• Dr. Barton L. Guthrie received his B.S. in psychology, followed by an M.D. degree from the University of Alabama at Birmingham in 1980. Dr. Guthrie then pursued post-doctoral studies in the Department of Physiology and Biophysics, at UAB. Subsequently, he trained in neurosurgery at the Mayo Clinic, followed by a fellowship at Stanford University. Between 1988-1992, Dr. Guthrie was an assistant professor at the George Washington University, before finally arriving to the UAB Division of Neurosurgery in 1993. He specializes in the treatment of movement disorders, surgery and radiosurgery of brain tumors, in addition to general neurosurgery practice.

    A board-certified diplomat of the American Association of Neurological Surgery, Dr. Guthrie has served on several editorial boards, including the Journal of Computer-aided Surgery, and the Journal of Radiosurgery. Additionally, he has served in leadership roles within the Neurosurgical Society of Alabama, and the Southern Neurosurgical Society.

    Throughout the years, Dr. Guthrie has led a career of innovation. He holds several patents for technology related to image-guided surgery, and was co-founder of Emageon, a now publicly traded company on NASDAQ. His original work with Emageon, pioneered the era of medical image viewing on the standard desktop computer. This work now resides in a permanent collection at the Smithsonian Museum of American History, in Washington D.C.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Frameless MLC-Based Radiosurgical Thalamotomies on the Modern Linear Accelerator Platform - Prospective Phase I/II Clinical Trial Results 2021
    2021 Incidence and risk factors for seizures associated with deep brain stimulation surgeryJournal of Neurosurgery.  135:279-283. 2021
    2021 Preoperative Decision-Making in Microvascular Decompression for Trigeminal Neuralgia: A Survey of Practicing NeurosurgeonsWorld Neurosurgery.  150:e741-e745. 2021
    2021 Subcortical short-term plasticity elicited by deep brain stimulationAnnals of Clinical and Translational Neurology.  8:1010-1023. 2021
    2021 Risk factors for wound-related complications after microvascular decompressionNeurosurgical Review.  44:1093-1101. 2021
    2021 The Use of MRI in Preoperative Decision-Making for Trigeminal Neuralgia: A Single-Center StudyWorld Neurosurgery.  146:e651-e657. 2021
    2021 Walking Speed Reliably Measures Clinically Significant Changes in Gait by Directional Deep Brain StimulationFrontiers in Human Neuroscience.  14. 2021
    2020 Emergency response plan during the COVID-19 pandemic: The University of Alabama at Birmingham experienceNeurosurgery.  87:E218-E219. 2020
    2020 Reoperation for device infection and erosion following deep brain stimulation implantable pulse generator placementJournal of Neurosurgery.  133:403-410. 2020
    2020 Efficacy of burosumab in a case of tumor-induced osteomalaciaRevue du Rhumatisme.  87:300-302. 2020
    2020 Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects 2020
    2020 Short latency cortical evoked potentials elicited by subthalamic nucleus deep brain stimulation: Commentary and results from paired pulse studies 2020
    2020 Subcortical Intermittent Theta-Burst Stimulation (iTBS) Increases Theta-Power in Dorsolateral Prefrontal Cortex (DLPFC)Frontiers in Neuroscience.  14. 2020
    2020 Burosumab in tumor-induced osteomalacia: A case report 2020
    2019 Repeat gamma knife stereotactic radiosurgery in the treatment of trigeminal neuralgia: A single-center experience and focused review of the literatureJournal of Clinical Neuroscience.  70:102-107. 2019
    2019 Cortical Activation Elicited by Subthalamic Deep Brain Stimulation Predicts Postoperative Motor Side EffectsNeuromodulation.  22:456-464. 2019
    2019 Stereotactic radiosurgery with MLC-defined arcs: Verification of dosimetry, spatial accuracy, and end-to-end testsJournal of Applied Clinical Medical Physics.  20:84-98. 2019
    2019 Patient Satisfaction in Surgery for Parkinson's Disease: A Systematic Review of the Literature.Cureus.  11:e4316. 2019
    2019 Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptomsParkinsonism and Related Disorders.  60:126-132. 2019
    2019 Awake testing during deep brain stimulation surgery predicts postoperative stimulation side effect thresholdsBrain Sciences.  9. 2019
    2019 Patient satisfaction in spine surgery: A systematic review of the literatureAsian Spine Journal.  13:1047-1057. 2019
    2018 Assessing the Economic Efficiency of Physician On-call Payments.Cureus.  10:e3768. 2018
    2018 The virtual cone: A novel technique to generate spherical dose distributions using a multileaf collimator and standardized control-point sequence for small target radiation surgeryAdvances in Radiation Oncology.  3:421-430. 2018
    2018 A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation 2018
    2018 Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal diseaseJournal of Clinical Neuroscience.  49:48-55. 2018
