• In October 2015, Dr. Herbert Chen was named as the new Chairman of the Department of Surgery. A native of Wisconsin, Chen received his undergraduate degree from Stanford University and began his medical education at the Duke University School of Medicine, graduating in 1992. He completed his surgical residency in general surgery at Johns Hopkins in 1999, along with a postdoctoral research fellowship in 1997 and a surgical oncology and endocrinology fellowship in 2000. Dr. Chen came to UAB from the University of Wisconsin, where he was the Layton F. Rikkers, M.D., Chair in Surgical Leadership, chair of the Division of General Surgery, vice chair of Research for the Department of Surgery and professor in the departments of Surgery, Biomedical Engineering and Pediatrics. Dr. Chen is a specialist in endocrine surgery, a funded surgeon scientist, and a dedicated educator. Dr. Chen is an Associate/Section Editor for Annals of Surgery, Annals of Surgical Oncology, Scientific American Surgery, The Oncologist, and Journal of Surgical Research, and serves on six other editorial boards. He is also the Past-President of Association for Academic Surgery, the current Secretary-Treasurer for Surgical Biology Club II, and the current President-Elect for the Society of Clinical Surgery. Dr. Chen has mentored over 100 faculty, post-doctoral fellows, residents, medical students, and undergraduates in his lab.

    Dr. Chen’s clinical interests include endocrine and neuroendocrine disease with a focus on minimally invasive endocrine surgery. He has one of the largest experiences with radioguided parathyroidectomy (MIRP), and performs high volume thyroid and adrenal surgery. Dr. Chen’s laboratory focuses on the role of cellular signaling pathways in the differentiation and growth of neuroendocrine (NE) tumors including carcinoid, pancreatic islet cell, pheochromocytoma, and medullary thyroid cancer.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Can imaging studies be omitted in patients with sporadic primary hyperparathyroidism? 2018
    2018 To admit or not to admit? Experience with outpatient thyroidectomy for Graves’ disease in a high-volume tertiary care center 2018
    2017 Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration 2017
    2017 AB3-loaded and tumor-targeted unimolecular micelles for medullary thyroid cancer treatment 2017
    2017 Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes 2017
    2017 Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo 2017
    2017 How long should we follow patients after apparently curative parathyroidectomy? 2017
    2017 The Epstein-Barr virus EBNA2 protein induces a subset of NOTCH target genes in thyroid cancer cell lines but fails to suppress proliferation 2017
    2017 The changing pattern of diagnosing primary hyperparathyroidism in young patients 2017
    2016 Generation of Novel Thyroid Cancer Stem-Like Cell Clones Effects of Resveratrol and Valproic Acid 2016
    2016 Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy 2016
    2015 Kidney Disease Improving Global Outcomes guidelines and parathyroidectomy for renal hyperparathyroidism 2015
    2014 Distinguishing classical papillary thyroid microcancers from follicular-variant microcancers 2014
    2014 Elevated parathyroid hormone after parathyroidectomy delays symptom improvement 2014
    2014 Failure of Radioactive Iodine in the Treatment of Hyperthyroidism 2014
    2014 Is central lymph node dissection necessary for parathyroid carcinoma? 2014
    2014 Is intraoperative parathyroid hormone monitoring necessary with ipsilateral parathyroid gland visualization during anticipated unilateral exploration for primary hyperparathyroidism: A two-institution analysis of more than 2,000 patients 2014
    2014 Novel approaches in anaplastic thyroid cancer therapy 2014
    2014 Novel thyroidectomy difficulty scale correlates with operative times 2014
    2014 Parathyroid conditions in childhood 2014
    2014 Postoperative surveillance of small appendiceal carcinoid tumors 2014
    2014 Radioactive iodine remnant uptake after completion thyroidectomy: Not such a complete cancer operation 2014
    2014 Recurrent and persistence primary hyperparathyroidism occurs more frequently in patients with double adenomas 2014
    2014 Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth 2014
    2014 Surgeon and Staff Radiation Exposure During Radioguided Parathyroidectomy at a High-Volume Institution 2014
    2014 Surgical site infection after thyroidectomy: A rare but significant complication 2014
    2014 The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression 2014
    2014 Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo 2014
