Positions

Overview

  • Dr. Eckhoff received his undergraduate degree at the University of Michigan in Ann Arbor and his medical diploma from the University of Minnesota. At the University of Wisconsin, he completed a general surgery residency, followed by a transplantation fellowship from 1986-1994. He joined the faculty at the University of Alabama at Birmingham in 1994. In May 2003, he was appointed director of the Division of Transplantation at UAB and in 2004 he became a full professor. Dr. Eckhoff is a member of twenty professional societies including Fellow of American College of Surgeons, American Society of Transplant Surgeons, American Surgical Association and Southern Surgical Association. Dr. Eckhoff serves on a number of councils and committees both for the professional societies as well as internally at UAB. In addition to his title of professor and director of the Division of Transplantation, he has various academic appointments, including medical director of the Alabama Organ Center (AOC), co-director of the UAB Comprehensive Transplant Institute, Arnold G. Diethelm Endowed Chair in Transplantation Surgery and the medical director of transplantation. Dr. Eckhoff is principal investigator on two research projects. He runs an active laboratory in xenotransplant with the desire to transplant genetically modified kidneys from pig models to humans in the near future. Under the progressive direction of Dr. Eckhoff, the transplant program has had significant growth with paired kidney exchange, living related liver donor transplant and various aggressive surgical techniques for tumors including ablation and tumor removal. He has authored, co-authored and collaborated on 132 published manuscripts.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Life-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens 2019
    2019 Mitigating Racial and Sex Disparities in Access to Living Donor Kidney Transplantation: Impact of the Nation's Longest Single-center Kidney Chain 2019
    2019 HLA Class I-sensitized Renal Transplant Patients Have Antibody Binding to SLA Class I Epitopes 2019
    2019 Ethnic and Age Disparities in Outcomes Among Liver Transplant Waitlist Candidates 2019
    2019 Effect of Renal Diagnosis on Survival in Simultaneous Liver-Kidney Transplantation 2019
    2018 B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy 2018
    2018 What's hot, what's new: Report from the American Transplant Congress 2018 2018
    2018 Heavy Alcohol Use among Deceased Donors Does Not Impact Recipient Outcomes after Liver Transplantation 2018
    2018 Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy 2018
    2018 Examining the biosynthesis and xenoantigenicity of Class II swine leukocyte antigen proteins 2018
    2018 Xenotransplantation - The current status and prospects 2018
    2018 Swine Leukocyte Antigen Class II Is a Xenoantigen 2018
    2018 Two cases and a review of graft-versus-host disease and the role of hepatitis C treatment in liver transplant patients 2018
    2018 Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival 2018
    2017 Current guidelines for chemoembolization for hepatocellular carcinoma: Room for improvement? 2017
    2017 Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells from GGTA1/CMAH/B4GalNT2, and SLA Class i Knockout Pigs 2017
    2017 A SEER Database Analysis of the Survival Advantage of Transarterial Chemoembolization for Hepatocellular Carcinoma: An Underutilized Therapy 2017
    2017 Current guidelines for chemoembolization for hepatocellular carcinoma. Room for improvement? 2017
    2017 Orthotopic liver transplantation changes the course of gastric antral vascular ectasia: A case series from a transplant center 2017
    2016 Insurance Type and Solid Organ Transplantation Outcomes: A Historical Perspective on How Medicaid Expansion Might Impact Transplantation Outcomes 2016
    2016 Does the Degree of Hepatocellular Carcinoma Tumor Necrosis following Transarterial Chemoembolization Impact Patient Survival? 2016
    2015 Resolution of post-liver transplant anastomotic biliary stricture with successful placement of a self-expanding metallic stent in a child 2015
    2015 Adjuvant stereotactic body radiotherapy following transarterial chemoembolization in patients with non-resectable hepatocellular carcinoma tumours of ≥3 cm 2015
    2015 The impact of proposed changes in liver allocation policy on cold ischemia times and organ transportation costs 2015
    2014 Predictors of repeat transarterial chemoembolization in the treatment of hepatocellular carcinoma. 2014
    2014 Resource utilization associated with procurement of transplantable organs from donors that do not meet OPTN eligible death criteria 2014
    2014 A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation 2014
    2014 Computed tomography predictors of hepatocellular carcinoma tumour necrosis after chemoembolization 2014
    2014 Conversion from twice daily tacrolimus capsules to once daily extended-release tacrolimus (LCP-Tacro): Phase 2 trial of stable liver transplant recipients 2014
    2014 Hemorrhagic shock one month following uncomplicated liver transplantation 2014
    2014 Risk factors associated with reoperation for bleeding following liver transplantation 2014
    2014 Safety and yield of diagnostic ERCP in liver transplant patients with abnormal liver function tests 2014
    2014 Transmission of Balamuthia mandrillaris through solid organ transplantation: Utility of organ recipient serology to guide clinical management 2014
    2013 Do trained specialists solicit familial authorization at equal frequency, regardless of deceased donor characteristics? 2013
    2013 Percutaneous balloon dilation and placement of endoscopic biliary stent by using the double-balloon enteroscopy ERCP rendezvous technique 2013
    2013 What liver transplant outcomes can be expected in the uninsured who become insured via the affordable care act? 2013
    2012 Is decedent race an independent predictor of organ donor consent or merely a surrogate marker of socioeconomic status? 2012
