• Dr. Siegal was born in New York where he attended college. He received his medical degree from the University of Louisville and his PhD from the University of Minnesota. He was a Resident and Research Fellow at the Mayo Graduate School of Medicine and completed both a post-doctoral fellowship at the National Cancer Institute, NIH and a surgical pathology fellowship at the University of Minnesota. Prior to coming to UAB in 1990, he was a tenured faculty member at the University of North Carolina at Chapel Hill. Dr. Siegal has been married for over 40 years and has 2 adult daughters and 4 grandchildren.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Return of Individual Research Results: A Guide for Biomedical Researchers Utilizing Human Biospecimens 2020
    2020 RANKLed by the Complexity of Signaling in Breast Cancer Metastasis to the Brain 2020
    2019 Synchronous and metachronous bilateral breast cancer: clinicopathologic characteristics and prognostic outcomes 2019
    2019 Erratum: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis (Cell Reports (2018) 25(7) (1938–1952.e5), (S2211124718316772), (10.1016/j.celrep.2018.10.073)) 2019
    2019 Bone Pathology for Hematopathologists 2019
    2019 Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification 2019
    2019 Let’s go swimming 2019
    2019 PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall 2019
    2019 Extraskeletal Myxoid Chondrosarcoma of the Midfoot Presenting as Charcot Arthropathy: A Case Report 2019
    2018 Comparison of AJCC Anatomic and Clinical Prognostic Stage Groups in Breast Cancer: Analysis of 3322 Cases From a Single Institution 2018
    2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis 2018
    2018 Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the Literature 2018
    2018 Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome 2018
    2018 Malignant Ewing-Like Neoplasm With an EWSR1-KLF15 Fusion: At the Crossroads of a Myoepithelial Carcinoma and a Ewing-Like Sarcoma. A Case Report With Treatment Options 2018
    2018 Detection of BRAF V600E mutations with next-generation sequencing in infarcted thyroid carcinomas after fine-needle aspiration 2018
    2018 Surviving at a distant site: The organotropism of metastatic breast cancer 2018
    2017 Prognostic outcomes in advanced breast cancer: the metastasis-free interval is important 2017
    2017 Clinical and pathological factors related to brain relapse-free survival in breast cancer patients—reply 2017
    2017 Corrigendum to “Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone” (Human Pathology (2017) 65 (239–246) (S0046817717301727) (10.1016/j.humpath.2017.05.015)) 2017
    2017 Extraskeletal aneurysmal bone cyst: Report of a case and review of the literature 2017
    2017 The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancer 2017
    2017 Implementation and utilization of the molecular tumor board to guide precision medicine. 2017
    2017 Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone 2017
    2017 Clinicopathological factors associated with survival in patients with breast cancer brain metastasis 2017
    2017 Reacquisition of E-cadherin expression in metastatic deposits of signet-ring cell carcinoma of the upper gastrointestinal system: A potential anchor for metastatic deposition 2017
    2017 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study. 2017
    2017 Implementation and utilization of the molecular tumor board to guide precision medicine 2017
    2017 Location of tumor affects local and distant immune cell type and number: 2017
    2017 Metastatic organotropism: An intrinsic property of breast cancer molecular subtypes 2017
    2017 Reduced E-Cadherin and Aberrant β-Catenin Expression are Associated with Advanced Disease in Signet-Ring Cell Carcinomas 2017
    2016 Clinicopathologic factors associated with de novo metastatic breast cancer 2016
    2016 Primary intraosseous smooth muscle tumor of uncertain malignant potential: Original report and molecular characterization 2016
    2016 In Memorium: Nathan Kaufman. 2016
    2016 Laboratory Investigation web focus on China 2016
    2016 A microscopic landscape of the invasive breast cancer genome 2016
    2016 ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast 2016
    2016 Prognostic factors in advanced breast cancer: Race and receptor status are significant after development of metastasis 2016
    2016 Prognostic value of E-cadherin and β-catenin in triple-negative breast cancer 2016
    2016 The rank pathway in advanced breast cancer: Does Src play a role? 2016
    2015 Characterization of estrogen receptor-negative/progesterone receptor-positive breast cancer 2015
    2015 Nucleic acid amplification from individual cells: Laser microdissection 2015
    2015 Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature 2015
    2015 Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1cpk mouse 2015
    2015 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: A comparative study 2015
    2015 Flexor tendon repair with a knotless, bidirectional barbed suture: An in vivo biomechanical analysis 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease 2015
