Selected Publications

Academic Article

Year Title Altmetric
2018 Glycosyltransferase mediated biofilm matrix dynamics and virulence of Streptococcus mutans.Applied and Environmental Microbiology2018
2018 Inhibition of Streptococcus mutans Biofilms by the Natural Stilbene Piceatannol Through the Inhibition of Glucosyltransferases.ACS Omega.  3:8378-8385. 2018
2018 Glucan Binding Protein C of Streptococcus mutans Mediates both Sucrose-Independent and Sucrose-Dependent Adherence.Infection and Immunity.  86. 2018
2018 Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans.Oral Microbiology and Immunology.  33:283-291. 2018
2018 AKT-independent activation of p38 MAP kinase promotes vascular calcification.Redox Biology.  16:97-103. 2018
2018 Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2.Infection and Immunity.  86. 2018
2018 Correction: "Activation of the innate immune system by Treponema denticola periplasmic flagella through Toll-like receptor 2" [Infection and Immunity, 86, 1, e00573-17, (2018)] doi: 10.1128/IAI.00573-17Infection and Immunity.  86. 2018
2017 Dietary potassium regulates vascular calcification and arterial stiffness.JCI insight.  2. 2017
2017 Deficiency of RgpG Causes Major Defects in Cell Division and Biofilm Formation, and Deficiency of LytR-CpsA-Psr Family Proteins Leads to Accumulation of Cell Wall Antigens in Culture Medium by Streptococcus mutans.Applied and Environmental Microbiology.  83. 2017
2017 Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence.Scientific Reports.  7:5974. 2017
2017 Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome.Journal of Dental Research.  96:807-814. 2017
2017 A commensal streptococcus hijacks a Pseudomonas aeruginosa exopolysaccharide to promote biofilm formation.PLoS Pathogens.  13:e1006300. 2017
2017 Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.Trends in Microbiology.  26:229-242. 2017
2016 Engineering and Dissecting the Glycosylation Pathway of a Streptococcal Serine-rich Repeat Adhesin.Journal of Biological Chemistry.  291:27354-27363. 2016
2016 Streptococcus mutans copper chaperone, CopZ, is critical for biofilm formation and competitiveness.Oral Microbiology and Immunology.  31:515-525. 2016
2016 Effects of diadenylate cyclase deficiency on synthesis of extracellular polysaccharide matrix of Streptococcus mutans revisit.Environmental Microbiology.  18:3612-3619. 2016
2016 Fine-tuned production of hydrogen peroxide promotes biofilm formation of Streptococcus parasanguinis by a pathogenic cohabitant Aggregatibacter actinomycetemcomitans.Environmental Microbiology.  18:4023-4036. 2016
2016 New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein.Journal of Biological Chemistry.  291:22106-22117. 2016
2016 A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property.Scientific Reports.  6:30966. 2016
2016 Cyclic di-AMP mediates biofilm formation.Microbiological sciences.  99:945-959. 2016
2016 Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis.Microbiology.  162:376-383. 2016
2016 Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein.EMBO Reports.  17:235-248. 2016
2016 Biomimetic microenvironments for regenerative endodontics.Biomaterials Research.  20:14. 2016
2016 Hydroxychalcone inhibitors of Streptococcus mutans glucosyl transferases and biofilms as potential anticaries agents.Bioorganic and Medicinal Chemistry Letters.  26:3508-3513. 2016
2016 Insights into bacterial protein glycosylation in human microbiota.Science China Life Sciences.  59:11-18. 2016
2016 TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling.Frontiers in Bioscience.  21:397-409. 2016
2015 Evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on Enterococcus faecalis and Treponema denticola.Biomaterials Research.  19:9. 2015
2015 A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivo.The Journal of applied bacteriology.  119:1403-1411. 2015
2015 New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans.International Journal of Antimicrobial Agents.  46:174-182. 2015
2015 Tribute.Oral Microbiology and Immunology.  30:253-254. 2015
2015 Kanamycin Resistance Cassette for Genetic Manipulation of Treponema denticola.Applied and Environmental Microbiology.  81:4329-4338. 2015
2015 Glycosyltransferase-mediated Sweet Modification in Oral Streptococci.Journal of Dental Research.  94:659-665. 2015
2015 NMR assignment of the amylase-binding protein A from Streptococcus parasanguinis.Biomolecular NMR Assignments.  9:173-175. 2015
2015 A conserved domain is crucial for acceptor substrate binding in a family of glucosyltransferases.Journal of Bacteriology.  197:510-517. 2015
2015 Inhibition of FOXO1/3 promotes vascular calcification.Arteriosclerosis, Thrombosis, and Vascular Biology.  35:175-183. 2015
2015 Oral streptococci and nitrite-mediated interference of Pseudomonas aeruginosa.Infection and Immunity.  83:101-107. 2015
2014 Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors.Oral Microbiology and Immunology.  29:185-193. 2014
2014 Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins.Journal of Biological Chemistry.  289:20898-20907. 2014
2014 The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold.Nature Communications.  5:4339. 2014
2014 Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus.Circulation Research.  114:1094-1102. 2014
2013 Gap2 promotes the formation of a stable protein complex required for mature Fap1 biogenesis.Journal of Bacteriology.  195:2166-2176. 2013
2013 Preliminary X-ray crystallographic studies of an N-terminal domain of unknown function from a putative glycosyltransferase from Streptococcus parasanguinis.Acta Crystallographica Section F: Structural Biology and Crystallization Communications.  69:520-523. 2013
2013 Structural and biochemical analysis of a bacterial glycosyltransferase.Methods in Molecular Biology.  1022:29-39. 2013
2012 Serum response factor regulates bone formation via IGF-1 and Runx2 signals.Journal of Bone and Mineral Research.  27:1659-1668. 2012
