Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles.Acta Physiologica Scandinavica.  222. 2018
2017 Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour.Acta Physiologica Scandinavica.  221:204-220. 2017
2016 "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  5. 2016
2016 Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.AJP - Renal Physiology.  310:F456-F465. 2016
2016 Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.BBA - Biochimica et Biophysica Acta.  1862:233-239. 2016
2015 Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.AJP - Renal Physiology.  309:F687-F696. 2015
2015 Regulation of renal function and blood pressure control by P2 purinoceptors in the kidney.Current Opinion in Pharmacology.  21:82-88. 2015
2015 Flow regulation of endothelin-1 production in the inner medullary collecting ductAJP - Renal Physiology.  308:F541-F552. 2015
2015 Flow regulation of endothelin-1 production in the inner medullary collecting duct.AJP - Renal Physiology.  308:F541-F552. 2015
2015 Endothelin and the renal microcirculation.Seminars in Nephrology.  35:145-155. 2015
2014 Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.Journal of the American Society of Nephrology.  25:1774-1785. 2014
2014 High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism.AJP - Renal Physiology.  307:F33-F40. 2014
2014 Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension.AJP - Renal Physiology.  306:F619-F628. 2014
2014 Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.PLoS ONE.  9:e91890. 2014
2014 P2 receptors in renal autoregulation.Current Vascular Pharmacology.  12:818-828. 2014
2013 Immunosuppression preserves renal autoregulatory function and microvascular P2X(1) receptor reactivity in ANG II-hypertensive rats.AJP - Renal Physiology.  304:F801-F807. 2013
2011 Endothelin and the renal vasculature.Contributions to Nephrology.  172:35-49. 2011
2011 Role of adenosine 5'-triphosphate in regulating renal microvascular function and in hypertension.Hypertension.  58:333-340. 2011
2011 P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt diet.Hypertension.  57:780-787. 2011
2011 Physiology of endothelin and the kidney.Comprehensive Physiology.  1:883-919. 2011
2011 Endothelin and the renal vasculature.Contributions to Nephrology.  172:35-49. 2011
2011 Regulation of blood pressure and salt homeostasis by endothelin.Physiological Reviews.  91:1-77. 2011
2010 p38 Mitogen-activated protein kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice.Journal of Sexual Medicine.  7:3857-3867. 2010
2010 Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation.Hypertension.  56:879-884. 2010
2010 Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.Journal of Pharmacology and Experimental Therapeutics.  334:430-438. 2010
2010 P2X(1) receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo.AJP - Renal Physiology.  298:F1360-F1368. 2010
2010 Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X1 receptor activation.AJP - Renal Physiology.  298:F1276-F1284. 2010
2010 Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats.Clinical Science.  118:463-471. 2010
2010 Response to Role of Epithelial Sodium Channels in the Renal Myogenic Response?Hypertension.  55:e8-e9. 2010
2009 ATP, P2 receptors and the renal microcirculation.Purinergic Signalling.  5:447-460. 2009
2009 Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.Hypertension.  54:1062-1069. 2009
2009 Purinoceptor regulation of renal tubular transport is coming of age.AJP - Renal Physiology.  297:F1166-F1167. 2009
2009 A true champion of Hungarian kidney research and nephrology education--tribute to László Rosivall.Acta Physiologica Hungarica.  96:375-382. 2009
2009 Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy.AJP - Renal Physiology.  296:F556-F563. 2009
2009 Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter.AJP - Renal Physiology.  296:F590-F597. 2009
2009 Lewis K. Dahl Memorial Lecture. Mysteries of renal autoregulation.Hypertension.  53:299-306. 2009
2008 Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.Journal of Sexual Medicine.  5:1156-1166. 2008
2007 Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension.Hypertension.  50:1069-1076. 2007