    2017 The relationship of electrophysiologic subthalamic nucleus length as a predictor of outcomes in deep brain stimulation for Parkinson diseaseStereotactic and Functional Neurosurgery.  95:341-347. 2017
    2017 Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trialParkinsonism and Related Disorders.  40:18-26. 2017
    2016 Coneless Linear Accelerator-Based Volumetric Modulated Arc Therapy Stereotactic Radiosurgery Technique for Functional Disorders. 2016
    2016 Identification and Cost of Potentially Avoidable Transfers to a Tertiary Care Neurosurgery Service: A Pilot StudyNeurosurgery.  79:541-548. 2016
    2016 Deep Brain Stimulation Battery Longevity: Comparison of Monopolar Versus Bipolar Stimulation ModesMovement Disorders Clinical Practice.  3:359-366. 2016
    2016 A phase 2 study of radiosurgery and temozolomide for patients with 1 to 4 brain metastasesAdvances in Radiation Oncology.  1:83-88. 2016
    2016 Lessons Learned from Google Glass: Telemedical Spark or Unfulfilled Promise?Surgical Innovation.  23:156-165. 2016
    2015 Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trialAnnals of Neurology.  78:248-257. 2015
    2015 Adverse events associated with deep brain stimulation for movement disorders: Analysis of 510 consecutive casesOperative Neurosurgery.  11:200. 2015
    2015 Spatial topographies of unilateral subthalamic nucleus deep brain stimulation efficacy for ipsilateral, contralateral, midline, and total Parkinson disease motor symptomsOperative Neurosurgery.  11:80-88. 2015
    2014 Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: The University of Alabama at Birmingham experience 2014
    2014 Comparison of plan quality and delivery time between volumetric arc therapy (rapidarc) and gamma knife radiosurgery for multiple cranial metastasesNeurosurgery.  75:409-417. 2014
    2014 Shorter pulse generator longevity and more frequent stimulator adjustments with pallidal DBS for dystonia versus other movement disordersBrain Stimulation.  7:345-349. 2014
    2014 Virtual interactive presence for real-time, long-distance surgical collaboration during complex microsurgical procedures: Technical noteJournal of Neurosurgery.  121:277-284. 2014
    2013 The relationship between clinical phenotype and early staged bilateral deep brain stimulation in Parkinson disease: Clinical articleJournal of Neurosurgery.  119:1530-1536. 2013
    2013 Noninvasive measurement of cortical activity during effective brain stimulation for movement disordersFuture Neurology.  8:9-12. 2013
    2012 Plan quality and treatment planning technique for single isocenter cranial radiosurgery with volumetric modulated arc therapyPractical Radiation Oncology.  2:306-313. 2012
    2012 Short latency activation of cortex by clinically effective thalamic brain stimulation for tremorMovement Disorders.  27:1404-1412. 2012
    2012 Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's diseaseMovement Disorders.  27:864-873. 2012
    2012 High-frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's diseaseMovement Disorders.  27:168-169. 2012
    2011 Pontine ring-enhancing glioblastoma multiforme-like fungal abscessArchives of Neurology.  68:1476-1477. 2011
    2011 High-frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's diseaseMovement Disorders.  26:2232-2238. 2011
    2011 Comparison of weight changes following unilateral and staged bilateral STN DBS for advanced PDBrain and Behavior.  1:12-18. 2011
    2011 Virtual interactive presence and augmented reality (VIPAR) for remote surgical assistanceNeurosurgery.  68. 2011
    2011 Activation of subthalamic neurons by contralateral subthalamic deep brain stimulation in parkinson diseaseJournal of Neurophysiology.  105:1112-1121. 2011
    2010 Gene delivery of AAV2-neurturin for Parkinson's disease: A double-blind, randomised, controlled trialLancet Neurology.  9:1164-1172. 2010
    2010 Commentary on "Does mild cognitive impairment increase the risk of developing postoperative cognitive dysfunction?" 2010
    2010 Construction of relational topographies from the quantitative measurements of functional deep brain stimulation using a 'roving window' interpolation algorithmStereotactic and Functional Neurosurgery.  88:16-23. 2010
    2010 Impact of Dose Rate on Outcomes of Gamma Knife® Radiosurgery in Patients with Face PainRadiosurgery.  7:360-365. 2010
    2009 Relief of acquired stuttering associated with Parkinson's disease by unilateral left subthalamic brain stimulationJournal of Speech, Language, and Hearing Research.  52:1652-1657. 2009
    2009 Weight changes associated with unilateral STN DBS and advanced PDParkinsonism and Related Disorders.  15:709-711. 2009
    2009 Bilateral effects of unilateral subthalamic deep brain stimulation on parkinson's disease at 1 yearNeurosurgery.  65:302-309. 2009
    2008 Hitting a moving target: Evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteriaNeurosurgical Focus.  24. 2008
    2008 Predictors of Distant Brain Recurrence for Patients With Newly Diagnosed Brain Metastases Treated With Stereotactic Radiosurgery Alone 2008