    2013 Erratum: Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro (Anti-Cancer Drugs (2013) 24 (66-72)) 2013
    2013 Utility of111indium-pentetreotide scintigraphy in patients with neuroendocrine tumors 2013
    2013 A short-stay unit for thyroidectomy patients increases discharge efficiency 2013
    2013 Cancer after thyroidectomy: A multi-institutional experience with 1,523 patients 2013
    2013 Clinicopathologic characteristics of colonic carcinoid tumors 2013
    2013 Increased efficiency of endocrine procedures performed in an ambulatory operating room 2013
    2013 Radioactive iodine scanning is not beneficial but its use persists for euthyroid patients 2013
    2013 Radioguided parathyroidectomy effective in pediatric patients 2013
    2013 Signaling pathways as specific pharmacologic targets for neuroendocrine tumor therapy: RET, PI3K, MEK, growth factors, and Notch 2013
    2013 Significance of rebounding parathyroid hormone levels during parathyroidectomy 2013
    2013 Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line 2013
    2013 Unilateral thyroidectomy for the treatment of benign multinodular goiter 2013
    2012 Preoperative ultrasonography findings predict the need for repeated surgery in papillary thyroid cancer 2012
    2012 Hürthle cell metaplasia on fine-needle aspiration biopsy is not by itself an indication for thyroid surgery 2012
    2012 Presurgical localization of parathyroid adenomas with magnetic resonance imaging at 3.0 T: An adjunct method to supplement traditional imaging 2012
    2012 Erratum: Advances in surgical therapy for thyroid cancer (Nature Reviews Endocrinology (2011) 7 (581-588) DOI: 10.1038/nrendo.2011.140) 2012
    2012 Evolution of pediatric thyroid surgery at a tertiary medical center 2012
    2012 In patients with thyroid cancer of follicular cell origin, a family history of nonmedullary thyroid cancer in one first-degree relative is associated with more aggressive disease 2012
    2010 Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism 2010
    2008 Carcinoid tumors 2008
    2008 Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells 2008
    2008 Multi-targeted approach in the treatment of thyroid cancer 2008
    2008 Principles of minimally invasive parathyroidectomy 2008
    2008 Older age and larger tumor size predict malignancy in Hürthle cell neoplasms of the thyroid 2008
    2007 Isolated adrenal mass in patients with a history of cancer: Remember pheochromocytoma 2007
    2007 Valproic acid activates Notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells 2007
    2006 Metastatic neuroendocrine hepatic tumors: Resection improves survival 2006
    2005 A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: Which is most reliable? 2005
    2005 Changing trends for surgery in elderly patients with hyperparathyroidism at a single institution 2005
    2005 Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling 2005
    2004 Chronic abdominal pain and upper gastrointestinal bleeding due to duodenal perforation caused by migrated inferior vena cava filter: A case report 2004
    2004 Subclinical Cushing's syndrome in adrenal incidentalomas 2004
    2002 Long-term follow-up of patients with tertiary hyperparathyroidism treated by resection of a single or double adenoma 2002
    "Doctor, my thyroid is choking me": Common sense and scientific inquiry
    2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the Postpartum
    A Prospective Evaluation of Novel Methods to Intraoperatively Distinguish Parathyroid Tissue Utilizing a Parathyroid Hormone Assay
    A comparison of the ligasure and harmonic scalpel in thyroid surgery: A single institution review
    A mouse model of carcinoid syndrome and heart disease
    A multi-institutional international study of risk factors for hematoma after thyroidectomy
    A phase II trial of a histone deacetylase inhibitor panobinostat in patients with low-grade neuroendocrine tumors
    A preclinical and clinical study of lithium in low-grade neuroendocrine tumors
    A rising IoPTH level immediately after parathyroid resection: Are additional hyperfunctioning glands always present? an application of the wisconsin criteria
    ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: A case report and review of the literature
    AKT and PTEN expression in human gastrointestinal carcinoid tumors
    Accuracy of fine-needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules 4 cm or larger
    Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation
    Acute Isovolemic Hemodilution during Major Hepatic Resection - An Initial Report: Does It Safely Reduce the Blood Transfusion Requirement?
