Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function.eNeuro.  6. 2019
2018 Klotho, the Key to Healthy Brain Aging?Brain Plasticity.  3:183-194. 2018
2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammationEuropean Respiratory Journal.  52. 2018
2017 Klotho regulates postnatal neurogenesis and protects against age-related spatial memory lossNeurobiology of Aging.  59:41-54. 2017
2017 Klotho regulates CA1 hippocampal synaptic plasticityNeuroscience.  347:123-133. 2017
2017 Adult-born neurons modify excitatory synaptic transmission to existing neuronseLife.  6. 2017
2015 Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junctionMolecular Neurodegeneration.  10. 2015
2015 Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGSPLoS Genetics.  11. 2015
2014 Development and characterization of monoclonal antibodies to detect KlothoMonoclonal Antibodies in Immunodiagnosis and Immunotherapy.  33:420-427. 2014
2014 MicroRNA-339 and microRNA-556 regulate Klotho expression in vitroAGE.  36:141-149. 2014
2013 Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease riskJournal of Biological Chemistry.  288:36302-36311. 2013
2013 The age-regulating protein klotho is vital to sustain retinal functionInvestigative Ophthalmology & Visual Science.  54:6675-6685. 2013
2013 Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthoodBrain Research.  1527:1-14. 2013
2012 Promoter methylation and age-related downregulation of Klotho in rhesus monkeyAGE.  34:1405-1419. 2012
2012 Identification of novel small molecules that elevate Klotho expressionBiochemical Journal.  441:453-461. 2012
2012 Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerizationAmerican Journal of Neurodegenerative Disease.  1:75-87. 2012
2012 Plasmacytoid dendritic cells in the tumor microenvironment: Immune targets for glioma therapeuticsNeoplasia : An International Journal for Oncology Research.  14:757-770. 2012
2011 Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen.Molecular Therapy.  19:1793-1801. 2011
2011 Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: Implications for clinical trial designClinical Cancer Research.  17:4705-4718. 2011
2011 Gene therapy and targeted toxins for gliomaCurrent Gene Therapy.  11:155-180. 2011
2011 Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor NeoantigenMolecular Therapy2011
2009 Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: Humoral and cellular immunity lead to tumor regressionClinical Cancer Research.  15:6113-6127. 2009
2009 Release of HMGB1 in response to proapoptotic glioma killing strategies: Efficacy and neurotoxicityClinical Cancer Research.  15:4401-4414. 2009
2008 High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunityJournal of Virology.  82:4680-4684. 2008
2008 Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor-induced Behavioral Deficits.Molecular Therapy.  16:682-690. 2008
2008 Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma modelNeuro-Oncology.  10:19-31. 2008
2008 Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficitsMolecular Therapy.  16:682-690. 2008
2007 Intracranial glioblastoma models in preclinical neuro-oncology: Neuropathological characterization and tumor progressionJournal of Neuro-Oncology.  85:133-148. 2007
2007 One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: Clinical implicationsMolecular Therapy.  15:2154-2163. 2007
2006 In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brainJournal of Experimental Medicine.  203:2095-2107. 2006
2006 Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain.Journal of Immunology.  176:3566-3577. 2006
2006 Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenovirusesJournal of Virology.  80:27-37. 2006
2005 Gene therapy and targeted toxins for gliomaCurrent Gene Therapy.  5:535-557. 2005
2005 Combining cytotoxic and immune-mediated gene therapy to treat brain tumorsCurrent Topics in Medicinal Chemistry.  5:1151-1170. 2005
2005 Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma modelCancer Research.  65:7194-7204. 2005
2005 Regulatable gene expression systems for gene therapy applications: Progress and future challengesMolecular Therapy.  12:189-211. 2005
2004 Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): Treatment with hsFlt3L inhibits intracranial glioma progressionMolecular Therapy.  10:1071-1084. 2004
2004 Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?Experimental Neurology.  185:208-219. 2004
2004 X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.Journal of Neurochemistry.  88:971-982. 2004
2004 X11α impairs γ- but not β-cleavage of amyloid precursor proteinJournal of Neurochemistry.  88:971-982. 2004
2003 X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.Neuroscience.  120:143-154. 2003

Education And Training

  • Doctor of Philosophy in Neuroscience, University of Michigan System : Ann Arbor 2004
  • Cedars Sinai Medical Center, Postdoctoral Fellowship 2008
  • Full Name

  • Gwendalyn King