2012 Gap1 functions as a molecular chaperone to stabilize its interactive partner Gap3 during biogenesis of serine-rich repeat bacterial adhesin.Microbiological sciences.  83:866-878. 2012
2012 Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation.Biochemical and Biophysical Research Communications.  417:421-426. 2012
2011 Canonical SecA associates with an accessory secretory protein complex involved in biogenesis of a streptococcal serine-rich repeat glycoprotein.Journal of Bacteriology.  193:6560-6566. 2011
2011 A molecular chaperone mediates a two-protein enzyme complex and glycosylation of serine-rich streptococcal adhesins.Journal of Biological Chemistry.  286:34923-34931. 2011
2011 New cell surface protein involved in biofilm formation by Streptococcus parasanguinis.Infection and Immunity.  79:3239-3248. 2011
2011 Structural and functional analysis of a new subfamily of glycosyltransferases required for glycosylation of serine-rich streptococcal adhesins.Journal of Biological Chemistry.  286:27048-27057. 2011
2011 Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK).Journal of Biological Chemistry.  286:24776-24784. 2011
2011 A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms.Antimicrobial Agents and Chemotherapy.  55:2679-2687. 2011
2010 Purification and characterization of an active N-acetylglucosaminyltransferase enzyme complex from Streptococci.Applied and Environmental Microbiology.  76:7966-7971. 2010
2010 RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.Journal of Biological Chemistry.  285:36315-36321. 2010
2010 Structural insights into serine-rich fimbriae from Gram-positive bacteria.Journal of Biological Chemistry.  285:32446-32457. 2010
2010 A novel glucosyltransferase is required for glycosylation of a serine-rich adhesin and biofilm formation by Streptococcus parasanguinis.Journal of Biological Chemistry.  285:12140-12148. 2010
2009 Study on Fapl glycosylation and maturation regulating by ORF3 coded by fap1-orf4 gene locus of Streptococcus parasanguisZhonghua Wei Sheng Wu Xue, He Mian Yi Xue Za Zhi ==.  29:460-465. 2009
2009 Comprehensive evaluation of Streptococcus sanguinis cell wall-anchored proteins in early infective endocarditis.Infection and Immunity.  77:4966-4975. 2009
2009 Glycosylation and biogenesis of a family of serine-rich bacterial adhesinsMicrobiology.  155:317-327. 2009
2008 A conserved C-terminal 13-amino-acid motif of Gap1 is required for Gap1 function and necessary for the biogenesis of a serine-rich glycoprotein of Streptococcus parasanguinis.Infection and Immunity.  76:5624-5631. 2008
2008 A conserved domain of previously unknown function in Gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesin.Microbiological sciences.  70:1094-1104. 2008
2008 Study on function and interaction of GTF and ORF4 coded by fap1-orf4 gene locus of Streptococcus parasanguisZhonghua Wei Sheng Wu Xue, He Mian Yi Xue Za Zhi ==.  28:771-776. 2008
2008 Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.Journal of Biological Chemistry.  283:29593-29601. 2008
2008 Identification of critical residues in Gap3 of Streptococcus parasanguinis involved in Fap1 glycosylation, fimbrial formation and in vitro adhesion.BMC Microbiology.  8:52. 2008
2008 The utility of affinity-tags for detection of a streptococcal protein from a variety of streptococcal species.Journal of Microbiological Methods.  72:249-256. 2008
2008 Interaction between two putative glycosyltransferases is required for glycosylation of a serine-rich streptococcal adhesin.Journal of Bacteriology.  190:1256-1266. 2008
2008 Role of gap3 in Fap1 glycosylation, stability, in vitro adhesion, and fimbrial and biofilm formation of Streptococcus parasanguinis.Oral Microbiology and Immunology.  23:70-78. 2008
2007 Differential roles of individual domains in selection of secretion route of a Streptococcus parasanguinis serine-rich adhesin, Fap1.Journal of Bacteriology.  189:7610-7617. 2007
2007 The glycan moieties and the N-terminal polypeptide backbone of a fimbria-associated adhesin, Fap1, play distinct roles in the biofilm development of Streptococcus parasanguinis.Infection and Immunity.  75:2181-2188. 2007
2007 Two gene determinants are differentially involved in the biogenesis of Fap1 precursors in Streptococcus parasanguis.Journal of Bacteriology.  189:1390-1398. 2007
2006 SecA2 is distinct from SecA in immunogenic specificity, subcellular distribution and requirement for membrane anchoring in Streptococcus parasanguis.FEMS Microbiology Letters.  264:174-181. 2006
2006 Inactivation of DNA adenine methyltransferase alters virulence factors in Actinobacillus actinomycetemcomitans.Oral Microbiology and Immunology.  21:238-244. 2006
2005 A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb.British Journal of Haematology.  129:101-109. 2005
2004 Investigating the role of secA2 in secretion and glycosylation of a fimbrial adhesin in Streptococcus parasanguis FW213.Microbiological sciences.  53:843-856. 2004
2002 Construction of a novel transposon mutagenesis system useful in the isolation of Streptococcus parasanguis mutants defective in Fap1 glycosylation.Infection and Immunity.  70:6534-6540. 2002
2002 Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus actinomycetemcomitans.Microbiology.  148:3695-3703. 2002
2002 The Fap1 fimbrial adhesin is a glycoprotein: antibodies specific for the glycan moiety block the adhesion of Streptococcus parasanguis in an in vitro tooth model.Microbiological sciences.  43:147-157. 2002
2001 Molecular strategies for fimbrial expression and assembly.Journal of Dental Research.  12:101-115. 2001
1999 Identification of dipeptide repeats and a cell wall sorting signal in the fimbriae-associated adhesin, Fap1, of Streptococcus parasanguis.Microbiological sciences.  34:1070-1081. 1999
1998 Isolation and characterization of Fap1, a fimbriae-associated adhesin of Streptococcus parasanguis FW213.Microbiological sciences.  28:487-500. 1998

