Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Editorial.Photodermatology, Photoimmunology & Photomedicine.  34:4. 2018
2018 Tea polyphenols for the prevention of UVB-induced skin cancer.Photodermatology, Photoimmunology & Photomedicine.  34:50-59. 2018
2017 Potential therapeutic targets of epithelial-mesenchymal transition in melanoma.Cancer Letters.  391:125-140. 2017
2017 Pomegranate for Prevention and Treatment of Cancer: An Update.Molecules.  22. 2017
2017 Phytochemicals for the Prevention of Photocarcinogenesis.Photochemistry and Photobiology.  93:956-974. 2017
2016 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis.Archives of Biochemistry and Biophysics.  609:39-50. 2016
2016 Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype.Scientific Reports.  6:34865. 2016
2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.American Journal of Pathology.  186:2637-2649. 2016
2016 Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma.Oncotarget.  7:1227-1241. 2016
2016 Phytochemicals for the Management of Melanoma.Mini-Reviews in Medicinal Chemistry.  16:953-979. 2016
2015 Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells.Oncotarget.  6:28296-28311. 2015
2015 Targeting drivers of melanoma with synthetic small molecules and phytochemicals.Cancer Letters.  359:20-35. 2015
2015 Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation.British Journal of Dermatology.  172:354-364. 2015
2015 Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice.Photochemistry and Photobiology.  91:225-234. 2015
2015 Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.Skin Pharmacology and Physiology.  28:177-188. 2015
2014 Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch.Biochemical and Biophysical Research Communications.  451:394-401. 2014
2014 Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway.Cancer Prevention Research.  7:186-198. 2014
2014 Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways.PLoS ONE.  9:e86338. 2014
2013 Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption.Toxicology and Applied Pharmacology.  272:879-887. 2013
2013 Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein.Biochemical and Biophysical Research Communications.  438:607-612. 2013
2013 Chlorine induces the unfolded protein response in murine lungs and skin.American Journal of Respiratory Cell and Molecular Biology.  49:197-203. 2013
2013 Fisetin inhibits growth, induces G₂ /M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation.Experimental Dermatology.  22:470-475. 2013
2013 Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three-dimensional epidermal equivalent models.Experimental Dermatology.  22:342-348. 2013
2013 Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways.PLoS ONE.  8:e77270. 2013
2013 Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.PLoS ONE.  8:e80076. 2013
2012 Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes.Photochemistry and Photobiology.  88:1184-1190. 2012
2012 Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-κB and MAPK signaling pathways in mouse skin.Photochemistry and Photobiology.  88:1126-1134. 2012
2012 Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs.Biochemical and Biophysical Research Communications.  425:177-181. 2012
2012 Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo.Antioxidants and Redox Signaling.  16:1195-1204. 2012
2012 Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.International Journal of Cancer.  130:1695-1705. 2012
2011 Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.Mini-Reviews in Medicinal Chemistry.  11:1200-1215. 2011
2011 Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.Journal of Investigative Dermatology.  131:1291-1299. 2011
2011 Natural agents: cellular and molecular mechanisms of photoprotection.Archives of Biochemistry and Biophysics.  508:144-151. 2011
2010 Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.Photochemistry and Photobiology.  86:1318-1326. 2010
2010 Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.Carcinogenesis.  31:1424-1433. 2010
2010 Lifestyle as risk factor for cancer: Evidence from human studies.Cancer Letters.  293:133-143. 2010
2010 In vitro and in vivo effects of water extract of white cocoa tea (Camellia ptilophylla) against human prostate cancer.Pharmaceutical Research.  27:1128-1137. 2010
2009 Aryl hydrocarbon receptor is an ozone sensor in human skin.Journal of Investigative Dermatology.  129:2396-2403. 2009
2009 Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin.Experimental Dermatology.  18:553-561. 2009
2009 Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells.Molecular Carcinogenesis.  48:260-270. 2009
2009 A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.Carcinogenesis.  30:300-307. 2009
2008 A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling.Cancer Research.  68:8564-8572. 2008
2008 A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.Cancer Research.  68:8555-8563. 2008
2008 Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.Carcinogenesis.  29:2011-2018. 2008
2008 Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables.International Journal of Cancer.  123:1508-1515. 2008
2008 Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation.Toxicology and Applied Pharmacology.  231:52-60. 2008
2008 Dietary agents for chemoprevention of prostate cancer.Cancer Letters.  265:167-176. 2008
2008 Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.Carcinogenesis.  29:1049-1056. 2008
2008 Cancer chemoprevention through dietary antioxidants: progress and promise.Antioxidants and Redox Signaling.  10:475-510. 2008
2008 Phytochemicals for prevention of solar ultraviolet radiation-induced damages.Photochemistry and Photobiology.  84:489-500. 2008
2008 Prevention of prostate cancer through custom tailoring of chemopreventive regimen.Chemico-Biological Interactions.  171:122-132. 2008
2008 Cannabinoids for cancer treatment: progress and promise.Cancer Research.  68:339-342. 2008
2007 Chemoprevention of prostate cancer through dietary agents: progress and promise.Cancer Epidemiology, Biomarkers and Prevention.  16:2193-2203. 2007
2007 Pomegranate derived products for cancer chemoprevention.Seminars in Cancer Biology.  17:377-385. 2007
2007 Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx.Photochemistry and Photobiology.  83:882-888. 2007
2007 Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: implications for prevention of skin cancer.Photochemistry and Photobiology.  83:986-993. 2007
