Positions

Overview

  • Deep brain stimulation (DBS) is more effective than medications and other conventional therapies for motor symptoms of Parkinson's disease, dystonia, and essential tremor. Emerging DBS technologies such as directional and closed loop stimulation have substantial potential to improve a variety of patient outcomes. However these devices are increasingly adaptable and complex, and we lack robust tools to fully realize their therapeutic potential. Dr. Walker's lab investigates how deep brain stimulation works using a multimodal approach that integrates electroencephalography, electrocorticography, single unit recordings, neuroimaging, and behavioral assessment in patients with movement disorders. Our goal is to obtain new knowledge about the therapeutic mechanism of DBS and apply these findings to guide technological innovation, both for established indications and for emerging indications in neurology and psychiatry.

    Originally from Starkville, Mississippi, Dr. Walker graduated Phi Beta Kappa and Summa Cum Laude from Birmingham-Southern College in 1997 with a BA in music. He attended medical school at the University of Alabama at Birmingham, where he participated in the Howard Hughes Medical Institute Research Scholars Program at the National Institutes of Health in Bethesda, Maryland. Following medical school, Dr. Walker pursued his neurology residency and movement disorders fellowship training at the University of Alabama at Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Reoperation for device infection and erosion following deep brain stimulation implantable pulse generator placement.Journal of Neurosurgery.  1-8. 2019
    2019 Cortical Activation Elicited by Subthalamic Deep Brain Stimulation Predicts Postoperative Motor Side EffectsNeuromodulation.  22:456-464. 2019
    2019 Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptomsParkinsonism and Related Disorders.  60:126-132. 2019
    2019 Awake testing during deep brain stimulation surgery predicts postoperative stimulation side effect thresholdsBrain Sciences.  9. 2019
    2019 A study on the feasibility of the Deep Brain Stimulation (DBS) electrode localization based on scalp electric potential recordingsFrontiers in Physiology.  10. 2019
    2018 A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulationNeuroradiology.  60:303-309. 2018
    2018 Efficacy and safety of deep brain stimulation in tourette syndrome the international tourette syndrome deep brain stimulation public database and registryJAMA Neurology.  75:353-359. 2018
    2018 Evolving applications, technological challenges and future opportunities in neuromodulation: Proceedings of the fifth annual deep brain stimulation think tankFrontiers in Neuroscience.  11. 2018
    2018 A feasibility study of combined intermittent theta burst stimulation and modified constraint-induced aphasia therapy in chronic post-stroke aphasiaRestorative Neurology and Neuroscience.  36:503-518. 2018
    2017 The relationship of electrophysiologic subthalamic nucleus length as a predictor of outcomes in deep brain stimulation for Parkinson diseaseStereotactic and Functional Neurosurgery.  95:341-347. 2017
    2017 Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trialParkinsonism and Related Disorders.  40:18-26. 2017
    2017 The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's diseaseBrain Stimulation.  10:651-656. 2017
    2017 Effects of Subthalamic Nucleus Deep Brain Stimulation on Objective Sleep Outcomes in Parkinson's DiseaseMovement Disorders Clinical Practice.  4:183-190. 2017
    2016 Proceedings of the fourth annual deep brain stimulation think tank: A review of emerging issues and technologiesFrontiers in Integrative Neuroscience.  10. 2016
    2016 Coneless Linear Accelerator-Based Volumetric Modulated Arc Therapy Stereotactic Radiosurgery Technique for Functional Disorders.International Journal of Radiation Oncology - Biology - Physics.  96:E657-E658. 2016
    2016 Deep Brain Stimulation Battery Longevity: Comparison of Monopolar Versus Bipolar Stimulation ModesMovement Disorders Clinical Practice.  3:359-366. 2016
    2016 The international deep brain stimulation registry and database for gilles de la tourette syndrome: How does it work?Frontiers in Neuroscience.  10. 2016
    2016 Pregnancy in a Series of Dystonia Patients Treated with Deep Brain Stimulation: Outcomes and Management RecommendationsStereotactic and Functional Neurosurgery.  94:60-65. 2016
    2015 Impact of Depression on Progression of Impairment and Disability in Early Parkinson's DiseaseMovement Disorders Clinical Practice.  2:371-378. 2015
    2015 Reversible improvement in severe freezing of gait from Parkinson's disease with unilateral interleaved subthalamic brain stimulationParkinsonism and Related Disorders.  21:1469-1470. 2015
    2015 Tourette syndrome deep brain stimulation: A review and updated recommendationsMovement Disorders.  30:448-471. 2015
    2015 Adverse events associated with deep brain stimulation for movement disorders: Analysis of 510 consecutive casesOperative Neurosurgery.  11:200. 2015
    2015 Spatial topographies of unilateral subthalamic nucleus deep brain stimulation efficacy for ipsilateral, contralateral, midline, and total Parkinson disease motor symptomsOperative Neurosurgery.  11:80-88. 2015
    2015 Prevalence and characteristics of tremor in the NARCOMS multiple sclerosis registry: A cross-sectional surveyBMJ Open.  5. 2015
    2015 Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the PipelineInternational Journal of Neuroscience.  125:475-485. 2015
    2014 Shorter pulse generator longevity and more frequent stimulator adjustments with pallidal DBS for dystonia versus other movement disordersBrain Stimulation.  7:345-349. 2014
    2013 The relationship between clinical phenotype and early staged bilateral deep brain stimulation in Parkinson disease: Clinical articleJournal of Neurosurgery.  119:1530-1536. 2013
    2013 A trial of scheduled deep brain stimulation for tourette syndrome: Moving away from continuous deep brain stimulation paradigmsArchives of Neurology -Chigago-.  70:85-94. 2013
    2013 Noninvasive measurement of cortical activity during effective brain stimulation for movement disordersFuture Neurology.  8:9-12. 2013
    2012 Short latency activation of cortex by clinically effective thalamic brain stimulation for tremorMovement Disorders.  27:1404-1412. 2012
    2012 Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's diseaseMovement Disorders.  27:864-873. 2012
    2012 Design innovations and baseline findings in a long-term parkinson’s trial: The national institute of neurological disorders and stroke exploratory trials in parkinson’s disease long-term study-1Movement Disorders.  27:1513-1521. 2012
    2012 High-frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's diseaseMovement Disorders.  27:168-169. 2012
    2012 Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson's diseaseParkinsonism and Related Disorders.  18:63-68. 2012
    2011 High-frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's diseaseMovement Disorders.  26:2232-2238. 2011
    2011 Challenges in diagnosis of isolated central nervous system vasculitisBrain and Behavior.  1:57-61. 2011
    2011 Comparison of weight changes following unilateral and staged bilateral STN DBS for advanced PDBrain and Behavior.  1:12-18. 2011
    2011 Activation of subthalamic neurons by contralateral subthalamic deep brain stimulation in parkinson diseaseJournal of Neurophysiology.  105:1112-1121. 2011
    2011 The effects of deep brain stimulation on sleep in Parkinson’s diseaseTherapeutic Advances in Neurological Disorders.  4:15-24. 2011
    2010 Construction of relational topographies from the quantitative measurements of functional deep brain stimulation using a 'roving window' interpolation algorithmStereotactic and Functional Neurosurgery.  88:16-23. 2010
    2010 Step activity in persons with Parkinsons diseaseJournal of Physical Activity and Health.  7:724-729. 2010
    2009 Relief of acquired stuttering associated with Parkinson's disease by unilateral left subthalamic brain stimulationJournal of Speech, Language, and Hearing Research.  52:1652-1657. 2009
    2009 Weight changes associated with unilateral STN DBS and advanced PDParkinsonism and Related Disorders.  15:709-711. 2009
    2009 Bilateral effects of unilateral subthalamic deep brain stimulation on parkinson's disease at 1 yearNeurosurgery.  65:302-309. 2009
    2007 Corticobasal degenerationHandbook of Clinical Neurology.  84:351-372. 2007
    2002 Activation of kinetically distinct synaptic conductances on inhibitory interneurons by electrotonically overlapping afferentsNeuron.  35:161-171. 2002

