Positions

Overview

  • Dr. Duncan is a Professor in the Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine. He attended medical school at the University of Washington (Seattle) and served as a Medical Intern and Resident there. His subsequent clinical and research training fellowships were at the University of Pittsburgh, Stanford University, and The Scripps Research Institute. Dr. Duncan has had prior faculty appointments at Stanford University and the University of Pittsburgh.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 What Lies Beneath: Preformed Autoantibodies and Lung Transplantation.American Journal of Respiratory Cell and Molecular Biology2019
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of AsthmaticsScientific Reports.  8. 2018
    2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cellsRedox Biology.  18:54-64. 2018
    2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5Journal of Immunology.  201:278-295. 2018
    2018 Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed modelBioData Mining.  11. 2018
    2017 The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA WorkshopJournals of Gerontology, Series A.  72:1492-1500. 2017
    2017 Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosisJournal of Immunology.  199:1596-1605. 2017
    2017 Exosomes in immunoregulation of chronic lung diseasesAllergy.  72:534-544. 2017
    2017 Epigenetic regulation of caveolin-1 gene expression in lung fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  56:50-61. 2017
    2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infectionsAJP - Lung Cellular and Molecular Physiology.  311:L928-L940. 2016
    2015 Erratum: Autoantibody-targeted treatments for acute exacerbations of idiopathic pulmonary fibrosis (PLoS ONE (2015) 10:6 (e0127771) DOI: 10.1371/journal.pone.0127771)PLoS ONE.  10. 2015
    2015 Autoantibody-targeted treatments for acute exacerbations of idiopathic pulmonary fibrosisPLoS ONE.  10. 2015
    2015 PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosisJournal of Clinical Investigation.  125:521-538. 2015
    2014 Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokersPLoS ONE.  9. 2014
    2014 C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  189:966-974. 2014
    2014 Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)Journal of Biological Chemistry.  289:6383-6393. 2014
    2014 Retraction: Down-regulated peroxisome proliferator-activated receptor γ(PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD) (Journal of Biological Chemistry (2014) 289 (6383–6393) DOI: 10.1074/jbc.M113.536805)Journal of Biological Chemistry.  294:69. 2014
    2014 Fibrosis: Ultimate and proximate causesJournal of Clinical Investigation.  124:4673-4677. 2014
    2013 Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosisScience Translational Medicine.  5. 2013
    2013 Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patientsJournal of Immunology.  191:2089-2095. 2013
    2013 Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognosesAmerican Journal of Respiratory and Critical Care Medicine.  187:768-775. 2013
    2013 Patients with cystic fibrosis have inducible IL-17+IL-22 + memory cells in lung draining lymph nodesJournal of Allergy and Clinical Immunology.  131. 2013
    2012 Clues, not conclusionsNature.  489. 2012
    2012 Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysemaAmerican Journal of Respiratory and Critical Care Medicine.  186:412-419. 2012
    2012 Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipientsClinical Transplantation.  26:105-110. 2012
    2012 Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace ec-sod after interstitial pulmonary injuryAJP - Lung Cellular and Molecular Physiology.  302. 2012
    2012 The relationship between pulmonary emphysema and kidney function in smokersChest.  142:655-662. 2012
    2011 The missing link between smoking and COPD autoreactivity?American Journal of Respiratory and Critical Care Medicine.  184:747-749. 2011
    2011 Distribution of Pneumocystis jirovecii in lungs from colonized COPD patientsDiagnostic Microbiology and Infectious Disease.  71:24-28. 2011
    2011 A human-mouse chimeric model of obliterative bronchiolitis after lung transplantationAmerican Journal of Pathology.  179:745-753. 2011
    2011 Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohortAmerican Journal of Respiratory and Critical Care Medicine.  183:885-890. 2011
    2011 The HLA class II allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosisPLoS ONE.  6. 2011