2007 P2X receptors as regulators of the renal microvasculature.Trends in Pharmacological Sciences.  28:646-652. 2007
2007 Determination of adenosine effects and adenosine receptors in murine corpus cavernosum.Journal of Pharmacology and Experimental Therapeutics.  322:678-685. 2007
2007 Purinoceptors in the kidney.Proceedings of the Society for Experimental Biology and Medicine.  232:715-726. 2007
2007 P2 receptor regulation of [Ca2+]i in cultured mouse mesangial cells.AJP - Renal Physiology.  292:F1380-F1389. 2007
2007 Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet.AJP - Renal Physiology.  292:F1208-F1214. 2007
2005 ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin.British Journal of Pharmacology.  146:1019-1026. 2005
2005 Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells.AJP - Renal Physiology.  289:F760-F767. 2005
2005 Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension.Hypertension.  46:562-568. 2005
2005 TGF-beta impairs renal autoregulation via generation of ROS.AJP - Renal Physiology.  288:F1069-F1077. 2005
2005 L-type calcium channels in the renal microcirculatory response to endothelin.AJP - Renal Physiology.  288:F771-F777. 2005
2004 P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid.Journal of Pharmacology and Experimental Therapeutics.  311:1211-1217. 2004
2004 Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function.Hypertension Research.  27:791-804. 2004
2004 Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats.Journal of applied physiology: respiratory, environmental and exercise physiology.  97:1268-1274. 2004
2004 Renal autoregulation in P2X1 knockout mice.Acta Physiologica Scandinavica.  181:445-453. 2004
2004 Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation.Journal of Hypertension.  22:811-818. 2004
2003 12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels.Journal of Lipid Research.  44:2391-2399. 2003
2003 Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.Journal of Clinical Investigation.  112:1895-1905. 2003
2003 Purinergic Receptors in the Glomerulus and Vasculature of the KidneyCurrent Topics in Membranes.  54:453-478. 2003
2003 Modulation of renal microvascular function by adenosine.AJP - Regulatory, Integrative and Comparative Physiology.  285:R23-R25. 2003
2003 Physiological role for P2X1receptors in renal microvascular autoregulatory behaviorJournal of Clinical Investigation.  112:1895-1905. 2003
2002 Comparative responses to alpha,beta-methylene-ATP in cat pulmonary, mesenteric, and hindquarter vascular beds.Journal of applied physiology: respiratory, environmental and exercise physiology.  93:1287-1295. 2002
2002 P2 receptor-mediated afferent arteriolar vasoconstriction during calcium blockadeAJP - Renal Physiology.  282. 2002
2002 Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells.Journal of Pineal Research.  32:112-119. 2002
2002 P2 receptor-mediated afferent arteriolar vasoconstriction during calcium blockade.AJP - Renal Physiology.  282:F245-F255. 2002
2002 Adaptations of the renal microcirculation to hypertension.Microcirculation.  9:315-328. 2002
2001 The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstrictionAJP - Heart and Circulatory Physiology.  281. 2001
2001 The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction.AJP - Heart and Circulatory Physiology.  281:H2089-H2096. 2001
2001 Calcium signaling pathways utilized by P2X receptors in freshly isolated preglomerular MVSMCAJP - Renal Physiology.  280. 2001
2001 P2 receptors in regulation of renal microvascular functionAJP - Renal Physiology.  280. 2001
2001 Interactions of adenosine A1 and A2a receptors on renal microvascular reactivityAJP - Renal Physiology.  280. 2001
2001 Calcium signaling pathways utilized by P2X receptors in freshly isolated preglomerular MVSMC.AJP - Renal Physiology.  280:F1054-F1061. 2001
2001 P2 receptors in regulation of renal microvascular function.AJP - Renal Physiology.  280:F927-F944. 2001
2001 Interactions of adenosine A1 and A2a receptors on renal microvascular reactivity.AJP - Renal Physiology.  280:F406-F414. 2001
2000 Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium release.General Pharmacology.  34:409-415. 2000