    2015 Autosomal-dominant familial angiolipomatosis 2015
    2015 Breast cancer subtypes predispose the site of distant metastases 2015
    2015 Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones 2015
    2015 GATA3 expression in advanced breast cancer: Prognostic value and organ-specific relapse 2015
    2015 Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage 2015
    2015 Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS 2015
    2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity 2015
    2015 The utility of phosphohistone H3 in breast cancer grading 2015
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis 2014
    2014 Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice 2014
    2014 Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancer 2014
    2014 Changing prognostic factors in osteosarcoma: Analysis of 381 cases from two institutions 2014
    2014 Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of merkel cell carcinoma and correlation with prognosis 2014
    2014 Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasis 2014
    2014 GSK3β-Dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury 2014
    2014 Mining genome sequencing data to identify the genomic features linked to breast cancer histopathology. 2014
    2014 Optimal handling of bone tumor specimens 2014
    2014 Prognostic factors in patients with metastatic breast cancer at the time of diagnosis 2014
    2014 Round cell tumors of bone: An update on recent molecular genetic advances 2014
    2013 A decade in banking Ewing sarcoma: A report from the Children's Oncology Group 2013
    2013 LRRK2 secretion in exosomes is regulated by 14-3-3 2013
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways 2013
    2013 Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer 2013
    2013 A phase i clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688)) 2013
    2013 Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma 2013
    2013 Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model 2013
    2013 Glycoengineering in cancer therapeutics: A review with fucose-depleted trastuzumab as the model 2013
    2013 Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation. 2013
    2013 Finding a new generation of spies and manuscript reviewers 2013
    2012 Bilateral mesenchymal hamartoma of the chest wall in an infant boy 2012
    2012 Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells 2012
    2012 Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivo 2012
    2012 Metastatic inflammatory myofibroblastic tumor identified by EUS-FNA in mediastinal lymph nodes with ancillary FISH studies for ALK rearrangement 2012
    2012 Nicotine exposure and the progression of chronic kidney disease: Role of the α7-nicotinic acetylcholine receptor 2012
    2012 Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: A report from the children's oncology group 2012
    2012 A phase I clinical trial of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in patients with recurrent gynecologic cancer 2012
    2012 A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst) 2012
    2012 Foxp3 expression patterns in microscopic colitides: A clinicopathologic study of 69 patients 2012
    2012 Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin 2012
    2012 CD138 (syndecan-1) expression in bone-forming tumors 2012
    2012 Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts 2012
    2012 Intracranial meningeal hemangiopericytoma metastatic to the scapula 2012
    2012 Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic Osteomalacia 2012
    2012 The dark side of publishing: Promoting ethics in AJP 2003 to 2008 2012
    2011 A 23-year-old woman with a right femoral neck fracture 2011
    2011 Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesis 2011
    2011 Conditionally replicating adenovirus expressing TIMP2 increases survival in a mouse model of disseminated ovarian cancer 2011
    2011 The emerging importance of α-L-fucose in human breast cancer: A review 2011
    2011 Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate 2011
    2011 A new generation of serotype chimeric infectivity-enhanced conditionally replicative adenovirals: The safety profile of Ad5/3-Δ24 in advance of a phase i clinical trial in ovarian cancer patients 2011
    2011 Characterization of CXCR4 expression in chondrosarcoma of bone 2011
    2011 Elevated levels of NO are localized to distal airways in asthma 2011
    2011 Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer 2011
    2011 LL-37 as a therapeutic target for late stage prostate cancer 2011
    2011 Laboratory Investigation editorial internship program 2011
    2011 Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis 2011
    2011 Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs 2011
    2011 Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy 2011
    2010 Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer 2010
    2010 Erratum: Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer (Cancer Gene Therapy (2010) 17 (893-905)) 2010
