Marques, Marisa

Marques, Marisa
Professor

Professor (P), Laboratory Medicine , Clinical Pathology 1999 -

Overview

I received my M.D. degree from the Federal University of Rio Grande do Sul in Brazil, followed by residency in Internal Medicine at the same institution. I moved to the United States with my husband in 1986 to become a Research Fellow at the National Institutes of Health in Bethesda, Maryland, for 2 years. We then moved to Boston, where I continued working as a fellow at Harvard Medical School. In 1993, we relocated to Birmingham, Alabama. I completed a residency in Pathology and a fellowship in Hematopathology at UAB and am Board certified in Anatomic and Clinical Pathology, with subspecialties in Hematology and Transfusion Medicine/Blood Banking. I am Professor of Pathology at UAB, serving medical director of Transfusion Services. I spent my time doing patient care, teaching, clinical research and administrative duties. In the clinical arena, I am particularly interested in improving appropriateness of utilization of blood products and laboratory tests. I thoroughly enjoy giving lectures locally and in other institutions on these topics and the role of the clinical pathologist in decreasing diagnostic error. Finally, UAB is a pioneer in Patient Blood Management through a collaboration between the Transfusion Services, clinicians and hospital administration since 2007.

Selected Publications

Academic Article

Year	Title	Altmetric
2019	In Reply: 2019
2019	Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial 2019
2019	Validation and cost-effectiveness of an in-house dithiothreitol (DTT)treatment protocol for daratumumab patients in a large tertiary care hospital provides gateway for implementation in smaller community hospitals 2019
2019	Three neglected numbers in the CBC: The RDW, MPV, and NRBC count 2019
2019	Fat embolism syndrome due to bone marrow necrosis in patients with hemoglobinopathies: A life-threatening complication mimicking thrombotic thrombocytopenic purpura 2019
2019	Mobilization of Hematopoietic Progenitor Cells for Autologous Transplantation Using Pegfilgrastim and Plerixafor: Efficacy and Cost Implications 2019
2019	An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura 2019
2019	Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura 2019
2019	Revisiting fat embolism in sickle syndromes: diagnostic and emergency therapeutic measures 2019
2019	Solving the calcium gluconate shortage in real-time: Mistakes made and lessons learned 2019
2018	Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial 2018
2018	Older blood is associated with increased mortality and adverse events in massively transfused trauma patients: secondary analysis of the PROPPR trial 2018
2018	Rat poisoning: A challenging diagnosis with clinical and psychological implications 2018
2018	Therapeutic plasma exchange For Hashimoto's encephalopathy 2018
2018	Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study 2018
2018	Hospital-acquired anemia due to diagnostic and therapy-related blood loss in inpatients with myasthenia gravis receiving therapeutic plasma exchange 2018
2018	Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literature 2018
2018	Vascular access for therapeutic plasma exchange 2018
2018	Characterization of storage-induced red blood cell hemolysis using Raman spectroscopy 2018
2018	New subcutaneous PowerFlow port results in cost and time-savings in a busy outpatient apheresis clinic 2018
2017	Increased troponin I is associated with fatal outcome in acquired thrombotic thrombocytopenic purpura 2017
2017	Do Institution-Level Blood Utilization and Blood Management Initiatives Meaningfully Impact Transfusion Practices in Cardiac Surgery? 2017
2017	An Unusual Presentation of Thrombotic Thrombocytopenic Purpura 2017
2017	Extracorporeal photopheresis practice patterns: An international survey by the ASFA ECP subcommittee 2017
2017	Clinical Scoring Systems in Thrombotic Microangiopathies 2017
2017	Assuring hospital supply of fresh red blood cells for critically ill patients 2017
2017	Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study 2017
2017	Increased Plasma Levels of Human Neutrophil Peptides and Complement Activation Markers in Patients With Acquired Thrombotic Thrombocytopenic Purpura. 2017
2017	Usage Pattern of 4-Factor Prothrombin Complex Concentrate in a Tertiary Care Center. 2017
2017	A safe and effective management strategy for BCVI 2017
2017	Ficin-treated red cells help identify clinically significant alloantibodies masked as reactions of undetermined specificity in gel microtubes 2017
2017	Opportunities to enhance laboratory professionals' role on the diagnostic team 2017
2017	Zika Virus and Patient Blood Management 2017
2016	Establishing an institutional therapeutic apheresis registry 2016
2016	Inside Out: Bone Marrow Necrosis and Fat Embolism Complicating Sickle-β+ Thalassemia 2016
2016	Use of hydroxyethyl starch in leukocytapheresis procedures does not increase renal toxicity 2016
2016	Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura 2016
2016	Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices 2016
2016	Cryoprecipitate AHF vs. fibrinogen concentrates for fibrinogen replacement in acquired bleeding patients – an economic evaluation 2016
2016	Patient Blood Management as Standard of Care 2016
2016	Society for the Advancement of Patient Blood Management and Anesthesia & Analgesia: A New Collaboration and Home for Blood Management Research 2016
2016	The thrombotic microangiopathy Registry of North America: A United States multi-institutional TMA network 2016
2016	Therapeutic plasma exchange for intractable pruritus secondary to primary sclerosing cholangitis 2016
2016	Fat embolism syndrome secondary to bone marrow necrosis in patients with hemoglobinopathies 2016
2016	High percentage of evanescent red cell antibodies in patients with sickle cell disease highlights need for a national antibody database 2016