    2006 Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade gliomaJournal of Clinical Oncology.  24:3644-3650. 2006
    2006 Safety and tolerance of multiple weekly intracavitary injections of 131I-chlorotoxin (TM-601): Preliminary results of a prospective clinical trial in patients with recurrent glioblastoma multiforme.Journal of Clinical Oncology.  24:1555. 2006
    2004 Initial treatment of melanoma brain metastases using gamma knife radiosurgery: An evaluation of efficacy and toxicityCancer.  101:825-833. 2004
    2003 Stereotactic surgical approach to hypothalamic hamartomas 2003
    2001 Support of clinician image-related workflow by a user-edited, web-based patient list manager.Journal of Digital Imaging.  14:140-142. 2001
    2001 The Digital Imaging and Communications in Medicine (DICOM) archive is a dynamic component of a clinician image-related workflow solution.Journal of Digital Imaging.  14:190-193. 2001
    2001 Support of clinician image-related workflow by a user-edited, web-based patient list managerJournal of Digital Imaging.  14:140-142. 2001
    2001 The digital imaging and communications in medicine (DICOM) archive is a dynamic component of a clinician image-related workflow solutionJournal of Digital Imaging.  14:190-193. 2001
    1999 Design considerations for a transcranial doppler coupled to a stereotactic position armUltrasound in Medicine and Biology.  25:111-119. 1999
    1999 Proprioceptive and retinal afference modify postsaccadic ocular driftJournal of Neurophysiology.  82:551-563. 1999
    1998 Bilateral cholesterol granulomas of the temporal boneORL.  60:318-321. 1998
    1998 Phase II study of intracarotid or selective intracerebral infusion of cisplatin for treatment of recurrent anaplastic gliomasJournal of Neuro-Oncology.  36:191-198. 1998
    1998 Surgical treatment of hypothalamic hamartoma [3]Annals of Neurology.  43:273-274. 1998
    1997 Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsyAnnals of Neurology.  42:60-67. 1997
    1997 Pituitary carcinoma: A clinicopathologic study of 15 casesCancer.  79:804-812. 1997
    1997 Pituitary carcinoma: a clinicopathologic study of 15 cases.Cancer.  79:804-812. 1997
    1996 Resection of multiple pulmonary metastases from a recurrent intracranial meningiomaAnnals of Thoracic Surgery.  61:1823-1824. 1996
    1994 Peripheral benzodiazepine receptors and glucose metabolism in human gliomasJournal of Neuro-Oncology.  22:15-22. 1994
    1994 Extraocular muscle proprioception functions in the control of ocular alignment and eye movement conjugacyJournal of Neurophysiology.  72:1028-1031. 1994
    1994 Graphic-interactive cranial surgery.Clinical Neurosurgery.  41:489-516. 1994
    1994 Lymphocytic hypophysitis: Occurrence in two menNeurosurgery.  34:159-163. 1994
    1994 The medical videoscope: Neurosurgery into the 21st centuryMicrosurgery.  15:547-554. 1994
    1992 A tumor-associated cell surface protease in human astrocytomasNeurosurgery.  30:804. 1992
    1992 Computer-assisted preoperative planning, interactive surgery, and frameless stereotaxy.Clinical Neurosurgery.  38:112-131. 1992
    1992 The role of stereotactic biopsy in the management of hiv-related focal brain lesionsNeurosurgery.  30:825-829. 1992
    1990 Interstitial brachytherapy for malignant brain tumors: Preliminary resultsNeurosurgery.  26:371-380. 1990
    1990 L-Buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic miceNeurosurgery.  26:255-260. 1990
    1990 Radiosurgery for acoustic neurinomas: Early experience: CommentsNeurosurgery.  26:744-745. 1990
    1990 Supratentorial low-grade gliomas.Neurosurgery Clinics of North America.  1:37-48. 1990
    1990 The effect of pin location on the rigidity of the halo pin-bone interfaceNeurosurgery.  26:238-241. 1990
    1989 Alumina ceramic as a biomaterial for use in afterloading radiation catheters for hyperthermiaNeurosurgery.  25:209-213. 1989
    1989 MRI assessment of ventricular CSF dynamics in the presence of lesions of the foramen of Monro.Neurosurgery.  25:319. 1989
    1989 Meningeal hemangiopericytoma: Histopathological features, treatment, and long-term follow-up of 44 casesNeurosurgery.  25:514-522. 1989
    1989 Posterior fossa stereotaxic biopsy using the Brown-Roberts-Wells stereotaxic system. Technical noteJournal of Neurosurgery.  70:649-652. 1989
    1985 Selective retrograde transneuronal transport of wheat germ agglutinin-conjugated horseradish peroxidase in the oculomotor systemExperimental Brain Research.  57:411-416. 1985
    1983 Corollary discharge provides accurate eye position information to the oculomotor systemScience.  221:1193-1195. 1983
    1983 Innervation of monkey extraocular muscles: Localization of sensory and motor neurons by retrograde transport of horseradish peroxidaseJournal of Comparative Neurology.  218:208-219. 1983
    1976 Size and distribution of movement fields in the monkey superior colliculusBrain Research.  113:21-34. 1976