    2012 Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function 2012
    2012 Equivalent survival following liver transplantation in patients with non-alcoholic steatohepatitis compared with patients with other liver diseases 2012
    2011 A randomized, multicenter study comparing steroid-free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C 2011
    2011 Discussion 2011
    2010 Inflammation anergy in human intestinal macrophages is due to Smad-induced IκBα expression and NF-κB inactivation 2010
    2010 Human primary gastric dendritic cells induce a Th1 response to H. pylori 2010
    2009 Retraction notice to "The immune decision toward allograft tolerance in nonhuman primates requires early inhibition of innate immunity and induction of immune regulation" [Transpl Immunol 11 (2003) 335-344] (DOI:10.1016/S0966-3274(03)00054-6) 2009
    2008 Risk factors and impact of chronic obstructive pulmonary disease in candidates for liver transplantation 2008
    2008 Erratum: Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin (Transplantation (1999) 68:11 (1660-1673)) 2008
    2008 Erratum: Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients (Transplantation (1999) 68:2 (215-219)) 2008
    2008 Radiofrequency ablation for unresectable tumors of the liver 2008
    2008 Retraction: Peritransplant tolerance induction with anti-CD3-immunotoxin: A matter of proinflammatory cytokine control (Transplantation (1998) 65, 9, (1159-1169)) 2008
    2008 Selection of candidates for islet xenotransplantation 2008
    2007 Corticosteroid-free immunosuppression with daclizumab in HCV+ liver transplant recipients: 1-year interim results of the HCV-3 study 2007
    2007 Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation 2007
    2007 Racial Disparities in Renal Allograft Survival: A Public Health Issue? 2007
    2007 Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer 2007
    2006 Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection 2006
    2006 Mucosal IL-8 and TGF-β recruit blood monocytes: Evidence for cross-talk between the lamina propria stroma and myeloid cells 2006
    2006 Erratum (Retracted): Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: Absence of chronic allograft nephropathy (Transplantation (June 27, 2000) 69, 12, (2497-2503)) 2006
    2006 Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation 2006
    2005 Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis 2005
    2005 Liver transplantation of living donor adult-to-adult 2005
    2005 Recipient selection for liver transplantation 2005
    2005 Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation 2005
    2005 17β-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice 2005
    2004 Current Opinion in Organ Transplantation: Editorial introductions 2004
    2004 Activated protein C preserves functional islet mass after intraportal transplantation: A novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death 2004
    2004 Two-dose daclizumab induction therapy in 209 liver transplants: A single-center analysis 2004
    2004 A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets 2004
    2004 Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice 2004
    2004 Enhanced isolated pancreatic islet recovery and functionality in rats by 17β-estradiol treatment of brain death donors 2004
    2004 Beyond MELD: Toward an outcome-based liver allocation policy? 2004
    2004 Nonhuman primate models in type 1 diabetes research 2004
    2004 Whither Living Donors? 2004
    2003 Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo after Transplantation in Rats 2003
    2003 Radio-frequency ablation in cirrhotic patients with hepatocellular carcinoma 2003
    2003 Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys 2003
    2003 Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation 2003
    2003 Suppression of the c-Jun N-terminal kinase pathway by 17β-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction 2003
    2003 Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isoiated human pancreatic islets 2003
    2003 Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: Effects of gene transfer of Bcl-2 2003
    2003 Stable α- and β-islet cell function after tolerance induction to pancreatic islet allografts in diabetic primates 2003
    2003 New immunosuppressive strategies in liver transplantation: Balancing efficacy and toxicity 2003
    2003 Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys. 2003
    2003 The immune decision toward allograft tolerance in non-human primates requires early inhibition of innate immunity and induction of immune regulation 2003
    2002 17beta-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality. 2002
    2002 17β-estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: Molecular mechanisms and islet functionality 2002
    2002 Islet transplantation in the twenty-first century 2002
    2002 Simvastatin induces activation of the serine-threonine protein kinase Akt and increases survival of isolated human pancreatic islets 2002
    2002 STEALTH on the preclinical path to tolerance 2002
    2002 Impact of noncompliance and donor/recipient race matching on chronic liver rejection 2002
    2002 Use of preserved vascular homografts in liver transplantation: Hepatic artery aneurysms and other complications 2002
    2002 Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets 2002
    2002 17-Beta-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha 2002
    2002 Cytoprotection of pancreatic islets before and early after transplantation using gene therapy 2002
    2002 Quercetin inhibits human vascular smooth muscle cell proliferation and migration 2002
    2001 Combined cardiac surgery and liver transplantation 2001
    2001 Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene 2001
    2001 Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement 2001
    2001 Multimodality Treatment for Patients with Hepatocellular Carcinoma: Analysis of Prognostic Factors in a Single Western Institution Series 2001
