Corrigendum to "Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage" [J. Mol. Cell. Cardiol. 40 (2006) 570-579] (DOI:10.1016/j.yjmcc.2006.01.008)Journal of Molecular and Cellular Cardiology.  48:428. 2010
    2010 Lidocaine enhances apoptosis and suppresses mitochondrial functions of human neutrophil in vitroJournal of Trauma.  68:401-408. 2010
    2010 Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotensionMolecular Medicine.  16:254-261. 2010
    2010 Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: Role of Bnip3 and Pdk1Shock.  34:169-175. 2010
    2010 Mechanism of the anti-inflammatory effect of 17β-estradiol on brain following trauma-hemorrhageShock.  33:43-48. 2010
    2009 Gut dysfunction following alcohol exposure and traumaJournal of Organ Dysfunction.  5:171-181. 2009
    2009 Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: Role of hypoxia-inducible-factor-1α and phosphoinositide 3-kinase/akt activationAnnals of Surgery.  250:995-1001. 2009
    2009 Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulatedCell Cycle.  8:3770-3776. 2009
    2009 Erratum: Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels (Shock (2008) 30 (372-378))Shock.  32:563. 2009
    2009 Cellular mechanisms of injury after major traumaBritish Journal of Surgery.  96:1097-1098. 2009
    2009 Analysis of the relationship between longitudinal gene expressions and ordered categorical event dataStatistics in Medicine.  28:2817-2832. 2009
    2009 ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-γ in a rodent model of alcohol intoxication and burn injuryJournal of Immunology.  183:3955-3962. 2009
    2009 The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhageInnate Immunity.  15:233-241. 2009
    2009 Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patientsJournal of Trauma.  67:384-388. 2009
    2009 Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O-2 production and intestinal edema following alcohol intoxication and burn injuryAJP - Gastrointestinal and Liver Physiology.  297. 2009
    2009 Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: Heme oxygenase-1-derived normalization of hepatic inflammatory responsesJournal of Leukocyte Biology.  85:1015-1026. 2009
    2009 Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via a hypoxia-inducible factor 1α-mediated pathwayShock.  31:354-358. 2009
    2009 Mechanism of the salutary effects of estrogen on Kupffer cell phagocytic capacity following trauma-hemorrhage: Pivotal role of Akt activationJournal of Immunology.  182:4406-4414. 2009
    2009 Therapy of hemorrhagic shock : New strategies based on experimental resultsNotfall and Rettungsmedizin.  12:193-200. 2009
    2009 The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhageShock.  31:227-237. 2009
    2009 When apoptosis meets autophagy: deciding cell fate after trauma and sepsisMolecular Medicine Today.  15:129-138. 2009
    2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signalingAJP - Heart and Circulatory Physiology.  296. 2009
    2009 Role of extracellular signal-regulated protein kinase (ERK) in 17β-estradiol-mediated attenuation of lung injury after trauma-hemorrhageSurgery.  145:226-234. 2009
    2009 Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  296. 2009
    2009 Large-scale multiplexed quantitative discovery proteomics enabled by the use of an M 18O-labeled universal reference sampleJournal of Proteome Research.  8:290-299. 2009
    2009 Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulationCritical Care Medicine.  37:2338-2344. 2009
    2009 Suppression of activation and costimulatory signaling in splenic CD4 + T cells after trauma-hemorrhage reduces t-cell function: A mechanism of post-traumatic immune suppressionAmerican Journal of Pathology.  175:1504-1514. 2009
    2008 Estrogen and multiple organ dysfunction syndrome in critical illness: From bench to bedsideJournal of Organ Dysfunction.  4:230-238. 2008
    2008 Activation of endoplasmic reticulum stress response following trauma-hemorrhageBBA - Molecular Basis of Disease.  1782:621-626. 2008
    2008 Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-α and ER-βMolecular Medicine.  14:689-696. 2008
    2008 Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptorAJP - Gastrointestinal and Liver Physiology.  295. 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations (Molecular Medicine (2008) 14, 3-4, (213-221))Molecular Medicine.  14:752. 2008
    2008 Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhageAJP - Heart and Circulatory Physiology.  295. 2008
    2008 Systematic analysis of the salutary effect of estrogen on cardiac performance after trauma-hemorrhageShock.  30:585-589. 2008
    2008 Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levelsShock.  30:372-378. 2008
    2008 Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation- induced hepatic injuryJournal of applied physiology: respiratory, environmental and exercise physiology.  105:1076-1082. 2008
    2008 The role of MIP-1α in the development of systemic inflammatory response and organ injury following trauma hemorrhageJournal of Immunology.  181:2806-2812. 2008
    2008 Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase GAnnals of Surgery.  248:294-302. 2008
    2008 Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosisJournal of applied physiology: respiratory, environmental and exercise physiology.  105:595-602. 2008
    2008 Bench-to-bedside review: Latest results in hemorrhagic shockCritical Care.  12. 2008
    2008 Alcohol, burn injury, and the intestine.Journal of Emergencies, Trauma and Shock.  1:81-87. 2008
    2008 The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cellsCytokine.  43:88-92. 2008
    2008 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage (Journal of Leukocyte Biology (2006) 79,5,(963-970) DOI: 10.1189/jlb.1005596)Journal of Leukocyte Biology.  84:329. 2008
    2008 Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1AJP - Regulatory, Integrative and Comparative Physiology.  294. 2008
    2008 p38 MAPK-dependent eNOS upregulation is critical for 17β-estradiol- mediated cardioprotection following trauma-hemorrhageAJP - Heart and Circulatory Physiology.  294. 2008
    2008 Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injuryJournal of Burn Care and Rehabilitation.  29:519-530. 2008
    2008 Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patientsClinical Chemistry.  54:891-900. 2008
    2008 Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhageCytokine.  42:32-38. 2008
    2008 Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injuryShock.  29:377-383. 2008
    2008 Effect of 17β-estradiol on signal transduction pathways and secondary damage in experimental spinal cord traumaShock.  29:362-371. 2008
    2008 Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhageJournal of Cellular Physiology.  214:662-672. 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterationsMolecular Medicine.  14:213-221. 2008
    2008 Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase processAmerican Journal of Physiology - Cell Physiology.  294. 2008
    2008 Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in micePhysiological Genomics.  32:299-310. 2008
    2008 17β-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-αMolecular Immunology.  45:376-385. 2008
    2008 Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injuryJournal of Immunology.  180:6933-6940. 2008
    2008 Sex steroids/receptor antagonist: Their use as adjuncts after trauma-hemorrhage for improving immune/cardiovascular responses and for decreasing mortality from subsequent sepsisAnesthesia and Analgesia.  107:159-166. 2008
    2007 Trauma and immune response-Effect of gender differencesInjury.  38:1382-1391. 2007
    2007 Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhageShock.  28:576-581. 2007
    2007 Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: Upregulation of estradiol synthesisAnnals of Surgery.  246:836-843. 2007
    2007 Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulationJournal of Leukocyte Biology.  82:1019-1026. 2007
    2007 V. Guidelines for sedation and analgesia during mechanical ventilation general overviewJournal of Trauma.  63:945-950. 2007
    2007 Estrogen receptor-α predominantly mediates the salutary effects of 17β-estradiol on splenic macrophages following trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  293. 2007
    2007 Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: Up-regulation of the PI-3K/Akt pathwayJournal of Leukocyte Biology.  82:774-780. 2007
    2007 Metabolic modulators following trauma sepsis: Sex hormonesCritical Care Medicine.  35. 2007
    2007 Regulation of the postburn wound inflammatory response by γδ T-cellsShock.  28:278-283. 2007
    2007 Surgical trauma-induced adrenal insufficiency is associated with postoperative inflammatory responsesJournal of Nippon Medical School.  74:274-283. 2007
    2007 17β-Estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhageMolecular Immunology.  44:3317-3323. 2007
    2007 Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhageAJP - Heart and Circulatory Physiology.  292. 2007
    2007 Salutary effects of 17β-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-αAmerican Journal of Physiology - Cell Physiology.  292. 2007
    2007 The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhageAnnals of Surgery.  245:971-977. 2007
    2007 The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhageJournal of Hepatology.  46:1047-1054. 2007
    2007 Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in ratsAJP - Lung Cellular and Molecular Physiology.  292. 2007
    2007 Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhageJournal of Cellular Physiology.  211:364-370. 2007
    2007 Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhageAJP - Lung Cellular and Molecular Physiology.  292. 2007
    2007 Erratum: Mitochondria play an important role in 17β-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis (American Journal of Physiology Endocrinology and Metabolism (2007) 292 (E585-E593))AJP - Endocrinology and Metabolism.  292. 2007
    2007 TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhageMolecular Immunology.  44:2625-2630. 2007
    2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levelsShock.  27:402-408. 2007
    2007 17β-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhageMolecular Immunology.  44:2165-2172. 2007
    2007 Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathwayJournal of applied physiology: respiratory, environmental and exercise physiology.  102:933-941. 2007
    2007 Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhageJournal of Molecular and Cellular Cardiology.  42:620-630. 2007
    2007 Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine productionAJP - Regulatory, Integrative and Comparative Physiology.  292. 2007
    2007 The role of MAPK in Kupffer cell Toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhageJournal of Cellular Physiology.  210:667-675. 2007
    2007 17β-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhageAJP - Lung Cellular and Molecular Physiology.  292. 2007
    2007 Does estrogen contribute to the hepatic regeneration following portal branch ligation in rats?AJP - Gastrointestinal and Liver Physiology.  292. 2007
    2007 Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathwayAnnals of Surgery.  245:297-304. 2007
    2007 Influence of sex and age on mods and cytokines after multiple injuriesShock.  27:151-156. 2007
    2007 Mitochondria play an important role in 17β-estradiol attenuation of H2O2-induced rat endothelial cell apoptosisAJP - Endocrinology and Metabolism.  292. 2007
    2007 17β-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhageAJP - Heart and Circulatory Physiology.  292. 2007
