• Daniel L. Smith Jr., Ph.D., is an Assistant Professor in the Department of Nutrition Sciences at UAB. His research focuses on the interaction of nutrition and metabolism in relationship to aging and disease. Topics include: obesity, calorie restriction, calorie restriction mimetics, brown adipose tissue, ulcerative dermatitis in C57BL/6 mice, and systems biology of aging using budding yeast chronological lifespan.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Randomization, design and analysis for interdependency in aging research: no person or mouse is an island 2022
    2022 Effects of an exogenous ketone ester using multi-omics in skeletal muscle of aging C57BL/6J male miceFrontiers in Nutrition.  9. 2022
    2022 Macronutrient Ratio Modification in a Semi-Purified Diet Composition: Effects on Growth and Body Composition of Juvenile Zebrafish Danio rerioProgressive Fish-Culturist.  84:493-504. 2022
    2022 A modified standard American diet induces physiological parameters associated with metabolic syndrome in C57BL/6J miceFrontiers in Nutrition.  9. 2022
    2022 French-fried potato consumption and energy balance: A randomized controlled trialAmerican Journal of Clinical Nutrition.  115:1626-1636. 2022
    2022 Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's diseaseActa Pharmaceutica Sinica B.  12:511-531. 2022
    2021 University of Alabama at Birmingham Nathan Shock Center: comparative energetics of agingGeroscience.  43:2149-2160. 2021
    2021 Diabetes medications as potential calorie restriction mimetics—a focus on the alpha-glucosidase inhibitor acarboseGeroscience.  43:1123-1133. 2021
    2021 High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal SignalingFrontiers in Neuroscience.  15. 2021
    2021 Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy xray absorptiometry in a prospective studyPLoS One.  16. 2021
    2021 High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availabilityGeroscience.  43:941-964. 2021
    2020 A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.Journal of Biological Chemistry.  296:100125. 2020
    2020 Canagliflozin extends life span in genetically heterogeneous male but not female miceJCI Insight.  5. 2020
    2020 The antidiabetic agent acarbose improves anti-PD-1 and rapamycin efficacy in preclinical renal cancerCancers.  12:1-19. 2020
    2020 Exogenous Dietary Ketone Ester Decreases Body Weight and Adiposity in Mice Housed at ThermoneutralityObesity.  28:1447-1455. 2020
    2020 A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism 2020
    2020 Energy Balance as a Moderator of Neurologic Disease Risk and ProgressionNeurotoxicity Research.  38:242-248. 2020
    2020 Murine genetic models of obesity: type I error rates and the power of commonly used analyses as assessed by plasmode-based simulationInternational Journal of Obesity.  44:1440-1449. 2020
    2020 High-resolution yeast quiescence profiling in human-like media reveals interacting influences of auxotrophy and nutrient availability 2020
    2020 Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice 2020
    2019 Differences in Glucose Metabolism Among Women With Spinal Cord Injury May Not Be Fully Explained by Variations in Body CompositionArchives of Physical Medicine and Rehabilitation.  100:1061-1067.e1. 2019
    2019 A Systematic Scoping Review of Surgically Manipulated Adipose Tissue and the Regulation of Energetics and Body Fat in AnimalsObesity.  27:1404-1417. 2019
    2019 Dietary R,S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet 2019
    2018 Weight Cycling Increases Longevity Compared with Sustained Obesity in MiceObesity.  26:1733-1739. 2018
    2018 A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring 2018
    2018 Regression to the mean, apparent data errors and biologically extraordinary results: Letter regarding 'changes in telomere length 3-5 years after gastric bypass surgery'International Journal of Obesity.  42:949-950. 2018
    2018 Sex-dependent differences in liver and gut metabolomic profiles with acarbose and calorie restriction in C57BL/6 mice 2018
    2016 Gene-nutrient interaction markedly influences yeast chronological lifespanExperimental Gerontology.  86:113-123. 2016
    2016 Nutrition and energetics in rodent longevity researchExperimental Gerontology.  86:90-96. 2016
    2016 Observational research rigour alone does not justify causal inferenceEuropean Journal of Clinical Investigation.  46:985-993. 2016
    2016 Targeting glucose metabolism for healthy aging. 2016
