Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload.  JACC: Basic to Translational Science.  3:230-244. 2018
2017 Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia.  Circulation Research.  120:e7-e23. 2017
2017 Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure.  Circulation: Heart Failure.  10. 2017
2017 Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.  Basic Research in Cardiology.  112. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.  Cardiovascular Research.  112:532-542. 2016
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice..  Cardiovascular Research.  112:532-542. 2016
2016 Long-Term Outcome of Administration of c-kitPOS Cardiac Progenitor Cells after Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year.  Circulation Research.  118:1091-1105. 2016
2015 Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling.  Basic Research in Cardiology.  110. 2015
2015 Effects of intracoronary infusion of escalating doses of cardiac stem cells in rats with acute myocardial infarction.  Circulation: Heart Failure.  8:757-765. 2015
2015 Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow.  Oncotarget.  6:18819-18828. 2015
2015 Feasibility Study of Particulate Extracellular Matrix (P-ECM) and Left Ventricular Assist Device (HVAD) Therapy in Chronic Ischemic Heart Failure Bovine Model.  ASAIO Journal.  61:161-169. 2015
2015 Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.  Circulation Research.  117:437-449. 2015
2015 Identification of Heme Oxygenase 1 (HO-1) as a Novel Negative Regulator of Mobilization of Hematopoietic Stem/Progenitor Cells.  Stem Cell Reviews and Reports.  11:110-118. 2015
2014 Co-activation of nuclear factor-κB and myocardin/serum response factor conveys the hypertrophy signal of high insulin levels in cardiac myoblasts.  Journal of Biological Chemistry.  289:19585-19598. 2014
2014 Stromal cell derived factor-1α promotes C-Kit+ cardiac stem/progenitor cell quiescence through casein kinase 1α and GSK3β.  STEM CELLS.  32:487-499. 2014
2014 Cigarette smoke adversely affects functions and cell membrane integrity in c-kit+ cardiac stem cells.  Cell Biology and Toxicology.  30:113-125. 2014
2014 Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarction.  STEM CELLS.  32:2502-2515. 2014
2013 Mechanisms of stem cell effects: Insights from MRI.  Minerva Cardioangliologica.  61:605-616. 2013
2013 Long-term engraftment and angiogenic properties of lentivirally transduced adipose tissue-derived stromal cells.  Molecular Biotechnology.  54:13-24. 2013
2013 Targeting phosphatidylinositol 3-kinase-Akt through hepatocyte growth factor for cardioprotection.  Journal of Cardiovascular Medicine.  14:249-253. 2013
2013 Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca(2+) induced permeability transition..  Frontiers in Physiology.  4:295. 2013
2012 Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion.  Basic Research in Cardiology.  107. 2012
2012 The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release.  Journal of Biological Chemistry.  287:33720-33732. 2012
2012 Insights into gene therapy for critical limb ischemia: The devil is in the details.  Vascular Pharmacology.  57:10-14. 2012
2012 The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning.  PLoS ONE.  7. 2012
2011 A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning.  Journal of Molecular and Cellular Cardiology.  50:589-597. 2011
2011 Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): Initial results of a randomised phase 1 trial.  Lancet.  378:1847-1857. 2011
2010 Late-breaking basic science abstracts from the American Heart Association's Scientific Sessions 2010.  Circulation Research.  107. 2010
2010 Chronic AMD3100 antagonism of SDF-1α-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction.  Journal of Molecular and Cellular Cardiology.  49:587-597. 2010
2010 Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair.  Basic Research in Cardiology.  105:443-452. 2010
2010 Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.  Circulation.  121:1912-1925. 2010
2010 Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction.  Circulation Journal.  74:390-404. 2010
2010 Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction.  Circulation.  121:293-305. 2010
2009 Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-κb-dependent pathway.  Circulation.  120:1222-1230. 2009
2009 Cell therapy for ischaemic heart disease: Focus on the role of resident cardiac stem cells.  Netherlands Heart Journal.  17:199-207. 2009
2008 Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.  Circulation.  118:1970-1978. 2008
2008 Heme-Egr-1: New partners in atherosclerotic progression?.  Circulation Research.  102:6-8. 2008
2007 The late phase of preconditioning and its natural clinical application - Gene therapy.  Heart Failure Reviews.  12:189-199. 2007
2007 The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats.  AJP - Heart and Circulatory Physiology.  293. 2007
2007 Stromal cell-derived factor-1α confers protection against myocardial ischemia/reperfusion injury: Role of the cardiac stromal cell-derived factor-1α-CXCR4 axis.  Circulation.  116:654-663. 2007
2007 Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase Cε-p44/42 mitogen-activated protein kinase-pSer-signal transducers and activators of transcription1/3 pathway.  Circulation.  116:535-544. 2007
2005 Role of the protein kinase C-ε-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning.  Circulation.  112:1971-1978. 2005
2003 The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse..  Journal of Clinical Investigation.  111:1783-1791. 2003
2003 The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.  Journal of Clinical Investigation.  111:1783-1791. 2003
2002 Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice..  Journal of Molecular and Cellular Cardiology.  34:1007-1017. 2002
2002 Knockout of the α1A/C-adrenergic receptor subtype: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.  Proceedings of the National Academy of Sciences.  99:9474-9479. 2002
2001 LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice..  AJP - Heart and Circulatory Physiology.  281:H1104-H1112. 2001
2001 Cloning and characterization of the mouse α1C/A-adrenergic receptor gene and analysis of an α1C promoter in cardiac myocytes: Role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1).  Molecular Pharmacology.  59:1225-1234. 2001
2000 Autonomous and growth factor - Induced hypertrophy in cultured neonatal mouse cardiac myocytes: Comparison with rat.  Circulation Research.  87:781-788. 2000
1999 Two-dimensional echocardiography with a 15-MHz transducer is a promising alternative for in vivo measurement of left ventricular mass in mice.  Journal of The American Society of Echocardiography.  12:70-75. 1999
1997 Cross talk between angiotensin AT1 and α1-adrenergic receptors: Angiotensin II downregulates α(1a)-adrenergic receptor subtype mRNA and density in neonatal rat cardiac myocytes.  Circulation Research.  81:396-403. 1997
1996 Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C..  Journal of Biological Chemistry.  271:5839-5843. 1996
1996 α1-adrenergic receptor subtype mRNAs are differentially regulated by α1-Adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo: Repression of α1B and α1D but induction of α1C.  Journal of Biological Chemistry.  271:5839-5843. 1996
1995 Chronic hypoxia differentially regulates α1-adrenergic receptor subtype mRNAs and inhibits α1-adrenergic receptor-stimulated cardiac hypertrophy and signaling.  Circulation.  92:918-925. 1995
1994 Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts..  Circulation Research.  75:796-802. 1994
1994 Distribution of α1C-Adrenergic Receptor mRNA in Adult-Rat Tissues by RNase Protection Assay and Comparison with α1B and α1D.  Biochemical and Biophysical Research Communications.  200:1177-1184. 1994

Education And Training

  • Doctor of Philosophy in Cell Biology and Anatomy, University of Saskatchewan 1993

    • Full Name

  • Donald Rokosh