2016	Anti–Blood Group Antibodies in Intravenous Immunoglobulin May Complicate Interpretation of Antibody Titers in ABO-Incompatible Transplantation 2016
2016	Apheresis research–more abstracts should be published as full manuscripts to provide more evidence for clinical practice guidelines 2016
2016	The American Society for Apheresis (ASFA) is pleased to offer a Qualification in Apheresis (QIA) in partnership with The Board of Certification (BOC) of the American Society for Clinical Pathology (ASCP) starting in January of 2016! 2016
2016	Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism 2016
2016	Pathology consultation on the diagnosis and treatment of thrombotic microangiopathies (TMAs) 2016
2015	Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements 2015
2015	Defining the effects of storage on platelet bioenergetics: The role of increased proton leak 2015
2015	Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage 2015
2015	Metabolic plasticity in resting and thrombin activated platelets 2015
2015	Peroxiredoxin-2 recycling is inhibited during erythrocyte storage 2015
2015	Adverse Effects of Transfusion 2015
2015	Apheresis in developing countries around the World 2015
2015	Influence of Kidney Function on Risk of Supratherapeutic International Normalized Ratio-Related Hemorrhage in Warfarin Users: A Prospective Cohort Study 2015
2015	Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: Experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial 2015
2015	Rhesus immune globulin dosing in the obesity epidemic era 2015
2014	Perioperative management of the patient with a coronary artery stent 2014
2014	Compliance rates and outcomes associated with a restrictive transfusion policy in gynecologic oncology patients 2014
2014	Extracorporeal photopheresis: Technique, established and novel indications 2014
2014	Membrane attack complex generation increases as a function of time in stored blood 2014
2014	Out with the bad and in with the good; Red cell exchange, white cell reduction, and platelet reduction 2014
2014	Perceptions about blood transfusion: A survey of surgical patients and their anesthesiologists and surgeons 2014
2014	Periprocedural management of patients on anticoagulants 2014
2014	Primary care physicians and the laboratory now and the future 2014
2014	Single-center experience with extracorporeal photopheresis in pediatric heart transplantation 2014
2014	Successful pulmonary thromboendarterectomy in a patient with sickle cell disease treated with a single preoperative red blood cell exchange 2014
2014	The success of our patient blood management program depended on an institution-wide change in transfusion practices 2014
2014	Therapeutic apheresis academy 2013: Beyond borders 2014
2014	Therapeutic plasma exchange rapidly improves cardiac allograft function in patients with presumed antibody-mediated rejection 2014
2014	Thrombotic thrombocytopenic purpura: 2012 American Society for Apheresis (ASFA) consensus conference on classification, diagnosis, management, and future research 2014
2013	Relapses of thrombotic thrombocytopenic purpura after treatment with rituximab 2013
2013	The level of complement activation fragments is higher in red blood cell units than segments 2013
2013	Novel ADAMTS13 mutations in an obstetric patient with Upshaw-Schulman syndrome 2013
2013	Thrombotic thrombocytopenic purpura does not show seasonal variation in Alabama 2013
2013	Acquired von Willebrand's disease in myelofibrosis and essential thrombocythemia 2013
2013	Decoding laboratory test names: A major challenge to appropriate patient care 2013
2013	Letters to the editor 2013
2013	The isolated prolonged PTT 2013
2012	Erythrocyte storage increases rates of NO and nitrite scavenging: Implications for transfusion-related toxicity 2012
2012	How we closed the gap between red blood cell utilization and whole blood collections in our institution 2012
2012	Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury 2012
2012	Massive hemolysis due to thrombotic thrombocytopenic purpura in a patient with AIDS 2012
2012	Multiorgan failure and bone marrow necrosis in three adults with sickle cell-β ⁺ -thalassemia 2012
2012	Recommendations for appropriate activated partial thromboplastin time reagent selection and utilization 2012
2012	Pathology consultation on the laboratory evaluation of thrombophilia when, how, and why 2012
2012	Red blood cell transfusion: A Clinical practice guideline from the AABB 2012
2011	Update on extracorporeal photopheresis in heart and lung transplantation 2011
2011	Von Willebrand disease laboratory diagnosis: The Saga continues 2011
2011	The clinical pathologist as consultant 2011
2010	Duration of red cell storage influences mortality after trauma 2010
2010	Systemic neutrophilic aggregates in transfusion-related acute lung injury 2010
2010	Educating medical students in laboratory medicine: A proposed curriculum 2010
2010	Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults 2010
2010	Guidelines on the use of therapeutic apheresis in clinical practice - Evidence-based approach from the apheresis applications committee of the American Society for Apheresis 2010
2009	Is therapeutic plasma exchange indicated for patients with gemcitabine-induced hemolytic uremic syndrome? 2009
2009	Transfusion and pneumonia in the trauma intensive care unit: An examination of the temporal relationship 2009
2009	A simple tool to educate laboratory staff about anticoagulation 2009
2009	Blood utilization at a level I trauma center: Is this as good as it gets? 2009
2009	Transfusion and pneumonia in the trauma intensive care unit: an examination of the temporal relationship. 2009
2009	Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia: Two Unique Causes of Life-Threatening Thrombocytopenia 2009
2009	An adolescent with a history of menorrhagia 2009
2009	An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura 2009
2009	Free flap failure secondary to dual thrombophilia 2009
2009	Genetic susceptibility to VTE: a primary care approach. 2009