    2010 A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseases 2010
    2010 Juxtatumoral stromal reactions in uterine endometrioid adenocarcinoma and their prognostic significance 2010
    2010 Merkel cell carcinoma: Correlation of KIT expression with survival and evaluation of KIT gene mutational status 2010
    2010 Aggressive osteoblastoma: A case report involving a unique chromosomal aberration 2010
    2010 Ex vivo transfer of the Hoxc-8-interacting domain of smad1 by a tropism-modified adenoviral vector results in efficient bone formation in a rabbit model of spinal fusion 2010
    2010 Small cell tumors of bone 2010
    2010 What editors want in an abstract 2010
    2009 E-cadherin/β-catenin and CD10: A limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas 2009
    2009 Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis 2009
    2009 Novel infectivity-enhanced oncolytic adenovirus With a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer 2009
    2009 Stearate preferentially induces apoptosis in human breast cancer cells 2009
    2009 Identifying the safety profile of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in anticipation of a phase I clinical trial in patients with recurrent ovarian cancer 2009
    2009 Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice 2009
    2009 Promotion of incisional wound repair by human mesenchymal stem cell transplantation 2009
    2009 Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1 2009
    2009 Navigating interpersonal conflict and peer review 2009
    2009 Unplanned surgical excision of extremity soft tissue sarcomas: patient profile and referral patterns. 2009
    2009 Who's on first? 2009
    2008 Immunohistochemistry in the evaluation of neovascularization in tumor xenografts 2008
    2008 Role of oxygen availability in CFTR expression and function 2008
    2008 Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosis 2008
    2008 Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets 2008
    2008 Reporting guidelines for clinical laboratory reports in surgical pathology 2008
    2008 Large, clear cytoplasmic vacuolation : An under-recognized cytologic clue to distinguish solid pseudopapillary neoplasms of the pancreas from pancreatic endocrine neoplasms on fine-needle aspiration 2008
    2008 Silencing of transforming growth factor-β1 in situ by RNA interference for breast cancer: Implications for proliferation and migration in vitro and metastasis in vivo 2008
    2008 Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury 2008
    2008 A fiber-modified mesothelin promoter-based conditionally replicating adenovirus fortreatment of ovarian cancer 2008
    2008 Cell surface associated alpha-L-fucose moieties modulate human breast cancer neoplastic progression 2008
    2008 Development of an optimized conditionally replicative adenoviral agent for ovarian cancer 2008
    2008 Juvenile juxtacortical chondromyxoid fibroma of bone: a case report 2008
    2008 Characterization of infectivity of knob-modified adenoviral vectors in glioma 2008
    2008 Characterization of infectivity of knob-modified adenoviral vectors in glioma. 2008
    2008 Alterations in human breast cancer adhesion-motility in response to changes in cell surface glycoproteins displaying α-L-fucose moieties 2008
    2008 Intracranial metastasis from synovial sarcoma. 2008
    2008 Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control 2008
    2008 p53 nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior 2008
    2008 Osteosarcoma: The addition of muramyl tripeptide to chemotherapy improves overall survival - A report from the children's oncology group 2008
    2008 Targeting p38 MAPK for the treatment of inflammatory arthritis 2008
    2008 In the blink of an eye... 2008
    2008 Intracranial metastasis from synovial sarcoma 2008
    2008 Solid pseudopapillary tumor of the pancreas: A review of salient clinical and pathologic features 2008
    2008 Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of beast cancer bone metastasis 2008
    2007 Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy 2007
    2007 Involvement of vitronectin in lipopolysaccaride-induced acute lung injury 2007
    2007 Juxtacortical chondromyxoid fibroma of bone: A unique variant - A case study of 20 patients 2007
    2007 Targeting of a conditionally replicative adenovirus agent to human squamous cell carcinomas of the head and neck 2007
    2007 Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma 2007
    2007 Breast cancer metastasis to bone: Evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient mice 2007
    2007 α-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression 2007
    2007 Fine-needle aspiration: A powerful modality in the preoperative diagnosis of solid pseudopapillary neoplasm of the pancreas 2007
    2007 A mosaic fiber adenovirus serotype 5 vector containing reovirus σ1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway 2007
    2007 Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds 2007
    2007 A three-dimensional assay for measurement of viral-induced oncolysis 2007
