Positions

Selected Publications

Academic Article

Year Title Altmetric
2016 The Notch pathway in colorectal cancer.International Journal of Cancer.  138:1835-1842. 2016
2015 Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer.Journal of Cellular Biochemistry.  116:2517-2527. 2015
2014 NOTCH and PTEN in prostate cancer.Advances in Biological Regulation.  56:51-65. 2014
2014 GSK-3 as potential target for therapeutic intervention in cancer.Oncotarget.  5:2881-2911. 2014
2014 Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.Leukemia.  28:15-33. 2014
2012 Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.Cell Cycle.  11:4344-4351. 2012
2011 Label-free classification of cultured cells through diffraction imaging.Biomedical Optics Express.  2:1717-1726. 2011
2009 Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression.Journal of Cellular Biochemistry.  107:992-1001. 2009
2009 Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.Leukemia.  23:25-42. 2009
2008 HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia.Leukemia.  22:1161-1169. 2008
2008 Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Leukemia.  22:686-707. 2008
2008 Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.Leukemia.  22:708-722. 2008
2007 Chromosomal analysis and identification based on optical tweezers and Raman spectroscopy: reply.Optics Express.  15:6000-6002. 2007
2007 CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expression.Cell Cycle.  6:80-84. 2007
2006 The MLL partial tandem duplication in acute myeloid leukaemia.British Journal of Haematology.  135:438-449. 2006
2006 Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.Leukemia.  20:1254-1260. 2006
2006 Chromosomal analysis and identification based on optical tweezers and Raman spectroscopy.Optics Express.  14:5385-5393. 2006
2006 Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.Advances in Enzyme Regulation.  46:249-279. 2006
2005 Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1.Cell Cycle.  4:1389-1395. 2005
2005 The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?Expert Opinion on Therapeutic Targets.  9:1009-1030. 2005
2005 Acquired immunodeficiency syndrome associated lymphoma.Frontiers in Bioscience.  10:2972-2977. 2005
2005 Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines.Cell Cycle.  4:822-830. 2005
2005 Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line.Cell Cycle.  4:818-821. 2005
2005 Upping the bid on engineered inducible cell death.Cancer Biology and Therapy.  4:537. 2005
2005 Activated EGFR promotes the survival of B-lineage acute leukemia in the absence of stromal cells.Cell Cycle.  4:483-487. 2005
2005 Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support.Leukemia.  19:98-102. 2005
2004 The complexity of PTEN: mutation, marker and potential target for therapeutic intervention.Expert Opinion on Therapeutic Targets.  8:537-550. 2004
2004 JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Leukemia.  18:189-218. 2004
2003 B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression.Leukemia.  17:2454-2459. 2003
2003 Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002.Leukemia.  17:2358-2382. 2003
2002 Microarray analysis of a t(4;11)q(21;23) cell line with B-lineage developmental potential reveals a distinct pattern of Hox geneBlood.  100:195B-195B. 2002
2001 Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein.Blood.  98:3398-3405. 2001
2001 VH gene replacement in thymocytes.Journal of Immunology.  166:855-860. 2001
2000 Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells.Leukemia.  14:2095-2102. 2000
2000 De novo IgH gene segment rearrangement leads to functional pre-BCR expression in a novel B-lineage all cell like expressing MLL/AF4.Blood.  96:617A-+. 2000
2000 Endogenous Notch-1 cleavage in human B-lineage cells.Blood.  96:615A-+. 2000
2000 Microenvironmental influences on human B-cell development.Immunological Reviews.  175:175-186. 2000
1999 Notch expression and signaling in normal and leukemic human B-lineage cells.Blood.  94:436A-436A. 1999
1999 IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth.Journal of Immunology.  162:6060-6070. 1999
1999 Analysis of notch during human B-lineage development.Federation proceedings.  13:A966-A966. 1999
1999 The expression of long HCDR3 intervals is constrained by both genetic and somatic mechanisms during human B-cell ontogenyJournal of Investigative Medicine.  47. 1999
1998 V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice.European Journal of Immunology.  28:3362-3370. 1998
1998 Molecular mechanisms involved in receptor editing at the Ig heavy chain locus.International Immunology.  10:241-246. 1998
1998 Sequence analysis of the mouse RAG locus intergenic region.Autoimmunity.  5:215-222. 1998
1998 Sequence of the rag1 and rag2 intergenic region in zebrafish (Danio rerio).Autoimmunity.  5:211-214. 1998
1997 Ig D(H) gene segment transcription and rearrangement before surface expression of the pan-B-cell marker CD19 in normal human bone marrow.Blood.  90:736-744. 1997
1996 Transcriptional regulation of the recombinase activating genes in murine pre-b cellsFederation proceedings.  10. 1996
1996 The J chain gene is transcribed during B and T lymphopoiesis in humans.Journal of Immunology.  156:4240-4244. 1996
1995 Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors.Journal of Experimental Medicine.  182:973-982. 1995
1995 Analysis of DHQ52 gene segment transcription and rearrangement during B-cell development in human fetal bone marrow.Annals of the New York Academy of Sciences.  764:228-230. 1995
1995 Developmental regulation of the human antibody repertoire.Annals of the New York Academy of Sciences.  764:242-260. 1995
1995 ACTIVATION AND REGULATION OF HUMAN DJC-MU-GENE SEGMENT REARRANGEMENT PRIOR TO SURFACE EXPRESSION OF THE B-CELL MARKER-CD19Journal of Cellular Biochemistry.  112-112. 1995
1995 DJC-MU REARRANGEMENTS ARE PRESENT BUT NOT TRANSCRIBED IN HUMAN THYMOCYTESFederation proceedings.  9:A816-A816. 1995
1995 J-CHAIN EXPRESSION DURING NORMAL HUMAN B-LINEAGE DEVELOPMENTFederation proceedings.  9:A495-A495. 1995
1994 REGULATION OF EARLY HUMAN B-LYMPHOCYTE DIFFERENTIATION BY INTERLEUKIN-7Experimental Hematology.  22:717-717. 1994
1994 EARLY ACTIVATION OF THE DHQ52 PROMOTER DURING HUMAN B-CELL ONTOGENYFederation proceedings.  8:A467-A467. 1994
1993 DEVELOPMENTAL REGULATION OF IMMUNOGLOBULIN DH AND JH GENE SEGMENT EXPRESSION IN MANJournal of Immunology.  150:A151-A151. 1993
1993 TRANSGENIC EXPRESSION OF HUMAN TERMINAL DEOXYNUCLEOTIDYL-TRANSFERASE IN MOUSE THYMUSJournal of Immunology.  150:A33-A33. 1993
1993 DEVELOPMENTAL REGULATION OF DH AND JH GENE SEGMENT REARRANGEMENT IN MANJournal of Cellular Biochemistry.  220-220. 1993
1992 ANALYSIS OF IMMUNOGLOBULIN DJ TRANSCRIPTS FROM BONE-MARROW AND FETAL LIVER INDICATES DEVELOPMENTAL REGULATION OF DH AND J(H) GENE SEGMENT REARRANGEMENTClinical research.  40:A820-A820. 1992

