Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes.Diabetes.  71:2793-2803. 2022
2022 Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes AutoimmunityDiabetes.  71:1979-1993. 2022
2022 Islet transplantation into brown adipose tissue can delay immune rejectionJCI insight.  7. 2022
2021 Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizerActa Biomaterialia.  136:558-569. 2021
2021 P.162: Enhancing Islet Allotransplantation With Antioxidant-based Encapsulation StrategiesTransplantation.  105:S69. 2021
2021 The role of NADPH oxidases in infectious and inflammatory diseasesRedox Biology.  48. 2021
2021 Proinsulin to C-Peptide Ratio in the First Year after Diagnosis of Type 1 DiabetesJournal of Clinical Endocrinology and Metabolism.  106:E4318-E4326. 2021
2021 Xenotransplantation of tannic acid-encapsulated neonatal porcine islets decreases proinflammatory innate immune responsesXenotransplantation.  28. 2021
2021 Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes PathogenesisFrontiers in Immunology.  12. 2021
2021 Targeting Mitochondrial-Derived Reactive Oxygen Species in T Cell-Mediated Autoimmune DiseasesFrontiers in Immunology.  12. 2021
2021 Auranofin-mediated nrf2 induction attenuates interleukin 1 beta expression in alveolar macrophagesAntioxidants.  10. 2021
2021 ICOS ligand and IL-10 synergize to promote host–microbiota mutualismProceedings of the National Academy of Sciences of USA.  118. 2021
2021 The Importance of Proper Oxygenation in 3D CultureFrontiers in Bioengineering and Biotechnology.  9. 2021
2020 A small molecule, UAB126, reverses diet-induced obesity and its associated metabolic disordersDiabetes.  69:2003-2016. 2020
2020 Dampening Antigen-Specific T Cell Responses with Antigens Encapsulated in Polyphenolic Microcapsules 2020
2020 Localized immunosuppression with tannic acid encapsulation delays islet allograft and autoimmune-mediated rejectionDiabetes.  69:1948-1960. 2020
2020 Innate viral sensor MDA5 and coxsackievirus interplay in type 1 diabetes developmentMicroorganisms.  8:1-23. 2020
2019 Serum mir-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell lossAmerican Journal of Physiology: Endocrinology and Metabolism.  317:E723-E730. 2019
2019 LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet-cell functionJournal of Biological Chemistry.  294:11728-11740. 2019
2019 Effect of gamma aminobutyric acid (GABA) or GABA with glutamic acid decarboxylase (GAD) on the progression of type 1 diabetes mellitus in children: Trial design and methodologyContemporary Clinical Trials.  82:93-100. 2019
2019 Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4 + T CellsCell Reports.  27:129-141.e4. 2019
2019 Editorial: Fresh ideas, foundational experiments: Immunology and diabetesFrontiers in Endocrinology.  10. 2019
2018 Redox-Sensitive Innate Immune Pathways during Macrophage Activation in Type 1 DiabetesAntioxidants and Redox Signaling.  29:1373-1398. 2018
2018 Sex differences underlying pancreatic islet biology and its dysfunctionMolecular Metabolism.  15:82-91. 2018
2018 The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetesFree Radical Biology and Medicine.  125:81-89. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intoleranceMolecular Metabolism.  12:48-61. 2018
2018 Redox-dependent inflammation in islet transplantation rejectionFrontiers in Endocrinology.  9. 2018
2018 Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) ScavengersChemistry of Materials.  30:344-357. 2018
2018 Superoxide production by NADPH oxidase intensifies macrophage antiviral responses during diabetogenic coxsackievirus infectionJournal of Immunology.  200:61-70. 2018
2017 Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell traffickingBiomaterials.  128:19-32. 2017
2016 Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β Group VIA phospholipase a2Journal of Biological Chemistry.  291:23268-23281. 2016
2016 NADPH oxidase-derived superoxide provides a third signal for CD4 T cell effector responsesJournal of Immunology.  197:1733-1742. 2016
2015 Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in type 1 diabetesDiabetes.  64:4171-4183. 2015
2015 Minireview: Directed differentiation and encapsulation of Islet β-cells—Recent advances and future considerationsMolecular Endocrinology.  29:1388-1399. 2015
2015 Diabetes: hydrogen-bonded multilayers of tannic Acid as mediators of T-cell immunity (adv. Healthcare mater. 5/2015).Advanced Healthcare Materials.  4:685. 2015
