Positions

Overview

  • Dr. Beierle received her undergraduate degree and medical degree from the University of North Dakota, graduating in 1989. She completed a general surgery internship at Baylor College of Medicine in Houston and subsequently completed her surgical residency at the University of Florida in 1996. She completed her pediatric surgery fellowship training in Philadelphia at St. Christopher’s Hospital for Children in 1998. Dr. Beierle came to the University of Alabama at Birmingham in 2009, after spending over nine years on the faculty at the University of Florida. She specializes in the surgical care of children and neonates with a special emphasis upon pediatric surgical oncology. She has an active basic science research laboratory that focuses on novel therapeutics for pediatric solid tumors. She has mentored a number of undergraduate students, medical students, residents and graduate students in her lab.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth.Translational Oncology.  12:84-95. 2019
    2018 UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts.Journal of Neuro-Oncology.  140:209-224. 2018
    2018 Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression.Scientific Reports.  8:13930. 2018
    2018 Pediatric Patients with Small-Cell Carcinoma of the Ovary Have Similar Survival to Adults: A Review of the National Cancer Database.American Surgeon.  84:e362-e365. 2018
    2018 Systemic Thrombolysis of an Occlusive Aortic Thrombus in a Neonate on Extracorporeal Membrane Oxygenation.American Surgeon.  84:e372-e374. 2018
    2018 Testicular tumors in prepubescent patients.Journal of Pediatric Surgery.  53:1748-1752. 2018
    2018 A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro.Journal of Surgical Research.  228:54-62. 2018
    2018 FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts.Scientific Reports.  8:6913. 2018
    2018 Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma.Oncotarget.  9:22665-22679. 2018
    2018 Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma.Journal of Surgical Research.  224:38-43. 2018
    2018 Partial Nephrectomy for Nephroblastoma: A National Cancer Data Base Review.American Surgeon.  84:338-343. 2018
    2017 Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors.Scientific Reports.  7:17787. 2017
    2017 Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002.Molecular Therapy - Oncolytics.  7:27-36. 2017
    2017 Pediatric-protocol of multimodal therapy is associated with improved survival in AYAs and adults with rhabdomyosarcoma.Surgery.  163:324-329. 2017
    2017 Open versus laparoscopic approach to gastric fundoplication in children with cardiac risk factors.Journal of Surgical Research.  220:52-58. 2017
    2017 Socioeconomic disparities affect survival in malignant ovarian germ cell tumors in AYA population.Journal of Surgical Research.  222:180-186.e3. 2017
    2017 Breast Malignancies in Children: Presentation, Management, and Survival.Annals of Surgical Oncology.  24:1482-1491. 2017
    2017 Utilization of the NSQIP-Pediatric Database in Development and Validation of a New Predictive Model of Pediatric Postoperative Wound Complications.Journal of The American College of Surgeons.  224:532-544. 2017
    2017 Effects of socioeconomic status on children with well-differentiated thyroid cancer.Surgery.  162:662-669. 2017
    2017 Pediatric Anaplastic Embryonal Rhabdomyosarcoma: Targeted Therapy Guided by Genetic Analysis and a Patient-Derived Xenograft Study.Frontiers in Oncology.  7:327. 2017
    2017 The association between nephroblastoma-specific outcomes and high versus low volume treatment centers.Journal of Pediatric Surgery.  52:104-108. 2017
    2016 Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database.Medical and Pediatric Oncology.  64. 2016
    2016 Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma.Translational Oncology.  9:419-430. 2016
