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Donald Rokosh
Associate Professor
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E-mail
grokosh@uab.edu
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Donald Rokosh
Associate Professor
Positions
Associate Professor (P)
,
Medicine - Cardiovascular Disease
,
Department of Medicine
2015 -
Publications
Research
Teaching
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Publications
Selected Publications
Academic Article
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Year
Title
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2019
Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury
.
Basic Research in Cardiology
. 114.
2019
2019
Optimized protocols for isolation, fixation, and flow cytometric characterization of leukocytes in ischemic hearts
2019
2019
SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice
.
Developmental Biology
. 452:1-7.
2019
2019
Response by Bansal et al to Letter Regarding Article, "dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy"
.
Circulation
. 139:E1035-E1036.
2019
2019
Correction: The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-related kinase (ERK)/NRF2 signaling pathway and cytokine release (Journal of Biological Chemistry (2012) 287:40 (33720-33732) DOI:10.1074/jbc.M112.385542)
.
Journal of Biological Chemistry
. 294:4725-4727.
2019
2019
Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy
.
Circulation
. 139:206-221.
2019
2018
CCR2
+
Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload
.
JACC: Basic to Translational Science
. 3:230-244.
2018
2017
Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia
.
Circulation Research
. 120:e7-e23.
2017
2017
Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure
.
Circulation: Heart Failure
. 10.
2017
2017
Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure
.
Basic Research in Cardiology
. 112.
2017
2016
Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
.
Cardiovascular Research
. 112:532-542.
2016
2016
Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.
.
Cardiovascular Research
. 112:532-542.
2016
2016
Long-Term Outcome of Administration of c-kit
POS
Cardiac Progenitor Cells after Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year
.
Circulation Research
. 118:1091-1105.
2016
2015
Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury
.
Circulation Research
. 117:437-449.
2015
2015
Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
.
Basic Research in Cardiology
. 110.
2015
2015
Identification of Heme Oxygenase 1 (HO-1) as a Novel Negative Regulator of Mobilization of Hematopoietic Stem/Progenitor Cells
.
Stem Cell Reviews and Reports
. 11:110-118.
2015
2015
Effects of intracoronary infusion of escalating doses of cardiac stem cells in rats with acute myocardial infarction
.
Circulation: Heart Failure
. 8:757-765.
2015
2015
Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow
.
Oncotarget
. 6:18819-18828.
2015
2015
Feasibility Study of Particulate Extracellular Matrix (P-ECM) and Left Ventricular Assist Device (HVAD) Therapy in Chronic Ischemic Heart Failure Bovine Model
.
ASAIO Journal
. 61:161-169.
2015
2014
Co-activation of nuclear factor-κB and myocardin/serum response factor conveys the hypertrophy signal of high insulin levels in cardiac myoblasts
.
Journal of Biological Chemistry
. 289:19585-19598.
2014
2014
Stromal cell derived factor-1α promotes C-Kit
+
cardiac stem/progenitor cell quiescence through casein kinase 1α and GSK3β
.
STEM CELLS
. 32:487-499.
2014
2014
Cigarette smoke adversely affects functions and cell membrane integrity in c-kit+ cardiac stem cells
2014
2014
Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarction
.
STEM CELLS
. 32:2502-2515.
2014
2013
Mechanisms of stem cell effects: Insights from MRI
.
Minerva Cardioangliologica
. 61:605-616.
2013
2013
Long-term engraftment and angiogenic properties of lentivirally transduced adipose tissue-derived stromal cells
.
Molecular Biotechnology
. 54:13-24.
2013
2013
Targeting phosphatidylinositol 3-kinase-Akt through hepatocyte growth factor for cardioprotection
.
Journal of Cardiovascular Medicine
. 14:249-253.
2013
2013
Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca(2+) induced permeability transition.
.
Frontiers in Physiology
. 4:295.
2013
2012
Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion
.
Basic Research in Cardiology
. 107.
2012
2012
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release
.
Journal of Biological Chemistry
. 287:33720-33732.
2012
2012
Insights into gene therapy for critical limb ischemia: The devil is in the details
.
Vascular Pharmacology
. 57:10-14.
2012
2012
The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning
.
PLoS ONE
. 7.
2012
2011
A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning
.
Journal of Molecular and Cellular Cardiology
. 50:589-597.
2011
2011
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): Initial results of a randomised phase 1 trial
2011
2010
Late-breaking basic science abstracts from the American Heart Association's Scientific Sessions 2010
.
Circulation Research
. 107.
2010
2010
Chronic AMD3100 antagonism of SDF-1α-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction
.
Journal of Molecular and Cellular Cardiology
. 49:587-597.
2010
2010
Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair
.
Basic Research in Cardiology
. 105:443-452.
2010
2010
Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart
.
Circulation
. 121:1912-1925.