Chapter

Year Title Altmetric
2007 Critical roles of the Raf/MEK/ERK pathway in apoptosis and drug resistance.  101-134. 2007

Teaching Activities

  • BMD430 - Clin Immunology for HP (Fall Term 2018) 2018
  • BMD430 - Clin Immunology for HP (Fall Term 2018) 2018
  • HRP200 - Responsible Conduct Research (Fall Term 2018) 2018
  • HRP401 - Honors Seminar I (Fall Term 2018) 2018
  • HRP405 - Team-Based Prob Solving in HP (Fall Term 2018) 2018
  • HRP411 - Honors Community Service Proj (Fall Term 2018) 2018
  • HRP415 - Mentored Res in the Hlth Profs (Fall Term 2018) 2018
  • HRP475 - Special Tops in HS or Clin Res (Fall Term 2018) 2018
  • HRP415 - Mentored Res in the Hlth Profs (Summer Term 2018) 2018
  • HRP200 - Responsible Conduct Research (Summer Term 2018) 2018
  • HRP411 - Honors Community Service Proj (Summer Term 2018) 2018
  • HRP475 - Special Tops in HS or Clin Res (Summer Term 2018) 2018
  • BMD330 - Clin Microbiology for HP (Spring Term 2018) 2018
  • BMD330 - Clin Microbiology for HP (Spring Term 2018) 2018
  • HRP200 - Responsible Conduct Research (Spring Term 2018) 2018
  • HRP402 - Honors Seminar II (Spring Term 2018) 2018
  • HRP410 - Honors Research Project (Spring Term 2018) 2018
  • HRP411 - Honors Community Service Proj (Spring Term 2018) 2018
  • HRP415 - Mentored Res in the Hlth Profs (Spring Term 2018) 2018
  • HRP475 - Special Tops in HS or Clin Res (Spring Term 2018) 2018
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2017) 2017
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2017) 2017
  • HRP200 - Responsible Conduct Research (Fall Term 2017) 2017
  • HRP401 - Honors Seminar I (Fall Term 2017) 2017
  • HRP405 - Team-Based Prob Solving in HP (Fall Term 2017) 2017
  • HRP411 - Honors Community Service Proj (Fall Term 2017) 2017
  • HRP415 - Mentored Res in the Hlth Profs (Fall Term 2017) 2017
  • BMD497 - Dir BMD Research Studies (Summer Term 2017) 2017
  • BMD330 - Clin Microbiology for HP (Spring Term 2017) 2017
  • BMD330 - Clin Microbiology for HP (Spring Term 2017) 2017
  • BMD497 - Dir BMD Research Studies (Spring Term 2017) 2017
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2016) 2016
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2016) 2016
  • BMD497 - Dir BMD Research Studies (Fall Term 2016) 2016
  • BMD497 - Dir BMD Research Studies (Fall Term 2016) 2016
  • BMD497 - Dir BMD Research Studies (Summer Term 2016) 2016
  • BMD202 - Surv of BioMed Sciences Lit (Spring Term 2016) 2016
  • BMD202 - Surv of BioMed Sciences Lit (Spring Term 2016) 2016
  • BMD330 - Clin Microbiology for HP (Spring Term 2016) 2016
  • HRP410 - Honors Project (Spring Term 2016) 2016
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2015) 2015
  • BMD430 - Clin Immunology for HP (Fall Term 2015) 2015
  • CLS518 - Immunology (Fall Term 2015) 2015
  • MT418 - Immunology (Fall Term 2015) 2015
  • BMD497 - Dir BMD Research Studies (Summer Term 2015) 2015
  • BMD330 - Clin Microbiology for HP (Spring Term 2015) 2015
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2014) 2014
  • CLS518 - Immunology (Fall Term 2014) 2014
  • MT418 - Immunology (Fall Term 2014) 2014
  • Education And Training

  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham
  • Full Name

  • Fred Bertrand
  • Blazerid

  • fbrtrnd