    2016 Survival and Surgical Outcomes for Pediatric Head and Neck Melanoma.JAMA Otolaryngology-Head and Neck Surgery.  143:34-40. 2016
    2016 Ileocolic and Jejunal Intussusceptions Requiring Surgical Intervention in a Pediatric Patient with Posttransplant Lymphoproliferative Disorder.American Surgeon.  82:792-793. 2016
    2016 Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells.Translational Oncology.  9:263-273. 2016
    2016 Colorectal carcinoma in pediatric patients: A comparison with adult tumors, treatment and outcomes from the National Cancer Database.Journal of Pediatric Surgery.  51:1061-1066. 2016
    2016 Outcome assessment of renal replacement therapy in neonates.Journal of Surgical Research.  204:34-38. 2016
    2016 Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies.Molecular Cancer Therapeutics.  15:911-921. 2016
    2016 Risk Factors for Stricture Formation After Esophageal Atresia Repair.Pediatric Endosurgery and Innovative Techniques.  26:393-398. 2016
    2016 Factors Associated With Mortality in Pediatric vs Adult Nasopharyngeal Carcinoma.JAMA Otolaryngology-Head and Neck Surgery.  142:217-222. 2016
    2016 Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses.Neuro-Oncology.  18:227-235. 2016
    2016 Cell Proliferation in Neuroblastoma.Cancers.  8. 2016
    2015 Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma.Cancers.  8. 2015
    2015 Surgical management and morbidity of pediatric magnet ingestions.Journal of Surgical Research.  199:137-140. 2015
    2015 Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma.Molecular Cancer Therapeutics.  14:1559-1569. 2015
    2015 Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.Journal of Surgical Research.  196:339-349. 2015
    2015 Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?Journal of Pediatric Surgery.  50:1009-1013. 2015
    2015 Primary malignant pulmonary tumors in children: a review of the national cancer data base.Journal of Pediatric Surgery.  50:1004-1008. 2015
    2015 γ₁34.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia.Gene Therapy.  22:356. 2015
    2015 γ₁34.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia.Gene Therapy.  22:348-355. 2015
    2015 Routine utilization of single-incision pediatric endosurgery (SIPES): a 5-year institutional experience.Pediatric Endosurgery and Innovative Techniques.  25:252-255. 2015
    2015 Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.Molecular Carcinogenesis.  54:9-23. 2015
    2015 Pediatric cancer gone viral. Part I: strategies for utilizing oncolytic herpes simplex virus-1 in children.Molecular Therapy - Oncolytics.  2. 2015
    2015 Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children.Molecular Therapy - Oncolytics.  2. 2015
    2015 Single-incision pediatric endosurgery (SIPES) splenectomy: what dictates the need for additional ports?Surgical Endoscopy.  29:30-33. 2015
    2014 Parathyroid carcinoma in more than 1,000 patients: A population-level analysis.Surgery.  156:1622-1629. 2014
    2014 Role of laparoscopy in the prevention and in the treatment of adhesions.Seminars in Pediatric Surgery.  23:353-356. 2014
    2014 Utility of immature granulocyte percentage in pediatric appendicitis.Journal of Surgical Research.  190:230-234. 2014
    2014 Extraction of esophageal foreign bodies in children: rigid versus flexible endoscopy.Pediatric Surgery International.  30:417-422. 2014
    2014 FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors.Cell Growth and Differentiation.  12:514-526. 2014
    2014 Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.Molecular Carcinogenesis.  53:230-242. 2014
    2014 Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors.PLoS ONE.  9:e86843. 2014
    2014 The interaction between FAK, MYCN, p53 and Mdm2 in neuroblastoma.Current Medicinal Chemistry Anticancer Agents.  14:46-51. 2014
    2013 Neonatal spiradenoma.Pediatric Dermatology.  30:e228-e229. 2013
