Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 The islet-expressed Lhx1 transcription factor interacts with islet-1 and contributes to glucose homeostasisAJP - Endocrinology and Metabolism.  316:E397-E409. 2019
2018 Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemiaMolecular Metabolism.  17:28-38. 2018
2018 Hepatic glucagon receptor signaling enhances insulin-stimulated glucose disposal in rodentsDiabetes.  67:2157-2166. 2018
2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intoleranceMolecular Metabolism.  12:48-61. 2018
2018 Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: A potential role for fibroblast growth factor-21Endocrinology.  159:400-413. 2018
2017 LDB1 regulates energy homeostasis during diet-induced obesityEndocrinology.  158:1289-1297. 2017
2017 Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF ratsInternational Journal of Obesity.  41:381-389. 2017
2016 Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic DiseaseCell.  167:843-857.e14. 2016
2016 Fibroblast activation protein (FAP) as a novel metabolic targetMolecular Metabolism.  5:1015-1024. 2016
2016 Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feedingJournal of applied physiology: respiratory, environmental and exercise physiology.  121:687-698. 2016
2015 FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in miceDiabetologia.  58:2414-2423. 2015
2015 GhrelinMolecular Metabolism.  4:437-460. 2015
2014 A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodentsNature Medicine2014
2014 GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in ratsDiabetes.  63:505-513. 2014
2014 Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptorsDiabetes.  63:122-131. 2014
2014 Chromium enhances insulin responsiveness via AMPKJournal of Nutritional Biochemistry.  25:565-572. 2014
2014 Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasiaGut.  63:1238-1246. 2014
2013 The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanismsNature Communications.  4. 2013
2013 High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in miceCirculation.  128:2364-2371. 2013
2013 Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humansScience Translational Medicine.  5. 2013
2013 GLP-1R agonism enhances adjustable gastric banding in diet-induced obese ratsDiabetes.  62:3261-3267. 2013
2013 Fibroblast growth factor 21 mediates specific glucagon actionsDiabetes.  62:1453-1463. 2013
2013 P62 Links β-adrenergic input to mitochondrial function and thermogenesisJournal of Clinical Investigation.  123:469-478. 2013
2012 Targeted estrogen delivery reverses the metabolic syndromeNature Medicine.  18:1847-1856. 2012
2012 Caloric restriction chronically impairs metabolic programming in miceDiabetes.  61:2734-2742. 2012
2012 Acylation type determines Ghrelin's effects on energy homeostasis in rodentsEndocrinology.  153:4687-4695. 2012
2012 Sirtuin 1 and sirtuin 3: Physiological modulators of metabolismPhysiological Reviews.  92:1479-1514. 2012
2012 MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: Is there relevance for body weight regulation?Neuroendocrinology.  95:277-288. 2012
2012 AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterolEndocrinology.  153:2130-2141. 2012
2012 The goat-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restrictionPLoS ONE.  7. 2012
2012 Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscleDiabetologia.  55:457-467. 2012
2012 Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese ratsObesity Surgery.  22:140-151. 2012
2012 Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21Journal of Peptide Science.  18:383-393. 2012
2011 Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null miceFrontiers in Endocrinology.  2. 2011
2011 Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistanceEndocrinology.  152:3373-3384. 2011
2011 Neural regulation of cholesterol metabolismCurrent Opinion in Lipidology.  22:283-287. 2011
2011 A role for astrocytes in the central control of metabolismNeuroendocrinology.  93:143-149. 2011
2010 The metabolic actions of glucagon revisitedNature Reviews Endocrinology.  6:689-697. 2010
2010 Glucagon regulation of energy metabolismPhysiology and Behavior.  100:545-548. 2010
2010 CNS leptin action modulates immune response and survival in sepsisJournal of Neuroscience.  30:6036-6047. 2010
2010 Erratum: Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin (Endocrinology (2009) 150, (1636-1645) DOI: 10.1210/en.2008-1102)Endocrinology.  151:2967. 2010
2009 Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actinEndocrinology.  150:1636-1645. 2009
2006 Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring ratsBehavior Genetics.  36:285-290. 2006
2005 Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring ratsNeuroscience.  131:871-876. 2005
2004 Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring ratsAlcoholism: Clinical and Experimental Research.  28:1622-1628. 2004
2003 Analyses of Quantitative Trait Loci Contributing to Alcohol Preference in HAD1/LAD1 and HAD2/LAD2 RatsAlcoholism: Clinical and Experimental Research.  27:1710-1717. 2003

Full Name

  • Kirk Habegger