    Adenomas of cervical maldescended parathyroid glands: Pearls and pitfalls
    Adrenocorticotropic hormone-secreting pheochromocytomas: The exception to the rule
    Advances in surgical therapy for thyroid cancer
    All Thyroid Ultrasound Evaluations are Not Equal: Sonographers Specialized in Thyroid Cancer Correctly Label Clinical N0 Disease in Well Differentiated Thyroid Cancer
    An achaete-scute homologue essential for neuroendocrine differentiation in the lung
    An update on carcinoid tumors
    Anal ultrasound predicts the response to nonoperative treatment of fecal incontinence in men
    Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1
    Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
    Are Surgical Progeny More Likely to Pursue a Surgical Career?
    Are there predictors of malignancy in patients with multinodular goiter?
    Association for Academic Surgery Presidential Address Episode VI: The Return of the Surgeon1
    Author reply [2]
    Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids
    CaPTHUS Scoring Model in Primary Hyperparathyroidism: Can It Eliminate the Need for ioPTH Testing?
    Calciphylaxis in the absence of end-stage renal disease
    Carcinoid Tumors
    Catecholamine excess in pheochromocytoma inducing insulin resistance
    Changes in swallowing-related quality of life after parathyroidectomy for hyperparathyroidism: A prospective cohort study
    Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers
    Chrysin suppresses achaete-scute complex-like 1 and alters the neuroendocrine phenotype of carcinoids
    Clinical Efficacy of Fine-Needle Aspiration Biopsy of Thyroid Nodules in Males
    Clinically significant, isolated metastatic disease to the thyroid gland
    Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy
    Combination therapy with histone deacetylase inhibitors and lithium chloride: A novel treatment for carcinoid tumors
    Complete Hepatic Resection of Metastases from Leiomyosarcoma Prolongs Survival
    Compromised Outcome of Papillary Thyroid Cancer at Low-Volume Treatment Centers: Practice Makes Perfect?
    Consensus guidelines for the management and treatment of neuroendocrine tumors
    Consequences of parathyroidectomy in patients with "mild" sporadic primary hyperparathyroidism
    Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells
    Contralateral papillary thyroid cancer: does size matter?
    Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer
    Current Treatment of Papillary Thyroid Microcarcinoma
    Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis
    Do additional imaging studies change operative management in patients undergoing adrenalectomy? Presented at Central Surgical Association, Chicago, IL March 2015.
    Do the best students go into general surgery?
    Do the national institutes of health consensus guidelines for parathyroidectomy predict symptom severity and surgical outcome in patients with primary hyperparathyroidism?
    Does levothyroxine administration impact parathyroid localization?
    Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism?
    Does the final intraoperative PTH level really have to fall into the normal range to signify cure?
    Doing away with the rule of 10 %
    Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma
    Early-phase technetium-99m sestamibi scintigraphy can improve preoperative localization in primary hyperparathyroidism
    Editorial: The phantom menace: implications of polyclonality for surgical treatment of primary hyperparathyroidism
    Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection
    Encapsulated follicular variant of papillary thyroid cancer: are these tumors really benign?
    Endoscopie Transanal Resection Provides Palliation Equivalent to Transabdominal Resection in Patients with Metastatic Rectal Cancer
    Equal Oncologic Results for Laparoscopic and Open Resection of Adrenal Metastases
    Evaluation and management of the pediatric thyroid nodule
    Ex Vivo Radioactive Counts and Decay Rates of Tissues Resected During Radioguided Parathyroidectomy
    Fine-needle aspiration optimizes surgical management in patients with thyroid cancer
    Follicular lesions of the thyroid: Does frozen section evaluation alter operative management?
    Follicular variant of papillary thyroid carcinoma is a unique clinical entity: A population-based study of 10,740 cases
    Gastrointestinal Carcinoid Tumors: Factors that Predict Outcome
    General surgery and fellowship training: Opinions of surgical intern applicants and fellowship directors
    Growing Human Parathyroids in a Microphysiological System: A Novel Approach to Understanding and Developing New Treatments for Hyperparathyroidism
    Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells
    Health-related quality of life in hyperparathyroidism measurably improves after parathyroidectomy
    Hepatic Resection Using Intermittent Vascular Inflow Occlusion and Low Central Venous Pressure Anesthesia Improves Morbidity and Mortality
    Hereditary medullary thyroid cancer: Age-appropriate thyroidectomy improves disease-free survival
    Hesperetin, a potential therapy for carcinoid cancer
    Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage
    How academically productive are endocrine surgeons in the United States?
    Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors
    Hypoparathyroidism after total thyroidectomy: Incidence and resolution
    Hypothyroidism after a cancer diagnosis: Etiology, diagnosis, complications, and management
    Improvement of sleep disturbance and insomnia following parathyroidectomy for primary hyperparathyroidism
    In Brief
    In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer
    Inadequate cytology of thyroid nodules. Repeat it or live with it
    Influence of Surgical Volume on Operative Failures for Hyperparathyroidism
    Inhibition of Growth in Medullary Thyroid Cancer Cells with Histone Deacetylase Inhibitors and Lithium Chloride
    Inhibition of phosphatidylinositol 3-kinase/akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors
    Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells
    Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer
    Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
    Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cells
    Intraoperative Parathyroid Hormone Levels at 5 min Can Identify Multigland Disease
    Intraoperative adjuncts for parathyroid surgery
    Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy
    Intrathyroidal parathyroid glands: Small, but mighty (a Napoleon phenomenon)
    Is intraoperative parathyroid hormone testing in patients with renal insufficiency undergoing parathyroidectomy for primary hyperparathyroidism accurate?
    Is minimally invasive parathyroidectomy associated with greater recurrence compared to bilateral exploration? Analysis of more than 1,000 cases
    Is there still a glass ceiling for women in academic surgery?
    Is thyroidectomy in patients with Hashimoto thyroiditis more risky?
    Justified Follow-Up: A Final Intraoperative Parathyroid Hormone (ioPTH) Over 40 pg/mL is Associated with an Increased Risk of Persistence and Recurrence in Primary Hyperparathyroidism
    Laparoscopic resection of adrenal cortical carcinoma: A cautionary note
    Leflunomide suppresses growth in human medullary thyroid cancer cells
    Limitations of the ACS NSQIP in thyroid surgery
    Lithium inhibits carcinoid cell growth in vitro
    Long-term outcomes in patients with calciphylaxis from hyperparathyroidism
    Lymph Node Metastases do not Impact Survival in Follicular Variant Papillary Thyroid Cancer
    Lymph node ratio predicts recurrence in papillary thyroid cancer
    MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype
    MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through akt inhibition
    Markedly elevated thyroglobulin levels in the preoperative thyroidectomy patient correlates with metastatic burden
    Medical student operative experience correlates with a match to a categorical surgical program
    Medullary thyroid carcinoma: Targeted therapies and future directions
    MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets
    MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma
    Minimal benefit to subsequent intraoperative parathyroid hormone testing after all four glands have been identified
    Motivation to Pursue Surgical Subspecialty Training: Is There a Gender Difference?
    Multi-targeted approach in the treatment of thyroid cancer
    Multigland disease and slower decline in intraoperative PTH characterize mild primary hyperparathyroidism
    National Cancer Institute Centers and Society of Surgical Oncology Cancer Research Synergy
    New Trends in Parathyroid Surgery
    New developments in the diagnosis and treatment of thyroid cancer
    Nondiagnostic fine-needle aspirations of the thyroid: Is the risk of malignancy higher?
    Nonoperative management of primary hyperparathyroidism: The exception rather than the rule
    Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer
    Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors
    Notch1 signaling regulates the aggressiveness of differentiated thyroid cancer and inhibits SERPINE1 expression
    Notch3 as a novel therapeutic target in metastatic medullary thyroid cancer
    Novel analogs targeting histone deacetylase suppress aggressive thyroid cancer cell growth and induce re-differentiation
    Novel parathyroid hormone (1-84) assay as basis for parathyroid hormone monitoring in renal hyperparathyroidism - Invited critique
    Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors
    Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapy
    Operative failures after parathyroidectomy for hyperparathyroidism: The influence of surgical volume
    Outcomes After Subtotal Parathyroidectomy for Primary Hyperparathyroidism due to Hyperplasia: Significance of Whole vs. Partial Gland Remnant
    Outcomes of Surgically Managed Pediatric Thyroid Cancer
    Outpatient minimally invasive parathyroidectomy: A combination of sestamibi-SPECT localization, cervical block anesthesia, and intraoperative parathyroid hormone assay
    Palliative thyroidectomy for malignant lymphoma of the thyroid
    Parathyroid cryopreservation after parathyroidectomy: A worthwhile practice?