2015 Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunityAdvanced Healthcare Materials.  4:686-694. 2015
2015 Loss of NADPH oxidase-derived superoxide skews macrophage phenotypes to delay type 1 diabetesDiabetes.  64:937-946. 2015
2015 Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD miceDiabetes.  64:541-554. 2015
2014 Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D developmentEndocrinology.  155:3352-3364. 2014
2014 Effects of metalloporphyrins on reducing inflammation and autoimmunityAntioxidants and Redox Signaling.  20:2465-2477. 2014
2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
2013 Diabetes-related impairment in bone strength is established early in the life course.World Journal of Diabetes.  4:145-150. 2013
2013 The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesisAnnals of the New York Academy of Sciences.  1281:16-35. 2013
2012 Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cellsAdvanced Functional Materials.  22:3389-3398. 2012
2012 Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic miceFree Radical Biology and Medicine.  52:2047-2056. 2012
2012 Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS)Journal of Inherited Metabolic Disease.  35:159-168. 2012
2012 Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activitiesAmino Acids.  42:95-113. 2012
2012 Erratum: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities (Amino Acids DOI: 10.1007/s00726-010-0603-6)Amino Acids.  42:115-116. 2012
2011 Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent models of ischemic stroke and subarachnoid hemorrhageJournal of Pharmacology and Experimental Therapeutics.  338:906-916. 2011
2011 A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD miceImmunologic Research.  50:213-220. 2011
2011 Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetesDiabetes.  60:2144-2151. 2011
2010 NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunityJournal of Immunology.  185:5247-5258. 2010
2010 Redox modulation protects islets from transplant-related injuryDiabetes.  59:1731-1738. 2010
2010 Macrophage and T Cell ROS Production Is Critical for T1D PathogenesisDiabetes.  59:A361-A361. 2010
2009 FoxO1 links insulin resistance to proinflammatory cytokine IL-1β production in macrophagesDiabetes.  58:2624-2633. 2009
2009 Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the ratFree Radical Biology and Medicine.  47:917-923. 2009
2009 Inhibition of Superoxide Synthesis Prevents T Cell AutoreactivityDiabetes.  58:A50-A50. 2009
2009 Redox Modulation Ablates Adaptive Immune Effector Response by Inhibiting IL-12-IL-12R SignalingDiabetes.  58:A327-A328. 2009
2008 Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-κB activation in vascular smooth muscle cellsAtherosclerosis.  201:248-257. 2008
2008 Redox modulation inhibits CD8 T cell effector functionFree Radical Biology and Medicine.  45:1477-1486. 2008
2008 Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-κB pathwayDiabetologia.  51:1534-1543. 2008
2008 Reactive oxygen species generation is necessary for diabetogenic T cell effector functionDiabetes.  57:A354-A354. 2008
2008 Redox modulation impairs allograft rejectionDiabetes.  57:A543-A544. 2008
2008 Redox modulation regulates T cell activation and effector function through a tumor necrosis factor alpha converting enzyme (TACE) dependent mechanismDiabetes.  57:A53-A53. 2008
2007 A catalytic antioxidant quells the response to alloantigenActa Diabetologica: an international journal devoted to the study of clinical and experimental diabetes and metabolism.  44:S48-S48. 2007
2007 Autoimmune diabetes is dependent on a proinflammatory third signalActa Diabetologica: an international journal devoted to the study of clinical and experimental diabetes and metabolism.  44:S52-S52. 2007
2007 Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndromeJournal of Inherited Metabolic Disease.  30:888-895. 2007
2007 Critical role of superoxide (O2-) production in the pathogenesis of autoimmune diabetes (T1D)Diabetes.  56:A59-A59. 2007
2007 Reactive oxygen species generation is necessary for autoimmune T cell effector functionDiabetes.  56:A58-A59. 2007
2007 Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsivenessJournal of Immunology.  178:908-917. 2007
2006 Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibilityDiabetes.  55:3455-3462. 2006