    2007 Evolving gene therapy approaches for osteosarcoma using viral vectors: Review 2007
    2007 Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism 2007
    2007 Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer 2007
    2007 Targeting lung cancer using an infectivity enhanced CXCR4-CRAd 2007
    2007 An 18-year-old man with knee pain 2007
    2007 Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones 2007
    2007 Wandering chordoma - A mid-line crisis? 2007
    2007 p38 MAPK as a potential therapeutic target for inflammatory osteolysis 2007
    2006 Administration of a conditionally replicative oncolytic canine adenovirus in normal dogs 2006
    2006 Molecular pathology of chondroid neoplasms: Part 2, malignant lesions 2006
    2006 Solid-pseudopapillary neoplasm of the pancreas: Three cases with a literature review 2006
    2006 Molecular pathology of chondroid neoplasms: Part 1, benign lesions 2006
    2006 Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma 2006
    2006 227 RNA interference against Hec1 targets malignant mesothelioma (MM) 2006
    2006 Signal transduction cross-talk during colorectal tumorigenesis 2006
    2006 Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenoviruses 2006
    2006 Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma 2006
    2006 Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents 2006
    2006 The human survivin promoter: A novel transcriptional targeting strategy for treatment of glioma 2006
    2006 Infectivity enhancement for adenoviral transduction of canine osteosarcoma cells 2006
    2006 Desmoplastic fibroma of the jaw: A case report and review of literature 2006
    2006 Introducing biological perspectives 2006
    2006 Osteosarcoma: Anatomic and histologic variants 2006
    2005 Fluorescently tagged canine adenovirus via modification with protein IX-enhanced green fluorescent protein 2005
    2005 Osteosarcoma: A randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate 2005
    2005 Cytologic grade independently predicts survival of patients with pancreatic adenocarcinoma 2005
    2005 Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo 2005
    2005 A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer 2005
    2005 Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery 2005
    2005 Optimal molecular profiling of tissue and tissue components: Defining the best processing and microdissection methods for biomedical applications 2005
    2005 Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor 2005
    2005 Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system 2005
    2005 Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis 2005
    2005 Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications. 2005
    2005 Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system 2005
    2005 Productive replication of human adenovirus type 5 in canine cells 2005
    2005 The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma 2005
    2004 Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy 2004
    2004 Evaluation of tissue-specific promoters in carcinomas of the cervix uteri 2004
    2004 Transport across a polarized monolayer of Caco-2 cells by transferrin receptor-mediated adenovirus transcytosis 2004
    2004 An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism 2004
    2004 A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma 2004
    2004 A 32-year-old man with knee pain 2004
    2004 A 36-Year-Old Woman with a Toe Mass 2004
    2004 Evolutionary change and The American Journal of Pathology 2004
    2004 Recommendations for the reporting of bone tumors 2004
    2004 Ulnar mass in a 51-year-old woman 2004
    2003 MUC1 and MUC2 Expression in Pancreatic Ductal Carcinoma Obtained by Fine-Needle Aspiration 2003
    2003 Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer 2003
    2003 Painful sclerotic medial clavicle in a 46-year-old woman 2003
    2003 Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity 2003
    2003 Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids 2003
    2003 Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression 2003
    2003 A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model 2003
    2003 Infiltration of Helicobacter pylori in the gastric mucosa 2003
    2003 Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome: A case report emphasizing the cytological and cytogenetic findings 2003
    2003 Prosthetic implant associated sarcomas: A case report emphasizing surface evaluation and spectroscopic trace metal analysis 2003
    2002 Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations 2002
    2002 MDA-7: a novel prognostic marker? 2002
    2002 Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv 2002
    2002 Chondromyxoid fibroma of the cervical spine: Case report 2002
    2002 Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: A pediatric oncology group trial 2002
    2002 Cytogenetics and molecular biology of osteosarcoma 2002
    2002 Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv 2002
    2002 Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses 2002