    2016 Contributors to Metabolic Disease Risk Following Spinal Cord InjuryCurrent Physical Medicine and Rehabilitation Reports.  4:190-199. 2016
    2016 In Vivo Determination of Body Composition in Zebrafish (Danio rerio) by Quantitative Magnetic ResonanceZebrafish.  13:170-176. 2016
    2015 Weighing the Evidence of Common Beliefs in Obesity ResearchCritical Reviews in Food Science and Nutrition.  55:2014-2053. 2015
    2015 Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence?Aging Cell.  14:483-490. 2015
    2015 Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populationsAging.  7:177-194. 2015
    2014 Impact of weight cycling on risk of morbidity and mortalityObesity Reviews.  15:870-881. 2014
    2014 Variations in body weight, Food Intake and body composition after long-term high-fat diet feeding in C57BL/6J miceObesity.  22:2147-2155. 2014
    2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
    2014 Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in malesAging Cell.  13:273-282. 2014
    2013 Measurement of interscapular brown adipose tissue of mice in differentially housed temperatures by chemical-shift-encoded water-fat MRIJournal of Magnetic Resonance Imaging.  38:1425-1433. 2013
    2013 Sarcopenia and piscines: The case for indeterminate-growing fish as unique genetic model organisms in aging and longevity researchFrontiers in Genetics.  4. 2013
    2013 Dietary protein source influence on body size and composition in growing zebrafishZebrafish.  10:439-446. 2013
    2013 Effects of risperidone on energy balance in female C57BL/6J miceObesity.  21:1850-1857. 2013
    2013 Myths, presumptions, and facts about obesityNew England Journal of Medicine.  368:446-454. 2013
    2013 Chemical-shift water-fat MRI of white adipose depots: inability to resolve cell size differences.International Journal of Body Composition Research.  11:9-16. 2013
    2012 Variations in T 2* and fat content of murine brown and white adipose tissues by chemical-shift MRIMagnetic Resonance Imaging.  30:323-329. 2012
    2012 Ambient Temperature and ObesityCurrent Obesity Reports.  1:26-34. 2012
    2012 Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevityAnnals of the New York Academy of Sciences.  1264:1-12. 2012
    2011 Telomere dynamics in rhesus monkeys: No apparent effect of caloric restriction 2011
    2011 MR properties of brown and white adipose tissuesJournal of Magnetic Resonance Imaging.  34:468-473. 2011
    2011 No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weightInternational Journal of Obesity.  35:652-657. 2011
    2011 Can rodent longevity studies be both short and powerful? 2011
    2010 Identification of brown adipose tissue in mice with fat-water IDEAL-MRIJournal of Magnetic Resonance Imaging.  31:1195-1202. 2010
    2010 Metformin supplementation and life span in fischer-344 rats 2010
    2010 The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J miceObesity.  18:995-999. 2010
    2010 A microarray-based genetic screen for yeast chronological aging factorsPLoS Genetics.  6. 2010
    2010 Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in ratsToxicology and Applied Pharmacology.  243:332-339. 2010
    2010 Mild calorie restriction induces fat accumulation in female C57BL/6J miceObesity.  18:456-462. 2010
    2010 Calorie restriction: What recent results suggest for the future of ageing researchEuropean Journal of Clinical Investigation.  40:440-450. 2010
    2009 Calorie restriction effects on silencing and recombination at the yeast rDNAAging Cell.  8:633-642. 2009
    2009 Validation of quantitative magnetic resonance (QMR) for determination of body composition in rats.International Journal of Body Composition Research.  7:99-107. 2009
    2009 Precision and accuracy of bioimpedance spectroscopy for determination of in vivo body composition in rats.International Journal of Body Composition Research.  7:21-26. 2009
    2008 Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae 2008
    2007 Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the SirtuinsAging Cell.  6:649-662. 2007
    2007 DNA replication stress is a determinant of chronological lifespan in budding yeastPLoS One.  2. 2007
    2004 Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and LongevityMolecular and Cellular Biology.  24:1301-1312. 2004

    Education And Training

  • Doctor of Philosophy in Molecular Biochemistry, University of Virginia 2007
  • Master of Science in Biological and Physical Sciences, University of Virginia 2004
  • Full Name

  • Daniel Smith