2008	Transfusions in the less severely injured: Does age of transfused blood affect outcomes? 2008
2008	Transfusions in the less severely injured: does age of transfused blood affect outcomes? 2008
2008	Age of transfused blood: an independent predictor of mortality despite universal leukoreduction. 2008
2008	A new "initial" case of transfusion-related acute lung injury 2008
2008	Screening with the activated protein C resistance assay yields significant savings in a patient population with low prevalence of factor V Leiden 2008
2008	Transfusion-related acute lung injury: Past, present, and future 2008
2007	Continuous infusion of calcium gluconate in 5% albumin is safe and prevents most hypocalcemic reactions during therapeutic plasma exchange 2007
2007	Category IV indications for therapeutic apheresis - ASFA fourth special issue 2007
2007	Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis 2007
2007	Teaching Medical Students Basic Principles of Laboratory Medicine 2007
2007	Refractory thrombocytopenia and positive platelet crossmatches without HLA or platelet-specific antibodies 2007
2007	Predictors of response and relapse in a cohort of adults with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: A single-institution experience 2007
2007	Thrombelastographic measures of clot propagation: A comparison of alpha with the maximum rate of thrombus generation 2007
2006	Estimating blood needs for very-low-birth-weight infants 2006
2006	Autoimmune hemolytic anemia in an infant with giant cell hepatitis. 2006
2006	Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin 2006
2006	Rejection with hemodynamic compromise: Objective evidence for efficacy of photopheresis 2006
2006	A neonate with bleeding and multiple factor deficiencies 2006
2006	Bilateral pulmonary thromboembolism in a 42-year-old woman 2006
2006	Evaluation of thrombocytopenia 2006
2006	Laboratory evaluation and transfusion support of patients with autoimmune hemolytic anemia. 2006
2006	Photopheresis in solid organ transplant rejection. 2006
2005	Current diagnosis and management of Thrombotic Thrombocytopenic Purpura: Utility of von-Willebrand Factor cleaving protease (ADAMTS 13) 2005
2005	Acute transient leukopenia as a sign of TRALI [5] 2005
2005	Unusual thromboses associated with protein S deficiency in patients with acquired immunodeficiency syndrome: Case reports and review of the literature 2005
2005	A 34-year-old-male with progressive neurologic decline 2005
2005	Thrombosis risk testing in the clinical laboratory 2005
2005	Transfusion safety: what has been done; what is still needed? 2005
2004	Point-of-care testing in oral anticoagulation: what is the point? 2004
2004	Hemolytic uremic syndrome revisited: Shiga toxin, factor H, and fibrin generation. 2004
2004	Thrombotic thrombocytopenic purpura: from platelet aggregates to plasma. 2004
2003	Etiology of Pulmonary Thromboembolism in the Absence of Commonly Recognized Risk Factors 2003
2003	Phase II study of docetaxel plus enoxaparin in chemotherapy-naive patients with metastatic non-small cell lung cancer: Preliminary results 2003
2003	Scurvy: An often forgotten cause of bleeding [2] 2003
2003	Laboratory evaluation of coagulation inhibitors 2003
2003	Treatment of single factor deficiencies: a case study approach. 2003
2003	Clinical Pathology Consultation Improves Coagulation Factor Utilization in Hospitalized Adults 2003
2003	The effect of lupus anticoagulant in the second-generation assay for activated protein C resistance 2003
2003	Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura. 2003
2002	Altering interface detector positioning in combination with prestorage filtration to achieve a better quality of single donor platelet concentrates using the CS 3000 Plus blood separator 2002
2002	Management of a patient with HIV infection-induced anemia and thrombocytopenia who presented with thrombotic thrombocytopenic purpura 2002
2002	Characteristics of photopheresis treatments for the management of rejection in heart and lung transplant recipients. 2002
2002	Testing for genetic predisposition to venous thrombosis. 2002
2001	Patients with thrombotic thrombocytopenic purpura commonly develop metabolic alkalosis during therapeutic plasma exchange 2001
2001	When to suspect hypercoagulability and how to investigate it 2001
2000	Defining/Measuring the Value of Clinical Information 2000
2000	A pregnant patient with sickle cell disease and cefotetan-induced immune hemolysis 2000
2000	Histologic examination of bone marrow core biopsy specimens has limited value in the diagnosis of mycobacterial and fungal infections in patients with the acquired immunodeficiency syndrome 2000
1998	The yield of bone marrow biopsy and culture compared with blood culture in the evaluation of HIV-infected patients for mycobacterial and fungal infections 1998
1998	Bone marrow biopsy and blood culture in evaluating HIV patients [5] (multiple letters) 1998
1998	Two acute pediatric abdominal catastrophes from strangulated left paraduodenal hernias 1998
1997	Comparative in vitro antimicrobial susceptibilities of nosocomial isolates of Acinetobacter baumannii and synergistic activities of nine antimicrobial combinations 1997
1997	Detection of Kingella kingae bacteremia and identification of the organism in the clinical laboratory: Experience from two cases 1997
1997	Genotypic investigation of multidrug-resistant Acinetobacter baumannii infections in a medical intensive care unit 1997
1994	Functional activity of antibodies to the group B polysaccharide of group B streptococci elicited by a polysaccharide-protein conjugate vaccine. 1994
1992	Prevention of C3 deposition by capsular polysaccharide is a virulence mechanism of type III group B streptococci. 1992
1992	Growth in acidic media increases production of phosphatidylinositol-specific phospholipase C byStaphylococcus aureus 1992
1989	High-dose intravenous immunoglobulin modifies complement-mediated in vivo clearance 1989
1989	Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus 1989