    2002 Microdissection of histologic sections: Past, present, and future 2002
    2001 Cell surface fucose ablation as a therapeutic strategy for malignant neoplasms 2001
    2001 Use of the internet in pathology resident training and education 2001
    2001 Adeno-associated virus for cancer gene therapy 2001
    2001 Laser capture microdissection. 2001
    2001 Pathologic quiz case: An asymptomatic patient with a large renal mass 2001
    2001 Osteochondromyxoma of bone: A lot more than fodder for the spelling-challenged 2001
    2001 Adenovirus-mediated soluble FLT-1 gene therapy for ovarian carcinoma 2001
    2001 Aggressive osteoblastoma of the mandible closely simulating calcifying epithelial odontogenic tumor. Report of two cases with unusual histopathologic findings 2001
    2001 An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression 2001
    2001 An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascites 2001
    2001 Enlarging toe mass in a 13-year-old girl 2001
    2001 Eradication of c-erbB-2-Positive Ovarian Cancer Cells Mediated by Intracellular Expression of Anti-c-erbB-2 Antibody. 2001
    2001 Laser capture microdissection. 2001
    2001 Paraspinal mass in a 14-year-old girl 2001
    2001 Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric oncology group trial 2001
    2001 Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications 2001
    2001 Transcriptional targeting for ovarian cancer gene therapy 2001
    2000 A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): A phase I trial 2000
    2000 A prospective trial of telepathology for intraoperative consultation (frozen sections) 2000
    2000 Adenoviral-mediated suicide gene therapy for ovarian cancer 2000
    2000 An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancer 2000
    2000 Antineoplastic effect of anti-erbB-2 intrabody is not correlated with scFv affinity for its target 2000
    2000 Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer cells 2000
    2000 Osteoblastoma: A mimic of osteosarcoma 2000
    2000 Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer 2000
    1999 Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome 1999
    1999 An inducible recombinant adenoviral vector encoding Bax selectively induces apoptosis in ovarian cancer cells 1999
    1999 Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapy 1999
    1999 An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches 1999
    1999 Apoptosis and tumorigenesis in human cholangiocarcinoma cells: Involvement of Fas/APO-1 (CD95) and calmodulin 1999
    1999 Detection of coxsackie-adenovirus receptor (CAR) immunoreactivity in ovarian tumors of epithelial derivation 1999
    1999 Epithelioid variant of malignant peripheral nerve sheath tumor (malignant schwannoma) of the urinary bladder. 1999
    1999 Examination of tumor and tumor-like conditions of bone 1999
    1999 Pathologic femoral fracture in a 76-year-old woman 1999
    1998 Modulation of drug-induced apoptosis by an anti-Bcl-2 single-chain antibody in ovarian cancer cells 1998
    1998 Transcomplementation of a replication-incompetent adenovirus expressing herpes simplex virus thymidine kinase in ovarian carcinoma cells produces progeny virus capable of killing after treatment with ganciclovir 1998
    1998 Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells 1998
    1998 Alpha-L-fucose: a potentially critical molecule in pathologic processes including neoplasia. 1998
    1998 Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer 1998
    1998 Intracellular expression of the anti-erbB-2 sFv N29 fails to accomplish efficient target modulation 1998
    1998 Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate 1998
    1998 Gene therapy for ovarian carcinoma 1998
    1998 The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv 1998
    1998 Intracellular expression of a single-chain antibody directed against human papillomavirus type 16 E7 oncoprotein achieves targeted antineoplastic effects 1998
    1998 Endothelial cell vehicles for delivery of cytotoxic genes as a gene therapy approach for carcinoma of the ovary 1998
    1998 A potentially critical molecule in pathologic processes including neoplasia 1998
    1998 An initial trial of a prototype telepathology system featuring static imaging with discrete control of the remote microscope 1998
    1998 Gene therapy: Ovarian carcinoma as the paradigm 1998
    1998 High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type I vector 1998
    1998 Orthopaedic · Radiology · Pathology conference: Shoulder mass in a 38- year-old woman 1998
    1998 Orthopaedic · Radiology · Pathology conference: Shoulder mass in a 38- year-old woman 1998
    1998 Shoulder mass in a 38-year-old woman. 1998
    1997 1α,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells 1997
    1997 1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. 1997
    1997 Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts 1997
    1997 Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor 1997
    1997 An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2 1997
    1997 Gene therapy and ovarian cancer: A review 1997