    2007 G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhageAmerican Journal of Pathology.  170:1210-1218. 2007
    2007 Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhageJournal of applied physiology: respiratory, environmental and exercise physiology.  102:113-121. 2007
    2007 Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged miceAJP - Gastrointestinal and Liver Physiology.  292. 2007
    2007 Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhageJournal of applied physiology: respiratory, environmental and exercise physiology.  102:163-168. 2007
    2007 Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhageAmerican Journal of Surgery.  193:61-68. 2007
    2006 Estrus cycle: Influence on cardiac function following trauma-hemorrhageAJP - Heart and Circulatory Physiology.  291. 2006
    2006 Erratum: Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice (Journal of Immunology (2006) 177 (4514-4520))Journal of Immunology.  177:8877. 2006
    2006 A role for corticosterone in impaired intestinal immunity and barrier function in a rodent model of acute alcohol intoxication and burn injuryJournal of Neuroimmune Pharmacology.  1:428-434. 2006
    2006 Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in miceAmerican Journal of Physiology - Cell Physiology.  291. 2006
    2006 Effects of 17β-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhageCytokine.  36:107-114. 2006
    2006 Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathwaysProceedings of the National Academy of Sciences.  103:15564-15569. 2006
    2006 Effects of 17β-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus femalesJournal of Leukocyte Biology.  80:759-765. 2006
    2006 High dynamic range characterization of the trauma patient plasma proteomeMolecular and Cellular Proteomics.  5:1899-1913. 2006
    2006 Trauma-hemorrhage induces depressed splenic dendritic cell functions in miceJournal of Immunology.  177:4514-4520. 2006
    2006 Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: Upregulation of heme oxygenase-1AJP - Lung Cellular and Molecular Physiology.  291. 2006
    2006 Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxiaAmerican Journal of Physiology - Cell Physiology.  291. 2006
    2006 Upregulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhageJournal of Molecular and Cellular Cardiology.  41:511-521. 2006
    2006 Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhageJournal of applied physiology: respiratory, environmental and exercise physiology.  101:448-453. 2006
    2006 17β-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-αSurgery.  140:141-148. 2006
    2006 A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injuryJournal of Leukocyte Biology.  80:367-375. 2006
    2006 Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunctionJournal of Cellular Physiology.  208:418-427. 2006
    2006 Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsisAJP - Gastrointestinal and Liver Physiology.  291. 2006
    2006 A role of PPAR-γ in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhageAnnals of Surgery.  244:131-138. 2006
    2006 Inflammation and the Host Response to Injury: An overview of the multicenter study of the genomic and proteomic response to burn injuryJournal of Burn Care and Rehabilitation.  27:448-451. 2006
    2006 Sex differences in mortality after burn injury: Results of analysis of the National Burn Repository of the American Burn AssociationJournal of Burn Care and Rehabilitation.  27:452-456. 2006
    2006 Are the protective effects of 17β-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-α or ER-β?Journal of Leukocyte Biology.  79:1173-1180. 2006
    2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhageShock.  25:600-607. 2006
    2006 Inhibition of cardiac PGC-1α expression abolishes ERβ agonist-mediated cardioprotection following trauma-hemorrhageFederation proceedings.  20:1109-1117. 2006
    2006 Better understanding of organ dysfunction requires proteomic involvementJournal of Proteome Research.  5:1060-1062. 2006
    2006 Salutary effects of estrogen receptor-β agonist on lung injury after trauma-hemorrhageAJP - Lung Cellular and Molecular Physiology.  290. 2006
    2006 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhageJournal of Leukocyte Biology.  79:963-970. 2006
    2006 Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsisCytokine.  34:76-84. 2006
    2006 Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhageJournal of Molecular and Cellular Cardiology.  40:570-579. 2006
    2006 MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxiaMolecular Medicine.  12:65-73. 2006
    2006 A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injuryJournal of Leukocyte Biology.  79:453-462. 2006
    2006 Estradiol improves cardiac and hepatic function after trauma-hemorrhage: Role of enhanced heat shock protein expressionAJP - Regulatory, Integrative and Comparative Physiology.  290. 2006
    2006 Influence of gender and age on T-cell responses in a murine model of trauma-hemorrhage: Differences between circulating and tissue-fixed cellsJournal of applied physiology: respiratory, environmental and exercise physiology.  100:826-833. 2006
    2006 Alcohol intoxication and post-burn complicationsFrontiers in Bioscience.  11:998-1005. 2006
    2006 Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injuryPhysiological Genomics.  24:298-309. 2006
    2006 Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: Up-regulation of estrogen receptor-β-dependent HO-1Journal of Leukocyte Biology.  79:277-284. 2006
    2006 Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1AJP - Heart and Circulatory Physiology.  290. 2006
    2006 Gender and sex hormones influence the response to trauma and sepsis - Potential therapeutic approachesClinics.  61:479-488. 2006
    2006 Gender and susceptibility to sepsis following traumaEndocrine, Metabolic and Immune Disorders - Drug Targets.  6:127-135. 2006
    2006 Kupffer cells and their mediators: The culprits in producing distant organ damage after trauma-hemorrhageAmerican Journal of Pathology.  169:784-794. 2006
    2006 Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-β agonist: Up-regulation of cardiac heat shock factor-1 and heat shock proteinsJournal of Molecular and Cellular Cardiology.  40:185-194. 2006
    2006 T cells of the γδ T-cell receptor lineage play an important role in the postburn wound healing processJournal of Burn Care and Rehabilitation.  27:18-25. 2006
    2005 Cecal ligation and punctureShock.  24:52-57. 2005
    2005 Erratum: A network-based analysis of systemic inflammation in humans (Nature (2005) 437 (1032-1037) DOI: 10.1038/nature03985)Nature.  438:696. 2005
    2005 Gender differences in acute response to trauma-hemorrhageShock.  24:101-106. 2005
    2005 PGC-1 upregulation via estrogen receptors: A common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhageAJP - Heart and Circulatory Physiology.  289. 2005
    2005 Opiate analgesics contribute to the development of post-injury immunosuppressionJournal of Surgical Research.  129:161-168. 2005
    2005 Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsisShock.  24:364-369. 2005
    2005 Current understanding of gender dimorphism in hepatic pathophysiologyJournal of Surgical Research.  128:147-156. 2005
    2005 The association between sex and mortality among burn patients as modified by ageJournal of Burn Care and Rehabilitation.  26:416-421. 2005
    2005 Role of thromboxane in producing hepatic injury during hepatic stressArchives of Surgery -New York-.  140:801-807. 2005
    2005 Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gammaSurgery.  138:204-211. 2005
    2005 Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injuryAJP - Regulatory, Integrative and Comparative Physiology.  289. 2005
    2005 L-arginine improves wound healing after trauma-hemorrhage by increasing collagen synthesisJournal of Trauma.  59:162-168. 2005
    2005 Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: Upregulation of heme oxygenaseAJP - Heart and Circulatory Physiology.  289. 2005
    2005 Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptorsSurgery.  138:85-92. 2005
    2005 Surgical trauma and immunosuppression: Pathophysiology and potential immunomodulatory approachesLangenbeck's Archives of Surgery.  390:333-341. 2005
    2005 Mouse genetic background influences severity of immune responses following trauma-hemorrhageCytokine.  30:168-176. 2005
    2005 Gender differences in small intestinal perfusion following trauma hemorrhage: The role of endothelin-1AJP - Gastrointestinal and Liver Physiology.  288. 2005
    2005 Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injuryJournal of Leukocyte Biology.  77:719-728. 2005
    2005 Quantitative proteome analysis of human plasma following in vivo lypopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approachMolecular and Cellular Proteomics.  4:700-709. 2005
    2005 Transgenic prolactin-/- mice: Effect of trauma-hemorrhage on splenocyte functionsAmerican Journal of Physiology - Cell Physiology.  288. 2005
    2005 Application of genome-wide expression analysis to human health and diseaseProceedings of the National Academy of Sciences.  102:4801-4806. 2005
    2005 Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen deliveryAJP - Heart and Circulatory Physiology.  288. 2005
    2005 Genetic variability in the immune-inflammatory response after major burn injuryShock.  23:123-128. 2005
    2005 Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: Role of endothelial and inducible nitric oxide synthaseAJP - Gastrointestinal and Liver Physiology.  288. 2005
    2005 Dehydroepiandrosterone restores depressed peripheral blood mononuclear cell function following major abdominal surgery via the estrogen receptorsCritical Care Medicine.  33:1779-1786. 2005
    2004 Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shockJournal of applied physiology: respiratory, environmental and exercise physiology.  97:2184-2189. 2004
    2004 Splenectomy differentially influences immune responses in various tissue compartments of the bodyCytokine.  28:101-108. 2004
    2004 Mechanism of cardiac depression after trauma-hemorrhage: Increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac functionAJP - Heart and Circulatory Physiology.  287. 2004
    2004 Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-αEndocrinology.  145:5168-5176. 2004
    2004 The role of the mitochondrion in trauma and shockShock.  22:395-402. 2004
    2004 MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injuryJournal of Cellular Physiology.  201:35-44. 2004
    2004 Cellular Alterations Following Shock and Trauma and Their ModulationJournal- Japanese Association for Acute Medicine.  15:324-325. 2004
    2004 Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhageJournal of Surgical Research.  121:25-30. 2004
    2004 The role of γδ T cells in the regulation of neutrophil-mediated tissue damage after thermal injuryJournal of Leukocyte Biology.  76:545-552. 2004
    2004 Enhanced isolated pancreatic islet recovery and functionality in rats by 17β-estradiol treatment of brain death donorsSurgery.  136:336-345. 2004
    2004 Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhageAJP - Regulatory, Integrative and Comparative Physiology.  287. 2004
    2004 The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levelsArchives of Surgery -New York-.  139:896-901. 2004
    2004 Differences in the expression of LPS-receptors are not responsible for the sex-specific immune response after trauma and hemorrhagic shockCellular Immunology.  230:17-22. 2004
    2004 Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage?Cytokine.  26:223-230. 2004
    2004 Alpha1-acid-glycoprotein protects against trauma-hemorrhagic shockJournal of Surgical Research.  119:21-28. 2004
