Selected Publications

Academic Article

Year Title Altmetric
2023 Obesity and Overweight: Probing Causes, Consequences, and Novel Therapeutic Approaches Through the American Heart Association’s Strategically Focused Research NetworkJournal of the American Heart Association.  12. 2023
2022 Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in MiceDiabetes.  71:2123-2135. 2022
2022 Mother-child cardiometabolic health 4–10 years after pregnancy complicated by obesity with and without gestational diabetes 2022
2022 Cross Talk Between Insulin and Glucagon Receptor Signaling in the HepatocyteDiabetes.  71:1842-1851. 2022
2021 Sam68 promotes hepatic gluconeogenesis via CRTC2Nature Communications.  12. 2021
2021 The transcriptional co-regulator LDB1 is required for brown adipose functionMolecular Metabolism.  53. 2021
2021 Mito: Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice 2021
2021 Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure 2021
2021 Glucagon’s Metabolic Action in Health and DiseaseComprehensive Physiology.  11:1759-1783. 2021
2021 Glucagon receptor signaling regulates weight loss via central KLB receptor complexesJCI Insight.  6. 2021
2020 High-Fat and High-Sucrose Diets Impair Time-of-Day Differences in Spatial Working Memory of Male MiceObesity.  28:2347-2356. 2020
2020 A small molecule, UAB126, reverses diet-induced obesity and its associated metabolic disordersDiabetes.  69:2003-2016. 2020
2020 In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthoodLife Sciences.  254. 2020
2020 Revisiting the pharmacological value of glucagon: An editorial for the special issue “the biology and pharmacology of Glucagon”International Journal of Molecular Sciences.  21. 2020
2020 Glucagon-receptor signaling reverses hepatic steatosis independent of leptin receptor expression 2020
2020 Increased glucose availability attenuates myocardial ketone body utilizationJournal of the American Heart Association.  9. 2020
2019 Glucagon regulation of energy expenditureInternational Journal of Molecular Sciences.  20. 2019
2019 The islet-expressed Lhx1 transcription factor interacts with islet-1 and contributes to glucose homeostasis 2019
2018 Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemiaMolecular Metabolism.  17:28-38. 2018
2018 Hepatic glucagon receptor signaling enhances insulin-stimulated glucose disposal in rodentsDiabetes.  67:2157-2166. 2018
2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intoleranceMolecular Metabolism.  12:48-61. 2018
2018 Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: A potential role for fibroblast growth factor-21 2018
2017 LDB1 regulates energy homeostasis during diet-induced obesity 2017
2017 Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF ratsInternational Journal of Obesity.  41:381-389. 2017
2016 Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic DiseaseCell.  167:843-857.e14. 2016
2016 Fibroblast activation protein (FAP) as a novel metabolic targetMolecular Metabolism.  5:1015-1024. 2016
2016 Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feedingJournal of Applied Physiology.  121:687-698. 2016
2015 FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in miceDiabetologia.  58:2414-2423. 2015
2015 GhrelinMolecular Metabolism.  4:437-460. 2015
2015 A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodentsNature Medicine.  21:27-36. 2015
2014 GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in ratsDiabetes.  63:505-513. 2014
2014 Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptorsDiabetes.  63:122-131. 2014
2014 Chromium enhances insulin responsiveness via AMPKJournal of Nutritional Biochemistry.  25:565-572. 2014
2014 Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasiaGut.  63:1238-1246. 2014
2013 The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanismsNature Communications.  4. 2013
2013 High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in miceCirculation.  128:2364-2371. 2013
2013 Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humansScience Translational Medicine.  5. 2013
2013 GLP-1R agonism enhances adjustable gastric banding in diet-induced obese ratsDiabetes.  62:3261-3267. 2013
2013 Fibroblast growth factor 21 mediates specific glucagon actionsDiabetes.  62:1453-1463. 2013
2013 P62 Links β-adrenergic input to mitochondrial function and thermogenesisJournal of Clinical Investigation.  123:469-478. 2013
2012 Targeted estrogen delivery reverses the metabolic syndromeNature Medicine.  18:1847-1856. 2012
2012 Caloric restriction chronically impairs metabolic programming in miceDiabetes.  61:2734-2742. 2012
2012 Acylation type determines Ghrelin's effects on energy homeostasis in rodents 2012
2012 Sirtuin 1 and sirtuin 3: Physiological modulators of metabolismPhysiological Reviews.  92:1479-1514. 2012
2012 MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: Is there relevance for body weight regulation? 2012
2012 AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol 2012
2012 The goat-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restrictionPLoS One.  7. 2012
2012 Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscleDiabetologia.  55:457-467. 2012
2012 Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese ratsObesity Surgery.  22:140-151. 2012
2012 Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21Journal of Peptide Science.  18:383-393. 2012
2011 Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null miceFrontiers in Endocrinology.  2. 2011
2011 Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance 2011
2011 Neural regulation of cholesterol metabolism.Current Opinion in Lipidology.  22:283-287. 2011
2011 A role for astrocytes in the central control of metabolism 2011
2010 The metabolic actions of glucagon revisitedNature Reviews Endocrinology.  6:689-697. 2010
2010 Glucagon regulation of energy metabolismPhysiology and Behavior.  100:545-548. 2010
2010 CNS leptin action modulates immune response and survival in sepsis 2010
2010 Erratum: Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin (Endocrinology (2009) 150, (1636-1645) DOI: 10.1210/en.2008-1102) 2010
2009 Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin 2009
2006 Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats 2006
2005 Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring ratsNeuroscience.  131:871-876. 2005
2004 Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring ratsAlcoholism: Clinical and Experimental Research.  28:1622-1628. 2004
2003 Analyses of Quantitative Trait Loci Contributing to Alcohol Preference in HAD1/LAD1 and HAD2/LAD2 RatsAlcoholism: Clinical and Experimental Research.  27:1710-1717. 2003

Full Name

  • Kirk Habegger