    Parathyroid hormone deficiency after total thyroidectomy: Incidence and time
    Parathyroidectomy promotes wound healing and prolongs survival in patients with calciphylaxis from secondary hyperparathyroidism
    Perforated Amyand's Hernia
    Persistent hypertension after adrenalectomy for an aldosterone-producing adenoma: Weight as a critical prognostic factor for aldosterone's lasting effect on the cardiac and vascular systems
    Postacute care after major abdominal surgery in elderly patients intersection of age, functional status, and postoperative complications
    Postoperative parathyroid hormone testing decreases symptomatic hypocalcemia and associated emergency room visits after total thyroidectomy
    Pre-operative management of patients with Graves' disease
    Presentation, management, and outcomes of hyperparathyroidism in octogenarians and nonagenarians
    Preserving function and quality of life after thyroid and parathyroid surgery
    Primary hyperparathyroidism
    Primary thyroid lymphoma: Can the diagnosis be made solely by fine-needle aspiration?
    Prospective Intervention of a Novel Levothyroxine Dosing Protocol Based on Body Mass Index after Thyroidectomy Presented at the American College of Surgeons 100th Annual Clinical Congress, San Francisco, CA, October 2014.
    Radioguided Parathyroidectomy for Recurrent Hyperparathyroidism Caused by Forearm Graft Hyperplasia
    Radioguided parathyroidectomy for hyperparathyroidism in the reoperative neck
    Radioguided parathyroidectomy for tertiary hyperparathyroidism
    Radioguided parathyroidectomy in patients with familial hyperparathyroidism
    Radioguided parathyroidectomy in patients with secondary and tertiary hyperparathyroidism
    Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands.
    Radioguided techniques for parathyroid surgery
    Radioguided thoracoscopic mediastinal parathyroidectomy with intraoperative parathyroid hormone testing
    Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion
    Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells
    Reduced disparities and improved surgical outcomes for Asian Americans with colorectal cancer
    Reducing cost and improving operating room efficiency: examination of surgical instrument processing
    Remnant uptake as a postoperative oncologic quality indicator
    Reply: A rising ioPTH level immediately after parathyroid resection: Are additional hyperfunctioning glands always present? An application of the wisconsin criteria
    Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer
    Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth
    Revisiting Adrenal Mass Size as an Indication for Adrenalectomy
    Role of postoperative vitamindand/or calcium routine supplementation in preventing hypocalcemia after thyroidectomy:Asystematic review and meta-analysis
    Routine chest X-ray prior to thyroid surgery: Is it always necessary?
    Safety and feasibility of laparoscopic resection for large (≥6 cm) pheochromocytomas without suspected malignancy
    Same-day thyroidectomy program: Eligibility and safety evaluation
    Secondary and tertiary hyperparathyroidism: The utility of ioPTH monitoring
    Sestamibi imaging for primary hyperparathyroidism: The impact of surgeon interpretation and radiologist volume
    Should patients with symptomatic Hashimoto's thyroiditis pursue surgery?
    Surgery improves quality of life in patients with "mild" hyperparathyroidism
    Surgery: Papillary thyroid cancer-how aggressive should surgery be?
    Surveillance of small rectal carcinoid tumors in the absence of metastatic disease
    Synchronous and antecedent nonthyroidal malignancies in patients with papillary thyroid carcinoma
    Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro
    Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3β
    Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway
    Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid
    Tertiary hyperparathyroidism: Is less than a subtotal resection ever appropriate? A study of long-term outcomes
    The Association for Academic Surgeons 2001-2010: a decade of inclusiveness
    The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids
    The Raf-1 pathway: A molecular target for treatment of select neuroendocrine tumors?
    The Surgical Management of Graves' Disease
    The current management of thyroid cancer.
