Positions

Overview

  • Trained in molecular genetics, Dr Gibson is keenly interested in understanding the molecular mechanisms underlying complex genetic diseases, like autoimmune SLE, as a first step to identifying therapeutics for disease intervention. Dr Gibson’s original training is in the structure and function of activator genes regulating gene expression in unicellular eukaryotes, but he has since focused on structural genetic and epigenetic mechanisms driving autoimmune SLE. Using cutting-edge biochemical and genetic tools in model cellular systems and in human primary cells, Dr Gibson works on identifying and characterizing SLE-linked genetic variants that confer disease risk or severity, including genes encoded at the chromosome 1q21-q23 locus. In this effort, he has examined the genetic structure and expression of FcRL3 variants and their role in SLE, and the structure and function of FcgammaRI-FcRg, the high-affinity IgG receptor complex that mediates ADCP and clearance of immune complexes in phagocytes. His work on the alpha-chain of FcgRI, which binds IgG and IgG-immune complexes, has revealed contributions of the cytoplasmic domain to receptor signal transduction, and his work on the structure/function of gamma chain, the signaling molecule in the receptor complex, has identified specific residues (beyond the traditional ITAM tyrosine phosphorylation) that regulate function as well as intracellular molecular players that modify these residues. Dr Gibson’s more recent work has focused on the characterization of novel structural genomic variation at 1q23 which may alter the balance of activation vs inhibitory Fc receptor gene expression and alter downstream functions like ADCP that impact SLE disease. Ultimately, Dr Gibson’s work will identify novel molecular targets for improved ADCP and vaccine efficacy, and for therapeutic intervention in management of immunologic diseases.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Skewed allelic expression on X chromosome associated with aberrant expression of XIST on systemic lupus erythematosus lymphocytesHuman Molecular Genetics.  29:2523-2534. 2020
    2018 C-reactive protein impairs dendritic cell development, maturation, and function: Implications for peripheral toleranceFrontiers in Immunology.  9. 2018
    2017 Regulation of FcRγ function by site-specific serine phosphorylationJournal of Leukocyte Biology.  101:421-428. 2017
    2016 Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray dataFrontiers in Genetics.  7. 2016
    2014 Human FcR polymorphism and diseaseCurrent Topics in Microbiology and Immunology.  382:275-302. 2014
    2013 Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell PopulationsPLoS Genetics.  9. 2013
    2012 The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated functionJournal of Immunology.  189:4284-4294. 2012
    2012 Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1GJournal of Leukocyte Biology.  91:97-103. 2012
    2011 FAS mRNA editing in human systemic lupus erythematosusHuman Mutation.  32:1268-1277. 2011
    2011 Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functionsPLoS ONE.  6. 2011
    2009 The FCRL3 -169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cellsArthritis and Rheumatism.  60:3510-3512. 2009
    2008 Functional expression of IgA receptor FcαRI on human plateletsJournal of Leukocyte Biology.  84:1492-1500. 2008
    2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African AmericansGenes and Immunity.  9:187-194. 2008
    2007 FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.Journal of Immunology.  178:3973-3982. 2007
    2007 FcαRI (CD89) alleles determine the proinflammatory potential of serum IgAJournal of Immunology.  178:3973-3982. 2007
    2007 Expression profile of FcγRIIb on leukocytes and its dysregulation in systemic lupus erythematosusJournal of Immunology.  178:3272-3280. 2007
    2004 Differential gene expression modulated by the cytoplasmic domain of FcγRIa (CD64) α-chainJournal of Immunology.  173:6211-6219. 2004
    2003 A novel polymorphic CAAT/enhancer-binding protein β element in the FasL gene promoter alters Fas ligand expression: A candidate background gene in African American systemic lupus erythematosus patientsJournal of Immunology.  170:132-138. 2003
    2002 Fc receptor homologs: Newest members of a remarkably diverse Fc receptor gene familyImmunological Reviews.  190:123-136. 2002
    2002 Diversity and duplicity: Human Fcγ receptors in host defense and autoimmunityImmunologic Research.  26:177-189. 2002
    2002 The CY domain of the FcγRIa α-chain (CD64) alters γ-chain tyrosine-based signaling and phagocytosisJournal of Biological Chemistry.  277:41287-41293. 2002
    2002 AP2 adaptor complex-dependent internalization of CD5: Differential regulation in T and B cellsJournal of Immunology.  168:5612-5620. 2002
    2002 Conservation of FcεRI gamma chain coding region in normals and in SLE patientsLupus.  11:42-45. 2002
    2001 Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosusJournal of Immunology.  166:3915-3922. 2001
    2001 Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infectionHepatology.  33:708-712. 2001
    1999 Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus.Arthritis and Rheumatism.  42:2601-2605. 1999
    1999 Single-nucleotide polymorphisms of T cell receptor ζ chain in patients with systemic lupus erythematosusArthritis and Rheumatism.  42:2601-2605. 1999
    1997 Constitutive mutations of the saccharomyces cerevisiae mal-activator genes MAL23, MAL43, MAL63, and MAL64 1997

    Book

    Year Title Altmetric
    2014 Human FcR polymorphism and disease.  Ed. 382.  2014

    Research Overview

  • Molecular genetics and epigenetics of autoimmune diseases: Characterization of genetic variants on the SLE-linked q21-q23 region of chromosome 1; Structure and function of Fc gamma receptors in inflammation.
  • Education And Training

  • Doctor of Philosophy in Molecular Genetics, City University of New York System : Queens College 1995
  • Full Name

  • Andrew Gibson