Positions

Overview

  • Daniel L. Smith Jr., Ph.D., is an Assistant Professor in the Department of Nutrition Sciences at UAB. His research focuses on the interaction of nutrition and metabolism in relationship to aging and disease. Topics include: obesity, calorie restriction, calorie restriction mimetics, brown adipose tissue, ulcerative dermatitis in C57BL/6 mice, and systems biology of aging using budding yeast chronological lifespan.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Canagliflozin extends life span in genetically heterogeneous male but not female mice.  JCI insight.  5. 2020
    2020 The antidiabetic agent acarbose improves anti-PD-1 and rapamycin efficacy in preclinical renal cancer.  Cancers.  12:1-19. 2020
    2020 Exogenous Dietary Ketone Ester Decreases Body Weight and Adiposity in Mice Housed at Thermoneutrality 2020
    2020 Energy Balance as a Moderator of Neurologic Disease Risk and Progression.  Neurotoxicity Research.  38:242-248. 2020
    2020 Murine genetic models of obesity: type I error rates and the power of commonly used analyses as assessed by plasmode-based simulation.  International Journal of Obesity.  44:1440-1449. 2020
    2020 Diabetes medications as potential calorie restriction mimetics—a focus on the alpha-glucosidase inhibitor acarbose.  Geroscience.  2020
    2020 High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availability.  Geroscience.  2020
    2019 Differences in Glucose Metabolism Among Women With Spinal Cord Injury May Not Be Fully Explained by Variations in Body Composition.  Archives of Physical Medicine and Rehabilitation.  100:1061-1067.e1. 2019
    2019 A Systematic Scoping Review of Surgically Manipulated Adipose Tissue and the Regulation of Energetics and Body Fat in Animals 2019
    2019 Dietary R,S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet.  The FASEB Journal.  33:2409-2421. 2019
    2018 Weight Cycling Increases Longevity Compared with Sustained Obesity in Mice 2018
    2018 A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring 2018
    2018 Regression to the mean, apparent data errors and biologically extraordinary results: Letter regarding 'changes in telomere length 3-5 years after gastric bypass surgery'.  International Journal of Obesity.  42:949-950. 2018
    2018 Sex-dependent differences in liver and gut metabolomic profiles with acarbose and calorie restriction in C57BL/6 mice 2018
    2016 Gene-nutrient interaction markedly influences yeast chronological lifespan.  Experimental Gerontology.  86:113-123. 2016
    2016 Nutrition and energetics in rodent longevity research.  Experimental Gerontology.  86:90-96. 2016
    2016 Observational research rigour alone does not justify causal inference.  European Journal of Clinical Investigation.  46:985-993. 2016
    2016 Targeting glucose metabolism for healthy aging..  Nutr Healthy Aging.  4:31-46. 2016
    2016 Contributors to Metabolic Disease Risk Following Spinal Cord Injury.  Current Physical Medicine and Rehabilitation Reports.  4:190-199. 2016
    2016 In Vivo Determination of Body Composition in Zebrafish (Danio rerio) by Quantitative Magnetic Resonance.  Zebrafish.  13:170-176. 2016
    2015 Weighing the Evidence of Common Beliefs in Obesity Research 2015
    2015 Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence?.  Aging Cell.  14:483-490. 2015
    2015 Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations.  Aging.  7:177-194. 2015
    2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013.  F1000Research.  3. 2014
    2014 Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.  Aging Cell.  13:273-282. 2014
    2014 Impact of weight cycling on risk of morbidity and mortality.  Obesity Reviews.  15:870-881. 2014
    2014 Variations in body weight, Food Intake and body composition after long-term high-fat diet feeding in C57BL/6J mice 2014
    2013 Measurement of interscapular brown adipose tissue of mice in differentially housed temperatures by chemical-shift-encoded water-fat MRI.  Journal of Magnetic Resonance Imaging.  38:1425-1433. 2013
    2013 Sarcopenia and piscines: The case for indeterminate-growing fish as unique genetic model organisms in aging and longevity research.  Frontiers in Genetics.  4. 2013
    2013 Dietary protein source influence on body size and composition in growing zebrafish.  Zebrafish.  10:439-446. 2013
    2013 Effects of risperidone on energy balance in female C57BL/6J mice 2013
    2013 Myths, presumptions, and facts about obesity.  New England Journal of Medicine.  368:446-454. 2013
    2013 Chemical-shift water-fat MRI of white adipose depots: inability to resolve cell size differences..  International Journal of Body Composition Research.  11:9-16. 2013
    2012 Variations in T 2* and fat content of murine brown and white adipose tissues by chemical-shift MRI.  Magnetic Resonance Imaging.  30:323-329. 2012
    2012 Ambient Temperature and Obesity.  Current Obesity Reports.  1:26-34. 2012
    2012 Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevity.  Annals of the New York Academy of Sciences.  1264:1-12. 2012
    2011 Telomere dynamics in rhesus monkeys: No apparent effect of caloric restriction 2011
    2011 MR properties of brown and white adipose tissues.  Journal of Magnetic Resonance Imaging.  34:468-473. 2011
    2011 No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.  International Journal of Obesity.  35:652-657. 2011
    2011 Can rodent longevity studies be both short and powerful? 2011
    2010 Identification of brown adipose tissue in mice with fat-water IDEAL-MRI.  Journal of Magnetic Resonance Imaging.  31:1195-1202. 2010
    2010 Metformin supplementation and life span in fischer-344 rats 2010
    2010 The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice 2010
    2010 A microarray-based genetic screen for yeast chronological aging factors.  PLoS Genetics.  6. 2010
    2010 Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats.  Toxicology and Applied Pharmacology.  243:332-339. 2010
    2010 Mild calorie restriction induces fat accumulation in female C57BL/6J mice 2010
    2010 Calorie restriction: What recent results suggest for the future of ageing research.  European Journal of Clinical Investigation.  40:440-450. 2010
    2009 Calorie restriction effects on silencing and recombination at the yeast rDNA.  Aging Cell.  8:633-642. 2009
    2009 Validation of quantitative magnetic resonance (QMR) for determination of body composition in rats..  International Journal of Body Composition Research.  7:99-107. 2009
    2008 Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae 2008
    2007 Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.  Aging Cell.  6:649-662. 2007
    2007 DNA replication stress is a determinant of chronological lifespan in budding yeast.  PLoS ONE.  2. 2007
    2004 Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity.  Molecular and Cellular Biology.  24:1301-1312. 2004