    2004 Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhageAJP - Gastrointestinal and Liver Physiology.  286. 2004
    2004 The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhageBBA - Molecular Basis of Disease.  1689:22-32. 2004
    2004 Gender differences in small intestinal endothelial function: Inhibitory role of androgensAJP - Gastrointestinal and Liver Physiology.  286. 2004
    2004 Gender differences in small intestinal endothelial function: inhibitory role of androgens.AJP - Gastrointestinal and Liver Physiology.  286:G452-G457. 2004
    2004 Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsisCytokine.  25:110-118. 2004
    2004 Physiological Levels of 5α-Dihydrotestosterone Depress Wound Immune Function and Impair Wound Healing Following Trauma-HemorrhageArchives of Surgery -New York-.  139:157-163. 2004
    2004 Metabolic disturbances in shock, and the role of ATP-MgCl2 and sex steroidsMedical Principles and Practice.  13:2-9. 2004
    2003 Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo after Transplantation in RatsDiabetes.  52:2935-2942. 2003
    2003 Role of thromboxane in producing portal hypertension following trauma-hemorrhageAJP - Gastrointestinal and Liver Physiology.  285. 2003
    2003 Role of thromboxane in producing portal hypertension following trauma-hemorrhage.AJP - Gastrointestinal and Liver Physiology.  285:G1293-G1299. 2003
    2003 Sex Differences in Hepatic Heme Oxygenase Expression and Activity Following Trauma and Hemorrhagic ShockArchives of Surgery -New York-.  138:1375-1382. 2003
    2003 Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacityJournal of Leukocyte Biology.  74:344-351. 2003
    2003 Cellular, molecular and sexual dimorphic response to trauma-hemorrhageInternational Congress Series.  1255:25-38. 2003
    2003 Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhageJournal of applied physiology: respiratory, environmental and exercise physiology.  95:529-535. 2003
    2003 Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injuryArchives of Surgery -New York-.  138:727-734. 2003
    2003 Androgen-mediated modulation of macrophage function after trauma-hemorrhage: Central role of 5α-dihydrotestosteroneJournal of applied physiology: respiratory, environmental and exercise physiology.  95:104-112. 2003
    2003 Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: Enhanced local synthesis of 17β-estradiolAmerican Journal of Physiology - Cell Physiology.  285. 2003
    2003 Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: enhanced local synthesis of 17beta-estradiol.American Journal of Physiology - Cell Physiology.  285:C139-C149. 2003
    2003 Sex-specific p38 MAP kinase activation following trauma-hemorrhage: Involvement of testosterone and estradiolAJP - Endocrinology and Metabolism.  285. 2003
    2003 Differential alterations in intestinal permeability after trauma-hemorrhageJournal of Surgical Research.  112:198-204. 2003
    2003 Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: Role of vascular endothelial cell functionAJP - Heart and Circulatory Physiology.  284. 2003
    2003 Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function.AJP - Heart and Circulatory Physiology.  284:H2162-H2169. 2003
    2003 Progesterone administration after trauma and hemorrhagic shock improves cardiovascular responsesCritical Care Medicine.  31:1786-1793. 2003
    2003 Endocrine targets in experimental shock.Journal of Trauma.  54. 2003
    2003 Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsisCurrent Opinion in Critical Care.  9:137-142. 2003
    2003 Mechanism of the salutary effects of 17β-estradiol following trauma-hemorrhage: Direct downregulation of Kupffer cell proinflammatory cytokine productionCytokine.  21:91-97. 2003
    2003 Adrenomedullin and adrenomedullin binding protein-1: Their role in the septic responseJournal of Surgical Research.  109:175-181. 2003
    2003 Age-related gender differential in outcome after blunt or penetrating trauma.Shock.  19:28-32. 2003
    2003 Differential fluid regulation during and after soft tissue trauma and hemorrhagic shock in males and proestrus females.Shock.  20:144-148. 2003
    2003 Hemorrhage induces the rapid development of hepatic insulin resistanceAJP - Gastrointestinal and Liver Physiology.  284. 2003
    2003 Hemorrhage induces the rapid development of hepatic insulin resistance.AJP - Gastrointestinal and Liver Physiology.  284:G107-G115. 2003
    2003 Immunoprotection in proestrus females following trauma-hemorrhage: The pivotal role of estrogen receptorsCellular Immunology.  222:27-34. 2003
    2003 Regulation of macrophage IL-10 production postinjury via beta2 integrin signaling and the P38 MAP kinase pathway.Shock.  20:529-535. 2003
    2003 The association between gender and mortality among trauma patients as modified by ageJournal of Trauma.  54:464-471. 2003
    2003 Upregulation of hepatic prolactin receptor gene expression by 17β-estradiol following trauma-hemorrhageJournal of applied physiology: respiratory, environmental and exercise physiology.  95:2530-2536. 2003
    2002 Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: Role of adrenomedullin and adrenomedullin binding protein-1Annals of Surgery.  236:625-633. 2002
    2002 Gender dimorphism in immune responses following trauma and hemorrhageImmunologic Research.  26:63-76. 2002
    2002 Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms.AJP - Lung Cellular and Molecular Physiology.  283:L799-L805. 2002
    2002 Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-κB and MAPK/ERK mechanismsAJP - Lung Cellular and Molecular Physiology.  283. 2002
    2002 Flutamide induces relaxation in large and small blood vesselsArchives of Surgery -New York-.  137:1180-1186. 2002
    2002 Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsisAJP - Regulatory, Integrative and Comparative Physiology.  283. 2002
    2002 Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injuryAmerican Journal of Physiology - Cell Physiology.  282. 2002
    2002 Decreased 5α-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  282. 2002
    2002 Estrogen pretreatment protects males against hypoxia-induced immune depressionAmerican Journal of Physiology - Cell Physiology.  282. 2002
    2002 Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage.American Journal of Physiology - Cell Physiology.  282:C1332-C1338. 2002
    2002 Estrogen pretreatment protects males against hypoxia-induced immune depression.American Journal of Physiology - Cell Physiology.  282:C1087-C1092. 2002
    2002 Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsisBBA - Molecular Basis of Disease.  1586:-306. 2002
    2002 L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhageEuropean Surgical Research.  34:53-60. 2002
    2002 Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury.American Journal of Physiology - Cell Physiology.  282:C263-C270. 2002
    2002 Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsisAnnals of Surgery.  235:105-112. 2002
    2002 A universal distribution for component failure timesMeasurement Techniques.  45:710-713. 2002
    2002 Administration of human inter-α-inhibitors maintains hemodynamic stability and improves survival during sepsisCritical Care Medicine.  30:617-622. 2002
    2002 Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouseShock.  17:55-60. 2002
    2002 Differential expression and tissue compartmentalization of the inflammatory response following thermal injuryCytokine.  17:266-274. 2002
    2002 Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsisArchives of Surgery -New York-.  137:74-79. 2002
    2002 Gender differences in mortality following burn injuryShock.  18:311-315. 2002
    2002 Gender dimorphism in immune responses following trauma and hemorrhage.Immunologic Research.  26:63-76. 2002
    2002 Preservation of splenic immune functions by female sex hormones after trauma-hemorrhageCritical Care Medicine.  30:888-893. 2002
    2002 Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injuryCellular Immunology.  220:63-69. 2002
    2002 Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the PULSE Trauma Work GroupShock.  17:165-168. 2002
    2002 Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the PULSE Trauma Work GroupAcademic Emergency Medicine.  9:621-626. 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cellsCell Death and Differentiation.  9:626-635. 2002
    2002 The cellular basis of post-burn immunosuppression: macrophages and mediators.International Journal of Molecular Medicine.  10:239-243. 2002
    2002 Trauma-haemorrhage-induced alterations in thymic prolactin receptor expression: Implications in immune dysfunctionCytokine.  18:127-132. 2002
    2001 Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of α2-adrenoceptorsAJP - Gastrointestinal and Liver Physiology.  281. 2001
    2001 17β-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  281. 2001
    2001 Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injuryAmerican Journal of Physiology - Cell Physiology.  281. 2001
    2001 Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury.American Journal of Physiology - Cell Physiology.  281:C1180-C1187. 2001
    2001 The role of lipopolysaccharide in stimulating adrenomedullin production during polymicrobial sepsisBBA - Molecular Basis of Disease.  1537:167-174. 2001
    2001 The small intestine is an important source of adrenomedullin release during polymicrobial sepsisAJP - Regulatory, Integrative and Comparative Physiology.  281. 2001
    2001 MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsisAmerican Journal of Physiology - Cell Physiology.  281. 2001
    2001 Divergent Immune Responses in Male and Female Mice after Trauma-Hemorrhage: Dimorphic Alterations in T Lymphocyte Steroidogenic Enzyme Activities.Endocrinology.  142:3519-3529. 2001
    2001 The role of Kupffer cell α2-adrenoceptors in norepinephrine-induced TNF-α productionBBA - Molecular Basis of Disease.  1537:49-57. 2001
    2001 Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsisCytokine.  14:162-169. 2001
    2001 Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediatedAJP - Gastrointestinal and Liver Physiology.  280. 2001
    2001 IL-10 mediation of activation-induced Th1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsisCytokine.  14:37-48. 2001
    2001 The small intestine plays an important role in upregulating CGRP during sepsisAJP - Regulatory, Integrative and Comparative Physiology.  280. 2001
    2001 Adrenal insufficiency during the late stage of polymicrobial sepsisCritical Care Medicine.  29:618-622. 2001
    2001 Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shockArchives of Surgery -New York-.  136:1158-1163. 2001
    2001 Continuous resuscitation after hemorrhage and acute fluid replacement improves cardiovascular responsesSurgery.  129:559-566. 2001
    2001 Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsisShock.  16:479-483. 2001
    2001 DHEA: A novel adjunct for the treatment of male trauma patientsMolecular Medicine Today.  7:81-85. 2001
    2001 Dehydroepiandrosterone restores hepatocellular function and prevents liver damage in estrogen-deficient females following trauma and hemorrhageJournal of Surgical Research.  97:196-201. 2001
    2001 Divergent immune responses in male and female mice after trauma-hemorrhage: Dimorphic alterations in T lymphocyte steroidogenic enzyme activitiesEndocrinology.  142:3519-3529. 2001
    2001 Evolution of an immune suppressive macrophage phenotype as a product of p38 MAPK activation in polymicrobial sepsisShock.  15:42-48. 2001
    2001 Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortalityCritical Care Medicine.  29:1201-1206. 2001
    2001 Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsisSurgery.  130:339-345. 2001