    2013 Laparoscopic cholecystectomy for biliary dyskinesia in children: frequency increasing.Journal of Pediatric Surgery.  48:1716-1721. 2013
    2013 Mentoring in pediatric oncology: a report from the Children's Oncology Group Young Investigator Committee.Journal of Pediatric Hematology/Oncology.  35:456-461. 2013
    2013 FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastoma.Clinical and Experimental Metastasis.  30:555-568. 2013
    2013 Single incision pediatric endosurgery (SIPES) appendectomy--is obesity a contraindication?Journal of Pediatric Surgery.  48:1399-1404. 2013
    2013 Cell survival signaling in neuroblastoma.Current Medicinal Chemistry Anticancer Agents.  13:563-575. 2013
    2013 FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo.Translational Oncology.  6:206-215. 2013
    2013 Single-incision pediatric endosurgery for ovarian pathology.Pediatric Endosurgery and Innovative Techniques.  23:291-296. 2013
    2013 Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma.PLoS ONE.  8:e77753. 2013
    2012 Angiodysplasia (vascular malformations) of the colon presenting as an acute abdomen.Journal of Pediatric Surgery.  47:e37-e40. 2012
    2012 Feasibility of single-incision pediatric endosurgery for treatment of appendicitis in 415 children.Pediatric Endosurgery and Innovative Techniques.  22:604-608. 2012
    2012 Laparoscopic surgery in children with congenital heart disease.Journal of Pediatric Surgery.  47:1084-1088. 2012
    2012 Targeting pediatric cancer stem cells with oncolytic virotherapy.Pediatric Research.  71:500-510. 2012
    2011 MYCN, neuroblastoma and focal adhesion kinase (FAK).Frontiers in bioscience (Elite edition).  3:421-433. 2011
    2010 Targeting focal adhesion kinase in neuroblastoma.Current Medicinal Chemistry Anticancer Agents.  10:714-721. 2010
    2010 Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines.Molecular Carcinogenesis.  49:224-234. 2010
    2010 Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma.Cell Cycle.  9:1005-1015. 2010
    2010 All-terrain vehicle safety in Florida: is legislation really the answer?American Surgeon.  76:149-153. 2010
    2009 Infectious risk to ventriculo-peritoneal shunts from gastrointestinal surgery in the pediatric population.Journal of Pediatric Surgery.  44:1201-1204. 2009
    2009 Equestrian injuries in children.Journal of Pediatric Surgery.  44:148-150. 2009
    2009 Ketone bodies inhibit the viability of human neuroblastoma cells.Journal of Pediatric Surgery.  44:212-216. 2009
    2008 Mesenteric lipoblastoma: a rare location in children.Journal of Pediatric Surgery.  43:e5-e7. 2008
    2008 Pediatric basal cell carcinoma: case reports and literature review.Journal of Pediatric Surgery.  43:2277-2280. 2008
    2008 Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses.Clinical Cancer Research.  14:3299-3305. 2008
    2008 Traumatic aortic injuries in the pediatric population.Journal of Pediatric Surgery.  43:1077-1081. 2008
    2008 TAE226 inhibits human neuroblastoma cell survival.Cancer Investigation.  26:145-151. 2008
    2008 Pulmonary surgery in cystic fibrosis.Seminars in Pediatric Surgery.  17:60-65. 2008
    2008 Ashes, embers, and coals: significant sources of burn-related morbidity in children.Journal of Burn Care and Rehabilitation.  29:109-113. 2008
    2007 Hydrofluoric acid burn in a child from a compressed air duster.Journal of Burn Care and Rehabilitation.  28:909-912. 2007
    2007 The use of Seprafilm in pediatric surgical patients.American Surgeon.  73:792-795. 2007
    2007 N-MYC regulates focal adhesion kinase expression in human neuroblastoma.Journal of Biological Chemistry.  282:12503-12516. 2007
    2006 Differential response of neuroblastoma cells to TRAIL is independent of PI3K/AKT.Journal of Pediatric Surgery.  41:1072-1080. 2006
    2006 Pediatric surgical issues in meconium disease and cystic fibrosis.Surgical Clinics of North America.  86:317-ix. 2006
    2006 Recurrent pneumonia in children: a case report and approach to diagnosis.Clinical Pediatrics.  45:15-22. 2006