    Principal Investigator On

    Investigator On

  • Comparative Bioenergetics of Aging  awarded by National Institute on Aging/NIH/DHHS 2020 - 2025
  • Comparative Bioenergetics of Aging - Core C - Comparative Organismal Energetics Core  awarded by National Institute on Aging/NIH/DHHS 2020 - 2025
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • UAB Nutrition Obesity Research Center - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • Osteoblasts Role in Dysfunction of Body Adiposity and Bone Metabolism  awarded by National Institute on Aging/NIH/DHHS 2020 - 2021
  • Systems Level Analysis of the Interplay Between Metabolism, Cell-Cell Communication, and Aging  awarded by National Institute on Aging/NIH/DHHS 2018 - 2020
  • Comparative Energetics and Aging  awarded by National Institute on Aging/NIH/DHHS 2015 - 2020
  • Comparative Energetics and Aging - Comparative Organismal Energetics Core C  awarded by National Institute on Aging/NIH/DHHS 2015 - 2020
  • Identifying Outcome Mediators of Calorie Restriction Mimetic use in Renal Cancer  awarded by National Cancer Institute/NIH/DHHS 2018 - 2020
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • UAB Nutrition Obesity Research Center - Enrichment Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • Constructing Gene-Regulatory Networks to Reveal the Metabolic Basis of Lifespan in Yeast  awarded by National Institute on Aging/NIH/DHHS 2012 - 2018
  • Energetics, Disparities, & Lifespan: A Unified Hypothesis  awarded by National Institute on Aging/NIH/DHHS 2012 - 2017
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • UAB Nutrition Obesity Research Center - UAB NORC Supplement: Rigor in Sample Size Selection in Murine Model Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • Body Composition, Energetics and Longevity  awarded by National Institute on Aging/NIH/DHHS 2010 - 2016

    • Education And Training

  • Doctor of Philosophy in Molecular Biochemistry, University of Virginia 2007
  • Master of Science in Biological and Physical Sciences, University of Virginia 2004

    • Full Name

  • Daniel Smith