    2010 CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosisPLoS ONE.  5. 2010
    2010 Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease.Biology of Blood and Marrow Transplantation.  16. 2010
    2010 Emerging bacterial, fungal, and viral respiratory infections in transplantationInfectious Disease Clinics of North America.  24:541-555. 2010
    2010 Plasma inflammatory mediators associated with bone metabolism in COPDCOPD: Journal of Chronic Obstructive Pulmonary Disease.  7:186-191. 2010
    2010 What is autoimmunity and why is it likely to be important in chronic lung disease?American Journal of Respiratory and Critical Care Medicine.  181:4-5. 2010
    2009 Are telomere lengths of leukocytes from patients with pulmonary fibrosis really genetically determined?American Journal of Respiratory and Critical Care Medicine.  179:852. 2009
    2009 Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary diseaseJournal of Immunology.  182:3270-3277. 2009
    2008 Role of T-lymphocytes and pro-inflammatory mediators in the pathogenesis of chronic obstructive pulmonary diseaseInternational Journal of COPD.  3:531-541. 2008
    2008 CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipientsAmerican Journal of Respiratory and Critical Care Medicine.  178:765-773. 2008
    2008 Autoantibodies in patients with chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  177:156-163. 2008
    2007 Cellular and humoral autoreactivity in idiopathic pulmonary fibrosisJournal of Immunology.  179:2592-2599. 2007
    2006 Altered T-cell phenotypes in chronic obstructive pulmonary diseaseProceedings of the American Thoracic Society.  3:487-488. 2006
    2003 Statin use is associated with improved function and survival of lung allograftsAmerican Journal of Respiratory and Critical Care Medicine.  167:1271-1278. 2003
    2002 PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft modelThe Journal of heart transplantation.  21:1314-1318. 2002
    2002 Oligoclonal CD4+T cell expansions in lung transplant recipients with obliterative bronchiolitisAmerican Journal of Respiratory and Critical Care Medicine.  165:1439-1444. 2002
    2002 Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survivalJournal of Clinical Investigation.  109:755-764. 2002
    1999 Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12Proceedings of the National Academy of Sciences.  96:8591-8596. 1999
    1999 Clonal characteristics of T cell infiltrates in skin and synovium of patients with psoriatic arthritisHuman Immunology.  60:479-491. 1999
    1997 Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-γ and fasAJP - Lung Cellular and Molecular Physiology.  273. 1997
    1997 T Cell receptor biasis and clonal proliferations among lung transplant recipients with obliterative bronchiolitisPneumologie.  51:151-152. 1997
    1997 Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupusJournal of Clinical Investigation.  99:1888-1896. 1997
    1997 T-cell receptor biases and clonal proliferations in blood and pleural effusions of patients with lung cancerHuman Immunology.  53:39-48. 1997
    1997 T cell receptor (TCR) BV gene repertoires and clonal expansions of CD4 cells in patients with HIV infectionsClinical and Experimental Immunology.  107:21-30. 1997
    1996 Pulmonary capillaritis and alveolar hemorrhage. Update on diagnosis and management.Chest.  110:1305-1316. 1996
    1996 T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitisJournal of Clinical Investigation.  97:2642-2650. 1996
    1996 Aerosolized cyclosporine in lung recipients with refractory chronic rejectionAmerican Journal of Respiratory and Critical Care Medicine.  153:1451-1455. 1996
    1996 Intrathymic injection of polynucteosomes delays autoantibody production in BXSB miceClinical immunology and immunopathology.  79:171-181. 1996
    1995 Delivery and distribution of aerosolized cyclosporine in lung allograft recipientsAmerican Journal of Respiratory and Critical Care Medicine.  151:516-521. 1995
    1995 T‐Cell Repertoires in Health and DiseaseAnnals of the New York Academy of Sciences.  756:53-65. 1995
    1994 Monitoring of acute lung rejection and infection by bronchoalveolar lavage and plasma levels of hyaluronic acid in clinical lung transplantationThe Journal of heart transplantation.  13:958-962. 1994
    1994 A comparison of ganciclovir and acyclovir to prevent cytomegalovirus after lung transplantationAmerican Journal of Respiratory and Critical Care Medicine.  150:146-152. 1994
    1994 Load detection in subjects with sleep-induced upper airway obstructionAmerican Journal of Respiratory and Critical Care Medicine.  149:727-730. 1994