    2005 VEGF-mediated survivin expression in neuroblastoma cells.Journal of Surgical Research.  127:21-28. 2005
    2005 Exhaust system burn injuries in children.Journal of Pediatric Surgery.  40:E43-E46. 2005
    2004 Administration of prenatal betamethasone suppresses the adrenal-hypophyseal axis in newborns with congenital diaphragmatic hernia.Journal of Pediatric Surgery.  39:1176-1182. 2004
    2004 Artificial rearing of mouse pups: development of a mouse pup in a cup model.Pediatric Research.  56:250-255. 2004
    2004 Expression of VEGF receptors in cocultured neuroblastoma cells.Journal of Surgical Research.  119:56-65. 2004
    2004 Animal models for intestinal tissue engineering.Biomaterials.  25:1675-1681. 2004
    2004 Extracorporeal membrane oxygenation combined with endovascular embolization for management of neonatal high-output cardiac failure secondary to intracranial arteriovenous fistula: Case reportJournal of Neurosurgery.  100:197-200. 2004
    2003 Analysis of gene expression patterns in human postburn hypertrophic scars.Journal of Burn Care and Rehabilitation.  24:371-377. 2003
    2003 Pediatric sand aspiration: case report and literature review.Pediatric Surgery International.  19:409-412. 2003
    2003 Differential expression of Bcl-2 and Bax may enhance neuroblastoma survival.Journal of Pediatric Surgery.  38:486-491. 2003
    2003 VEGF receptors are differentially expressed by neuroblastoma cells in culture.Journal of Pediatric Surgery.  38:514-521. 2003
    2003 Neuroblastoma, apoptosis, and growth factors.American Surgeon.  69:28-31. 2003
    2003 Twenty years of progress in congenital diaphragmatic hernia at the University of Florida.American Surgeon.  69:45-52. 2003
    2002 Caspase 3 expression is altered in a coculture model of neuroblastoma.Journal of Surgical Research.  106:323-327. 2002
    2002 Competency-based student self-assessment on a surgery rotation.Journal of Surgical Research.  105:31-34. 2002
    2002 Small watercraft injuries in children.American Surgeon.  68:535-538. 2002
    2002 Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression.Journal of Pediatric Surgery.  37:472-476. 2002
    2002 VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells.Journal of Pediatric Surgery.  37:467-471. 2002
    2001 Gastrointestinal foreign bodies.Pediatric Annals.  30:736-742. 2001
    2001 VEGF is upregulated in a neuroblastoma and hepatocyte coculture model.Journal of Surgical Research.  97:34-40. 2001
    2000 Free fluid on abdominal computed tomography scan after blunt trauma does not mandate exploratory laparotomy in children.Journal of Pediatric Surgery.  35:990-992. 2000
    2000 Neuroblastoma and hepatocyte coculture conditioned media alter apoptosis.Journal of Surgical Research.  90:113-118. 2000
    1999 Fas-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model.Journal of Surgical Research.  84:82-87. 1999
    1998 Gastrointestinal surgery in cystic fibrosis.Current Opinion in Pulmonary Medicine.  4:319-325. 1998
    1998 Gastrointestinal perforation after pediatric orthotopic liver transplantation.Journal of Pediatric Surgery.  33:240-242. 1998
    1996 Hepatic tumor necrosis factor-alpha production and distant organ dysfunction in a murine model of obstructive jaundice.American Journal of Surgery.  171:202-206. 1996
    1996 In utero lung growth of fetal sheep with diaphragmatic hernia and tracheal stenosis.Journal of Pediatric Surgery.  31:141-146. 1996
    1995 PEG-BP-30 monotherapy attenuates the cytokine-mediated inflammatory cascade in baboon Escherichia coli septic shock.Journal of Surgical Research.  59:153-158. 1995

    Chapter

    Year Title Altmetric
    2010 Focal adhesion kinase with the interacting proteins and signaling in cancer.  275-305. 2010
    2007 Surgical management of complications of burn injury.  502-512. 2007

    Full Name

  • Elizabeth Beierle Chen
  • Blazerid

  • ebchen