Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behaviorCollagen and related research.  65:104-118. 2018
2017 Transancestral mapping and genetic load in systemic lupus erythematosusNature Communications.  8. 2017
2017 Young adult and usual adult body mass index and multiple myeloma risk: A pooled analysis in the international multiple myeloma consortium (IMMC)Cancer Epidemiology, Biomarkers and Prevention.  26:876-885. 2017
2017 Recent trends in multiple myeloma incidence and survival by age, race, and ethnicity in the United StatesBlood Advances.  1:282-287. 2017
2016 A meta-analysis of multiple myeloma risk regions in African and European ancestry populations identifies putatively functional lociCancer Epidemiology, Biomarkers and Prevention.  25:1609-1618. 2016
2016 Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesisJournal of Allergy and Clinical Immunology.  138:1495-1498. 2016
2016 Impact of marital status, insurance status, income, and race/ethnicity on the survival of younger patients diagnosed with multiple myeloma in the United StatesCancer.  122:3183-3190. 2016
2016 Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical featuresCancer Causes and Control.  27:81-91. 2016
2016 Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNAAnnals of the Rheumatic Diseases.  75:242-252. 2016
2014 Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcriptionAmerican Journal of Human Genetics.  94:586-598. 2014
2014 Complementary and alternative medicine use in African Americans with rheumatoid arthritisArthritis Care and Research.  66:180-189. 2014
2014 Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: Results from the treatment of early aggressive rheumatoid arthritis trialPharmacogenomics Journal.  14:48-53. 2014
2014 Brief report: A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosusArthritis and Rheumatology.  66:1882-1887. 2014
2014 End-stage renal disease in African Americans with lupus nephritis is associated with APOL1Arthritis and Rheumatology.  66:390-396. 2014
2014 Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African AmericansArthritis and Rheumatology.  66:1291-1299. 2014
2014 Host genetics and immune control of HIV-1 infection: Fine mapping for the extended human MHC region in an African cohortGenes and Immunity.  15:275-281. 2014
2014 Lupus risk variants in the PXK locus alter B-cell receptor internalizationFrontiers in Genetics.  5. 2014
2013 Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4PLoS Genetics.  9. 2013
2013 Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody ProductionPLoS Genetics.  9. 2013
2013 Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in AsiansArthritis and Rheumatism.  65:211-215. 2013
2012 Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosusArthritis and Rheumatism.  64:3695-3705. 2012
2012 Evidence of genetic susceptibility to infectious mononucleosis: A twin studyEpidemiology and Infection.  140:2089-2095. 2012
2012 Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populationsArthritis and Rheumatism.  64:3687-3694. 2012
2012 Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestriesAnnals of the Rheumatic Diseases.  71:1809-1814. 2012
2012 Genetic risk factors for thrombosis in systemic lupus erythematosusJournal of Rheumatology.  39:1603-1610. 2012
2011 Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groupsArthritis and Rheumatism.  63:2755-2763. 2011
2011 Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosusArthritis and Rheumatism.  63:2049-2057. 2011
2011 Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Arthritis and Rheumatism.  63:1689-1697. 2011
2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibilityPLoS Genetics.  7. 2011
2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.PLoS Genetics.  7:e1002079. 2011
2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosusNature Genetics.  43:253-258. 2011
2011 Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic studyAmerican Journal of Human Genetics.  88:83-91. 2011
2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African AmericansArthritis and Rheumatism.  62:3547-3553. 2010
2010 Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologistsCancer Causes and Control.  21:1857-1866. 2010
2010 Measurement of erythrocyte methotrexate polyglutamate levels: Ready for clinical use in rheumatoid arthritis?Current Rheumatology Reports.  12:342-347. 2010
2009 Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing (Genes and Immunity (2009) vol. 10 (457-469) 10.1038/gene.2009.27)Genes and Immunity.  10:606. 2009
2009 Identification of new SLE-associated genes with a two-step Bayesian study designGenes and Immunity.  10:446-456. 2009
2009 Fcγ receptors: Structure, function and role as genetic risk factors in SLEGenes and Immunity.  10:380-389. 2009
2009 Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived populationGenes and Immunity.  10:531-538. 2009
2009 Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicingGenes and Immunity.  10:457-469. 2009
2009 Genetic associations of LYN with systemic lupus erythematosusGenes and Immunity.  10:397-403. 2009
2008 Approaches to complex pathways in molecular epidemiology: Summary of a special conference of the american association for cancer researchCancer Research.  68:10028-10030. 2008
2008 Risk factors for classical Kaposi sarcoma in a population-based case-control study in sicilyCancer Epidemiology, Biomarkers and Prevention.  17:3435-3443. 2008
2008 Genetic variation in the CRP promoter: Association with systemic lupus erythematosusHuman Molecular Genetics.  17:1147-1155. 2008
2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African AmericansGenes and Immunity.  9:187-194. 2008
2007 Common variants in genes that mediate immunity and risk of multiple myelomaInternational Journal of Cancer.  120:2715-2722. 2007
2006 Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among childrenJournal of Infectious Diseases.  194:1565-1569. 2006
2006 Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcomaCancer.  107:2282-2290. 2006
2006 Host immunogenetics and control of human herpesvirus-8 infectionJournal of Infectious Diseases.  193:1054-1062. 2006
2006 Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunityCancer Epidemiology, Biomarkers and Prevention.  15:926-934. 2006
2005 Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcomaInternational Journal of Epidemiology.  34:1110-1117. 2005
2005 A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcomaCancer Epidemiology, Biomarkers and Prevention.  14:633-637. 2005

Research Overview

  • Molecular and Genetic Epidemiology of Immune-Mediated Clinical Phenotypes - The research conducted in Dr. Brown’s laboratory is mainly targeted to advance the understanding of aberrant immune function common to inflammatory-mediated chronic diseases, such as select autoimmune diseases as well as multiple myeloma and related precursor states, each with underlying B cell pathology. Within this purview, she uses a multidisciplinary functional genomics approach to explore pathways involved in chronic immune perturbation, inflammation as modifiers of disease, and B cell homeostasis. The objective of this research is to identify and validate molecular biomarkers, which may be used to target high-risk populations to improve disease surveillance and modify therapeutic intervention leading to significant reductions in morbidity and mortality associated with advanced stage disease.