    2001 Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhageCytokine.  16:22-30. 2001
    2001 The role of adrenomedullin in producing differential hemodynamic responses during sepsisJournal of Surgical Research.  95:207-218. 2001
    2000 Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsisAJP - Gastrointestinal and Liver Physiology.  279. 2000
    2000 Severe hypoxemia in the absence of blood loss causes a gender dimorphic immune responseAmerican Journal of Physiology - Cell Physiology.  279. 2000
    2000 Sustained elevation of norepinephrine depresses hepatocellular functionBBA - Molecular Basis of Disease.  1535:36-44. 2000
    2000 Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal functionAJP - Regulatory, Integrative and Comparative Physiology.  279. 2000
    2000 Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animalsAnnals of Surgery.  232:673-679. 2000
    2000 The female reproductive cycle is an important variable in the response to trauma-hemorrhageAJP - Heart and Circulatory Physiology.  279. 2000
    2000 Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  279. 2000
    2000 The dissociation between upregulated endothelins and hemodynamic responses during polymicrobial sepsisBBA - Molecular Basis of Disease.  1501:211-218. 2000
    2000 Mechanism of the beneficial effects of pentoxifylline during sepsis: Maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokinesJournal of Surgical Research.  91:70-76. 2000
    2000 Reversal of sexual dimorphism in splenic T lymphocyte responses after trauma-hemorrhage with agingAmerican Journal of Physiology - Cell Physiology.  278. 2000
    2000 Inhibition of tyrosine kinase signaling after trauma-hemorrhage: A novel approach for improving organ function and decreasing susceptibility to subsequent sepsisAnnals of Surgery.  231:399-407. 2000
    2000 Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhageAJP - Regulatory, Integrative and Comparative Physiology.  278. 2000
    2000 Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shockCritical Care Medicine.  28:2837-2842. 2000
    2000 Androgen and estrogen receptors in splenic T lymphocytes: Effects of flutamide and trauma-hemorrhageShock.  14:465-470. 2000
    2000 Critical role of oxygen radicals in the initiation of hepatic depression after trauma hemorrhageJournal of Trauma Injury Infection and Critical Care.  49:879-885. 2000
    2000 Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression?Shock.  14:623-628. 2000
    2000 Does early infusion of red blood cells after trauma and hemorrhage improve organ functions?Critical Care Medicine.  28:3498-3504. 2000
    2000 Effect of gender and sex hormones on immune responses following shockShock.  14:81-90. 2000
    2000 Effect of naloxone on immune responses after hemorrhagic shockCritical Care Medicine.  28:184-189. 2000
    2000 IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsisSurgery.  128:133-138. 2000
    2000 Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxinCritical Care Medicine.  28:2949-2955. 2000
    2000 Immune dysfunction following trauma-haemorrhage: Influence of gender and ageCytokine.  12:69-77. 2000
    2000 Insight into the mechanism by which estradiol improves organ functions after trauma-hemorrhageSurgery.  128:246-252. 2000
    2000 Insights into the role of γδ T lymphocytes in the immunopathogenic response to thermal injuryJournal of Leukocyte Biology.  67:644-650. 2000
    2000 Is prostacyclin responsible for producing the hyperdynamic response during early sepsis?Critical Care Medicine.  28:1534-1539. 2000
    2000 L-Arginine attenuates trauma-hemorrhage-induced liver injuryCritical Care Medicine.  28:3242-3248. 2000
    2000 Mechanism of hepatocellular dysfunction during sepsis: the role of gut-derived norepinephrine (review).International Journal of Molecular Medicine.  5:457-465. 2000
    2000 Metoclopramide: A novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhageAJP - Endocrinology and Metabolism.  278. 2000
    2000 Plasma α-glutathione S-transferase: A sensitive indicator of hepatocellular damage during polymicrobial sepsisArchives of Surgery -New York-.  135:198-203. 2000
    2000 Restoration of body temperature to normothermia during resuscitation following trauma-hemorrhage improves the depressed cardiovascular and hepatocellular functionsArchives of Surgery -New York-.  135:175-181. 2000
    2000 The aromatase inhibitor, 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsisShock.  14:347-353. 2000
    2000 The important role of the gut in initiating the hyperdynamic response during early sepsisJournal of Surgical Research.  89:31-37. 2000
    2000 Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsisShock.  13:325-329. 2000
    1999 Reply: Letters to the editorShock.  11:73-74. 1999
    1999 Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsisJournal of Trauma Injury Infection and Critical Care.  47:706-712. 1999
    1999 Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injuryBBA - Molecular Basis of Disease.  1455:45-53. 1999
    1999 Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsisAJP - Heart and Circulatory Physiology.  277. 1999
    1999 Is gut the major source of proinflammatory cytokine release during polymicrobial sepsis?BBA - Molecular Basis of Disease.  1454:289-295. 1999
    1999 Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  277. 1999
    1999 Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsisCritical Care Medicine.  27:959-964. 1999
    1999 Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxinImmunology.  97:45-55. 1999
    1999 Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsisJournal of Surgical Research.  83:151-157. 1999
    1999 Pulmonary clearance of adrenomedullin is reduced during the late stage of sepsisBBA - General Subjects.  1427:315-321. 1999
    1999 Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophagesAmerican Journal of Physiology - Cell Physiology.  276. 1999
    1999 Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsisBBA - Molecular Basis of Disease.  1453:273-283. 1999
    1999 L-arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flowAmerican Journal of Physiology - Cell Physiology.  276. 1999
    1999 Proteasome participates in the alteration of signal transduction in T and B lymphocytes following trauma-hemorrhageBBA - Molecular Basis of Disease.  1453:92-104. 1999
    1999 Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytesCytokine.  11:443-450. 1999
    1999 Does fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis?Shock.  11:211-217. 1999
    1999 Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosisShock.  12:316-322. 1999
    1999 Immunological consequences of trauma and shockAnnals of the Academy of Medicine, Singapore.  28:120-132. 1999
    1999 Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review).International Journal of Molecular Medicine.  4:575-583. 1999
    1999 Reduction in vascular responsiveness to adrenomedullin during sepsisJournal of Surgical Research.  85:59-65. 1999
    1999 Trauma-hemorrhage delays wound healing potentially by increasing pro- inflammatory cytokines at the wound siteSurgery.  126:279-285. 1999
    1999 What is the role of interleukin 10 in polymicrobial sepsis: Anti- inflammatory agent or immunosuppressant?Surgery.  126:378-383. 1999
    1998 Dehydroepiandrosterone: An inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhageArchives of Surgery -New York-.  133:1281-1288. 1998
    1998 The pivotal role of adrenomedullin in producing hyperdynamic circulation during the early stage of sepsisArchives of Surgery -New York-.  133:1298-1304. 1998
    1998 Upregulation of Kupffer cell β-adrenoceptors and cAMP levels during the late stage of sepsisBiochimica et Biophysica Acta (BBA) - Molecular Cell Research.  1404:377-384. 1998
    1998 Testosterone: The crucial hormone responsible for depressing myocardial function in males after trauma-hemorrhageAnnals of Surgery.  227:790-799. 1998
    1998 Testosterone: The culprit for producing splenocyte immune depression after trauma hemorrhageAmerican Journal of Physiology - Cell Physiology.  274. 1998
    1998 Trauma-hemorrhage activates signal transduction pathways in mouse splenic T cellsShock.  9:443-450. 1998
    1998 The organs responsible for increased nitric oxide production after trauma-hemorrhage and resuscitationArchives of Surgery -New York-.  133:399-405. 1998
    1998 Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokene gene expressionFederation proceedings.  12. 1998
    1998 Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated processBlood.  91:1362-1372. 1998
    1998 Left ventricular thrombusCirculation.  97:412. 1998
    1998 Is gut the 'motor' for producing hepatocellular dysfunction after trauma and hemorrhagic shock?Journal of Surgical Research.  74:141-148. 1998
    1998 Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shockCritical Care Medicine.  26:101-107. 1998
    1998 Cardiac contractility and structure are not significantly compromised even during the late, hypodynamic stage of sepsisShock.  9:352-358. 1998
    1998 Chronic resuscitation after trauma-hemorrhage and acute fluid replacement improves hepatocellular function and cardiac outputAnnals of Surgery.  227:112-119. 1998
    1998 Does neutrophil-mediated oxidative stress play any significant role in producing hepatocellular dysfunction during early sepsis?Journal of Surgical Research.  80:75-79. 1998
    1998 Hepatocellular dysfunction after severe hypotension in the absence of blood loss is associated with the increased IL-6 and PGE2Journal of Surgical Research.  80:136-142. 1998
    1998 Increased gut permeability after hemorrhage is associated with upregulation of local and systemic IL-6Journal of Surgical Research.  79:39-46. 1998
    1998 Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?Archives of Surgery -New York-.  133:1213-1220. 1998
    1998 L-arginine restores the depressed cardiac output and regional perfusion after trauma-hemorrhageSurgery.  124:394-402. 1998
    1998 Lymphocyte Apoptosis in SepsisSepsis.  2:55-71. 1998
    1998 Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expressionJournal of Surgical Research.  77:63-70. 1998
    1998 Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shockCritical Care Medicine.  26:1372-1378. 1998
    1998 The contribution of soft-tissue trauma and/or bone fracture to depressed immunity following hemorrhagic shock in an experimental settingUnfallchirurg.  101:37-41. 1998
    1998 Thermal injury alters macrophage responses to prostaglandin E2: Contribution to the enhancement of inducible nitric oxide synthase activityJournal of Leukocyte Biology.  64:740-746. 1998
    1998 Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsisShock.  10:118-122. 1998
    1997 Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in malesAJP - Heart and Circulatory Physiology.  273. 1997
    1997 Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in malesAmerican Journal of Physiology.  273. 1997
    1997 Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhageAmerican Journal of Physiology - Cell Physiology.  273. 1997
    1997 Administration of ATP-MgCl2 following hemorrhage and resuscitation increases hepatic phosphoenolpyruvate carboxykinase and decreases pyruvate kinase activitiesBBA - General Subjects.  1336:549-556. 1997
    1997 Severe hypoxemia in the absence of blood loss depresses hepatocellular function and up-regulates IL-6 and PGE2BBA - Molecular Basis of Disease.  1361:42-48. 1997
    1997 Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitation.Shock.  8:33-39. 1997
    1997 Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide releaseJournal of Surgical Research.  70:113-118. 1997
    1997 Intestinal alkaline phosphatase: role in the depressed gut lipid transport after trauma-hemorrhagic shock.Shock.  8:40-44. 1997
