Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 The Ldb1 transcriptional co-regulator is required for establishment and maintenance of the pancreatic endocrine lineage 2022
2022 Islet transplantation into brown adipose tissue can delay immune rejection.  JCI Insight.  7. 2022
2022 LDB1-mediated transcriptional complexes are sensitive to islet stress.  Islets.  14:58-68. 2022
2021 The transcriptional co-regulator LDB1 is required for brown adipose function.  Molecular Metabolism.  53. 2021
2021 Xenotransplantation of tannic acid-encapsulated neonatal porcine islets decreases proinflammatory innate immune responses.  Xenotransplantation.  28. 2021
2021 Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis.  Frontiers in Immunology.  12. 2021
2021 Glucagon receptor signaling regulates weight loss via central KLB receptor complexes.  JCI Insight.  6. 2021
2020 Glucagon-receptor signaling reverses hepatic steatosis independent of leptin receptor expression 2020
2019 LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet-cell function.  Journal of Biological Chemistry.  294:11728-11740. 2019
2019 The islet-expressed Lhx1 transcription factor interacts with islet-1 and contributes to glucose homeostasis 2019
2019 Prolactin receptor signaling regulates a pregnancy-specific transcriptional program in mouse islets 2019
2017 Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking.  Clinical materials.  128:19-32. 2017
2017 LDB1 regulates energy homeostasis during diet-induced obesity 2017
2017 Evidence for loss in identity, de-differentiation, and trans-differentiation of islet β-cells in type 2 diabetes.  Frontiers in Genetics.  8. 2017
2017 LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.  Journal of Clinical Investigation.  127:215-229. 2017
2015 SSBP3 interacts with islet-1 and ldb1 to impact pancreatic β-cell target genes 2015
2015 Minireview: Directed differentiation and encapsulation of Islet β-cells—Recent advances and future considerations 2015
2015 The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.  Diabetologia.  58:1836-1844. 2015
2015 Transcriptional activity of the islet β cell factor Pdx1 Is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.  Journal of Biological Chemistry.  290:9812-9822. 2015
2014 Islet-1 is essential for pancreatic β-cell function.  Diabetes.  63:4206-4217. 2014
2014 Revealing transcription factors during human pancreatic β cell development.  Trends in Endocrinology and Metabolism.  25:407-414. 2014
2013 LHX3 Interacts with Inhibitor of Histone Acetyltransferase Complex Subunits LANP and TAF-1β to Modulate Pituitary Gene Regulation.  PLoS One.  8. 2013
2013 Islet a-, b-, and d-Cell development is controlled by the ldb1 coregulator, acting primarily with the islet-1 transcription factor.  Diabetes.  62:875-886. 2013
2013 Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdxl genes.  Journal of Biological Chemistry.  288:3795-3803. 2013
2011 Islet-1 regulates Arx transcription during pancreatic islet α-cell development.  Journal of Biological Chemistry.  286:15352-15360. 2011
2011 Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression 2011
2010 Islet β-cell-specific MafA transcription requires the 5′-Flanking conserved region 3 control domain.  Molecular and Cellular Biology.  30:4234-4244. 2010
2009 Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.  Diabetes.  58:2059-2069. 2009
2008 Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies.  Journal of Clinical Endocrinology and Metabolism.  93:1062-1071. 2008
2007 Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes.  Gene.  400:44-51. 2007
2007 Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.  Molecular and Cellular Endocrinology.  265-266:190-195. 2007
2007 Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.  Journal of Clinical Endocrinology and Metabolism.  92:1909-1919. 2007
2005 LIM-homeodomain genes in mammalian development and human disease 2005
2005 DNA recognition properties of the LHX3b LIM homeodomain transcription factor 2005
2004 Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.  Gene.  336:263-273. 2004

Research Overview

  • Transcriptional control of pancreatic beta cell development and adult islet cell function - My lab is interested in understanding how transcription factors and transcriptional coregulators control decisions governing pancreatic beta-cell development and postnatal cell function. These topics are critical for developing future cell-based diabetes therapies. I utilize in vitro molecular biology/biochemical approaches and in vivo Cre/LoxP knockout strategies to determine the function of pancreatic islet-enriched factors. Specifically, I am interested in the pan-endocrine LIM-Homeodomain class Islet1 (Isl1) transcription factor and an interacting coregulator, Ldb1. These factors are required for beta- and alpha-cell development and postnatal function. However, little is known of target genes or additional binding factors comprising a transcriptional complex. Furthermore, Ldb1 appears to have Isl1-independent function in early pancreas progenitor cells. Thus, I am interested in determining roles for this coregulator in this context.

    Keywords - Diabetes, Transcription Factor, Coregulators, Gene Regulation, Organogenesis, Pancreas, Chromatin, Developmental Biology, Endocrinology

    • Principal Investigator On

    Investigator On

    Education And Training

    Full Name

  • Chad Hunter