Positions

Overview

  • Dr. Liu graduated from China Medical University with a D.M.D. degree in 1994 and from Wuhan University with a Ph.D. degree in 1999. He received postdoctoral training in the Medical College of Georgia and the University of Alabama at Birmingham through 2003. Dr. Liu worked as a Research Associate from 2003-2006 in the Department of Cell Biology at University of Alabama at Birmingham. He was appointed as Assistant Professor in the Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine in 2006 and was promoted to Associate Professor in 2012.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  61:492-500. 2019
    2019 PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.American Journal of Respiratory Cell and Molecular Biology2019
    2019 Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injuryJCI insight.  4. 2019
    2019 Cellular Metabolism in Lung Health and DiseaseAnnual Review of Physiology.  81:403-428. 2019
    2019 Impairment of fatty acid oxidation in alveolar epithelial cells mediates acute lung injuryAmerican Journal of Respiratory Cell and Molecular Biology.  60:167-178. 2019
    2018 IFN regulatory factor 2 inhibits expression of glycolytic genes and lipopolysaccharide-Induced proinflammatory responses in macrophagesJournal of Immunology.  200:3218-3230. 2018
    2018 Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylationAmerican Journal of Respiratory Cell and Molecular Biology.  58:378-390. 2018
    2018 MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway EpitheliaAmerican Journal of Respiratory and Critical Care Medicine.  197:632-643. 2018
    2017 The lung likes the little fella miR-29American Journal of Respiratory Cell and Molecular Biology.  57:637-638. 2017
    2017 Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosisAJP - Lung Cellular and Molecular Physiology.  313:L834-L844. 2017
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung diseaseAging Cell.  16:1114-1124. 2017
    2017 Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosisJournal of Immunology.  199:1596-1605. 2017
    2017 Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2Genes and Development.  31:1243-1256. 2017
    2017 miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctionsAJP - Lung Cellular and Molecular Physiology.  312:L415-L424. 2017
    2017 MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescenceAmerican Journal of Respiratory Cell and Molecular Biology.  56:168-178. 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.JCI insight.  2:e91377. 2017
    2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentinAJP - Lung Cellular and Molecular Physiology.  313:L80-L91. 2017
    2016 Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosisNature Communications.  7. 2016
    2016 MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiationAmerican Journal of Respiratory Cell and Molecular Biology.  54:843-852. 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthmaAJP - Lung Cellular and Molecular Physiology.  310:L328-L336. 2016
    2016 MicroRNAs for osteosarcoma in the mouse: A meta-analysisOncotarget.  7:85650-85674. 2016
    2015 Glycolytic reprogramming in myofibroblast differentiation and lung fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  192:1462-1474. 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiationJournal of Biological Chemistry.  290:25427-25438. 2015
    2015 The code of non-coding RNAs in lung fibrosisCellular and Molecular Life Sciences.  72:3507-3519. 2015
    2015 Monocyte chemotactic protein-induced protein 1 and 4 form a complex but act independently in regulation of interleukin-6 mRNA degradationJournal of Biological Chemistry.  290:20782-20792. 2015
    2015 Noninvasive imaging of experimental lung fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  53:8-13. 2015
    2015 IL-13 induces YY1 through the AKT pathway in lung fibroblastsPLoS ONE.  10. 2015
    2015 The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophagesJournal of Biological Chemistry.  290:46-55. 2015
    2015 Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescenceFree Radical Biology and Medicine.  79:197-205. 2015
    2015 Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolismJournal of Immunology.  194:6082-6089. 2015
    2015 ncRNA-regulated immune response and its role in inflammatory lung diseasesAJP - Lung Cellular and Molecular Physiology.  309:L1076-L1087. 2015
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosisJournal of Pharmacology and Experimental Therapeutics.  351:87-95. 2014
    2014 MiR-27a regulates inflammatory response of macrophages by targeting IL-10Journal of Immunology.  193:327-334. 2014
    2014 The human long noncoding RNA lnc-IL7R regulates the inflammatory responseEuropean Journal of Immunology.  44:2085-2095. 2014
    2013 MiR-125a-5p regulates differential activation of macrophages and inflammationJournal of Biological Chemistry.  288:35428-35436. 2013
    2013 MicroRNA let-7c regulates macrophage polarizationJournal of Immunology.  190:6542-6549. 2013
    2013 Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortalityProceedings of the National Academy of Sciences.  110:9362-9367. 2013
    2013 MiR-145 regulates myofibroblast differentiation and lung fibrosisFederation proceedings.  27:2382-2391. 2013
    2013 MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shockCellular Signalling.  25:1228-1234. 2013
    2013 Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory diseaseImmunology and Cell Biology.  91:368-376. 2013
    2013 MiR-21 mediates hematopoietic suppression in MDS by activating TGF-β signalingBlood.  121:2875-2881. 2013
    2013 MicroRNAs in immune response and macrophage polarizationArteriosclerosis, Thrombosis, and Vascular Biology.  33:170-177. 2013
    2013 Histone modifications in senescence-associated resistance to apoptosis by oxidative stressRedox Biology.  1:8-16. 2013
    2012 p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cellsJournal of Biological Chemistry.  287:30117-30127. 2012
    2012 Identification of TLT2 as a receptor for efferocytosisJournal of Immunology.  188. 2012
    2012 Identification of TLT2 as an engulfment receptor for apoptotic cellsJournal of Immunology.  188:6381-6388. 2012
    2012 Extracellular histones inhibit efferocytosisMolecular Medicine.  18:825-833. 2012