2007 A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21(WAF1/Cip1).Oncogene.  26:3559-3571. 2007
2007 Fishing for allergens hiding as prohaptens.Journal of Investigative Dermatology.  127:992-993. 2007
2007 Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.Cancer Research.  67:3475-3482. 2007
2007 Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo.Clinical Cancer Research.  13:1611-1619. 2007
2007 Apoptosis by dietary factors: the suicide solution for delaying cancer growth.Carcinogenesis.  28:233-239. 2007
2007 Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells.Oncogene.  26:673-682. 2007
2007 Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis.Journal of Investigative Dermatology.  127:222-232. 2007
2007 Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice.Carcinogenesis.  28:163-173. 2007
2006 Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest.Journal of Biological Chemistry.  281:39480-39491. 2006
2006 Insulin-like growth factor-I axis as a pathway for cancer chemoprevention.Clinical Cancer Research.  12:5611-5614. 2006
2006 Botanical antioxidants in the prevention of photocarcinogenesis and photoaging.Experimental Dermatology.  15:678-684. 2006
2006 Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes.Photochemistry and Photobiology.  82:398-405. 2006
2006 Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.Cancer Research.  66:2500-2505. 2006
2005 Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.Carcinogenesis.  26:1956-1964. 2005
2005 Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.Proceedings of the National Academy of Sciences.  102:14813-14818. 2005
2005 Photochemoprevention of ultraviolet B signaling and photocarcinogenesis.Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  571:153-173. 2005
2005 Cannabinoid receptor as a novel target for the treatment of prostate cancer.Cancer Research.  65:1635-1641. 2005
2005 Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.International Journal of Cancer.  113:423-433. 2005
2005 Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign.Photochemistry and Photobiology.  81:38-45. 2005
2005 Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin.Photochemistry and Photobiology.  81:25-31. 2005
2004 Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.Oncogene.  23:5203-5214. 2004
2004 Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin.Oncogene.  23:5151-5160. 2004
2004 Antioxidants of the beverage tea in promotion of human health.Antioxidants and Redox Signaling.  6:571-582. 2004
2004 Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis.Oncogene.  23:2507-2522. 2004
2004 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin.Toxicology and Applied Pharmacology.  195:361-369. 2004
2004 Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cells.Journal of Cellular Biochemistry.  91:232-242. 2004
2003 Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice.Oncogene.  22:9254-9264. 2003
2003 Photochemoprevention of skin cancer by botanical agents.Photodermatology, Photoimmunology & Photomedicine.  19:56-72. 2003
2003 Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate.Oncogene.  22:1035-1044. 2003
2003 Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless miceToxicol. Appl. Pharm..  186:28-37. 2003
2003 Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice.Toxicology and Applied Pharmacology.  186:28-37. 2003
2003 Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol.Neoplasia : An International Journal for Oncology Research.  5:74-82. 2003
2002 Photochemoprevention by botanical antioxidants.Skin Pharmacology and Applied Skin Physiology.  15:297-306. 2002
2002 Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cellsOncogene.  21:3727-3738. 2002
2002 Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.Oncogene.  21:3727-3738. 2002
2002 Botanical antioxidants for chemoprevention of photocarcinogenesis.Frontiers in Bioscience.  7:d784-d792. 2002
2001 Chapter 22 Effects of solar radiation on detoxification mechanisms in the skinComprehensive Series in Photosciences.  3:419-436. 2001
2001 Involvement of the retinoblastoma (pRb)-E2F/DP pathway during antiproliferative effects of resveratrol in human epidermoid carcinoma (A431) cells.Biochemical and Biophysical Research Communications.  288:579-585. 2001
2001 Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate.Toxicology and Applied Pharmacology.  176:110-117. 2001
2001 Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells.Biochemical and Biophysical Research Communications.  287:914-920. 2001
2001 Effects of solar radiation on cutaneous detoxification pathways.Journal of Photochemistry and Photobiology B: Biology.  63:61-69. 2001
2001 Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells.Clinical Cancer Research.  7:1466-1473. 2001
2001 Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.Carcinogenesis.  22:287-294. 2001
2000 N-acetyl L-cysteine attenuates oxidant-mediated toxicity induced by chrysotile fibers.Toxicology Letters.  117:53-60. 2000
1999 Glutathione redox system in oxidative lung injury.Critical Reviews in Toxicology.  29:543-568. 1999
1999 Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injury.Toxicology Letters.  106:31-39. 1999
1998 Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/particles.Toxicology Letters.  99:175-182. 1998
1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxideJournal of Applied Toxicology.  18:307-312. 1998
1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide.Journal of Applied Toxicology.  18:307-312. 1998
1995 Influence of hexachlorocyclohexane on phosphoinositides in rat erythrocyte membranes and brain.Toxicology.  95:135-140. 1995

Chapter

Year Title Altmetric
2016 Fisetin and Its Role in Chronic Diseases..  213-244. 2016
2012 Dietary phytochemicals and chemoprevention of solar ultraviolet radiation-induced skin cancer.  295-321. 2012
2011 Botanical antioxidants for skin protection: An overview.  51-63. 2011
2009 Botanical Antioxidants for Protection Against Damage from Sunlight.  161-183. 2009
2008 Dietary phytochemicals in the chemoprevention of prostate cancer.  221-244. 2008
2006 Vitamins and polyphenols in systemic photoprotection.  113-121. 2006
2006 Molecular mechanisms of chemoprevention of cancer by pomegranate.  117-131. 2006

Education And Training

  • Bachelor of Science or Mathematics in Biology, Aligarh Muslim University
  • Doctorate in Biochemistry, Foreign University
  • Master of Science in Biochemistry, Aligarh Muslim University
  • Full Name

  • Farrukh Afaq
  • Blazerid

  • fafaq