Positions

Overview

  • Dr. Amm received her BS in Biological Sciences from Saint Mary’s College and Ph.D. in Pharmacology and Toxicology from UAB with a focus on cancer biology and novel therapeutics. Dr. Amm completed the Dental Academic Research Training (DART) program as a post-doctoral scholar in the laboratory of Dr. Mary MacDougall and was a Mentored Experiences in Research, Instruction, and Teaching (MERIT) program Scholar-at-Large, which provided teaching experiences at a minority-partner institution. During her postdoctoral studies, she has collaborated on projects related to the genetic and molecular basis of craniofacial diseases, particularly odontogenic tumors. She has characterized numerous cellular models of odontogenic tumors and developed new in vivo models. In March 2017, she joined the faculty the Oral and Maxillofacial Surgery Department at UAB. Her work has been funded by the Department of Defense, Oral and Maxillofacial Surgery Foundation, and NIDCR. Her current research focuses on genetics and signaling pathways that play a role in the pathogenesis of human oral cancers and odontogenic tumors with a goal to develop targeted therapies and diagnostic tools.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2016 Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis. 2016
    2014 Establishment and characterization of a primary calcifying epithelial odontogenic tumor cell population 2014
    2014 Establishment of Singleton-Merten Syndrome pulp cells: Evidence of mineralization dysregulation 2014
    2014 Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells 2014
    2014 Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer 2014
    2013 Lung resistance-related protein (LRP) expression in malignant ascitic cells as a prognostic marker for advanced ovarian serous carcinoma 2013
    2012 Targeting the sonic hedgehog pathway in keratocystic odontogenic tumor 2012
    2012 MiR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors 2012
    2011 Differential enamel and osteogenic gene expression profiles in odontogenic tumors 2011
    2011 Relationship between galectin-3 expression and TRAIL sensitivity in breast cancer 2011
    2011 Anti-tumor activity of an anti-DR5 monoclonal antibody, TRA-8, in combination with taxane/platinum-based chemotherapy in an ovarian cancer model 2011
    2011 Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells 2011
    2011 Combined modality therapy with TRAIL or agonistic death receptor antibodies 2011
    2010 Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer 2010

    Education And Training

  • UAB Institute of Oral Health Research, Postdoctoral Fellowship
  • Doctor of Philosophy in Pharmacology and Toxicology, University of Alabama at Birmingham 2010
  • Bachelor of Science or Mathematics in Biology / Biological Sciences, Saint Mary's College 2002
  • Full Name

  • Hope Amm