Positions

Overview

  • Dr. Charles Hoopes received his undergraduate degree from Lebanon Valley College before completing graduate studies in anthropology at Wake Forest University. He began his medical studies at the Duke University School of Medicine, graduating in 1992 and remained at Duke for his residency in general surgery. He completed a residency in cardiothoracic surgery at the University of Michigan before returning to Duke for fellowship training in thoracic transplantation. In 2002 he joined the faculty of the University of California San Francisco as an Assistant Professor of Surgery, rising to Associate Professor and Director of the Thoracic Transplant and Mechanical Circulatory Support programs in 2005. He was recruited to the University of Kentucky as the Jason Alexander Gill Professor in Thoracic Surgery in 2010 and served as Director of the UK Transplant Center from 2011 until 2015. He was appointed Section Chief of Thoracic Transplantation and Co-Director of the Comprehensive Transplant Institute at UAB in February of 2015. Dr. Hoopes holds an MPH degree from School of Public Health at the University of California (Berkeley).

    Historical research interests focused on (1) the evolutionary history, genomic organization and transcrptional regulation of the porcine alpha 1,3 galactosyltransferase gene responsible for hyperacute rejection of pig to primate xenotransplants (Hoopes and Platt, 1997, Transplantation 64:347), (2) the molecular biology and genomic organization of porcine endogenous retroviruses (PERVs) as infectious agents in clinical xenotransplantation (Hoopes and Platt, 1999, Transplantation 67:1391) and (3) molecular strategies for identifying novel specific endogenous retroviral transcripts in potential xenodonor genomes (Hoopes and Platt, 1997, Transplantation Proceedings 29:897).

    Current research interests focus on the role of the microbiome in pulmonary transplantation as it relates colonization kinetics of the allograft, the impact of microbiome data on regulatory aspects of the immune response, and the impact of species diversity on allograft function and chronic allograft loss.