    1997 Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector 1997
    1997 Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapy 1997
    1996 Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosis 1996
    1996 Epidermal growth factor modulates cell attachment to hyaluronic acid by the cell surface glycoprotein CD44 1996
    1996 Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivity 1996
    1996 Adenoviral-mediated deliver of herpes simplex virus thymidine kinase results in tumor rduction and prolonged survival in a SCID mouse model of human ovarian carcinoma 1996
    1996 In vitro AL-amyloid formation by rat and human mesangial cells 1996
    1996 Tumor cell invasion of basement membrane in vitro is regulated by amino acids 1996
    1995 Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium 1995
    1995 Stearate inhibits human tumor cell invasion 1995
    1995 In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals 1995
    1995 Adenoviral-Mediated Delivery of the Herpes Simplex Virus Thymidine Kinase Gene Selectively Sensitizes Human Ovarian Carcinoma Cells to Ganciclovir 1995
    1995 Small cell osteosarcoma of the soft tissue 1995
    1995 Amino acid transport systems modulate human tumor cell growth and invasion: A working hypothesis 1995
    1995 Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. 1995
    1995 Endocrine and metabolic characteristics of polyoma large T transgenic mice that develop ACTH-producing pituitary tumors 1995
    1995 Extraskeletal osteosarcoma: An unusual presentation as tarsal tunnel syndrome 1995
    1995 Recombinant adenovirus-mediated gene transfer to genitourinary epithelium in vitro and in vivo. 1995
    1995 Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbb-2 single-chain antibody 1995
    1995 Targeted tumor killing via an intracellular antibody against erbB-2 1995
    1994 Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines 1994
    1994 Development of a metastatic model for human endometrial carcinoma using orthotopic implantation in nude mice 1994
    1994 Developmental analysis of bone tumors in polyomavirus transgenic mice 1994
    1994 In vivo modulation of human tumor cell growth by normal human extracellular matrix 1994
    1993 Development of a novel human extracellular matrix for quantitation of the invasiveness of human cells 1993
    1993 Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. 1993
    1993 Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study. 1993
    1993 Ewing sarcoma of bone in infants and toddlers. A clnicopathologic report from the intergroup Ewing's study 1993
    1993 Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells 1993
    1992 Fibronectin as a component of pseudophakic acellular membranes 1992
    1992 Transgenic mice that develop pituitary tumors: A model for Cushing's disease 1992
    1991 Altered tenascin expression during spontaneous endometrial carcinogenesis in the bdii/han rat 1991
    1991 Altered tenascin expression during spontaneous endometrial carcinogenesis in the BDII/Han rat. 1991
    1990 Pathology 1990
    1990 Adenomatoid tumors: Adrenal cysts and being first 1990
    1990 Bronchial Carcinoids with S-100 Positive Sustentacular Cells: A Comparative Study with Gastrointestinal Carcinoids, Pheochromocytomas and Paragangliomas 1990
    1990 Immunoreactivity in malignant mesotheliomas with antibodies to basement membrane components and their receptors. 1990
    1990 Malignant transformation of human endometrial stromal cells by transfection of c-myc: Effects of pRSVneo cotransfection and treatment with MNNG 1990
    1990 Massive florid reactive periostitis 1990
    1990 Metastasizing Pleomorphic Adenoma with Myoepithelial Cell Predominance 1990
    1990 Tenascin expression in the human endometrium and in endometrial adenocarcinomas 1990
    1990 Ultrastructural characterization of two new human endometrial carcinoma cell lines and normal human endometrial epithelial cells cultured on extracellular matrix 1990
    1989 Central odontogenic fibroma, granular cell variant A case report with S-100 immunohistochemistry and a review of the literature 1989
    1989 Establishment and characterization of a human cell line from a serous papillary endometrial carcinoma 1989
    1988 Falsification of Credentials by Applicants for Medical Staffs 1988
    1988 A novel method for selection of invasive tumor cells: Derivation and characterization of highly metastatic K1735 melanoma cell lines based on in vitro and in vivo invasive capacity 1988
    1988 Flow cytometric analysis of DNA ploidy in lymphomas of the thyroid 1988
    1987 Primary Ewing's sarcoma involving the bones of the head and neck. 1987
    1987 Adenosquamous carcinoma of the fallopian tube. A clinicopathologic case report with verification of the diagnosis by immunohistochemical and ultrastructural studies. 1987
    1987 Flow Cytometric Analysis of Human Uterine Sarcomas and Cell Lines 1987
    1987 Adenosquamous carcinoma of the fallopian tube: A clinicopathologic case report with verification of the diagnosis by immunohistochemical and ultrastructural studies 1987
