Galin, Shawn F.

Galin, Shawn F.
Associate Professor

Assistant Professor - Research (P), Physiology & Biophysics , Academic Joint Departments 1996 -
Associate Professor (P), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine Chair Office 2010 -
Associate Professor (S), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments 2012 -
Associate Professor (S), Dept of Medical Education , School of Medicine 2015 -
Director, Dept of Medical Education , School of Medicine 2015 -
Scholar (C), Interprof Sim for Innov Clinical Practice , Office of the Provost 2017 -

Overview

Dr. Shawn Galin completed his undergraduate studies in Natural Sciences and Mathematics at the University of Alabama at Birmingham earning a BS in 1988. He then entered the MS graduate program in the Department of Physiology and Biophysics at the University of Alabama at Birmingham and completed his MS degree in 1990. He continued his graduate studies in the Department of Physiology and Biophysics and was awarded his PhD in 1994. He remained to continue his Post-Doctoral training and became a faculty member in 1996. Dr. Galin became a faculty member in the Department of Medicine, Division of Pulmonary, Allergy, and Critical Care in October, 2009.

Selected Publications

Academic Article

Year	Title	Altmetric
2009	Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.. Journal of Neuroimmunology. 217:51-54. 2009
2009	The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation.. Journal of Immunology. 182:4423-4431. 2009
2007	Possible therapeutic vaccines for canine myasthenia gravis: implications for the human disease and associated fatigue.. Brain, Behavior, and Immunity. 21:323-331. 2007
2006	Weathington et al. reply [2]. Nature Medicine. 12:604. 2006
2006	A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.. Nature Medicine. 12:317-323. 2006
2001	Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cells. Cellular Immunology. 208:107-114. 2001
2001	Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cells.. Cellular Immunology. 208:107-114. 2001
2001	An IgM anti-MBP Ab in a case of Waldenstrom's macroglobulinemia with polyneuropathy expressing an idiotype reactive with an MBP epitope immunodominant in MS and EAE.. Journal of Neuroimmunology. 113:163-169. 2001
1999	Highly related immunoglobulin light chain sequences in different multiple sclerosis patients.. Journal of Neuroimmunology. 100:98-101. 1999
1996	Preferential association of V lambda x light chains with gamma 2a heavy chains in naturally occurring human myelin basic protein reactive antibodies.. Journal of Neuroimmunology. 70:15-20. 1996
1996	Prevention of experimental autoimmune myasthenia gravis by a monoclonal antibody to a complementary peptide for the main immunogenic region of the acetylcholine receptors.. Journal of Immunology. 157:386-392. 1996
1996	Murine V lambda x and V lambda x-containing antibodies bind human myelin basic protein.. Journal of Clinical Investigation. 97:486-492. 1996
1994	A V lambda x-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cell receptors.. Journal of Immunology. 153:1132-1140. 1994
1994	A Vλx-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cell receptors. Journal of Immunology. 153:1132-1140. 1994
1991	Role of leukocyte-derived pro-opiomelanocortin peptides in endotoxic shock.. Circulatory shock. 35:181-191. 1991
1991	Detection of growth hormone and growth hormone-releasing hormone-related messenger RNA in rat leukocytes by the polymerase chain reaction.. Proceedings of the Society for Experimental Biology and Medicine. 198:643-648. 1991
1991	Corticotropin-releasing factor upregulates expression of two truncated pro-opiomelanocortin transcripts in murine lymphocytes.. Journal of Neuroimmunology. 31:51-58. 1991
1990	Possible alternate splicing or initiation of the pro-opiomelanocortin gene in lymphocytes.. International Journal of Neuroscience. 51:171-172. 1990
1990	Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide.. Proceedings of the National Academy of Sciences. 87:1057-1060. 1990
1990	Characteristics of Lymphocyte‐derived Proopiomelanocortin‐related mRNA. Annals of the New York Academy of Sciences. 594:382-384. 1990
1989	Cloning and sequencing of immunoglobulin variable-region genes using degenerate oligodeoxyribonucleotides and polymerase chain reaction.. Gene. 82:371-377. 1989

Research Overview

Dr. Galin's research interest focuses on the role of neutrophils in chronic lung transplantation rejection. Our group has recently described a novel chemotactic product of collagen breakdown, PGP (Pro-Gly-Pro), which has been shown to reside in CF airways and hypothesized to be associated with neurophil influx in CF patients. Since chronic allograft rejection has a strong neutrophil component, this may provide a biomarker for a potent collagen-derived chemoattractant, resulting in damage and rejection. We are also very interested in the enzymes associated with the breakdown of collagen that result in PGP production. These include, but are not limited, to MMP-9 and prolyl endopeptidase.