2010
2010
Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction
.
Circulation Journal
. 74:390-404.
2010
2010
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction
.
Circulation
. 121:293-305.
2010
2009
Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-κb-dependent pathway
.
Circulation
. 120:1222-1230.
2009
2009
Cell therapy for ischaemic heart disease: Focus on the role of resident cardiac stem cells
.
Netherlands Heart Journal
. 17:199-207.
2009
2008
Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition
.
Circulation
. 118:1970-1978.
2008
2008
Heme-Egr-1: New partners in atherosclerotic progression?
.
Circulation Research
. 102:6-8.
2008
2007
The late phase of preconditioning and its natural clinical application - Gene therapy
.
Heart Failure Reviews
. 12:189-199.
2007
2007
The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats
2007
2007
Stromal cell-derived factor-1α confers protection against myocardial ischemia/reperfusion injury: Role of the cardiac stromal cell-derived factor-1α-CXCR4 axis
.
Circulation
. 116:654-663.
2007
2007
Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase Cε-p44/42 mitogen-activated protein kinase-pSer-signal transducers and activators of transcription1/3 pathway
.
Circulation
. 116:535-544.
2007
2005
Role of the protein kinase C-ε-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning
.
Circulation
. 112:1971-1978.
2005
2003
The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.
.
Journal of Clinical Investigation
. 111:1783-1791.
2003
2003
The α
1A/C
- and α
1B
-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse
.
Journal of Clinical Investigation
. 111:1783-1791.
2003
2002
Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice.
.
Journal of Molecular and Cellular Cardiology
. 34:1007-1017.
2002
2002
Knockout of the α1A/C-adrenergic receptor subtype: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure
2002
2001
LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice.
2001
2001
Cloning and characterization of the mouse α1C/A-adrenergic receptor gene and analysis of an α1C promoter in cardiac myocytes: Role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1)
.
Molecular Pharmacology
. 59:1225-1234.
2001
2001
LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice
2001
2000
Autonomous and growth factor - Induced hypertrophy in cultured neonatal mouse cardiac myocytes: Comparison with rat
.
Circulation Research
. 87:781-788.
2000
1999
Two-dimensional echocardiography with a 15-MHz transducer is a promising alternative for in vivo measurement of left ventricular mass in mice
.
Journal of The American Society of Echocardiography
. 12:70-75.
1999
1997
Cross talk between angiotensin AT
1
and α
1
-adrenergic receptors: Angiotensin II downregulates α(1a)-adrenergic receptor subtype mRNA and density in neonatal rat cardiac myocytes
.
Circulation Research
. 81:396-403.
1997
1996
Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C.
.
Journal of Biological Chemistry
. 271:5839-5843.
1996
1996
α
1
-adrenergic receptor subtype mRNAs are differentially regulated by α
1
-Adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo: Repression of α
1B
and α
1D
but induction of α
1C
.
Journal of Biological Chemistry
. 271:5839-5843.
1996
1995
Chronic hypoxia differentially regulates α
1
-adrenergic receptor subtype mRNAs and inhibits α
1
-adrenergic receptor-stimulated cardiac hypertrophy and signaling
.
Circulation
. 92:918-925.
1995
1994
Distribution of α1C-Adrenergic Receptor mRNA in Adult-Rat Tissues by RNase Protection Assay and Comparison with α1B and α1D
.
Biochemical and Biophysical Research Communications
. 200:1177-1184.
1994
1994
Cloning of the rat α(1C)-adrenergic receptor from cardiac myocytes: α(1C), α(1B), and α(1D) mRNAs are present in cardiac myocytes but not in cardiac fibroblasts
.
Circulation Research
. 75:796-802.
1994
Book
Filter
Year
Title
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2007
Methods in Molecular Biology: Preface
. Ed. 366.
2007
Research
Principal Investigator On
A Novel Mechanism of Stromal Cell-Derived Factor 1 Protection Against Diabetic Cardiomyopathy
awarded by
University of Louisville
2017 - 2022
Investigator On
Lipoxygenase Signaling in Heart Failure Pathology
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2023
Macrophage Circadian Clock Disruption and Inflammation in Heart Failure
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2023
Examine the Impact of Congenital Heart Diseases on Alzheimer's Disease.
awarded by
American Heart Association
2019 - 2021
Test The Role Of Cardiac Expressed SEMA6D In Alzheimer's Disease
awarded by
National Institute on Aging/NIH/DHHS
2019 - 2021
Cardiomyocyte-Mediated Mechanisms of Ischemia
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2018 - 2020
Teaching
Teaching Activities
BY434 - Function Genomics Sys Bio (Fall Term 2019)
2019
BY634 - Function Genomics Sys Bio (Fall Term 2019)
2019
Contact
Full Name
Donald
Rokosh