Positions

Overview

  • Our eyes are composed of living tissues, which are constantly remodeling in response to mechanical, chemical, and visual stimuli. In particular, the loadbearing collagenous structures of the eye can undergo substantial growth and remodeling during physiological and pathophysiological conditions. I seek to elucidate the biomechanical mechanisms that underlie growth and remodeling in ocular diseases. My laboratory focuses on establishing experimental methods and predictive computational simulation tools for elucidating growth and remodeling mechanisms in glaucoma, keratoconus and myopia. My laboratory‚Äôs goal is to provide predictive computational simulation tools that support the development of new diagnostics and therapeutics in ocular diseases and conditions.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Matching the LenStar optical biometer to A-Scan ultrasonography for use in small animal eyes with application to tree shrews.Experimental Eye Research.  180:250-259. 2018
    2018 Experimental myopia increases and scleral crosslinking using genipin inhibits cyclic softening in the tree shrew sclera.Ophthalmic and Physiological Optics.  38:246-256. 2018
    2017 Multi-Scale Modeling of Vision-Guided Remodeling and Age-Dependent Growth of the Tree Shrew Sclera During Eye Development and Lens-Induced Myopia.Journal of Elasticity.  129:171-195. 2017
    2016 A Novel Organ Culture Model to Quantify Collagen Remodeling in Tree Shrew Sclera.PLoS ONE.  11:e0166644. 2016
    2015 Changing material properties of the tree shrew sclera during minus lens compensation and recovery.Investigative Ophthalmology & Visual Science.  56:2065-2078. 2015
    2014 Age- and race-related differences in human scleral material properties.Investigative Ophthalmology & Visual Science.  55:8163-8172. 2014
    2014 Human scleral structural stiffness increases more rapidly with age in donors of African descent compared to donors of European descent.Investigative Ophthalmology & Visual Science.  55:7189-7198. 2014
    2014 Age-related changes in human peripapillary scleral strain.Biomechanics and Modeling in Mechanobiology.  13:551-563. 2014
    2014 Material properties of the posterior human sclera.Journal of the Mechanical Behavior of Biomedical Materials.  29:602-617. 2014
    2013 A forward incremental prestressing method with application to inverse parameter estimations and eye-specific simulations of posterior scleral shells.Computer Methods in Biomechanics and Biomedical Engineering.  16:768-780. 2013
    2012 Regional variations in mechanical strain in the posterior human sclera.Investigative Ophthalmology & Visual Science.  53:5326-5333. 2012
    2012 Perspectives on biomechanical growth and remodeling mechanisms in glaucoma().Mechanics Research Communications.  42:92-106. 2012
    2012 Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Motivated Growth and Remodeling Approach.Mechanics of Materials.  44:99-109. 2012
    2011 The collagen fibril architecture in the lamina cribrosa and peripapillary sclera predicted by a computational remodeling approach.Biomechanics and Modeling in Mechanobiology.  10:371-382. 2011
    2010 A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells.Biomechanics and Modeling in Mechanobiology.  9:225-235. 2010
    2009 Constitutive modeling of crimped collagen fibrils in soft tissues.Journal of the Mechanical Behavior of Biomedical Materials.  2:522-533. 2009
    2008 Consistent micro-macro transitions at large objective strains in curvilinear convective coordinatesInternational Journal for Numerical Methods in Engineering.  73:805-824. 2008
    2004 Incompressibility at large strains and finite-element implementationActa Mechanica.  168:75-101. 2004

    Chapter

    Year Title Altmetric
    2018 Scleral Remodeling in Myopia 2018
    2016 Glaucoma and structure-based mechanics of the lamina cribrosa at multiple scales.  93-122. 2016
    2014 Mechanical Strain and Restructuring of the Optic Nerve Head.  67-87. 2014

    Full Name

  • Rafael Grytz
  • Fax

  • 205-934-3425