    Currently, in conjunction with the University of Kentucky Center for Muscle Biology, we are investigating the key proteomic and structural modifications that underpin increased systolic function in human patients after mechanical unloading with ventricular assist devices (Haynes et al, 2014, J Mol Cell Cardiol 72C:1-8). The aim of this project is to establish a mouse model of ventricular unloading (heterotopic cardiac transplant) to determine the time-course of unloading-induced recovery as an approach to sarcomere based therapies for the failing ventricle including an early analysis of microRNA expression patterns in the mechanically unloaded ventricle
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture modelThe Journal of heart transplantation.  38:456-465. 2019
    2019 Bridging to lung transplantation with double-lumen venovenous extracorporeal membrane oxygenationLife support systems : the journal of the European Society for Artificial Organs2019
    2018 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipientsThe Journal of heart transplantation.  37:206-216. 2018
    2018 Delayed sternal closure does not reduce complications associated with coagulopathy and right ventricular failure after left ventricular assist device implantationJournal of Artificial Organs.  21:46-51. 2018
    2017 Lung Transplant Candidates on Extracorporeal SupportChest.  151:1177-1178. 2017
    2017 Myocardial relaxation is accelerated by fast stretch, not reduced afterloadJournal of Molecular and Cellular Cardiology.  103:65-73. 2017
    2017 Diaphragm abnormalities in patients with end-stage heart failure: NADPH oxidase upregulation and protein oxidationFrontiers in Physiology.  7. 2017
    2016 Use of a novel pulmonary artery cannula to provide extracorporeal membrane oxygenation as a bridge to lung transplantationThe Journal of heart transplantation.  35:1051-1053. 2016
    2016 Safety of nurse-led ambulation for patients on venovenous extracorporeal membrane oxygenationJournal of Transplant Coordination.  26:112-116. 2016
    2016 Flexible bronchoscopy is safe and effective in adult subjects supported with extracorporeal membrane oxygenationRespiratory Care.  61:646-651. 2016
    2016 A Protocol for Collecting Human Cardiac Tissue for Research.The VAD Journal: The Journal of Mechanical Assisted Circulation and Heart Failure.  2. 2016
    2015 Use of ECMO in the management of severe acute respiratory distress syndrome: A survey of academic medical centers in the United StatesASAIO Journal.  61:556-563. 2015
    2015 Falsely incompatible b-cell flow cytometry crossmatch after pronase treatment: A case reportTransplantation Proceedings.  47:831-833. 2015
    2015 Short-term mechanical circulatory support: The problem of the uninsuredJournal of the American College of Cardiology.  65:1062-1063. 2015
    2014 Success of left ventricular assist device therapy in uninsured patientsInternational Journal of Cardiology.  177:1087-1088. 2014
    2014 Extracorporeal membrane oxygenation for acute respiratory failure in adults: The need for pulmonary INTERMACSAmerican Journal of Respiratory and Critical Care Medicine.  190:1321-1322. 2014
    2014 The feasibility of lung transplantation in HIV-seropositive patientsAnnals of the American Thoracic Society.  11:945-950. 2014
    2014 A randomized, double-blind, placebo-controlled, multicenter study of rabbit ATG in the prophylaxis of acute rejection in lung transplantationAmerican Journal of Transplantation.  14:1191-1198. 2014
    2014 Acute demyelinating polyneuropathy after lung transplantation: guillain-barré syndrome or tacrolimus toxicity?Case Reports in Transplantation.  2014:685010. 2014
    2014 Ambulatory extracorporeal membrane oxygenationOperative Techniques in Thoracic and Cardiovascular Surgery.  19:129-137. 2014
    2014 Insertion of impella 5.0 to improve candidacy for heartmate ii left ventricular assist device placementJournal of Invasive Cardiology.  26. 2014
    2014 Prolonged extracorporeal membrane oxygenation use as a bridge to lung transplantation: It is time for a national registryChest.  145:184-185. 2014
    2014 Role of left ventricular assist devices in assessment of patients for combined heart-kidney transplantationAmerican Journal of Transplantation.  14:1946-1947. 2014
    2014 Transmural heterogeneity of cellular level power output is reduced in human heart failureJournal of Molecular and Cellular Cardiology.  72:1-8. 2014
    2013 Hepatitis C virus infection in heart transplantation: Is ventricular assist device therapy an option?Transplantation.  96. 2013
    2013 Outcomes in systemic sclerosis-related lung disease after lung transplantationTransplantation.  95:975-980. 2013
    2013 Venovenous extracorporeal membrane oxygenation for the treatment of acute pulmonary embolism after ventral hernia repairAmerican Surgeon.  79:446-448. 2013
    2013 Extracorporeal membrane oxygenation as a bridge to pulmonary transplantationJournal of Thoracic and Cardiovascular Surgery.  145:862-868. 2013
    2013 Successful ventricular assist device placement in transposition of the great arteries with pulmonary hypertensionAnnals of Thoracic Surgery.  95. 2013
    2013 Elevated pulmonary artery systolic pressures are associated with a lower risk of atrial fibrillation following lung transplantationJournal of Electrocardiology.  46:38-42. 2013
    2013 Lung Transplant Curriculum in Pulmonary/Critical Care Fellowship TrainingTeaching and Learning in Medicine.  25:59-63. 2013
    2013 Synthetic ECG-gated cardiac computed tomography for in vivo imaging of the temporary total artificial heartCirculation.  127. 2013
    2013 The evolution of extracorporeal life support as a bridge to lung transplantationASAIO Journal.  59:3-10. 2013
    2013 Venovenous extracorporeal membrane oxygenation for the treatment of acute pulmonary embolism after ventral hernia repair.American Surgeon.  79:444-446. 2013
    2012 Mechanical Support for Pulmonary Veno-occlusive Disease: Combined Atrial Septostomy and Venovenous Extracorporeal Membrane OxygenationSeminars in Thoracic and Cardiovascular Surgery.  24:232-234. 2012