Principal Investigator On

  • Small Molecule Inhibitors of Carciogenic Biofilms  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2023
  • Glycosylation and Biogenesis of Streptococcal Adhesins  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2023
  • Dental Academic Research Training Program (DART)  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2022
  • Dental Academic Research Training Program (DART)  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2022
  • BrpA in Virulence Modulation of Streptococcus Mutans  awarded by Louisiana State University 2015 - 2020
  • Determination of the Role of Smu.833 in the Fitness and Virulence of Cariogenic Streptococcus Mutans  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2015 - 2019
  • Small Molecule Inhibitors of Cariogenic Biofilms  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2018
  • Glycosylation and Function of an Oral Streptococcal Adhesion  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2018
  • Amylase Binding and Gene Expression is Streptococcus Gordonii  awarded by UNIVERSITY OF BUFFALO (STATE UNIVERSITY OF NEW YORK) 2012 - 2017
  • Construction of Prokaryotic Expression Clone for Human Amelogenin and Biomimetic Mineralization Ex Vivo  awarded by SICHUAN MEDICAL SCIENCE ACADEMY AND SICHUAN PROVINCIAL PEOPLE'S HOSPITAL 2016 - 2017
  • Dispersion of Streptococcus Mutans Biofilms by a Novel Small Molecule  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2013 - 2016
  • Amylase Binding Streptococci, Dental Plaque and Caries  awarded by UNIVERSITY OF BUFFALO (STATE UNIVERSITY OF NEW YORK) 2011 - 2016
  • Biosynthesis and Function of Treponema Denticola Lipooligosaccharide  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2015
  • Development of Small Molecules That Inhibit and Disperse Carciogenic Biofilms  awarded by International Association for Dental Research 2011 - 2014
  • Private Grant  awarded by MICROBIOTIX, INC. 2012 - 2014
  • A Novel Glycosylation - Associated Protein is Required for Fimbriae Biogenesis  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2014
  • Glycosylation & Function of an Oral Streptococcal Adhesin  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2012
  • Genetic Analysis-Adhesion of S Sanguis to S Pellicle  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2011
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, University of Vermont
  • Full Name

  • Hui Wu
  • Blazerid

  • hwu