    1997 Salutary effects of ATP-MgCl2 on altered hepatocyte signal transduction after hemorrhagic shockAJP - Gastrointestinal and Liver Physiology.  272. 1997
    1997 Endothelial nitric oxide synthase is downregulated during hyperdynamic sepsisBBA - General Subjects.  1335:182-190. 1997
    1997 Liver endothelial cell function is depressed only during hypodynamic sepsisJournal of Surgical Research.  68:38-43. 1997
    1997 Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSFJournal of Surgical Research.  68:24-30. 1997
    1997 Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsisCytokine.  9:437-446. 1997
    1997 Females in proestrus state maintain splenic immune functions and tolerate sepsis better than malesCritical Care Medicine.  25:106-110. 1997
    1997 Flutamide: A novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shockShock.  8:242-248. 1997
    1997 Mechanism of intestinal mucosal immune dysfunction following trauma- hemorrhage: Increased apoptosis associated with elevated Fas expression in Peyer's patchesJournal of Surgical Research.  70:55-60. 1997
    1997 The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in ratsJournal of Surgical Research.  73:117-122. 1997
    1996 Prolactin Administration Following Hemorrhagic Shock Improves Macrophage Cytokine Release Capacity and Decreases Mortality from Subsequent SepsisJournal of Immunology.  157:5748-5754. 1996
    1996 Depressed osteoblast activity after trauma-hemorrhageFederation proceedings.  10. 1996
    1996 Immune dysfunction in murine polymicrobial sepsis: Mediators, macrophages, lymphocytes and apoptosisShock.  6. 1996
    1996 Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitationSensor Review.  16:33-39. 1996
    1996 Intestinal alkaline phosphatase: Role in the depressed gut lipid transport after trauma-hemorrhagic shockSensor Review.  16:40-44. 1996
    1996 Mechanism of hepatocellular dysfunction during hyperdynamic sepsisAmerican Journal of Physiology.  270. 1996
    1996 Mechanism of hepatocellular dysfunction following trauma and hemorrhagic shock: Key role of hypoxemiaFederation proceedings.  10. 1996
    1996 Metoclopramide improves splenocyte immune function and restores plasma corticosteroid levels after hemorrhagic shockFederation proceedings.  10. 1996
    1996 Prolactin improves depressed macrophage indugible cytokine gene expression in peritoneal macrophages (PMφ), splenic macrophages (SMφ) and kupffer cells (KC) following sepsisFederation proceedings.  10. 1996
    1996 Trauma-hemorrhage induces increased thymic apoptosis while decreasing il-3 releaseFederation proceedings.  10. 1996
    1996 Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shockJournal of Trauma Injury Infection and Critical Care.  41:628-634. 1996
    1996 Increased melatonin levels after hemorrhagic shock in male and female C3H/HeN miceExperientia.  52:587-590. 1996
    1996 Platelet activating factor and its role in trauma, shock, and sepsisNew Horizons -Baltimore-.  4:265-275. 1996
    1996 Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediatorsBlood.  87:4261-4275. 1996
    1996 Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shockAJP - Heart and Circulatory Physiology.  270. 1996
    1996 Inhibition of the Biologic Activity of Tumor Necrosis Factor Maintains Vascular Endothelial Cell Function during Hyperdynamic SepsisJournal of Trauma Injury Infection and Critical Care.  40:694-700. 1996
    1996 Is Sepsis-Induced Apoptosis Associated with Macrophage Dysfunction?Journal of Trauma Injury Infection and Critical Care.  40:568-573. 1996
    1996 A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsisShock.  6:46-51. 1996
    1996 Administration of a matrix metalloproteinase inhibitor after hemorrhage improves cardiovascular and hepatocellular functionShock.  6:377-382. 1996
    1996 Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitationCytokine.  8:853-863. 1996
    1996 Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage aloneArchives of Surgery -New York-.  131:995-1000. 1996
    1996 Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challengeJournal of Surgical Research.  65:109-114. 1996
    1996 Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsisSurgery.  120:367-373. 1996
    1996 Pentoxifylline restores the depressed cardiac performance after trauma- hemorrhage and resuscitationJournal of Surgical Research.  66:51-56. 1996
    1996 Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhageCytokine.  8:134-140. 1996
    1996 Relationship of pelvic radiation to intestinal blood flowJournal of Surgical Research.  60:239-244. 1996
    1996 Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytesShock.  5:79-90. 1996
    1995 Effect of surgical trauma on splenocyte and peritoneal macrophage immune functionJournal of Trauma Injury Infection and Critical Care.  39:645-650. 1995
    1995 ATP-MgCl2restores depressed endothelial cell function after hemorrhagic shock and resuscitationAJP - Heart and Circulatory Physiology.  268. 1995
    1995 Cytokine gene expression in splenic macrophages and kupffer cells following haemorrhageCytokine.  7:8-14. 1995
    1995 Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after traumaNutrition.  11:1-11. 1995
    1995 Does Endotoxin Play a Major Role in Inducing the Depression of Macrophage Function During Polymicrobial Sepsis?Archives of Surgery -New York-.  130:1178-1185. 1995
    1995 Downregulation of hepatic β-adrenergic receptors after trauma and hemorrhagic shockAJP - Gastrointestinal and Liver Physiology.  268. 1995
    1995 Effects of hydroxyethyl starch after trauma-hemorrhagic shock: Restoration of macrophage integrity and prevention of increased circulating interleukin- 6 levelsCritical Care Medicine.  23:806-814. 1995
    1995 Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsisAJP - Regulatory, Integrative and Comparative Physiology.  269. 1995
    1995 Hemorrhage affects the ability of murine peritoneal macrophages to alkanize intracellular ph in acidic environmentsJournal of Surgical Research.  58:682-686. 1995
    1995 Hepatocellular dysfunction occurs earlier than the onset of hyperdynamic circulation during sepsisShock.  3:21-26. 1995
    1995 Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine releaseAJP - Regulatory, Integrative and Comparative Physiology.  269. 1995
    1995 Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitationAJP - Regulatory, Integrative and Comparative Physiology.  269. 1995
    1995 Intraperitoneal sodium carboxymethylcellulose administration prevents reformation of peritoneal adhesions following surgical lysisJournal of Surgical Research.  59:97-102. 1995
    1995 PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepressionJournal of Surgical Research.  59:366-370. 1995
    1995 Sustained elevation in circulating catecholamine levels during polymicrobial sepsisShock.  4:269-273. 1995
    1995 The gut: A cytokine-generating organ in systemic inflammation?Shock.  4:193-199. 1995
    1995 The induction of accelerated thymic programmed cell death during polymicrobial sepsis: Control by corticosteroids but not tumor necrosis factorShock.  3:259-267. 1995
    1995 The role of bacterial translocation on Kupffer cell immune function following hemorrhage.Progress in clinical and biological research.  392:209-218. 1995
    1995 Trauma-hemorrhage causes prolonged depression in cellular immunityShock.  4:149-153. 1995
    1995 Tumor necrosis factor-α administration increases kupffer cell cyclic adenosine monophosphate levelsShock.  4:351-355. 1995
    1994 Methods to prevent colonic injury in pelvic radiationDiseases of the Colon and Rectum.  37:1090-1094. 1994
    1994 ATP-MgCl2 administration normalizes macrophage cAMP and gamma-adrenergic receptors after hemorrhage and resuscitationAmerican Journal of Physiology.  267. 1994
    1994 Downregulation of hepatocyte P2-purinoceptor binding capacity after trauma-hemorrhage/resuscitationAmerican Journal of Physiology.  266. 1994
    1994 ATP-MgCl2 administration normalizes macrophage cAMP and β-adrenergic receptors after hemorrhage and resuscitationAJP - Gastrointestinal and Liver Physiology.  267. 1994
    1994 ATP-MgCl2 treatment after trauma-hemorrhage/resuscitation increases hepatocyte P2-purinoceptor binding capacityAJP - Regulatory, Integrative and Comparative Physiology.  266. 1994
    1994 ATP-MgCl2treatment after trauma-hemorrhage/resuscitation increases hepatocyte P2-purinoceptor binding capacityAJP - Regulatory, Integrative and Comparative Physiology.  266. 1994
    1994 Administration of tumor necrosis factor-α in vivo depresses endothelium- dependent relaxationAJP - Heart and Circulatory Physiology.  266. 1994
    1994 Aggressive fluid resuscitation following intestinal ischemia-reperfusion in immature rats prevents metabolic derangements and down regulates interleukin-6 releaseShock.  1:381-387. 1994
    1994 Biological significance of elevated TNF levels: In vivo administration of monoclonal antibody against TNF following haemorrhage shock increases the capacity of macrophages to release TNF while restoring immuno-responsivenessCytokine.  6:624-632. 1994
    1994 Chemically modified heparin improves hepatocellular function, cardiac output, and microcirculation after trauma-hemorrhage and resuscitationSurgery.  116:169-176. 1994
    1994 Dextran 70 administration after trauma-hemorrhagic shock does not impair cellular immune functionsJournal of Critical Care.  9:244-254. 1994
    1994 Differential alterations in cyclic nucleotide levels in kupffer cells and hepatocytes following trauma-hemorrhage and resuscitationShock.  1:438-442. 1994
    1994 Does laser-Doppler flowmetry provide a quantitative measure of hepatic perfusionAJP - Gastrointestinal and Liver Physiology.  266. 1994
    1994 Downregulation of hepatocyte P 2 -purinoceptor binding capacity after trauma-hemorrhage/resuscitationAJP - Regulatory, Integrative and Comparative Physiology.  266. 1994
    1994 EditorialShock.  1:1-2. 1994
    1994 Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shockCritical Care Medicine.  22:1076-1083. 1994
    1994 Energetics of lymphocyte “Burnout” in late sepsis: Adjuvant treatment with ATP-MgCl2 improves energetics and decreases lethalityJournal of Surgical Research.  56:537-542. 1994
    1994 Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shockShock.  1:141-146. 1994
    1994 Hemorrhage induces a reduction in the capacity of macrophages to mobilize intracellular calcium secondary to formyl-methionyl-leucyl-phenylalanine stimulation: Association with alterations in cell surface Fc receptor expression and increased prostaglandin releaseShock.  1:228-235. 1994
    1994 Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilutionAmerican Journal of Physiology.  266. 1994
    1994 Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilutionAmerican Journal of Physiology.  266. 1994
    1994 Mechanism of Enhanced Susceptibility to Sepsis Following Hemorrhage: Interleukin-10 Suppression of T-Cell Response Is Mediated by Eicosanoid-Induced Interleukin-4 ReleaseArchives of Surgery -New York-.  129:1172-1178. 1994
    1994 Nitric Oxide: To Block or Enhance Its Production During Sepsis?Archives of Surgery -New York-.  129:1137-1143. 1994
    1994 Pentoxifylline attenuates oxygen-induced lung injuryJournal of Surgical Research.  56:543-548. 1994
    1994 Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shockImmunology.  83:378-383. 1994
    1994 Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-γ release while increasing IL-4/IL-10 productionJournal of Surgical Research.  56:579-585. 1994
    1994 Role of kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitationShock.  1:43-47. 1994
    1994 Severe depression of gut absorptive capacity in patients following trauma or sepsisJournal of Trauma.  36:803-809. 1994