    2012 MiR-21 regulates chronic hypoxia-induced pulmonary vascular remodelingAJP - Lung Cellular and Molecular Physiology.  302. 2012
    2012 Regulation of alveolar epithelial Na + channels by ERK1/2 in chlorine-breathing miceAmerican Journal of Respiratory Cell and Molecular Biology.  46:342-354. 2012
    2012 Participation of miR-200 in pulmonary fibrosisAmerican Journal of Pathology.  180:484-493. 2012
    2011 Intracellular HMGB1 Negatively regulates efferocytosisJournal of Immunology.  187:4686-4694. 2011
    2011 The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophilsPLoS ONE.  6. 2011
    2011 Identification of a microRNA signature in renal fibrosis: Role of miR-21AJP - Renal Physiology.  301. 2011
    2011 Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in miceAmerican Journal of Respiratory Cell and Molecular Biology.  45:88-94. 2011
    2011 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosisDrugs.  71:981-1001. 2011
    2011 Participation of the receptor for advanced glycation end products in efferocytosisJournal of Immunology.  186:6191-6198. 2011
    2010 Urokinase-type plasminogen activator inhibits efferocytosis of neutrophilsAmerican Journal of Respiratory and Critical Care Medicine.  182:1516-1523. 2010
    2010 HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrinAmerican Journal of Physiology - Cell Physiology.  299. 2010
    2010 The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosisJournal of Leukocyte Biology.  88:973-979. 2010
    2010 miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosisJournal of Experimental Medicine.  207:1589-1597. 2010
    2010 Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloraminesJournal of Biological Chemistry.  285:9716-9728. 2010
    2010 Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradationMolecular and Cellular Biology.  30:1041-1048. 2010
    2010 Modulation of SCFβ-TrCP-dependent IκBα ubiquitination by hydrogen peroxideJournal of Biological Chemistry.  285:2665-2675. 2010
    2009 Participation of the urokinase receptor in neutrophil efferocytosisBlood.  114:860-870. 2009
    2009 Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen speciesFederation proceedings.  23:3829-3842. 2009
    2009 miR-147, a microRNA that is induced upon toll-like receptor stimulation, regulates murine macrophage inflammatory responsesProceedings of the National Academy of Sciences.  106:15819-15824. 2009
    2009 Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injuryAmerican Journal of Respiratory Cell and Molecular Biology.  41:237-245. 2009
    2009 Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  179:694-704. 2009
    2009 p53 attenuates lipopolysaccharide-induced NF-κB activation and acute lung injuryJournal of Immunology.  182:5063-5071. 2009
    2009 Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthaseJournal of Biological Chemistry.  284:7294-7306. 2009
    2008 Potential role of high-mobility group box 1 in cystic fibrosis airway diseaseAmerican Journal of Respiratory and Critical Care Medicine.  178:822-831. 2008
    2008 High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserineJournal of Immunology.  181:4240-4246. 2008
    2008 Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injuryAJP - Lung Cellular and Molecular Physiology.  295. 2008
    2008 PAI-1 inhibits neutrophil efferocytosisProceedings of the National Academy of Sciences.  105:11784-11789. 2008
    2008 Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutationsCancer Research.  68:6789-6796. 2008
    2008 Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  178:168-179. 2008
    2008 Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-κB activation requires cytosolic and nuclear activityFederation proceedings.  22:2285-2296. 2008
    2008 Role of extracellular superoxide in neutrophil activation: Interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine productionAmerican Journal of Physiology - Cell Physiology.  294. 2008
    2007 Involvement of vitronectin in lipopolysaccaride-induced acute lung injuryJournal of Immunology.  179:7079-7086. 2007
    2007 Variant IL-1 receptor-associated kinase-1 mediates increased NF-κB activityJournal of Immunology.  179:4125-4134. 2007
    2007 Semi-quantitative RT-PCR analysis of LIM mineralization protein 1 and its associated molecules in cultured human dental pulp cellsArchives of Oral Biology.  52:720-726. 2007
    2006 Myosin VI is a mediator of the p53-dependent cell survival pathwayMolecular and Cellular Biology.  26:2175-2186. 2006
    2006 Regulation of the p53 transcriptional activityJournal of Cellular Biochemistry.  97:448-458. 2006
    2006 DNA polymerase η, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activationMolecular and Cellular Biology.  26:1398-1413. 2006
    2005 The C-terminal sterile α motif and the extreme C terminus regulate the transcriptional activity of the α isoform of p73Journal of Biological Chemistry.  280:20111-20119. 2005
    2004 DeltaNp73beta is active in transactivation and growth suppression.Molecular and Cellular Biology.  24:487-501. 2004
    2004 ΔNp73β Is Active in Transactivation and Growth SuppressionMolecular and Cellular Biology.  24:487-501. 2004
    2003 Characterization of p73 functional domains necessary for transactivation and growth suppressionOncogene.  22:4333-4347. 2003
    2003 The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding proteinJournal of Biological Chemistry.  278:17557-17565. 2003
    2003 Isolation and characterization of fourteen novel putative and nine known target genes of the p53 familyCancer Biology and Therapy.  2:55-62. 2003
    2002 The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosisOncogene.  21:7195-7204. 2002

    Chapter

    Year Title Altmetric
    2015 How noncoding RNAs contribute to macrophage polarization.  59-84. 2015

    Research Overview

  • Dr. Liu's research focuses on the role of non-coding RNAs in regulation of lung inflammation, injury and repair. Dr. Liu's research recently developed a new direction to study the role of cellular metabolism in the pathogenesis of lung injury and fibrosis.
  • Education And Training

  • Medical College of Georgia, Postdoctoral Research
  • University of Alabama at Birmingham Hospital, Postdoctoral Research
  • Doctor of Science in Biology / Biological Sciences, Wuhan University 1999
  • Doctor of Medicine, China Medical University 1994
  • Full Name

  • Gang Liu