2006 Preeclampsia activates circulating immune cells with engagement of the NF-κB pathwayAmerican Journal of Reproductive Immunology.  56:135-144. 2006
2006 Blockade of the inflammatory third signal in conjunction with antigenic immunization as a potentially novel immunosuppression strategyDiabetes.  55:A447-A447. 2006
2006 Redox modulation inhibits diabetogenic T cell activation and T1DDiabetes.  55:A89-A89. 2006
2006 The role of ER-stress in the antigenic response of the BDC-2.5 T cellDiabetes.  55:A88-A88. 2006
2006 Redox modulation of innate immune-derived pro-inflammatory third signals prevents diabetogenesisFree Radical Biology and Medicine.  41:S76-S76. 2006
2005 Catalytic antioxidant disruption of innate-mediated pro-inflammatory cytokine and reactive oxygen species third signal delays spontaneous autoimmune diabetes in the NOD mouseDiabetes.  54:A25-A25. 2005
2004 Response of human islets to isolation stress and the effect of antioxidant treatmentDiabetes.  53:2559-2568. 2004
2004 Disruption of pro-inflammatory cytokine and reactive oxygen species dependent third signal leads to antigen-specific hyporesponsiveness that is STAT-4 dependentDiabetes.  53:A301-A302. 2004
2004 Genetic ablation of macrophage/neutrophil NADPH oxidase activity inhibits T1D development in NOD miceDiabetes.  53:A26-A26. 2004
2004 Quelling oxidative stress during human islet isolation correlates with reduced NF-kappa B-dependent pro-inflammatory mediators: Implications for the development of footprint assays for transplant successDiabetes.  53:A454-A454. 2004
2004 Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunityFree Radical Biology and Medicine.  36:233-247. 2004
2004 Caspase-1 Is Not Required for Type 1 Diabetes in the NOD MouseDiabetes.  53:99-104. 2004
2002 Therapeutic induction of diabetes resistance and antigen-specific hyporesponsiveness using a superoxide dismutase mimic (AEOL 10113)Diabetes.  51:A288-A289. 2002
2002 Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophagesJournal of Immunology.  168:825-833. 2002
2002 Bypass of A- and B-signaling requirements for Myxococcus xanthus development by mutations in spdRJournal of Bacteriology.  184:1455-1457. 2002
2001 Identification and characterization of spdR mutations that bypass the BsgA protease-dependent regulation of developmental gene expression in Myxococcus xanthusMolecular Microbiology.  39:765-780. 2001
2001 A metalloporphyrin-based superoxide dismutase mimetic inhibits type I diabetesFree Radical Biology and Medicine.  31:S50-S50. 2001

Principal Investigator On

  • Altering the Immunometabolism of Dendritic Cells for Tolerance Induction  awarded by JUVENILE DIABETES RESEARCH FOUNDATION, USA
  • Beta-Cell Responses to Oxidative Stress and Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Beta-Cell Responses to Oxidative Stress and Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • CD4 T cell Metabolism as a Therapeutic Target in Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International
  • Determining the Mechanism of IFIH1 Disease-associated Variants on Beta-cell and Immune Responses in Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Encapsulation of Neonatal Porcine Islets with Novel Nano Thin lmmunomodulatory Coating of Polyphenolic Antioxidant  awarded by University of Alberta at Edmonton
  • HSF/GEF Scholar Award for Hubert Tse  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Islet Encapsulation with Immunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International
  • Islet Encapsulation with Immunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International
  • Islet Encapsulation with lmmunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International
  • Optimizing Encapsulation to Treat Type 1 Diabetes Mellitus: The Role of Oxygenation, Antigen Shedding and Innate Immune Response in Graft Success  awarded by University of Miami
  • Oxidative Post-Translational Modification of Type 1 Diabetes Autoantigens  awarded by Juvenile Diabetes Research Foundation International
  • Redox Regulation of Anti-Viral Responses in Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Rheumatic Diseases Core Center: Pilot Project - P & F 4  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Role of MDA5 Responses on Islet-Resident Macrophages in Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Synergism of Innate Immune-Derived Reactive Oxygen Species and T Cell Effector Responses in Type 1 Diabetes  awarded by American Diabetes Association, Inc.