    1994 Vascular smooth muscle contractile function is impaired during early and late stages of sepsisJournal of Surgical Research.  56:556-561. 1994
    1993 Reperfusion injury following testicular torsion and detorsion in prepubertal ratsUrological Research.  21:389-393. 1993
    1993 Tauromustine is more effective than conventional chemotherapy in the treatment of colonic tumorsDiseases of the Colon and Rectum.  36:394-399. 1993
    1993 A model of pulmonary atelectasis in rats: Activation of alveolar macrophage and cytokine releaseAmerican Journal of Physiology.  264. 1993
    1993 ATP-MgCl2 restores gut absorptive capacity early after trauma- hemorrhagic shockAmerican Journal of Physiology.  264. 1993
    1993 Alterations in circulating blood volume during polymicrobial sepsisCirculatory shock.  40:92-98. 1993
    1993 Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentationAmerican Journal of Physiology.  264. 1993
    1993 Chloroquine inhibits macrophage tumour necrosis factor-α mRNA transcriptionImmunology.  80:122-126. 1993
    1993 Diltiazem reduces whole blood viscosity following trauma-hemorrhagic shock and resuscitationCirculatory shock.  39:231-236. 1993
    1993 Endothelial cell dysfunction occurs after hemorrhage in nonheparinized but not in preheparinized modelsJournal of Surgical Research.  54:499-506. 1993
    1993 Endothelial cell dysfunction occurs very early following trauma- hemorrhage and persists despite fluid resuscitationAmerican Journal of Physiology.  265. 1993
    1993 Insights into the mechanism by which interferon-γ improves macrophage function following hemorrhage and resuscitationJournal of Surgical Research.  54:322-327. 1993
    1993 Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitationAmerican Journal of Physiology.  265. 1993
    1993 Mechanism of increased susceptibility to infection following hemorrhageAmerican Journal of Surgery.  165:59S-67S. 1993
    1993 Modulation of Macrophage Membrane Phospholipids by n-3 Polyunsaturated Fatty Acids Increases Interleukin 1 Release and Prevents Suppression of Cellular Immunity Following Hemorrhagic ShockArchives of Surgery -New York-.  128:15-21. 1993
    1993 Pentoxifylline restores cardiac output and tissue perfusion after trauma- hemorrhage and decreases susceptibility to sepsisSurgery.  114:352-359. 1993
    1993 Prevention of peritoneal adhesions by administration of sodium carboxymethyl cellulose and oral vitamin ESurgery.  114:907-910. 1993
    1993 Prevention of secondary cardiovascular instability after intestinal ischemia and reperfusion improves survivalAmerican Journal of Physiology.  264. 1993
    1993 Restoration of gut absorptive capacity following trauma-hemorrhagic shock by the adjuvant use of heparan sulfateJournal of Trauma.  34:645-652. 1993
    1993 Role of Interleukin 6 and Transforming Growth Factor–β in the Induction of Depressed Splenocyte Responses Following SepsisArchives of Surgery -New York-.  128:89-95. 1993
    1993 The release of transforming growth factor-β following haemorrhage: Its role as a mediator of host immunosuppressionImmunology.  79:479-484. 1993
    1993 Trauma-hemorrhage and resuscitation in the mouse: Effects on cardiac output and organ blood flowAmerican Journal of Physiology.  264. 1993
    1993 Tumor necrosis factor depresses gut absorptive functionCirculatory shock.  39:279-284. 1993
    1993 Tumor necrosis factor-α produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculationAmerican Journal of Physiology.  265. 1993
    1992 Differential effects of ATP-MgCl2on portal and hepatic arterial blood flow after hemorrhage and resuscitationAmerican Journal of Physiology.  263. 1992
    1992 Direct comparison between Czerny-Lembert and circular-stapled anastomotic techniques in colorectal anastomosis: A similar pattern of healing for bothDiseases of the Colon and Rectum.  35:862-869. 1992
    1992 Differential alterations in microvascular perfusion in various organs during early and late sepsis.American Journal of Physiology.  263:G38-G43. 1992
    1992 Omeprazole-induced hypergastrinemia does not influence growth of colon carcinomaDigestive Diseases and Sciences.  37:485-489. 1992
    1992 Does a proximal colostomy affect colorectal anastomotic healing?Diseases of the Colon and Rectum.  35:182-188. 1992
    1992 ATP-MgCl2 restores renal microcirculation following trauma and severe hemorrhageCanadian Journal of Physiology and Pharmacology.  70:349-357. 1992
    1992 ATP-MgCl2restores the depressed cardiac output following trauma and severe hemorrhage even in the absence of blood resuscitationCirculatory shock.  36:277-283. 1992
    1992 Adenosine triphosphate-magnesium chloride in radiation injurySurgery.  112:933-939. 1992
    1992 Chloroquine Attenuates Hemorrhagic Shock—Induced Immunosuppression and Decreases Susceptibility to SepsisArchives of Surgery -New York-.  127:70-76. 1992
    1992 Crystalloid is as effective as blood in the resuscitation of hemorrhagic shockAnnals of Surgery.  215:377-382. 1992
    1992 Differential alterations in microvascular perfusion in various organs during early and late sepsisAmerican Journal of Physiology.  263. 1992
    1992 Differential effects of hemorrhage on kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) releaseCytokine.  4:66-75. 1992
    1992 Diltiazem restores cardiac output and improves renal function after hemorrhagic shock and crystalloid resuscitationAmerican Journal of Physiology.  262. 1992
    1992 Does Endotoxin Tolerance Prevent the Release of Inflammatory Monokines (Interleukin 1, Interleukin 6, or Tumor Necrosis Factor) During Sepsis?Archives of Surgery -New York-.  127:191-197. 1992
    1992 Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: Restoration with adenosine triphosphate-MgCl2Surgery.  112:150-158. 1992
    1992 Erratum: Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: Restoration with adenosine triphosphate-MgCl2 (Surgery (1992) 112 (150-158))Surgery.  112:846. 1992
    1992 Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitationJournal of Trauma.  32:389-397. 1992
    1992 Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhageJournal of Surgical Research.  53:55-61. 1992
    1992 Interferon-γ attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsisSurgery.  111:177-187. 1992
    1992 Measurement of hepatic blood flow after severe hemorrhage: Lack of restoration despite adequate resuscitationAmerican Journal of Physiology.  262. 1992
    1992 Mechanism of the beneficial effects of ATP-MgCl 2 following trauma-hemorrhage and resuscitation: Downregulation of inflammatory cytokine (TNF, IL-6) releaseJournal of Surgical Research.  52:364-371. 1992
    1992 Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitationSurgery.  112:451-458. 1992
    1992 Pharmacologic agents in the treatment of ischemia, hemorrhagic shock, and sepsisJournal of Critical Care.  7:189-216. 1992
    1992 Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor)Circulatory shock.  36:191-199. 1992
    1992 Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flowJournal of Surgical Research.  53:464-469. 1992
    1992 Protective effects of preheparinization on the microvasculature during and after hemorrhagic shockJournal of Trauma.  32:420-426. 1992
    1992 Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant miceJournal of Surgical Research.  52:635-641. 1992
    1992 Sepsis produces early depression of gut absorptive capacity: Restoration with diltiazem treatmentAmerican Journal of Physiology.  263. 1992
    1991 Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: Involvement of cell-associated tumor necrosis factor and reactive nitrogenJournal of Immunology.  147:4147-4154. 1991
    1991 Increase in hepatic blood flow during early sepsis is due to increased portal blood flowAmerican Journal of Physiology.  261. 1991
    1991 Measurement of D-xylose gut absorptive capacity in conscious ratsAmerican Journal of Physiology.  261. 1991
    1991 Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin releaseBlood.  78:1781-1788. 1991
    1991 ATP-MgCl2 restores the depressed hepatocellular function and hepatic blood flow following hemorrhage and resuscitationJournal of Surgical Research.  50:368-374. 1991
    1991 Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shockJournal of Trauma.  31:601-608. 1991
    1991 Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expressionImmunology.  74:290-297. 1991
    1991 Association between decreased splenic ATP levels and immunodepression: Amelioration with ATP-MgCl2American Journal of Physiology.  261. 1991
    1991 Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shockAnnals of Surgery.  213:265-271. 1991
    1991 Crystalloid resuscitation restores but does not maintain cardiac output following severe hemorrhageJournal of Surgical Research.  50:163-169. 1991
    1991 Depressed gut absorptive capacity early after trauma-hemorrhagic shock: Restoration with diltiazem treatmentAnnals of Surgery.  214:712-718. 1991
    1991 Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhageAmerican Journal of Physiology.  260. 1991
    1991 Diltiazem restores IL-2, IL-3, IL-6, and IFN-γ synthesis and decreases host susceptibility to sepsis following hemorrhageJournal of Surgical Research.  51:158-164. 1991
    1991 Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivoJournal of Trauma.  31:609-616. 1991
    1991 Hepatic Extraction of Indocyanine Green Is Depressed Early in Sepsis Despite Increased Hepatic Blood Flow and Cardiac OutputArchives of Surgery -New York-.  126:219-224. 1991
    1991 Improved methodology for the evaluation of the velocity of clearance of indocyanine green in the ratCirculatory shock.  33:26-32. 1991
    1991 The complex pattern of cytokines in sepsis: Association between prostaglandins, cachectin, and interleukinsAnnals of Surgery.  214:141-148. 1991
    1990 Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitationCirculatory shock.  32:307-318. 1990
    1990 Passive immunization against cachectin (TNF-α) prevents hemorrhage-induced suppression of kupffer cell functionsSurgical Forum -Chicago-.  41:91-93. 1990
    1990 Sepsis selectively activates peritoneal but not alveolar macrophage to release inflammatory mediators (IL-1, IL-6, and TNF)Surgical Forum -Chicago-.  41:117-119. 1990
    1990 Intramural pH: A quantitative measurement for predicting colorectal anastomotic healingDiseases of the Colon and Rectum.  33:175-179. 1990
    1990 Cellular dysfunction in sepsisJournal of Critical Care.  5:62-69. 1990
    1990 Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immunoelectron microscopyJournal of Leukocyte Biology.  48:512-518. 1990
    1990 Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigensImmunology.  70:33-39. 1990
    1990 Enhanced Susceptibility to Sepsis After Simple Hemorrhage: Depression of Fc and C3b Receptor-Mediated PhagocytosisArchives of Surgery -New York-.  125:70-75. 1990
    1990 Hemorrhage and resuscitation: Immunological aspectsAmerican Journal of Physiology.  259. 1990
    1990 Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxinCytokine.  2:170-174. 1990
    1990 Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitationJournal of Surgical Research.  48:464-470. 1990
    1990 Preheparinization improves organ function after hemorrhage and resuscitationAmerican Journal of Physiology.  259. 1990
    1990 Use of ATP following Shock and IschemiaAnnals of the New York Academy of Sciences.  603:130-140. 1990
    1989 ATP-MgCl2 and liver blood flow following shock and ischemia.Progress in clinical and biological research.  299:19-31. 1989
    1989 Measurement of hepatocellular function, cardiac output, effective blood volume, and oxygen saturation in ratsAmerican Journal of Physiology.  257. 1989