    2012 Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptivesThe Journal of heart transplantation.  31:1031-1036. 2012
    2012 AngioJet rheolytic thrombectomy for thrombotic myocardial injury in a 15-year-old cystic fibrosis patient during lung transplantationAnnals of Thoracic Surgery.  94:626-628. 2012
    2012 Lung function and ECMO after lung transplantationAnnals of Thoracic Surgery.  94:686-687. 2012
    2012 Ventricular assist devices: Bridge to continued employmentInternational Journal of Cardiology.  158:468. 2012
    2012 Lung transplantation in patients with coal workers' pneumoconiosisClinical Transplantation.  26:629-634. 2012
    2012 Renal failure following ventricular assist device placementJournal of the American College of Cardiology.  59:2220. 2012
    2012 BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytesHeart Rhythm.  9:812-820. 2012
    2012 Organ donation and moyamoya diseaseAmerican Journal of Transplantation.  12:1353-1355. 2012
    2012 Venovenous extracorporeal membrane oxygenation in acute respiratory failure: Do we need a new configuration?Journal of Thoracic and Cardiovascular Surgery.  143:993-994. 2012
    2012 Use of sublingual tacrolimus in lung transplant recipientsThe Journal of heart transplantation.  31:127-132. 2012
    2012 Ambulatory venovenous extracorporeal respiratory support as a bridge for cystic fibrosis patients to emergent lung transplantationJournal of Cystic Fibrosis.  11:40-45. 2012
    2011 Rhodococcus equi infection after lung transplantationRespiratory Care.  56:1605-1607. 2011
    2011 The impact of pretransplant mechanical ventilation on short- and long-term survival after lung transplantationAmerican Journal of Transplantation.  11:2197-2204. 2011
    2011 Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosisAJP - Lung Cellular and Molecular Physiology.  301:71-78. 2011
    2011 Frequency of atrial flutter after adult lung transplantationAmerican Journal of Cardiology.  107:922-926. 2011
    2011 Lung transplantation in coal workers pneumoconiosisChest.  140:1387-1388. 2011
    2011 Refractory bilateral pneumothoraces in end-stage cystic fibrosisAnnals of Thoracic Surgery.  92:1905. 2011
    2010 Supratherapeutic anticoagulation from low-molecular-weight heparin in lung transplant recipientsThe Journal of heart transplantation.  29:1009-1013. 2010
    2009 α1-adrenergic receptor subtypes in nonfailing and failing human myocardiumCirculation: Heart Failure.  2:654-663. 2009
    2009 The Alpha-1D Is the Predominant Alpha-1-Adrenergic Receptor Subtype in Human Epicardial Coronary ArteriesJournal of the American College of Cardiology.  54:1137-1145. 2009
    2009 Impact of the lung allocation score on lung transplantation for pulmonary arterial hypertensionAmerican Journal of Respiratory and Critical Care Medicine.  180:468-474. 2009
    2009 Gastro-oesophageal reflux and aspiration in patients with advanced lung diseaseThorax.  64:167-173. 2009
    2008 Lung transplantation in patients with connective tissue disorders and esophageal dysmotilityDiseases of the Esophagus.  21:650-655. 2008
    2008 Antireflux surgery for patients with end-stage lung disease before and after lung transplantationSurgical Endoscopy.  22:495-500. 2008
    2007 Fatal Diffuse Alveolar Damage in Two Lung Transplant Patients Treated With CetuximabThe Journal of heart transplantation.  26:1340-1344. 2007
    2007 Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantationJournal of Thoracic and Cardiovascular Surgery.  133:1078-1084. 2007
    2006 Prevalence of Delayed Gastric Emptying and Gastroesophageal Reflux in Patients With End-Stage Lung DiseaseAnnals of Thoracic Surgery.  82:1570. 2006
    2006 The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantationAnnals of Surgery.  244:491-495. 2006
    2006 Invited commentaryAnnals of Thoracic Surgery.  82:1088-1089. 2006
    2005 Idiopathic pulmonary fibrosis: How often is it really idiopathic?Journal of Gastrointestinal Surgery.  9:1053-1058. 2005
    2005 c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseasesJournal of Pathology.  206:279-290. 2005
    2005 Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopeniaThe Journal of heart transplantation.  24:222-225. 2005
    2004 Profound Hypoxemia Resulting from Shunting Across an Inadvertent Atrial Septal Tear after Left Ventricular Assist Device PlacementAnesthesia and Analgesia.  98:937-940. 2004
    2004 Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopeniaAnesthesia and Analgesia.  98:1635-1639. 2004
    2003 Mechanical ventricular support lowers pulmonary vascular resistance in a patient with congential heart diseaseAnnals of Thoracic Surgery.  75:1005-1007. 2003
    1999 Screening by tRNA primer extension analysis of porcine kidney mRNA libraries defines a novel endogenous porcine retroviral long terminal repeatTransplantation.  67:1391-1395. 1999
    1998 The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplantsJournal of Clinical Investigation.  101:1745-1756. 1998
    1997 A molecular epidemiological probe for pig microchimerismTransplantation.  64:347-350. 1997
    1997 Molecular screening of xenodonor genomes for species-specific endogenous retroviral DNA sequencesTransplantation Proceedings.  29:897-898. 1997
    1997 The role of natural anti-Galα1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplantsTransplant Immunology.  5:212-218. 1997
    1996 Molecular strategies for clinical xenotransplantation in cardiothoracic surgery.Seminars in Thoracic and Cardiovascular Surgery.  8:156-174. 1996
    1993 Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma.Genes & Genetic Systems.  68:175-184. 1993
    1992 Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXRα, RXRβ, and RXRγGenomics.  14:611-617. 1992

    Research Overview

  • organ transplantation, microbiome in pulmonary transplantation, geographic information systems in public health
  • Investigator On

  • Private Grant  awarded by GAMBRO HEALTHCARE 2013 - 2014
  • Education And Training

  • Doctor of Medicine, Duke University 1992
  • University of Michigan Hospitals & Health Centers, Residency 2001
  • Duke University Medical Center, Residency 1999
  • Full Name

  • Charles Hoopes