1999 Extracellular uridine nucleotides initiate cytokine production by murine dendritic cells.Cellular Immunology.  195:147-156. 1999
1999 Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness.British Journal of Pharmacology.  127:1399-1405. 1999
1999 ATP-mediated Ca2+ signaling in preglomerular smooth muscle cellsAJP - Renal Physiology.  276. 1999
1999 ATP-mediated Ca2+ signaling in preglomerular smooth muscle cells.American Journal of Physiology.  276:F450-F456. 1999
1999 P2 purinoceptor saturation by adenosine triphosphate impairs renal autoregulation in dogs.Journal of the American Society of Nephrology.  10:492-498. 1999
1999 Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A.Hypertension.  33:408-413. 1999
1999 Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats.Journal of the American Society of Nephrology.  10 Suppl 11:S178-S183. 1999
1999 Purinoceptor-mediated calcium signaling in preglomerular smooth muscle cells.Hypertension.  33:195-200. 1999
1998 Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: Interaction with neuronal NOSAJP - Renal Physiology.  275. 1998
1998 Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS.American Journal of Physiology.  275:F605-F612. 1998
1998 Interactive nitric oxide-angiotensin II influences on renal microcirculation in angiotensin II-induced hypertension.Hypertension.  31:1255-1260. 1998
1998 Direct assessment of renal microvascular responses to P2-purinoceptor agonistsAJP - Renal Physiology.  274. 1998
1998 Direct assessment of renal microvascular responses to P2-purinoceptor agonists.American Journal of Physiology.  274:F718-F727. 1998
1998 Perfusion pressure dependent augmentation of afferent arteriolar vasoconstriction to increased distal nephron volume deliveryFederation proceedings.  12. 1998
1998 Neuronal nitric oxide synthase modulates rat renal microvascular functionAJP - Renal Physiology.  274. 1998
1998 Neuronal nitric oxide synthase modulates rat renal microvascular function.American Journal of Physiology.  274:F516-F524. 1998
1998 Calcium Mobilization Contributes to Pressure-Mediated Afferent Arteriolar VasoconstrictionHypertension.  31:421-428. 1998
1998 Calcium mobilization contributes to pressure-mediated afferent arteriolar vasoconstriction.Hypertension.  31:421-428. 1998
1997 ATP and UTP have novel cAMP-mediated vasodilator activity in the hindlimb vascular bed of the catFederation proceedings.  11. 1997
1997 ATP increases cytosolic CA2+ concentration in renal microvascular smooth muscle cells (MVSMC) through a thapsigargin-insensitive pathwayFederation proceedings.  11. 1997
1997 Influence of angiotensin II on the autoregulatory stability of afferent arteriolar diameterFederation proceedings.  11. 1997
1997 Neuronal nitric oxide synthase (nNOS) enhances efferent but not afferent arteriolar reactivity to angiotensin II (ANGII)Federation proceedings.  11. 1997
1997 Vascular responses to α,β methyl-ATP, a P2x selective agonist, are organ dependent in the catFederation proceedings.  11. 1997
1997 Agonist-induced calcium regulation in freshly isolated renal microvascular smooth muscle cells.Journal of the American Society of Nephrology.  8:569-579. 1997
1997 Afferent and efferent arteriolar vasoconstriction to angiotensin II and norepinephrine involves release of Ca2+ from intracellular stores.Hypertension.  29:222-227. 1997
1997 Role of renal nerves in afferent arteriolar reactivity in angiotensin-induced hypertension.Hypertension.  29:442-449. 1997
1996 Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activationAJP - Renal Physiology.  271. 1996
1996 P2-purinoceptor characterization in rat juxtamedullary afferent arteriolesFederation proceedings.  10. 1996
1996 Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activation.American Journal of Physiology.  271:F1077-F1085. 1996
1996 Extracellular ATP increases cytosolic calcium in cultured rat renal arterial smooth muscle cells.Clinical and Experimental Pharmacology and Physiology.  23:503-507. 1996
1996 Paracrine regulation of the renal microcirculation.Physiological Reviews.  76:425-536. 1996
1995 Calcium activation mechanisms in the renal microvascular response to extracellular ATPAJP - Renal Physiology.  268. 1995