  • The Role of Reactive Oxygen Species in Innate and Adaptive Immune Function in Type 1 Diabetes  awarded by American Diabetes Association, Inc.
  • Investigator On

  • Analysis of Human and Mouse Antibodies to Beta Cell Antigens Bearing N-Acetyl Glucosamine Post-Translation Modifications and their Potential to Prevent Human Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International
  • Antibodies to Beta Cell GlcNAc - Modified Autoantigens Blocks T1D in NOD Mice  awarded by Juvenile Diabetes Research Foundation International
  • Dampening Autoimmunity with Encapsulated Autoantigens in Polyphenolic Capsules  awarded by NSF - National Science Foundation
  • Glucose Regulation of Bacterial Virulence in Diabetes and Hyperglycemia  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunomodulatory Ultrathin Coatings for Pancreatic Islet Transplantation  awarded by NSF - National Science Foundation
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Oxalate-Driven Host Responses in Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Private Grant  awarded by DIAMYD MEDICAL AB
  • Reprogramming Redox-Controlled Innate and Adaptive Immune Responses by Antioxidant Polymer Microvesicles  awarded by NSF - National Science Foundation
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Diabetes Research Center - Enrichment Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Colorado System : Denver 1999
  • Bachelor of Science or Mathematics in Biochemistry, Virginia Polytechnic Institute and State University 1992
  • Awards And Honors

  • P30 Award UAB Comprehensive Diabetes Center, 2017
  • JDRF Post-doctoral fellowship (Ruth McDowell, Ph.D.) - declined, 2017
  • T32 Translational and Molecular Sciences (TMS) (T32.GM109780) pre-doctoral trainee slot – Jessie Barra (Rakesh Patel, PI), 2017
  • Associate Professor with tenure, 2016
  • UAB School of Medicine AMC21 R01 Award, 2016
  • AAI Early Career Faculty Travel Grant, 2015
  • T32 Immunologic Diseases and Basic Immunology (T32.AI007051-35) pre-doctoral trainee slot – Ashley Burg (Harry Schroeder, PI), 2015
  • T32 Dental Academic Research Training (DART) (T32.DE17607) post-doctoral trainee slot – Ruth McDowell (Mary MacDougall, PI), 2015
  • UAB Immunology, Autoimmunity, and Transplantation (IAT) Research Acceleration Project, 2014
  • UAB institutional nominee for the ADA Pathway to Stop Diabetes Award, 2014
  • AAI Early Career Faculty Travel Grant, 2014
  • American Association of Immunologists Travel for Techniques Award, 2014
  • NIH/NIDDK R01 Award DK099550, 2014
  • Featured on the cover of Diabetes Forecast (May 2013 issue), 2013
  • Pilot & Feasibility Award, 2012
  • American Diabetes Association Career Development Award, 2012
  • P30 Award UAB Comprehensive Diabetes Center, 2011
  • P30 Award UAB Comprehensive Diabetes Center, 2010
  • T32 Immunologic Diseases and Basic Immunology (T32.AI007051-35) pre-doctoral trainee slot – Lindsey Padgett (Harry Schroeder, PI), 2010
  • American Diabetes Association Junior Faculty Award, 2009
  • P30 Award UAB Rheumatic Diseases Core Center, 2009
  • 9th International Congress of the Immunology of Diabetes Society and American Diabetes Association Symposium Scholarship, 2007
  • Society for Free Radical Biology and Medicine Travel Award, 2006
  • NIH Loan Repayment Program Awardee, Pediatric Loan Repayment Program, 2004
  • Society for Free Radical Biology and Medicine Travel Award, 2004
  • Immunology of Diabetes Society Travel Award, 2002
  • Full Name

  • Hubert Tse