Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Redox-Sensitive Innate Immune Pathways during Macrophage Activation in Type 1 Diabetes 2018
2018 Sex differences underlying pancreatic islet biology and its dysfunction 2018
2018 The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance 2018
2018 Redox-dependent inflammation in islet transplantation rejection 2018
2018 Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers 2018
2018 Superoxide production by NADPH oxidase intensifies macrophage antiviral responses during diabetogenic coxsackievirus infection 2018
2017 Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking 2017
2016 Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β Group VIA phospholipase a2 2016
2016 NADPH oxidase-derived superoxide provides a third signal for CD4 T cell effector responses 2016
2015 Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in type 1 diabetes 2015
2015 Diabetes: hydrogen-bonded multilayers of tannic Acid as mediators of T-cell immunity (adv. Healthcare mater. 5/2015). 2015
2015 Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunity 2015
2015 Loss of NADPH oxidase-derived superoxide skews macrophage phenotypes to delay type 1 diabetes 2015
2015 Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice 2015
2015 Minireview: Directed differentiation and encapsulation of Islet β-cells—Recent advances and future considerations 2015
2014 Effects of metalloporphyrins on reducing inflammation and autoimmunity 2014
2014 Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development 2014
2014 Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunity 2014
2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways 2013
2013 Diabetes-related impairment in bone strength is established early in the life course. 2013
2013 The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis 2013
2012 Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells 2012
2012 Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice 2012
2012 Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS) 2012
2012 Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities 2012
2012 Erratum: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities (Amino Acids DOI: 10.1007/s00726-010-0603-6) 2012
2011 Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent models of ischemic stroke and subarachnoid hemorrhage 2011
2011 A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice 2011
2011 Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes 2011
2010 NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity 2010
2010 Redox modulation protects islets from transplant-related injury 2010
2010 Macrophage and T Cell ROS Production Is Critical for T1D Pathogenesis 2010
2009 FoxO1 links insulin resistance to proinflammatory cytokine IL-1β production in macrophages 2009
2009 Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat 2009
2009 Inhibition of Superoxide Synthesis Prevents T Cell Autoreactivity 2009
2009 Redox Modulation Ablates Adaptive Immune Effector Response by Inhibiting IL-12-IL-12R Signaling 2009
2008 Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-κB activation in vascular smooth muscle cells 2008
2008 Redox modulation inhibits CD8 T cell effector function 2008
2008 Redox modulation inhibits CD8 T cell effector function 2008
2008 Reactive oxygen species generation is necessary for diabetogenic T cell effector function 2008
2008 Redox modulation impairs allograft rejection 2008
2008 Redox modulation regulates T cell activation and effector function through a tumor necrosis factor alpha converting enzyme (TACE) dependent mechanism 2008
2007 A catalytic antioxidant quells the response to alloantigen 2007
2007 Autoimmune diabetes is dependent on a proinflammatory third signal 2007
2007 Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome 2007
2007 Critical role of superoxide (O2-) production in the pathogenesis of autoimmune diabetes (T1D) 2007
2007 Reactive oxygen species generation is necessary for autoimmune T cell effector function 2007
2007 Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness 2007
2006 Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility 2006
2006 Blockade of the inflammatory third signal in conjunction with antigenic immunization as a potentially novel immunosuppression strategy 2006
2006 Redox modulation inhibits diabetogenic T cell activation and T1D 2006
2006 The role of ER-stress in the antigenic response of the BDC-2.5 T cell 2006
2006 Redox modulation of innate immune-derived pro-inflammatory third signals prevents diabetogenesis 2006
2005 Catalytic antioxidant disruption of innate-mediated pro-inflammatory cytokine and reactive oxygen species third signal delays spontaneous autoimmune diabetes in the NOD mouse 2005
2004 Disruption of pro-inflammatory cytokine and reactive oxygen species dependent third signal leads to antigen-specific hyporesponsiveness that is STAT-4 dependent 2004
2004 Genetic ablation of macrophage/neutrophil NADPH oxidase activity inhibits T1D development in NOD mice 2004
2004 Quelling oxidative stress during human islet isolation correlates with reduced NF-kappa B-dependent pro-inflammatory mediators: Implications for the development of footprint assays for transplant success 2004
2004 Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunity 2004
2004 Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse 2004
2002 Therapeutic induction of diabetes resistance and antigen-specific hyporesponsiveness using a superoxide dismutase mimic (AEOL 10113) 2002
2002 Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages 2002
2001 A metalloporphyrin-based superoxide dismutase mimetic inhibits type I diabetes 2001

Chapter

Year Title Altmetric
2012 Reactive oxygen species - Key immune mediators in type 1 diabetes.  3493-3520. 2012