    2001 Successful reversal of streptozotocin-induced diabetes with stable allogeneic islet function in a preclinical model of type 1 diabetes 2001
    2000 Improved outcomes in cadaveric renal allografts with pulsatile preservation 2000
    2000 Experience with renal transplantation in the nonhuman primate: A modified ureteroneocystostomy to prevent urologic complications 2000
    2000 Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: Absence of chronic allograft nephropathy 2000
    2000 The safety and efficacy of a two-dose daclizumab (Zenapax) induction therapy in liver transplant recipients 2000
    2000 Liver transplantation in the era of cost constraints 2000
    2000 Cholecystitis caused by hemocholecyst from underlying malignancy. 2000
    2000 Long-term functional islet mass and metabolic function after xenoislet transplantation in primates 2000
    2000 Biliary cast syndrome: Successful endoscopic treatment 2000
    2000 Cholecystitis caused by hemocholecyst from underlying malignancy 2000
    2000 Laparoscopic lymphocelectomy: A multi-institutional analysis 2000
    2000 Role of ERCP in asymptomatic orthotopic liver transplant patients with abnormal liver enzymes 2000
    2000 Role of ERCP in asymptomatic orthotopic liver transplant patients with abnormal liver enzymes. 2000
    1999 Hepatopulmonary syndrome and venous emboli causing intracerebral hemorrhages after liver transplantation: A case report 1999
    1999 Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin 1999
    1999 Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene 1999
    1999 Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients 1999
    1999 Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation 1999
    1999 Reversal of naturally occurring diabetes in primates by unmodified islet xenografts without chronic immunosuppression 1999
    1999 Genetic cytoprotection of human endothelial cells during preservation time with an adenoviral vector encoding the anti-apoptotic human Bcl-2 gene 1999
    1999 Mycophenolate mofetil in pediatric renal transplantation 1999
    1999 Reversal of naturally occurring insulinopenic diabetes and induction of isolated islet xenograft tolerance in a preclinical study 1999
    1998 Conjugated estrogen reduces transfusion and coagulation factor requirements in orthotopic liver transplantation 1998
    1998 Peritransplant tolerance induction with anti-CD3 immunotoxin: A matter of proinflammatory cytokine control 1998
    1998 Effectiveness of conjugated estrogen in orthotopic liver transplantation 1998
    1998 Tacrolimus (FK506) and mycophenolate mofetil combination therapy versus tacrolimus in adult liver transplantation 1998
    1998 Race: A critical factor in organ donation, patient referral and selection, and orthotopic liver transplantation? 1998
    1997 Race is not a critical factor in orthotopic liver transplantation. 1997
    1997 Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: A report of the U.S. multicenter liver study group 1997
    1997 Preclinical studies of allograft tolerance in rhesus monkeys: A novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts 1997
    1997 Adenoviral vector infection of the human exocrine pancreas 1997
    1996 Five years of experience with percutaneous cannula for establishing venous bypass access in orthotopic liver transplantation 1996
    1996 Immunohistochemical evaluations of ultrashort-segment Hirschsprung's disease: Report of three cases 1996
    1995 A comparison of the sensitivities of contrast and isotope voiding cystourethrograms for the detection of pancreas transplant bladder leaks 1995
    1995 Clinical and laboratory features of pancreatic transplant bladder leaks 1995
    1995 Pretransplant status and patient survival following liver transplantation 1995
    1995 Successful extrarenal transplantation from non - Heart - Beating donors 1995
    1995 Controlled non-heart-beating donors: A potential source of extrarenal organs 1995
    1994 Treatment of a late renal allograft lymphocele with a Denver shunt 1994
    1994 100 Consecutive liver transplants in infants and children: An 8-year experience 1994
    1994 Clinical experience with human anodal trypsinogen (HAT) for detection of pancreatic allograft rejection 1994
    1994 Diagnosis of intestinal transplant rejection using technetium-99m-DTPA 1994
    1994 Efficacy of 99mTc voiding cystourethrogram for detection of duodenal leaks after pancreas transplantation 1994
    1994 Efficacy of human anodal trypsinogen for detection of rejection in clinical pancreas transplantation 1994
    1994 Proctocolectomy and quadruple-limb W pouch reconstruction for the management of pediatric ulcerative colitis and familial polyposis 1994
    1994 Urological complications and enteric conversion after pancreas transplantation with bladder drainage 1994
    1993 Impact of donor factors and preservation on function and survival after liver transplantation 1993
    1993 DAB486-IL-2 (IL-2-toxin) in combination with low-dose RS-61443 (mycophenolate mofetil) prolongs murine thyroid allograft survival. 1993
    1993 Long-term results of liver transplantation for biliary atresia 1993
    1993 Surgical complications after simultaneous pancreas-kidney transplant with bladder drainage. 1993
    1993 Two hundred consecutive simultaneous pancreas-kidney transplants with bladder drainage 1993
    1993 Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage 1993
    1992 Pancreatic and component transplantation for type I diabetes 1992
    1992 RS-61443 reverses acute renal allograft rejection in dogs. 1992
    1991 RS-61443 studies: review and proposal. 1991
    1991 Prolongation of dog renal allograft survival by RS-61443, a new, potent immunosuppressive agent. 1991
    1991 RS-61443 reverses acute allograft rejection in dogs 1991
    1991 RS-61443—A new, potent immunosuppressive agent 1991
    1991 Selective enhancement of β cell activity by preparation of fetal pancreatic proislets and culture with insulin growth factor 1 1991