    Year Title Altmetric
    2012 Meningeal Hemangiopericytomas.  630-637. 2012
    2010 Impact of dose rate on outcomes of Gamma Knife® radiosurgery in patients with face pain.  360-365. 2010

    Research Overview

  • Neuromodultation
    Brain Tumors
  • Investigator On

  • A Double-Blind, Placebo-Controlled (Sham Surgery), Randomized, Multicenter Study Evaluating CERE-110 Gene Delivery in Subjects with Mild to Moderate Alzheimer's Disease (CERE 110-3)  awarded by University of California, San Diego
  • A Phase 1 Study of M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma  awarded by National Cancer Institute/NIH/DHHS
  • Alzheimer's Disease Cooperative Study  awarded by University of California, San Diego
  • Investigating Inhibitory Control Networks in Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson’s Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Private Grant  awarded by SANGAMO BIOSCIENCES, INC.
  • Private Grant  awarded by MEDTRONIC, INC.
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC.
  • Private Grant  awarded by BOSTON SCIENTIFIC CORPORATION
  • Private Grant  awarded by NOVOCURE, INC.
  • Private Grant  awarded by NOVOCURE, INC.
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC.
  • TSA International Database of Deep Brain Stimulation Studies in Tourette Syndrome  awarded by Tourette Syndrome Association, Inc.
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB Research and Education Program in Neuroscience  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Unlocking Dystonia from Parkinson's Disease with Directional DBS Technology  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Education And Training

  • UAB Hospital, Internship
  • Mayo Clinic, Residency
  • Stanford University Medical Center, Residency
  • UAB Hospital, Postdoctoral Fellowship
  • Doctor of Medicine, University of Alabama at Birmingham 1980
  • Bachelor of Science or Mathematics in Psychology, University of Alabama at Birmingham 1976
  • Full Name

  • Barton Guthrie
  • Fax

  • 205-934-6507