    Chapter

    Year Title Altmetric
    2015 Basal ganglia physiology and dbs for parkinson's disease: Introduction and postulated mechanisms.  19-30. 2015
    2015 Impact of surgical therapies on sleep and alertness in Parkinson’s disease.  195-207. 2015

    Investigator On

  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC. 2018 - 2022
  • University of Alabama at Birmingham_The Edumond J. Safra Fellowship in Movement Disorders 2017  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2020
  • UAB Bachmann-Straus Dystonia and Parkinson's Disease Center of Excellence  awarded by Bachmann-Strauss Dystonia & Parkinson Foundation, Inc 2013 - 2018
  • Post-Stroke Aphasia and rTMS Treatment (PART) Study  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2012 - 2018
  • The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Private Grant  awarded by SANGAMO BIOSCIENCES, INC. 2013 - 2016
  • Alzheimer's Disease Cooperative Study  awarded by University of California, San Diego 2013 - 2015
  • UAB PD Neuroprotection Clinical Trial Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2014
  • A Double-Blind, Placebo-Controlled (Sham Surgery), Randomized, Multicenter Study Evaluating CERE-110 Gene Delivery in Subjects with Mild to Moderate Alzheimer's Disease (CERE 110-3)  awarded by University of California, San Diego 2011 - 2013
  • Stenting vs. Aggressive Medical Management for Preventing Recurrent Events in Intracranial Stenosis (SAMMPRIS)  awarded by Medical University of South Carolina 2008 - 2013
  • UAB Parkinson's Disease Neuroprotection Clinical Trial Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2008 - 2012
  • Education And Training

  • Doctor of Medicine, University of Alabama at Birmingham 2001
  • Bachelor of Humanities in Music, Birmingham-Southern College 1997
  • Baptist Medical Center - Montclair, Internship 2002
  • UAB Hospital Neurology, Residency 2006
  • Full Name

  • Harrison Walker