    The effectiveness of radioguided parathyroidectomy in patients with negative technetium Tc 99m-sestamibi scans
    The effects of tenure and promotion on surgeon productivity
    The incidence of thyroid cancer by f ine needle aspiration varies by age and gender
    The influence of surgical approach on quality of life after parathyroid surgery
    The necessity and reliability of intraoperative parathyroid hormone (PTH) Testing in patients with mild hyperparathyroidism and PTH levels in the normal range: Reply
    The necessity and reliability of intraoperative parathyroid hormone (PTH) testing in patients with mild hyperparathyroidism and PTH levels in the normal range
    The north american neuroendocrine tumor society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer
    The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer
    The role of fine-needle aspiration in the evaluation of thyroid nodules
    The role of gender in primary hyperparathyroidism: Same disease, different presentation
    The role of human achaete-scute homolog-1 in medullary thyroid cancer cells
    The role of intraoperative frozen section if suspicious for papillary thyroid cancer
    The role of intraoperative parathyroid hormone testing in patients with tertiary hyperparathyroidism after renal transplantation
    The utility of frozen section evaluation for follicular thyroid lesions
    The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing
    The utility of metaiodobenzylguanidine (MIBG) scintigraphy in patients with pheochromocytoma
    Thyroglobulin antibody resolution after total thyroidectomy for cancer
    Thyroid resection improves perception of swallowing function in patients with thyroid disease
    Treatment of advanced carcinoid tumors
    Treatment of advanced carcinoid tumors.
    Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.
    Tumor-suppressor role of notch3 in medullary thyroid carcinoma revealed by genetic and pharmacological induction
    Use of technetium Tc 99m sestamibi scintigraphy for recurrent tertiary hyperparathyroidism from a parathyroid forearm graft
    Utilization of fine-needle aspiration in patients undergoing thyroidectomy at two academic centers across the Atlantic
    Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells
    What is the Biology and Optimal Treatment for Papillary Microcarcinoma of the Thyroid?
    What is the Utility of distal forearm DXA in primary Hyperparathyroidism?
    What is the added benefit of cervical ultrasound to 99mTc- sestamibi scanning in primary hyperparathyroidism?
    What is the optimal treatment for children with primary hyperparathyroidism?
    When patients call their surgeon's office: An opportunity to improve the quality of surgical care and prevent readmissions
    Why do students choose careers in surgery?
    ZM336372 Induces Apoptosis Associated with Phosphorylation of GSK-3β in Pancreatic Adenocarcinoma Cell Lines
    ZM336372, A Raf-1 Activator, Causes Suppression of Proliferation in a Human Hepatocellular Carcinoma Cell Line
    ZM336372, A Raf-1 Activator, Inhibits Growth of Pheochromocytoma Cells
    ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells


    Year Title Altmetric
    2018 Diagnosis and Management of Hyperparathyroidism.  Ed. 52.  2018
    2012 Success in academic surgery: Part 1 2012
    2011 Preface 2011
    2011 The handbook of endocrine surgery 2011
    2010 Preface 2010
    2010 Preface 2010
    2010 Primary hyperparathyroidism.  Ed. 153.  2010


    Year Title Altmetric
    2017 Parathyroid surgery in children.  61-73. 2017
    2015 Thyroid cancer.  539-561. 2015
    2014 Radioguided parathyroidectomy.  151-156. 2014
    2013 Cancer of the Endocrine System.  1112-1142. 2013
    2012 Medullary thyroid cancer.  293-296. 2012
    2012 Thyroid lymphoma and other metastatic lesions.  259-267. 2012
    2012 Fine needle aspiration biopsy of the thyroid: Thyroid lobectomy and subtotal and total thyroidectomy 2012
    2011 Clinical management of primary hyperparathyroidism.  171-178. 2011
    2008 Reoperative Endocrine Surgery.  135-149. 2008
    2007 Thyroid lymphoma and other metastatic lesions.  171-177. 2007
    2005 Hürthle cell adenoma and carcinoma.  123-128. 2005

    Research Overview

  • thyroid and parathyroid surgery, minimally invasive radioguided parathyroidectomy, adrenal surgery, endocrine surgery, neuroendocrine cancer biology
  • Teaching Activities

  • STP299DI - ENDOCRINE SURGERY (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Spring Term 2018) 2018
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Spring Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Spring Term 2018) 2018
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Spring Term 2017) 2017
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016) 2016
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Spring Term 2016) 2016
  • Education And Training

  • Doctor of Medicine, Duke University 1992
  • Johns hopkins medical institutions, Residency 1999
  • Johns Hopkins Medical Institutions, Postdoctoral Fellowship 2000
  • Full Name

  • Herbert Chen