    Chapter

    Year Title Altmetric
    2014 Surgical management of gastroesophageal varices.  205-232. 2014

    Research Overview

  • pediatric and adult liver transplantation, complex hepatobiliary surgery, ischemia reperfusion injury, xenotransplantation
  • Principal Investigator On

  • Private Grant  awarded by LUNG BIOTECHNOLOGY PBC 2019 - 2024
  • Private Grant  awarded by ORGANOX LIMITED 2016 - 2021
  • Private Grant  awarded by UNITED THERAPEUTICS CORPORATION 2015 - 2021
  • Private Grant  awarded by LUNG BIOTECHNOLOGY PBC 2019
  • Private Grant  awarded by EMMES CORPORATION 2008 - 2013
  • Private Grant  awarded by APOIMMUNE, INC. 2010 - 2013
  • Investigator On

  • The Role of Spienic Autonomic Dysfunction in Critical Illness and End-Organ Injury  awarded by East Tennessee State University 2018 - 2023
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Private Grant  awarded by MERIT MEDICAL (*) 2012 - 2019
  • UAB 1356: A Phase II Randomized Multicenter Placebo-Controlled Blinded Study of Sorafenib Adjuvant Therapy in High Risk Orthotopic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC)  awarded by University of California, Los Angeles 2015 - 2018
  • Private Grant  awarded by BOSTON SCIENTIFIC CORPORATION 2016 - 2017
  • ACRIN 6690: A Prospective, Multi-Center Comparison of Multiphase Contrast-Enhanced CT and Multiphase Contrast-Enhanced MRI for Diagnosis of Hepatocellular Carcinoma and Liver Transplant Allocation (R10-122)  awarded by American College of Radiology Imaging Network 2014 - 2017
  • Pre-Transplant Infectious Diseases Evaluation Clinic  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2016
  • UAB 1356 - A Phase II Randomized Multicenter Placebo-Controlled Blinded Study of Sorafenib Adjuvant Therapy in High Risk Orthotropic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC)  awarded by University of California, Los Angeles 2014 - 2015
  • Private Grant  awarded by Society of Gastrointestinal Radiologists 2011 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2012 - 2014
  • Private Grant  awarded by VITAL THERAPIES, INC 2012 - 2014
  • ACRIN 6690: A Prospective, Multi-Center Comparison of Multiphase Contrast-Enhanced CT and Multiphase Contrast Enhanced MRI for Diagnosis of Hepatocellular Carcinoma and Liver Transplant Allocation (R10-122)  awarded by American College of Radiology Imaging Network 2011 - 2014
  • Education And Training

  • University of Wisconsin Hospital & Clinics, Internship 1988
  • University of Wisconsin Hospital & Clinics, Residency 1992
  • University of Wisconsin Hospital & Clinics, Postdoctoral Fellowship 1994
  • Full Name

  • Devin Eckhoff