    1993 Recurrence of sarcoidosis in pulmonary allograft recipientsThe American review of respiratory disease.  148:1373-1377. 1993
    1992 Distinguishing between infection, rejection, and the adult respiratory distress syndrome after human lung transplantation.The Journal of heart transplantation.  11:S232-S236. 1992
    1992 Acute rejection of lung allografts with various immunosuppressive protocolsAnnals of Thoracic Surgery.  54:846-851. 1992
    1992 Detection of inspiratory resistive loads by heart-lung transplant recipientsThe American review of respiratory disease.  145:458-460. 1992
    1992 Distinguishing between infection, rejection, and the adult respiratory distress syndrome after human lung transplantationThe Journal of heart transplantation.  11. 1992
    1992 Donor cerebral emboli as a cause of acute graft dysfunction in lung transplantationThe Journal of heart transplantation.  11:72-76. 1992
    1992 Donor cerebral emboli as a cause of acute graft dysfunction in lung transplantation.The Journal of heart transplantation.  11:72-76. 1992
    1992 Ganciclovir prophylaxis for cytomegalovirus infections in pulmonary allograft recipientsThe American review of respiratory disease.  146:1213-1215. 1992
    1992 Interstitial and airspace granulation tissue reactions in lung transplant recipientsAmerican Journal of Surgical Pathology.  16:877-884. 1992
    1992 Production of an Aerosol of Cyclosporine as a Prelude to Clinical StudiesJournal of Aerosol Medicine.  5:171-177. 1992
    1992 Proliferation of cytomegalovirus-primed lymphocytes in bronchoalveolar lavages from lung transplant patientsTransplantation.  54:635-639. 1992
    1992 Sequelae of cytomegalovirus pulmonary infections in lung allograft recipientsThe American review of respiratory disease.  146:1419-1425. 1992
    1991 A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplantsNew England Journal of Medicine.  324:1005-1011. 1991
    1991 Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipientsAnnals of Internal Medicine.  114:145-146. 1991
    1991 Effects of pulmonary restriction on hypercapnic responses of heart-lung transplant recipientsJournal of applied physiology: respiratory, environmental and exercise physiology.  71:322-327. 1991
    1991 Hypercarbic ventilatory responses of human heart-lung transplant recipientsThe American review of respiratory disease.  144:126-130. 1991
    1991 Inspiratory timing of heart-lung transplant recipients during progressive hypercapniaJournal of applied physiology: respiratory, environmental and exercise physiology.  71:945-950. 1991
    1991 Naloxone reversal of hypotension due to captopril overdoseAnnals of Emergency Medicine.  20:1125-1127. 1991
    1991 Snoring (I): Daytime sleepiness in regular heavy snorersChest.  99:40-48. 1991
    1991 Survival of ganciclovir-treated heart transplant recipients with cytomegalovirus pneumonitisTransplantation.  52:910-913. 1991
    1991 The evolution in lung transplantation.Contemporary internal medicine.  3:17-19. 1991
    1990 The diagnosis of Wegener's granulomatosis from transbronchial biopsy specimensHuman Pathology.  21:838-842. 1990
    1990 Update: Management of asthmaComprehensive Therapy.  16:24-33. 1990
    1987 Hemoptysis, large lung 'abscess' in alcoholic man with bad teeth.Hospital Practice.  22. 1987
    1987 Cough and spiking fever in a transfusion-dependent woman.Hospital Practice.  22. 1987
    1987 Inverse ratio ventilation. PEEP in disguise?Chest.  92:390-392. 1987
    1987 Nasal continuous positive airway pressure in atelectasisChest.  92:621-624. 1987
    1987 The antigen that was heard but not 'seen'Hospital Practice.  22:226-232. 1987
    1987 Young woman on a prednisone seesawHospital Practice.  22:82-88. 1987
    1986 A young woman with swollen arm, dyspneaHospital Practice.  21:13-21. 1986
    1986 Disabling dyspnea of sudden onsetHospital Practice.  21:103-104. 1986
    1986 Mechanisms and management of respiratory failureComprehensive Therapy.  12:55-63. 1986

    Education And Training

  • University of Washington, Other
  • Doctor of Medicine, University of Washington 1981
  • University of Washington School of Medicine, Internship 1982
  • University of Washington School of Medicine, Residency 1984
  • Scripps Research Institute, Postdoctoral Fellowship 1995
  • Stanford University Medical Center, Postdoctoral Fellowship 1987
  • University of Pittsburgh School of Medicine, Postdoctoral Fellowship 1985
  • Full Name

  • Steven Duncan