Selected Publications

Academic Article

Year Title Altmetric
2020 Is interleukin-6 receptor blockade (tocilizumab) beneficial or detrimental to pig-to-baboon organ xenotransplantation?American Journal of Transplantation.  20:999-1013. 2020
2020 Clinical pig kidney xenotransplantation: How close are we?Journal of the American Society of Nephrology.  31:12-21. 2020
2020 Fluid intake and output in baboonsXenotransplantation2020
2020 The final obstacle to successful pre-clinical xenotransplantation?Xenotransplantation2020
2019 Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantationTransplant Immunology.  57. 2019
2019 Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review articleInternational Journal of Surgery.  70:84-91. 2019
2019 Life-supporting Kidney Xenotransplantation from Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive RegimensTransplantation.  103:2090-2104. 2019
2019 Justification of specific genetic modifications in pigs for clinical organ xenotransplantationXenotransplantation.  26. 2019
2019 The “Baby Fae” baboon heart transplant—Potential cause of rejectionXenotransplantation.  26. 2019
2019 Evidence for the important role of inflammation in xenotransplantationJournal of inflammation.  16. 2019
2019 Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantationXenotransplantation.  26. 2019
2019 Life-supporting porcine cardiac xenotransplantation: The Munich studyXenotransplantation.  26. 2019
2019 Incidence of Neoplasia in Pigs and Its Relevance to Clinical Organ Xenotransplantation 2019
2019 Chronic dialysis in patients with end-stage renal disease: Relevance to kidney xenotransplantationXenotransplantation.  26. 2019
2019 Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?Xenotransplantation.  26. 2019
2019 Will donor-derived neoplasia be problematic after clinical pig organ or cell xenotransplantation?Xenotransplantation.  26. 2019
2018 B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapyTransplant Immunology.  51:12-20. 2018
2018 Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart XenotransplantationTransplantation.  102:1974-1982. 2018
2018 Serum amyloid a as an indicator of impending xenograft failure: Experimental studiesInternational Journal of Surgery.  60:283-290. 2018
2018 An approach to induction of tolerance to pig cardiac xenografts in neonatesXenotransplantation.  25. 2018
2018 Skin xenotransplantation: Historical review and clinical potentialBurns.  44:1738-1749. 2018
2018 Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapyData in Brief.  20:1965-1974. 2018
2018 Physiologic aspects of pig kidney transplantation in nonhuman primates 2018
2018 Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates: Recent ProgressTransplantation.  102:1050-1058. 2018
2018 Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig CellsTransplantation.  102:e195-e204. 2018
2018 Bringing Home the Bacon: Update on the State of Kidney XenotransplantationBlood Purification.  45:254-259. 2018
2018 Xenotransplantation - The current status and prospectsBritish Medical Bulletin.  125:5-14. 2018
2017 An Investigation of Extracellular Histones in Pig-To-Baboon Organ XenotransplantationTransplantation.  101:2330-2339. 2017
2017 Renal xenotransplantation: experimental progress and clinical prospectsKidney International.  91:790-796. 2017
2017 Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney graftsXenotransplantation.  24. 2017
2017 Therapeutic regulation of systemic inflammation in xenograft recipientsXenotransplantation.  24. 2017
2017 Transplantation of hepatocytes from genetically engineered pigs into baboonsXenotransplantation.  24. 2017
2016 Thyroid hormone: relevance to xenotransplantationXenotransplantation.  23:293-299. 2016
2016 Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigsXenotransplantation.  23:137-150. 2016
2016 The pathobiology of pig-to-primate xenotransplantation: A historical reviewXenotransplantation.  23:83-105. 2016
2016 Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigsIslets.  8:1-12. 2016
2015 Current status of pig kidney xenotransplantationInternational Journal of Surgery.  23:229-233. 2015
2015 In vitro testing of an anti-CD40 monoclonal antibody, clone 2C10, in primates and pigsTransplant Immunology.  33:185-191. 2015
2015 Further evidence for sustained systemic inflammation in xenograft recipients (SIXR)Xenotransplantation.  22:399-405. 2015
2015 Pig kidney graft survival in a baboon for 136 days: Longest life-supporting organ graft survival to dateXenotransplantation.  22:302-309. 2015
2015 Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigsTransplant Immunology.  32:99-108. 2015
2015 Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory proteinXenotransplantation.  22:310-316. 2015
2015 Glucose metabolism in pigs expressing human genes under an insulin promoterXenotransplantation.  22:70-79. 2015
2015 Pig-to-baboon heterotopic heart transplantation - Exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimensXenotransplantation.  22:211-220. 2015
2015 Systemic inflammation in xenograft recipients precedes activation of coagulationXenotransplantation.  22:32-47. 2015
2014 Increased soluble CD154 (CD40 Ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodiesTransplantation.  97:502-508. 2014
2014 Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?Xenotransplantation.  21:287-290. 2014
2014 Plasma free triiodothyronine (fT3) levels in baboons undergoing pig organ transplantation: Relevance to early recovery of organ functionXenotransplantation.  21:582-583. 2014
2014 Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibitionXenotransplantation.  21:72-83. 2014
2014 The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic optionsXenotransplantation.  21:201-220. 2014
2013 Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cellsCellular Immunology.  285:23-30. 2013
2012 Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate speciesXenotransplantation.  19:342-354. 2012
2012 Platelet aggregation in humans and nonhuman primates: Relevance to xenotransplantationXenotransplantation.  19:233-243. 2012
2011 Thrombocytopenia after pig-to-baboon liver xenotransplantation: Where do platelets go?Xenotransplantation.  18:320-327. 2011
2011 Clinical significance of regulatory T-cell-related gene expression in peripheral blood after renal transplantationTransplantation.  91:191-198. 2011

Education And Training

  • Doctor of Medicine in Surgical Critical Care Residency Program, Nagoya University 2011
  • Full Name

  • Hayato Iwase