    1989 Mechanism of immunosuppression following hemorrhage: Defective antigen presentation by macrophagesJournal of Surgical Research.  46:553-556. 1989
    1988 Effect of Blood Transfusion on Antigen Presentation Function and on Interleukin 2 GenerationArchives of Surgery -New York-.  123:235-240. 1988
    1988 Mechanism of calcium and magnesium translocation in acute pancreatitis: A temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissuesMagnesium.  7:91-102. 1988
    1988 Metabolic Interaction Between Skeletal Muscle and Liver During BacteremiaArchives of Surgery -New York-.  123:1415-1419. 1988
    1988 Prostaglandin E2 depresses antigen-presenting cell function of peritoneal macrophagesJournal of Surgical Research.  44:733-739. 1988
    1988 Use of magnesium-ATP following liver ischemiaMagnesium.  7:68-77. 1988
    1987 Alleviation of cyclosporine nephrotoxicity with verapamil and ATP-MgCl2: Mitochondrial respiratory and calcium studiesAnnals of Surgery.  206:655-660. 1987
    1987 Aterations in hepatic membrane potentials in vivo during early and late sepsisCirculatory shock.  22:1-9. 1987
    1987 Comparison effects of ATP-MgCl2and adenosine-MgCl2on renal function following ischemiaAJP - Regulatory, Integrative and Comparative Physiology.  252. 1987
    1987 Depressed antigen presentation function and membrane interleukin-1 activity of peritoneal macrophages after laparotomySurgery.  102:147-154. 1987
    1987 Hemorrhage Without Tissue Trauma Produces Immunosuppression and Enhances Susceptibility to SepsisArchives of Surgery -New York-.  122:62-68. 1987
    1987 Reperfusion with ATP-MgCl2 following prolonged ischemia improves myocardial performanceJournal of Surgical Research.  43:114-117. 1987
    1987 Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicitySurgery.  101:315-322. 1987
    1986 Reoxygenation injury in isolated hepatocytes: Effect of extracellular ATP on cation homeostasisAJP - Regulatory, Integrative and Comparative Physiology.  250. 1986
    1986 Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidneyBBA - Biomembranes.  862:303-308. 1986
    1986 Depression of Cellular Immunity After Major Injury: Its Association With Posttraumatic Complications and Its Reversal With ImmunomodulationArchives of Surgery -New York-.  121:1000-1005. 1986
    1986 Hepatic ischemia models for determining the effects of ATP-MgCl2 treatmentJournal of Surgical Research.  40:167-175. 1986
    1986 Improved myocardial performance after prolonged ischemia with ATP-MgCl2cardioplegiaSurgical Forum.  37:234-236. 1986
    1986 Salutary effects of ATP-MgCl2 are not dependent on the presence of vanadium or the source of ATP.Circulatory shock.  18:259-261. 1986
    1986 The role of ATP-magnesium in ischemia and shock.Magnesium.  5:211-220. 1986
    1986 Verapamil and ATP-MgCl2prevents cyclosporin-induced nephrotoxocity by improving mitochondrial and tissue Ca2+/Mg2+ratiosSurgical Forum.  37:349-351. 1986
    1985 Effects of regenerating liver cytosol on drug-induced hepatic failureSurgery.  97:455-462. 1985
    1985 Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment.American Journal of Physiology.  248. 1985
    1985 Adenine nucleotides and reversal of post-ischemic mitochondrial dysfunctionFederation proceedings.  44. 1985
    1985 Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic ResonanceArchives of Surgery -New York-.  120:233-240. 1985
    1985 Alleviation of cyclosporine nephrotoxicity with verapamil and adenosine triphosphate-magnesium chloride treatmentSurgical Forum -Chicago-.  VOL. 36:336-338. 1985
    1985 Cellular alterations in shock and ischemia and their correctionPhysiologist.  28:109-118. 1985
    1985 Effect of pyridoxalated stabilized stroma-free hemoglobin solution on the clearance of intravascular lipid by the reticuloendothelial systemCirculatory shock.  16:165-172. 1985
    1985 Effects of heart rate and extracellular calcium on the inotropic effects of ATP and adenosine in isolated rat heartFederation proceedings.  44. 1985
    1985 Hepatic microcirculatory failure after ischemia and reperfusion: Improvement with ATP-MgCl2 treatmentAJP - Heart and Circulatory Physiology.  17. 1985
    1985 Increased coronary flow and myocardial efficiency with systemic infusion of adenosine triphosphate-magnesium chlorideSurgical Forum -Chicago-.  VOL. 36:224-226. 1985
    1985 Phospholipid and adenine nucleotide metabolism in muscle after burn injuryAJP - Regulatory, Integrative and Comparative Physiology.  18. 1985
    1985 Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneysJournal of Surgical Research.  38:429-437. 1985
    1985 Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneysJournal of Surgical Research.  38:438-445. 1985
    1985 Renal handling of exogenous ATP-MgCl2 (ATP)Federation proceedings.  44. 1985
    1985 Restoration of post-ischemic tissue ATP+ADP and tissue and mitochondrial (Mt) magnesium (Mg) by ATP-MgCl2Federation proceedings.  44. 1985
    1984 Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemiaAJP - Regulatory, Integrative and Comparative Physiology.  16. 1984
    1984 A cyclophosphamide-sensitive suppressor T cell circuit induced by thermal injurySurgery.  95:699-706. 1984
    1984 Improved mitochondrial function following ischemia and reflow by ATP-MgCl2.American Journal of Physiology.  246. 1984
    1984 ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemiaJournal of Surgical Research.  37:226-234. 1984
    1984 ATP-MgCl2infusion in man: Increased cardiac output without adverse systemic hemodynamic effectsSurgical Forum -Chicago-.  VOL. 35:14-16. 1984
    1984 Accelerated functional recovery of isolated rat kidney with ATP-MgCl2after warm ischemiaAJP - Regulatory, Integrative and Comparative Physiology.  16. 1984
    1984 Alterations in Hepatic Water and Electrolyte Balance in SepsisArchives of Surgery -New York-.  119:44-48. 1984
    1984 Cellular energetics and ATP-MgCl2 therapy in sepsisAmerican Journal of Emergency Medicine.  2:38-44. 1984
    1984 Dissociation between the early and late effects of ATP- and adenosine-MgCl2 on hepatocellular function following ischemiaFederation proceedings.  43. 1984
    1984 Effect of exogenous ATP-MgCl2on contractility in the isolated rat heartFederation proceedings.  43. 1984
    1984 Hydroxyethylstarch administration does not depress reticuloendothelial function or increase mortality from sepsisCirculatory shock.  13:21-26. 1984
    1984 Hypothyroidism abolishes the hyperdynamic phase and increases susceptibility to sepsisJournal of Surgical Research.  36:265-273. 1984
    1984 Improved Myocardial Recovery From Ischemia: Treatment With Low-Dose Adenosine Triphosphate-Magnesium ChlorideArchives of Surgery -New York-.  119:1379-1384. 1984
    1984 Improved mitochondrial function following ischemia and reflow by ATP-MgCl2AJP - Regulatory, Integrative and Comparative Physiology.  15. 1984
    1984 Improved skin flap survival with adenosine triphosphate-magnesium chlorideSurgical Forum -Chicago-.  VOL. 35:576-578. 1984
    1984 Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsisJournal of Trauma.  24:701-708. 1984
    1984 Nuclear magnetic resonance studies showing the reperfusion injury following ischemia and its improvement with ATP-MgCl2treatmentSurgical Forum -Chicago-.  VOL. 35:17-19. 1984
    1983 Cellular mechanisms in shock and ischemia and their correction.American Journal of Physiology.  245. 1983
    1983 Studies on the mechanism of beneficial effects of ATP-MgCl2 following hepatic ischemia.American Journal of Physiology.  244. 1983
    1983 Adenosine triphosphate uptake by liver - leaky cells or specific transport?Surgical Forum -Chicago-.  VOL. 34:40-42. 1983
    1983 Alterations in electron transport and cellular metabolism with shock and trauma.Progress in clinical and biological research.  111:67-88. 1983
    1983 Beneficial effects of implanted muscle tissue on pulmonary particulate retention and survival following splenectomyJournal of Trauma.  23:584-590. 1983
    1983 Cellular mechanisms in shock and ischemia and their correctionAJP - Regulatory, Integrative and Comparative Physiology.  14. 1983
    1983 Effect of immunopotentiators on Kupffer cell function and DNA synthesis after ischemia and partial hepatectomySurgical Forum -Chicago-.  VOL. 34:105-107. 1983
    1983 Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture modelSurgery.  94:331-335. 1983
    1983 Regulation of glucose production from lactate in experimental sepsisAJP - Regulatory, Integrative and Comparative Physiology.  13. 1983
    1983 Regulation of glucose production from lactate in experimental sepsisAJP - Regulatory, Integrative and Comparative Physiology.  13. 1983
    1983 Studies on the mechanism of beneficial effects of ATP-MgCl2following hepatic ischemiaAJP - Regulatory, Integrative and Comparative Physiology.  13. 1983
    1982 Impairment of reticuloendothelial function following thermal injury and its restoration with ATP-MgCl2 administrationCirculatory shock.  9:297-305. 1982
    1982 Preparation of ATP-MgCl2 and precautions for its use in the study and treatment of shock and ischemia.American Journal of Physiology.  242. 1982
    1982 Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2Kidney International.  22:13-20. 1982
    1982 Altered Hepatocellular Active Transport: An Early Change in PeritonitisArchives of Surgery -New York-.  117:151-157. 1982
    1982 Comparison of the neuromuscular and central effects of 4-amino- and 3,4-diaminopyridineFederation proceedings.  41. 1982
    1982 Does ATP cross the cell plasma membrane?Yale Journal of Biology and Medicine.  55:1-10. 1982
    1982 Editorial Commentary: 'The effect of ATP on survival in intestinal ischemia shock, hemorrhagic shock, and endotoxin shock in rats'Circulatory shock.  9:629-631. 1982
    1982 Hemodynamic effects of ATP-MgCl2infusion in conscious normovolemic (NV) and hypovolemic (HV) dogsFederation proceedings.  41. 1982
    1982 Hemodynamic effects of ATP-MgCl2infusion in conscious normovolemic and hypovolemic primatesCirculatory shock.  9. 1982
    1982 Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capabilityJournal of Trauma.  22:723-729. 1982
    1982 Lysine restores gluconeogenic capability but not α-adrenergic sensitivity in livers from late septic ratsFederation proceedings.  41:7814. 1982
    1982 Preparation of ATP-MgCl2and precautions for its use in the study and treatment of shock and ischemiaAJP - Regulatory, Integrative and Comparative Physiology.  11. 1982
    1982 Restoration of hepatic mitochondrial function following global ischemia by ATP-MgCl2Federation proceedings.  41. 1982
    1982 Restoration of hepatocellular function and blood flow following hepatic ischemia with ATP-MgCl2.Advances in shock research.  8:177-186. 1982
    1981 Hepatocellular dysfunction in early sepsis despite increased hepatic blood flow.Advances in shock research.  6:65-74. 1981
    1981 Oxidative capability of hepatic tissue in late sepsis.Advances in shock research.  6:55-64. 1981
    1981 Alterations in Cell Function With Ischemia and Shock and Their CorrectionArchives of Surgery -New York-.  116:1309-1317. 1981
    1981 Effect of hemorrhagic shock on hepatic transmembrane potentials and intracellular electrolytes, in vivoAJP - Regulatory, Integrative and Comparative Physiology.  9. 1981
    1981 Effect of prolonged starvation on reticuloendothelial function and survival following traumaJournal of Trauma.  21:604-611. 1981
    1981 Effects of ATP-MgCl2on hepatic metabolism and oxygen consumptionPhysiologist.  24. 1981
    1981 Improved renal function using adenosine triphosphate-magnesium chloride in preservation of canine kidneys subjected to warm ischemiaTransplantation.  31:187-189. 1981
    1981 Local effect of thermal injury on skeletal muscle blood flow and nucleotide levelsCirculatory shock.  8:31-40. 1981