    1987 Analysis of changes in rat prostate carcinoma following hormone deprivation 1987
    1987 Dedifferentiated chondrosarcoma of bone - An immunohistochemical and lectin-histochemical study 1987
    1987 Gastroesophageal reflux and esophagitis in infants and children. 1987
    1987 Primary Ewing's sarcoma involving the bones of the head and neck 1987
    1987 Stromal proliferations of the breast: An ultrastructural and immunohistochemical evaluation of cystosarcoma phyllodes, juvenile fibroadenoma, and fibroadenoma 1987
    1987 The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostate 1987
    1986 In vitro inhibition of human sarcoma cells invasive ability by bis(5-amidino-2-benzimidazolyl)methane: A novel esteroprotease inhibitor 1986
    1986 Degradation of glycoprotein and collagenous components of the basement membrane: studies with urokinase-type plasminogen activator, alpha-thrombin, and plasmin. 1986
    1986 Immunohistochemical evidence for the vascular origin of primary adrenal pseudocysts 1986
    1986 Case report 362 1986
    1986 Collagen and laminin immunoreactivity in ewing's sarcoma: Support for an uncommitted mesenchymal cell derivation 1986
    1986 Degradation of glycoprotein and collagenous components of the basement membrane: Studies with urokinase-type plasminogen activator, α-thrombin, and plasmin 1986
    1986 Endometrial stromal cells in culture: An attempt to understand the genesis and biologic activity of uterine sarcomas 1986
    1986 Laminin promotes rabbit neutrophil motility and attachment 1986
    1986 Osteogenic sarcoma and soft tissue myxoma in a patient with fibrous dysplasia and hemoglobins J(Baltimore) and S 1986
    1985 Cellular immunolocalization of S100 protein within fixed tissue sections by monoclonal antibodies 1985
    1985 Analysis of isoenzymes in normal and carcinogen-treated human endometrial stromal cells in culture 1985
    1985 Chronic lymphocytic leukemia presenting as an anal mass 1985
    1985 Effect of a novel esteroprotease inhibitor on tumor cell invasion in vitro 1985
    1985 Esophagitis: A frequent consequence of gastroesophageal reflux in infancy 1985
    1985 Ewing's sarcoma in bones of the hands and feet: A clinicopathologic study and review of the literature 1985
    1985 Histiocytosis X (Langerhans' cell granulomatosis) of the thymus. A clinicopathologic study of four childhood cases 1985
    1985 Juxtadrenal schwannoma: Verification of the diagnosis by immunohistochemical and ultrastructural studies 1985
    1985 Neuron-specific enolase immunoreactivity in small-cell carcinoma of the uterine cervix. 1985
    1985 Primary transitional cell carcinoma of the female urethra with features of clear cell adenocarcinoma 1985
    1985 Radiographic appearance of Ewing sarcoma of the hands and feet: Report from the Intergroup Ewing Sarcoma Study 1985
    1984 The heterogeneity of LDH isoenzyme patterns of human uterine sarcomas and cultured sarcoma cell lines 1984
    1984 Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone 1984
    1983 Use of anti-basement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillaries 1983
    1983 Characterization of a pure heterologous sarcoma of the uterus: Rhabdomyosarcoma of the corpus 1983
    1983 Loss of basement membrane components by invasive tumors but not by their benign counterparts 1983
    1982 Interferon enhancement of the invasive capacity of Ewing sarcoma cells in vitro 1982
    1982 Enhancement of human cancer cell invasiveness by human interferons 1982
    1982 Interactions of tumor cells with whole basement membrane in the presence or absence of endothelium. 1982
    1981 Stages of neoplastic transformation of human breast tissue as monitored by dissolution of basement membrane components. An immunoperoxidase study 1981
    1981 Effect of Plasminogen Activator (Urokinase), Piasmin, and Thrombin on Glycoprotein and Collagenous Components of Basement Membrane 1981
    1981 Sarcomas of bone complicating osteitis deformans (Paget's disease). Fifty years' experience 1981
    1981 Antibodies to collagenase-resistant terminal regions of pro-type IV collagen recognize whole basement membrane and 7 S collagen 1981
    1981 Death by drowning. An overview. 1981
    1981 Spontaneous rupture of the kidney following renal artery revascularization. 1981
    1981 Antibodies to collagenase-resistant terminal regions of pro-type IV collagen recognize whole basement membrane and 7 S collagen 1981
    1981 Preparation of Interferon Messenger RNAs with the Use of Ribonucleoside-Vanadyl Complexes 1981
    1981 Preparation of interferon messenger RNAs with the use of ribonucleoside--vanadyl complexes. 1981
    1980 Primary mediastinal embryonal carcinoma 1980
    1980 Non-Hodgkin's lymphoma with features of "Sternberg's sarcoma" manifesting as a pelvic mass. 1980
    1980 Polyadenylate‐deficient analogues of poly(A)‐containing mRNA sequences in cultured AKR mouse embryo cells 1980
    1979 Testicular surprises in two apparently healthy young men. 1979
    1979 Frequency differences between nuclear and polysomal sequences of poly(A)‐containing RNA from cultured akr mouse embryo cells 1979