1995 Calcium activation mechanisms in the renal microvascular response to extracellular ATP.American Journal of Physiology.  268:F876-F884. 1995
1994 Autoregulation of afferent arteriolar blood flow in juxtamedullary nephronsAJP - Renal Physiology.  267. 1994
1994 Autoregulation of afferent arteriolar blood flow in juxtamedullary nephrons.American Journal of Physiology.  267:F879-F887. 1994
1994 Paracrine interactions regulating renal microcirculatory function.The Clinical investigator.  72:682-684. 1994
1994 Modulation of dihydropyridine receptors in vascular smooth muscle cells by membrane potential and cell proliferation.European Journal of Pharmacology.  268:311-318. 1994
1994 Extracellular ATP in the regulation of renal microvascular function.Federation proceedings.  8:319-328. 1994
1994 Autoregulation of afferent arteriolar blood flow in juxtamedullary nephronsAmerican Journal of Physiology.  267. 1994
1994 Renal arteriolar angiotensin responses during varied adenosine receptor activation.Hypertension.  23:I114-I119. 1994
1992 EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arteriolesAJP - Renal Physiology.  263. 1992
1992 EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles.American Journal of Physiology.  263:F900-F906. 1992
1992 Effects of ATP on pre- and postglomerular juxtamedullary microvasculatureAJP - Renal Physiology.  263. 1992
1992 Effects of ATP on pre- and postglomerular juxtamedullary microvasculature.American Journal of Physiology.  263:F886-F893. 1992
1992 Attenuated afferent arteriolar response to acetylcholine in Goldblatt hypertension.Hypertension.  19:785-789. 1992
1992 Perfusate composition modulates in vitro renal microvascular pressure responsiveness in a segment-specific manner.Microvascular Research.  43:347-351. 1992
1991 Influence of adenosine receptor blockade on renal function and renal autoregulation.Journal of the American Society of Nephrology.  2:991-999. 1991
1991 Communication between the macula densa cells and the afferent arteriole.Kidney international. Supplement.  32:S78-S82. 1991
1991 Determinants of renal microvascular autoregulatory behavior in normal and hypertensive rats.Kidney international. Supplement.  32:S89-S93. 1991
1991 Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulation.Hypertension.  17:1033-1037. 1991
1990 Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephronsAJP - Renal Physiology.  258. 1990
1990 Prostaglandin influences on afferent arteriolar responses to vasoconstrictor agonistsAJP - Renal Physiology.  259. 1990
1990 Prostaglandin influences on afferent arteriolar responses to vasoconstrictor agonists.American Journal of Physiology.  259:F157-F163. 1990
1990 Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertension.Hypertension.  15:748-752. 1990
1990 Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephrons.American Journal of Physiology.  258:F94-102. 1990
1989 The biological and immunological properties of fractionated atrial extracts from young and old rats.Life Sciences.  45:2333-2342. 1989
1988 Direct evaluation of the microvascular actions of ANP in juxtamedullary nephrons.American Journal of Physiology.  254:F440-F444. 1988
1988 Direct evaluation of the microvascular actions of ANP in juxtamedullary nephronsAmerican Journal of Physiology.  254. 1988
1987 Age-related differences in the natriuretic and hypotensive properties of rat atrial extracts.Endocrinology.  121:1662-1670. 1987
1986 Dissociation and enrichment of rat atrial myocytes containing atrial natriuretic factor (ANF).Hormone Research.  24:26-37. 1986
1984 Histamine H1 receptor antagonists inhibit autoregulation of renal blood flow in the dog.Circulation Research.  54:527-535. 1984
1982 Histamine H1receptors and renal autoregulationFederation proceedings.  41. 1982

Book

Year Title Altmetric
2000 Nonendothelial paracrine regulation of the renal microcirculation.  Ed. 9.  2000

Chapter

Year Title Altmetric
2008 The Renal Microcirculation.  550-683. 2008

Education And Training

  • Doctor of Philosophy in Physiology, Pathology, and Related Sciences, University of Cincinnati
  • Full Name

  • Edward Inscho
  • Blazerid

  • einscho