Book

Year	Title	Altmetric
2018	Blood management 2018
2015	A Quick Guide to Hemostasis (former Coagulation Testing) – third edition 2015
2009	A Quick Guide to Coagulation Testing – second edition 2009
2006	A Quick Guide to Coagulation Testing 2006
2006	A Quick Guide to Transfusion Medicine 2006

Chapter

Year	Title	Altmetric
2017	Hemostasis and thrombosis-laboratory diagnosis and treatment. 295-325. 2017
2017	Patient blood management. 201-218. 2017
2010	Apheresis in Solid Organ Transplantation 2010
2007	Hemorrhagic Coagulation Disorders 2007

Research Overview

Patient Blood Management - I am interested in various aspects of clinical research in the fields of coagulation and transfusion medicine. Since UAB is a center of reference for apheresis, we receive patients from throughout Alabama and neighboring states to be treated here for thrombotic thrombocytopenic purpura (TTP). In the last several years, I have been involved in several projects about TTP as seen in my list of publications. Other areas of interest in Transfusion Medicine include the effect of storage time on the red blood cells and the repercussion for the patients, as well as transfusion-related acute lung injury (TRALI). In the area of coagulation, I have an interest in hypercoagulability, heparin-induced thrombocytopenia diagnosis, and cost-effective utilization of laboratory assays.

Keywords - Thrombotic thrombocytopenic purpura (TTP), patient blood management