    1978 Idiopathic pulmonary hemosiderosis. Two cases in a family 1978
    1977 Gene expression in chemically transformed mouse embryo cells: Selective enhancement of the expression of C type RNA tumor virus genes 1977
    1976 Solitary leiomyomas arising from the tunica dartos scroti 1976
    1975 Osteoblastic osteogenic sarcoma in a 35 month old girl. Report of a case 1975


    Year Title Altmetric
    2017 Quality Assurance in Anatomic Pathology: Strategies for Assessment, Improvement and Management 2017
    2015 Practical Orthopedic Pathology: A Diagnostic Approach E-Book: A Volume in the Pattern Recognition Series 2015
    2014 Pathobiology of human disease: a dynamic encyclopedia of disease mechanisms 2014
    2013 Atlas of bone pathology 2013
    2011 Atlas of Nontumor Pathology Vol. 9:\lnotNon-Neoplastic Diseases of Bones and Joints 2011
    2011 Frozen Section Library: Bone 2011
    2011 Laboratory Administration for Pathologists 2011
    2007 Updates in Diagnostic Pathology 2007
    2005 Foreword - Another brief history in time.  Ed. 563.  2005
    1988 Monoclonal antibodies in diagnostic immunohistochemistry 1988


    Year Title Altmetric
    2017 Ceramic Coatings in Load-Bearing Articulating Joint Implants.  315-347. 2017
    2016 Ceramic Coatings in Load-Bearing Articulating Joint Implants 2016
    2016 Gene therapy in the treatment of human cancer.  811-841. 2016
    2015 Molecular pathology of osteosarcoma.  213-222. 2015
    2010 Molecular pathology of osteosarcoma.  193-199. 2010

    Research Overview

  • Dr. Siegal is an extramurally funded experimental and diagnostic pathologist whose research interest for more than 3 decades has been focused in Cancer Biology. Specifically, he has been interested in studying tumor-matrix interactions during angiogenesis, tumor invasion and metastasis in breast cancer. Previous efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on prostate and breast cancer progression in humans. He has participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms, principally ovarian carcinoma. He was most recently funded to develop a conditionally replicating canine adenovirus model that could be used to study host-vector interactions for more effective antitumor oncolytic effect. Dr. Siegal also directs the Histomorphometry & Molecular Analysis Core of the UAB Core Center for Musculoskeletal Disorders. Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions. He is the Editor-in-Chief of Laboratory Investigation and serves on the editorial board of an additional twenty journals.
  • Education And Training

  • Doctor of Philosophy in Pathology Residency Program, University of Minnesota System : Twin Cities 1979
  • Doctor of Medicine, University of Louisville 1974
  • Mayo Graduate School of Medicine, Internship 1975
  • Mayo Graduate School of Medicine, Residency 1979
  • Mayo Graduate School of Medicine, Residency 1978
  • Mayo Graduate School of Medicine, Residency 1976
  • ALABAMA MEDICAL LICENSURE COMMISSION, Postdoctoral Fellowship 1982
  • Warren G. Magnuson Clinical Center, Postdoctoral Fellowship 1981
  • Mayo Graduate School of Medicine, Postdoctoral Fellowship 1977
  • Awards And Honors

  • 3rd Jishuitan Pathology Forum Lecturer – Bone & Soft Tissue Tumours, 2018
  • C.A.P. Lifetime Achievement Award, 2017
  • Albert Nelson Marquis Lifetime Achievement Award, 2017
  • Vernie A. Stembridge Lecturer – 95th Ann. Meeting, Texas Soc. Of Pathologists, 2016
  • A.S.I.P. Robbins Distinguished Educator Award, 2015
  • Miembro Honorario, Asociacion Venezolana para el Estudio de Tumors Musculo-Esqueleticos (AVETME), 2013
  • Emma Sadler Moss Lecturer - Louisiana State University (LSU), 2012
  • The Griffin Society [UAB Scientific Society], 2009
  • Arthur Purdy Stout Lecturer - A.S.C.P. Annual Meeting, 2009
  • Citation Classic (Ref #18) Barsky S. et al. Lab Invest 49:140, 1983, 2003
  • Milton S. Hales Lecturer - West Virginia University, 2003
  • 1st Carter/Makley Lecturer -Case Western Reserve Univ., Institute of Pathology, 2003
  • 3rd Walter R. Benson Lecturer -University of North Carolina, 2003
  • Farrell Prize, International Skeletal Society [Shared with M.J. Pitt], 2001
  • Alpha Omega Alpha, the Medical Honor Society, 1996
  • International Skeletal Society, 1994
  • Phi Beta Delta, Honor Society for International Scholars, 1993
  • Fellow of the Royal Society of Medicine, London, 1992
  • Order of the Grail - Valkyries (UNC Honorary), 1990
  • Order of the Grail - Valkyries (UNC Honorary), 1990
  • Jefferson-Pilot Fellow in Academic Medicine, 1986
  • International Business Machines Corporation Junior Faculty Development Awardee, 1985
  • Junior Faculty Fellow of the American Cancer Society, 1983
  • Clinical Fellow of the American Cancer Society, 1981
  • Sigma Xi, The Scientific Research Society of North America, 1976
  • Omicron Delta Kappa, the National Leadership Honor Society, 1974
  • Who's Who Among Students in American Colleges & Universities, 1969
  • Beta Beta Beta, The National Biology Honor Society, 1968
  • Alpha Epsilon Delta, the International Premedical Honor Society, 1966
  • Full Name

  • Gene Siegal