Principal Investigator On

  • Oxidative Post-Translational Modification of Type 1 Diabetes Autoantigens  awarded by Juvenile Diabetes Research Foundation International 2018 - 2021
  • Optimizing Encapsulation to Treat Type 1 Diabetes Mellitus: The Role of Oxygenation, Antigen Shedding and Innate Immune Response in Graft Success  awarded by University of Miami 2019
  • Islet Encapsulation with lmmunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International 2019
  • Redox Regulation of Anti-Viral Responses in Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Encapsulation of Neonatal Porcine Islets with Novel Nano Thin lmmunomodulatory Coating of Polyphenolic Antioxidant  awarded by University of Alberta at Edmonton 2016 - 2018
  • Islet Encapsulation with Immunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International 2016 - 2018
  • CD4 T cell Metabolism as a Therapeutic Target in Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2017
  • Synergism of Innate Immune-Derived Reactive Oxygen Species and T Cell Effector Responses in Type 1 Diabetes  awarded by American Diabetes Association, Inc. 2012 - 2017
  • Islet Encapsulation with Immunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International 2015 - 2016
  • HSF/GEF Scholar Award for Hubert Tse  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2009 - 2014
  • Rheumatic Diseases Core Center: Pilot Project - P & F 4  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • The Role of Reactive Oxygen Species in Innate and Adaptive Immune Function in Type 1 Diabetes  awarded by American Diabetes Association, Inc. 2009 - 2012
  • Investigator On

  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Diabetes Research Center - Enrichment Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2021
  • Dampening Autoimmunity with Encapsulated Autoantigens in Polyphenolic Capsules  awarded by NSF - National Science Foundation 2016 - 2020
  • Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2013 - 2017
  • Immunomodulatory Ultrathin Coatings for Pancreatic Islet Transplantation  awarded by NSF - National Science Foundation 2013 - 2017
  • Analysis of Human and Mouse Antibodies to Beta Cell Antigens Bearing N-Acetyl Glucosamine Post-Translation Modifications and their Potential to Prevent Human Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2014 - 2016
  • Glucose Regulation of Bacterial Virulence in Diabetes and Hyperglycemia  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2016
  • Private Grant  awarded by DIAMYD MEDICAL AB 2014 - 2015
  • Antibodies to Beta Cell GlcNAc - Modified Autoantigens Blocks T1D in NOD Mice  awarded by Juvenile Diabetes Research Foundation International 2012 - 2014
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Awards And Honors

  • P30 Award UAB Comprehensive Diabetes Center, 2017
  • JDRF Post-doctoral fellowship (Ruth McDowell, Ph.D.) - declined, 2017
  • T32 Translational and Molecular Sciences (TMS) (T32.GM109780) pre-doctoral trainee slot – Jessie Barra (Rakesh Patel, PI), 2017
  • Associate Professor with tenure, 2016
  • UAB School of Medicine AMC21 R01 Award, 2016
  • AAI Early Career Faculty Travel Grant, 2015
  • T32 Immunologic Diseases and Basic Immunology (T32.AI007051-35) pre-doctoral trainee slot – Ashley Burg (Harry Schroeder, PI), 2015
  • T32 Dental Academic Research Training (DART) (T32.DE17607) post-doctoral trainee slot – Ruth McDowell (Mary MacDougall, PI), 2015
  • UAB Immunology, Autoimmunity, and Transplantation (IAT) Research Acceleration Project, 2014
  • UAB institutional nominee for the ADA Pathway to Stop Diabetes Award, 2014
  • AAI Early Career Faculty Travel Grant, 2014
  • American Association of Immunologists Travel for Techniques Award, 2014
  • NIH/NIDDK R01 Award DK099550, 2014
  • Featured on the cover of Diabetes Forecast (May 2013 issue), 2013
  • Pilot & Feasibility Award, 2012
  • American Diabetes Association Career Development Award, 2012
  • P30 Award UAB Comprehensive Diabetes Center, 2011
  • P30 Award UAB Comprehensive Diabetes Center, 2010
  • T32 Immunologic Diseases and Basic Immunology (T32.AI007051-35) pre-doctoral trainee slot – Lindsey Padgett (Harry Schroeder, PI), 2010
  • American Diabetes Association Junior Faculty Award, 2009
  • P30 Award UAB Rheumatic Diseases Core Center, 2009
  • 9th International Congress of the Immunology of Diabetes Society and American Diabetes Association Symposium Scholarship, 2007
  • Society for Free Radical Biology and Medicine Travel Award, 2006
  • NIH Loan Repayment Program Awardee, Pediatric Loan Repayment Program, 2004
  • Society for Free Radical Biology and Medicine Travel Award, 2004
  • Immunology of Diabetes Society Travel Award, 2002
  • Full Name

  • Hubert Tse