    1981 Red blood cell sodium, potassium, and ATP levels during hemorrhagic shockJournal of Surgical Research.  31:225-231. 1981
    1981 Restoration of the depressed immune response after burn injury with low-dose cyclophosphamideSurgical Forum -Chicago-.  Vol. 32:60-61. 1981
    1980 Some clinical adventures and misadventures.Advances in shock research.  3:67-75. 1980
    1980 The use of substrates and energy in the treatment of shock.Advances in shock research.  3:27-46. 1980
    1980 Amelioration of toxic acute renal failure by infusion of ATP-MgCl2Pediatric Research.  14. 1980
    1980 Effect of adenosine tri phosphate-glucose administration following sepsisJournal of Surgical Research.  29:348-356. 1980
    1980 Effect of splenectomy on reticuloendothelial function and survival following sepsisJournal of Trauma.  20:649-656. 1980
    1980 Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in ratsKidney International.  17:338-349. 1980
    1980 Further evidence for ATP uptake by rat tissuesBBA - General Subjects.  628:336-342. 1980
    1980 Improved myocardial performance with infusion of adenosine triphosphate-MgCl2Surgical Forum -Chicago-.  VOL. 31:260-262. 1980
    1980 Inhalation anesthetic-relaxant interactions in vitroAnesthesiology.  53. 1980
    1980 Is there a positive muscarinic feedback mechanism for acetylcholine release at the neuromuscular junction?Pharmacologist -Washington-.  22. 1980
    1980 Prevention of multiple systems failureSurgical Clinics of North America.  60:1167-1178. 1980
    1980 Sepsis and septic shock—A review of laboratory models and a proposalJournal of Surgical Research.  29:189-201. 1980
    1979 Impairment of reticuloendothelial system function with sepsis and its improvement with ATP-MgCl2 plus glucose administration.Advances in shock research.  2:153-162. 1979
    1979 Dose response and cardiovascular effects of ATP-MgCl2administration in intact dogsFederation proceedings.  38. 1979
    1979 Effect of sepsis on tissue adenine nucleotide levelsSurgery.  85:205-211. 1979
    1979 Prostaglandin metabolism, synthesis, and blockade in hemorrhage and sepsisSurgical Forum -Chicago-.  Vol. 30:476-477. 1979
    1979 Studies of Peripheral Glucose Uptake During SepsisArchives of Surgery -New York-.  114:740-745. 1979
    1978 Improved hepatic function and survival with adenosine triphosphate magnesium chloride after hepatic ischemiaSurgery.  83:655-662. 1978
    1978 The use of adenosine triphosphate with magnesium chloride in the treatment of post ischemic renal injury.Transactions of the American Association of Genito-Urinary Surgeons.  70:145-148. 1978
    1978 Beneficial effect of ATP-MgCl2-glucose administration on survival following sepsisSurgical Forum -Chicago-.  Vol 29:11-14. 1978
    1978 Effect of insulin on glucose uptake in muscle during sepsisFederation proceedings.  37. 1978
    1978 Enhanced recovery from severe ischemic renal injury with adenosine triphosphate-magnesium chloride: Administration after the insultSurgical Forum -Chicago-.  Vol 29:82-84. 1978
    1978 Glucocorticoid effects on gluconeogenesis during hemorrhagic shockJournal of Surgical Research.  24:26-34. 1978
    1978 Impairment of reticuloendothelial system (RES) function with sepsis and its improvement with ATP-MgCl2and glucose administrationCirculatory shock.  5. 1978
    1978 Interaction of muscle relaxants and local anesthetics at the neuromuscular junctionAnesthesia and Analgesia.  57:580-587. 1978
    1977 Depletion and replenishment of cellular cyclic adenosine monophosphate in hemorrhagic shockSurgery, gynecology & obstetrics.  145:877-881. 1977
    1977 Accelerated recovery of acute renal failure by infusion of adenine nucleotides - MgCl2Kidney International.  12:534. 1977
    1977 Amelioration of acute renal failure with ATP MgCl2 infusionPediatric Research.  11:1117. 1977
    1977 Evidence for enhanced uptake of ATP by liver and kidney in hemorrhagic shockAJP - Regulatory, Integrative and Comparative Physiology.  2:83-88. 1977
    1977 Evidence for enhanced uptake of ATP by liver and kidney in hemorrhagic shockAJP - Regulatory, Integrative and Comparative Physiology.  2:83-88. 1977
    1977 Postischemic Renal Failure: Accelerated Recovery With Adenosine Triphosphate-Magnesium Chloride InfusionArchives of Surgery -New York-.  112:729-731. 1977
    1977 Restoration of cellular adenosine 3'-5'-monophosphate levels by ATP-MgCl2in hemorrhagic shockFederation proceedings.  36. 1977
    1976 Alterations in adenosine 3',5' monophosphate levels in hemorrhagic shockSurgical Forum -Chicago-.  Vol.27:51-53. 1976
    1976 Alterations in high-energy phosphates in hemorrhagic shock as related to tissue and organ functionSurgery.  79:666-668. 1976
    1976 Differences in the altered energy metabolism of hemorrhagic shock and hypoxemiaCanadian Journal of Physiology and Pharmacology.  54:750-756. 1976
    1976 Effect of glucocorticoids on gluconeogenesis during hemorhagic shockFederation proceedings.  35. 1976
    1976 Failure of nicotinamide in the treatment of hemorrhagic shockJournal of Surgical Research.  21:27-32. 1976
    1976 Insulin resistance and its reversal by in vivo infusion of ATP in hemorrhagic shockCanadian Journal of Physiology and Pharmacology.  54:736-741. 1976
    1976 The effects of atherosclerosis on the hypertrophied rabbit heartExperimental and Molecular Pathology.  25:293-300. 1976
    1976 Uptake of ATP by liver and kidney in vitroCanadian Journal of Physiology and Pharmacology.  54:742-749. 1976
    1975 Characteristics of sodium and potassium transport in the lungAmerican Journal of Physiology.  229:1073-1079. 1975
    1975 Effect of hydrocortisone and dexamethasone on xylose uptake by isolated rat soleus muscleBBA - General Subjects.  399:85-89. 1975
    1975 Degradation of adenine nucleotides by the soleus muscle in hemorrhagic shockSurgery.  77:180-185. 1975
    1975 Enhanced uptake of14C ATP by liver and kidney of animals in shockFederation proceedings.  34. 1975
    1975 Evidence for enhanced uptake of adenosme triphosphate by muscle of animals in shockSurgery.  77:833-840. 1975
    1975 Na+-K+ transport and adenosine nucleotides in the lung in hemorrhagic shockSurgery.  77:395-402. 1975
    1975 Relationship between nicotinamide adenine dinucleotide and survival in hemorrhagic shockPhysiologist.  18:165. 1975
    1975 Reversal of insulin resistance by ATP in hemorrhagic shockCanadian Journal of Physiology and Pharmacology.  53:859-865. 1975
    1975 Reversal of insulin resistance by in vivo infusion of ATP in experimental shockSurgical Forum -Chicago-.  Vol. 26:44-46. 1975
    1975 The effect of insulin on glucose uptake in soleus muscle during hemorrhagic shockCanadian Journal of Physiology and Pharmacology.  53:67-73. 1975
    1974 Active sodium potassium transport and ATP levels in lung and liver during shockSurgical Forum -Chicago-.  VOL. 25:5-7. 1974
    1974 Cation transport in the liver in hemorrhagic shockCIRC.SHOCK.  1:195-207. 1974
    1974 Cellular alterations with shock and ischemiaAngiology.  25:31-42. 1974
    1974 Depletion and Restoration of Tissue ATP in Hemorrhagic ShockArchives of Surgery -New York-.  108:208-211. 1974
    1974 Distribution of High-Energy Phosphates in the HeartProceedings of the Society for Experimental Biology and Medicine.  145:1382-1385. 1974
    1974 Effect of adenosine triphosphate-magnesium chloride administration in shockSurgery.  75:220-227. 1974
    1974 Effect of hemorrhagic shock on tissue adenine nucleotides in conscious ratsCanadian Journal of Physiology and Pharmacology.  52:131-137. 1974
    1974 Insulin Resistance in Experimental ShockArchives of Surgery -New York-.  109:412-415. 1974
    1974 Protein synthesis by rat liver slices in hemorrhagic shockFederation proceedings.  33:645. 1974
    1973 ATP depletion and replenishment in hemorrhagic shock.Surgical Forum -Chicago-.  24:77-79. 1973
    1973 Impairment of cell membrane transport during shock and after treatmentAnnals of Surgery.  178:412-422. 1973
    1973 The Effect of Low ATP on Glucose Uptake in Soleus Muscle During Hemorrhagic ShockProceedings of the Society for Experimental Biology and Medicine.  144:321-325. 1973
    1973 The effect of insulin and low ATP on glucose uptake in muscle during shockFederation proceedings.  32:869. 1973
    1972 Alterations in adenosine nucleotides in hemorrhagic shockSurgical Forum -Chicago-.  Vol. 23:1-3. 1972
    1972 Insulin: an allosteric modifier of the sugar carrier mechanismPakistan Journal of Biochemistry.  5:44-48. 1972
    1970 The action of insulin on glucose uptake by isolated rat soleus muscle I. Effects of cationsBBA - General Subjects.  215:249-257. 1970
    1970 The action of insulin on glucose uptake by isolated rat soleus muscle II. Dissociation of a priming effect of insulin from its stimulatory effectBBA - General Subjects.  215:258-263. 1970
    1970 Effect of externally added ATP on glucose uptake by isolated rat soleus muscleBBA - Biomembranes.  196:327-335. 1970
    1970 Evidence for the uptake of ATP by rat soleus muscle in vitroBBA - Biomembranes.  196:320-326. 1970
    1969 Kinetics of glucose uptake in isolated soleus muscleBBA - General Subjects.  177:527-536. 1969

    Chapter

    Year Title Altmetric
    2016 The Use of Estrogen for the Treatment of Traumatic Brain Injury.  161-177. 2016
    2015 Sex differences in sepsis following trauma and injury.  255-271. 2015
    2012 Metabolic and inflammatory responses to trauma and infection 2012
    2009 Experimental Models of Sepsis and Non-Infectious SIRS.  373-389. 2009
    2007 Insight into the mechanism of gender-specific response to trauma-hemorrhage.  869-879. 2007
    2007 Trauma-hemorrhage and its effects on the endothelium.  1513-1522. 2007
    2006 Gender dimorphism and the use of sex steroid/receptor antagonist after trauma.  101-121. 2006
    2004 Ischemia and Reperfusion Injury.  73-84. 2004
    2003 The immune/inflammatory system.  377-390. 2003

    Research Overview

  • trauma, hemorrhage, sepsis, gender dimorphism, immune functions, cardiovascular functions
  • Principal Investigator On

  • Increasing Survival Rate Following Hemorrhagic Shock and Traumatic Brain Injury in Austere Environments  awarded by THE MIND RESEARCH NETWORK 2018 - 2020
  • Part B - Surviving Blood Loss: First in Human Studies to Assess Safety and Physiological Effects of Synthetic Ethinyl Estradiol-3-Sulfate (EE·3·SO4) in Healthy Subjects, Both Euvolemic and Following 10-20% Iatrogenic Blood Loss  awarded by DOD - Department of Defense 2015 - 2018
  • Treatment of Traumatic Brain Injury (TBI) with Hormonal and Pharmacological Support--Preclinical Validation Using Diffuse and Mechanical TBI Animal Models  awarded by DOD - ARMY MEDICAL RESEARCH AND MATERIAL COMMAND 2008 - 2016
  • Maintenance of Organ Function Following Injury  awarded by National Institute of General Medical Sciences/NIH/DHHS 2009 - 2014
  • Development of a Controlled Hemorrhage Model in Mature, Miniature Pigs for Multi-Center Applications and Trial of Novel Field Expedient Treatment  awarded by Texas A&M University 2012 - 2013
  • Immunological Aspects of Hemorrhage  awarded by National Institute of General Medical Sciences/NIH/DHHS 2007 - 2013
  • Evaluation of Premarin in a Rat Model of Mild and Severe Hemorrhage  awarded by Defense Advanced Research Projects Agency 2010 - 2012
  • Trauma and Inflammation Research Training  awarded by National Institute of General Medical Sciences/NIH/DHHS 2006 - 2012
  • Role of Zinc in Estrogen-Mediated Salutary Effects on Cardiovascular Functions Following Trauma-Hemorrhage  awarded by American Heart Association (Southeast Affiliate) 2009 - 2011
  • Private Grant  awarded by AKEBIA THERAPEUTICS, INC. 2010 - 2011
  • Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, 1969
  • Full Name

  • Irshad Chaudry