    Keywords - multiple myeloma, autoimmune, lupus, genetics, genomics, epidemiology
  • Principal Investigator On

  • Characterization of the Lupus Nephritis microRNAome  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Molecular Characterization of Myeloma and Related Asymptomatic Precursor States  awarded by National Cancer Institute/NIH/DHHS 2014 - 2020
  • A Genome-Wide Methylation Study of Multiple Myeloma  awarded by HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY 2018 - 2019
  • Association of Genetic and Autoantibody Signatures with SLE Clinical Course  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2014 - 2019
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • The Role of Exosome Heparanase and miRNAs as Biomarkers for Myeloma  awarded by National Cancer Institute/NIH/DHHS 2014 - 2018
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • A Genome-Wide Methylation Study of Epigenetic Contributions to Multiple Myeloma  awarded by National Cancer Institute/NIH/DHHS 2011 - 2015
  • A Genome Wide Admixture Scan of Multiple Myeloma in African-Americans  awarded by University of Southern California 2010 - 2013
  • Program Project in the Genetics of SLE - Project 4 (A Genetic Risk Profile on Longitudinal SLE Cohorts)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2013
  • Rheumatic Diseases Core Center: Pilot Project - P & F 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2010
  • Investigator On

  • Heparanase In Tumor Progression, Metastasis and Chemoresistance  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Heparanase Regulation of Myeloma Metastasis: Mechanism and Therapy  awarded by National Cancer Institute/NIH/DHHS 2014 - 2020
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Inhibition of Herpes Simplex Viruses Type 2 by Tenofovir  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Genome-Wide Association Study in African-Americans With Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2016
  • Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • HLA Region and KIR Genomics in Common Variable Immune Deficiency  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2010 - 2015
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF) 2009 - 2014
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Teaching Activities

  • EPI610 - Prin of Epidemiologic Research (Fall Term 2014) 2014
  • EPI697 - Internship (Fall Term 2014) 2014
  • EPI698 - Directed Research (Fall Term 2014) 2014
  • EPI798 - Doctoral Directed Research (Fall Term 2014) 2014
  • EPI798 - Doctoral Directed Research (Summer Term 2014) 2014
  • EPI699 - Project Research (Spring Term 2014) 2014
  • EPI699 - Project Research (Fall Term 2013) 2013
  • EPI798 - Doctoral Directed Research (Fall Term 2013) 2013
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2013) 2013
  • EPI798 - Doctoral Directed Research (Summer Term 2013) 2013
  • EPI697 - Internship (Summer Term 2013) 2013
  • EPI699 - Project Research (Summer Term 2013) 2013
  • EPI699 - Project Research (Spring Term 2013) 2013
  • EPI798 - Doctoral Directed Research (Spring Term 2013) 2013
  • EPI799 - Dissertation Research (Spring Term 2013) 2013
  • EPI698 - Directed Research (Fall Term 2012) 2012
  • EPI790 - Doctoral Seminar (Fall Term 2012) 2012
  • EPI799 - Dissertation Research (Fall Term 2012) 2012
  • EPI798 - Doctoral Directed Research (Summer Term 2012) 2012
  • EPI799 - Dissertation Research (Summer Term 2012) 2012
  • EPI798 - Doctoral Directed Research (Spring Term 2012) 2012
  • EPI798 - Doctoral Directed Research (Fall Term 2011) 2011
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2011) 2011
  • EPI798 - Doctoral Directed Research (Summer Term 2011) 2011
  • EPI697 - Internship (Spring Term 2011) 2011
  • EPI698 - Directed Research (Spring Term 2011) 2011
  • EPI699 - Project Research (Spring Term 2011) 2011
  • EPI798 - Doctoral Directed Research (Spring Term 2011) 2011
  • EPI698 - Directed Research (Fall Term 2010) 2010
  • EPI699 - Project Research (Fall Term 2010) 2010
  • EPI798 - Doctoral Directed Research (Fall Term 2010) 2010
  • EPI699 - Project Research (Summer Term 2010) 2010
  • EPI697 - Internship (Spring Term 2010) 2010
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2009) 2009
  • EPI697 - Internship (Summer Term 2009) 2009
  • EPI798 - Doctoral Directed Research (Summer Term 2009) 2009
  • EPI695 - Epidemiology Seminar (Spring Term 2009) 2009
  • EPI697 - Internship (Spring Term 2009) 2009
  • EPI698 - Directed Research (Spring Term 2009) 2009
  • EPI795 - Epidemiology Seminar (Spring Term 2009) 2009
  • EPI695 - Epidemiology Seminar (Fall Term 2008) 2008
  • EPI795 - Epidemiology Seminar (Fall Term 2008) 2008
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2008) 2008
  • EPI695 - Epidemiology Seminar (Spring Term 2008) 2008
  • EPI698 - Directed Research (Spring Term 2008) 2008
  • EPI795 - Epidemiology Seminar (Spring Term 2008) 2008
  • Education And Training

  • Doctor of Philosophy in Epidemiology, Johns Hopkins University 2004
  • Master of Public Health in Epidemiology, Oregon Health Sciences University 2003
  • Bachelor of Science or Mathematics in Biology, University of Oregon 1992
  • Full Name

  • Elizabeth Brown