Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 The islet-expressed Lhx1 transcription factor interacts with islet-1 and contributes to glucose homeostasisAJP - Endocrinology and Metabolism.  316:E397-E409. 2019
2019 LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet-cell functionJournal of Biological Chemistry.  294:11728-11740. 2019
2019 Prolactin receptor signaling regulates a pregnancy-specific transcriptional program in mouse isletsEndocrinology.  160:1150-1163. 2019
2017 Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell traffickingBiomaterials.  128:19-32. 2017
2017 LDB1 regulates energy homeostasis during diet-induced obesityEndocrinology.  158:1289-1297. 2017
2017 Evidence for loss in identity, de-differentiation, and trans-differentiation of islet β-cells in type 2 diabetesFrontiers in Genetics.  8. 2017
2017 LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cellsJournal of Clinical Investigation.  127:215-229. 2017
2015 SSBP3 interacts with islet-1 and ldb1 to impact pancreatic β-cell target genesMolecular Endocrinology -Baltimore-.  29:1774-1786. 2015
2015 The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in miceDiabetologia.  58:1836-1844. 2015
2015 Transcriptional activity of the islet β cell factor Pdx1 Is augmented by lysine methylation catalyzed by the methyltransferase Set7/9Journal of Biological Chemistry.  290:9812-9822. 2015
2015 Minireview: Directed differentiation and encapsulation of Islet β-cells—Recent advances and future considerationsMolecular Endocrinology -Baltimore-.  29:1388-1399. 2015
2014 Islet-1 is essential for pancreatic β-cell functionDiabetes.  63:4206-4217. 2014
2014 Revealing transcription factors during human pancreatic β cell developmentTrends in Endocrinology and Metabolism.  25:407-414. 2014
2013 LHX3 Interacts with Inhibitor of Histone Acetyltransferase Complex Subunits LANP and TAF-1β to Modulate Pituitary Gene RegulationPLoS ONE.  8. 2013
2013 Islet a-, b-, and d-Cell development is controlled by the ldb1 coregulator, acting primarily with the islet-1 transcription factorDiabetes.  62:875-886. 2013
2013 Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdxl genesJournal of Biological Chemistry.  288:3795-3803. 2013
2011 Islet-1 regulates Arx transcription during pancreatic islet α-cell developmentJournal of Biological Chemistry.  286:15352-15360. 2011
2011 Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expressionMolecular Endocrinology -Baltimore-.  25:339-347. 2011
2010 Islet β-cell-specific MafA transcription requires the 5′-Flanking conserved region 3 control domainMolecular and Cellular Biology.  30:4234-4244. 2010
2009 Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreasDiabetes.  58:2059-2069. 2009
2008 Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficienciesJournal of Clinical Endocrinology and Metabolism.  93:1062-1071. 2008
2007 Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary developmentMolecular and Cellular Endocrinology.  265-266:190-195. 2007
2007 Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotationJournal of Clinical Endocrinology and Metabolism.  92:1909-1919. 2007
2005 LIM-homeodomain genes in mammalian development and human diseaseMolecular Biology Reports.  32:67-77. 2005
2005 DNA recognition properties of the LHX3b LIM homeodomain transcription factorMolecular Biology Reports.  32:1-6. 2005
2004 Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor proteinGene.  336:263-273. 2004

Research Overview

  • Transcriptional control of pancreatic beta cell development and adult islet cell function - My lab is interested in understanding how transcription factors and transcriptional coregulators control decisions governing pancreatic beta-cell development and postnatal cell function. These topics are critical for developing future cell-based diabetes therapies. I utilize in vitro molecular biology/biochemical approaches and in vivo Cre/LoxP knockout strategies to determine the function of pancreatic islet-enriched factors. Specifically, I am interested in the pan-endocrine LIM-Homeodomain class Islet1 (Isl1) transcription factor and an interacting coregulator, Ldb1. These factors are required for beta- and alpha-cell development and postnatal function. However, little is known of target genes or additional binding factors comprising a transcriptional complex. Furthermore, Ldb1 appears to have Isl1-independent function in early pancreas progenitor cells. Thus, I am interested in determining roles for this coregulator in this context.

    Keywords - Diabetes, Transcription Factor, Coregulators, Gene Regulation, Organogenesis, Pancreas, Chromatin, Developmental Biology, Endocrinology
  • Education And Training

    Full Name

  • Chad Hunter