Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma AngiogenesisSTEM CELLS.  37:453-462. 2019
2018 Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in VitroACS Chemical Biology.  13:2048-2057. 2018
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenanceNeuro-Oncology.  20:1055-1067. 2018
2018 Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucoseBiomarker Research.  6. 2018
2018 The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cellsBiochimica et Biophysica Acta (BBA) - Reviews on Cancer.  1869:175-188. 2018
2018 The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1 signalingJournal of Biological Chemistry.  293:5659-5667. 2018
2017 Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.JCI insight.  2. 2017
2017 NOS Expression and NO Function in Glioma and Implications for Patient TherapiesAntioxidants and Redox Signaling.  26:986-999. 2017
2017 Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cellsJournal of Neuro-Oncology.  132:219-229. 2017
2017 Modeling Physiologic Microenvironments in Three-Dimensional Microtumors Maintains Brain Tumor Initiating Cells.Journal of cancer stem cell research.  5. 2017
2017 The Arf activator GBF1 localizes to plasma membrane sites involved in cell adhesion and motility.Cellular Logistics.  7:e1308900. 2017
2016 Metabolic, autophagic, and mitophagic activities in cancer initiation and progressionBiomedical Journal.  39:98-106. 2016
2015 Kinome-wide shRNA screen identifies the receptor tyrosine kinase AXL as a key regulator for mesenchymal glioblastoma stem-like cellsStem Cell Reports.  4:899-913. 2015
2015 Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastomaCell Death and Disease.  6. 2015
2015 A new mitochondrial pool of cyclin E, regulated by Drp1, is linked to cell-density-dependent cell proliferationJournal of Cell Science.  128:4171-4182. 2015
2015 Development of a Sox2 reporter system modeling cellular heterogeneity in gliomaNeuro-Oncology.  17:361-371. 2015
2014 Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cellsCell Death and Differentiation.  21:258-269. 2014
2014 Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchyGenes and Development.  28:1085-1100. 2014
2014 High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factorCell Reports.  6:117-129. 2014
2014 Method for Efficient Transduction of Cancer Stem Cells.Journal of cancer stem cell research.  2. 2014
2014 Microenvironmental Variables Must Influence Intrinsic Phenotypic Parameters of Cancer Stem Cells to Affect TumourigenicityPLoS Computational Biology.  10. 2014
2014 Phage display discovery of novel molecular targets in glioblastoma- initiating cellsCell Death and Differentiation.  21:1325-1339. 2014
2013 Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17AJournal of Experimental Medicine.  210:2851-2872. 2013
2013 Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptakeNature Neuroscience.  16:1373-1382. 2013
2013 Aptamer identification of brain tumor-initiating cellsCancer Research.  73:4923-4936. 2013
2013 Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell LinesPLoS ONE.  8. 2013
2013 Intrinsic cell factors that influence tumourigenicity in cancer stem cells - towards hallmarks of cancer stem cellsCoRR.  abs/1301.3934. 2013
2012 Laminin alpha 2 enables glioblastoma stem cell growthAnnals of Neurology.  72:766-778. 2012
2012 The quest for self-identity: Not all cancer stem cells are the sameClinical Cancer Research.  18:3495-3498. 2012
2012 Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneityGenes and Development.  26:1247-1262. 2012
2012 Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potentialCell Death and Differentiation.  19:428-439. 2012
2011 Twisted tango: Brain tumor neurovascular interactionsNature Neuroscience.  14:1375-1381. 2011
2011 Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2Cell.  146:53-66. 2011
2011 Acidic stress promotes a glioma stem cell phenotypeCell Death and Differentiation.  18:829-840. 2011
2011 Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3Cancer Cell.  19:498-511. 2011
2011 Molecular targeting of neural cancer stem cells: TTAGGG, you're it!Clinical Cancer Research.  17:3-5. 2011
2010 Notch promotes radioresistance of glioma stem cellsSTEM CELLS.  28:17-28. 2010
2009 NDRG4 is required for cell cycle progression and survival in glioblastoma cellsJournal of Biological Chemistry.  284:25160-25169. 2009
2009 Turning cancer stem cells inside out: An exploration of glioma stem cells signalling pathwaysJournal of Biological Chemistry.  284:16705-16709. 2009
2009 Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem CellsCancer Cell.  15:501-513. 2009
2008 Brain cancer stem cells display preferential sensitivity to Akt inhibitionSTEM CELLS.  26:3027-3036. 2008
2008 c-Myc is required for maintenance of glioma cancer stem cellsPLoS ONE.  3. 2008
2008 Targeting cancer stem cells through L1CAM suppresses glioma growthCancer Research.  68:6043-6048. 2008
2007 The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasionMolecular Cancer Therapeutics.  6:2449-2457. 2007
2007 Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinasesOncogene.  26:4084-4094. 2007
2007 A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growthMolecular Carcinogenesis.  46:488-496. 2007
2006 Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseNature.  444:756-760. 2006
2006 APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt pathway via the phosphoinositol phosphatase SHIP2Circulation Research.  99:829-836. 2006
2006 AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant gliomaCancer Research.  66:8722-8730. 2006
2006 Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factorCancer Research.  66:7843-7848. 2006
2006 A novel low molecular weight inhibitor of focal adhesion kinase and insulin-like growth factor-1 receptor, TAE226, inhibits glioma growth.Journal of Clinical Oncology.  24:11505. 2006
2005 Loss of phosphatase and tensin homologue increases transforming growth factor β-mediated invasion with enhanced SMAD3 transcriptional activityCancer Research.  65:11276-11281. 2005
2005 Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determinationMolecular and Cellular Biology.  25:9460-9468. 2005
2004 SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motilityMolecular Cancer Therapeutics.  3:737-745. 2004
2004 Selective Deficiency of the "Bone-related" Runx2-II Unexpectedly Preserves Osteoblast-mediated SkeletogenesisJournal of Biological Chemistry.  279:20307-20313. 2004
2003 Methyl parathion: A review of health effectsJournal of Toxicology and Environmental Health, Part B: Critical Reviews.  6:185-210. 2003
2001 An Essential Role for Mad Homology Domain 1 in the Association of Smad3 with Histone Deacetylase ActivityJournal of Biological Chemistry.  276:22595-22603. 2001
2001 Transforming growth factor-β signaling in cancerMicroscopy Research and Technique.  52:363-373. 2001
2001 The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosisJournal of Bone and Mineral Research.  16:1754-1764. 2001
1999 Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transductionMolecular and Cellular Biology.  19:2495-2504. 1999

Education And Training

  • Doctor of Philosophy in Pharmacology, Duke University 2003
  • Bachelor of Science or Mathematics in Biochemistry, North Carolina State University 1997
  • Full Name

  • Anita Hjelmeland