Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancerCell Death and Disease.  12. 2021
2021 Spt4 promotes pol i processivity and transcription elongationGenes.  12. 2021
2021 Defining the divergent enzymatic properties of RNA polymerases I and IIJournal of Biological Chemistry.  296. 2021
2021 The N-terminal domain of the A12.2 subunit stimulates RNA polymerase I transcription elongationBiophysical Journal2021
2020 Defining the divergent enzymatic properties of RNA polymerases I and II.Journal of Biological Chemistry.  296:100051. 2020
2020 Downstream sequence-dependent RNA cleavage and pausing by RNA polymerase IJournal of Biological Chemistry.  295:1288-1299. 2020
2020 Downstream sequence-dependent RNA cleavage and pausing by RNA polymerase IJournal of Biological Chemistry.  295:1288-1299. 2020
2019 Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategiesBiochemical Journal.  476:2209-2219. 2019
2019 A Novel Assay for RNA Polymerase i Transcription Elongation Sheds Light on the Evolutionary Divergence of Eukaryotic RNA PolymerasesBiochemistry2019
2018 The A12.2 Subunit Is an Intrinsic Destabilizer of the RNA Polymerase I Elongation ComplexBiophysical Journal.  114:2507-2515. 2018
2018 Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation CheckpointCell Reports.  23:404-414. 2018
2017 Quantifying the influence of 5′-RNA modifications on RNA polymerase I activityBiophysical Chemistry.  230:84-88. 2017
2017 Targeting RNA-polymerase I in both chemosensitive and chemoresistant populations in epithelial ovarian cancerClinical Cancer Research.  23:6529-6540. 2017
2017 Multisubunit RNA Polymerase Cleavage Factors Modulate the Kinetics and Energetics of Nucleotide Incorporation: An RNA Polymerase i Case StudyBiochemistry.  56:5654-5662. 2017
2017 The voice of lived experience: mobile video narratives in the courtroomInformation, Communication and Society.  20:335-350. 2017
2017 Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved? 2017
2016 The transcription factor THO promotes transcription initiation and elongation by RNA Polymerase IJournal of Biological Chemistry.  291:3010-3018. 2016
2015 Transient-State Kinetic Analysis of the RNA Polymerase i Nucleotide Incorporation MechanismBiophysical Journal.  109:2382-2393. 2015
2015 A Single Molecule Perspective of Elongation by RNA Polymerase IBiophysical Journal.  108:508a-508a. 2015
2015 Functional divergence of eukaryotic RNA polymerases: Unique properties of RNA polymerase I suit its cellular roleGene.  556:19-26. 2015
2014 Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: Implications for amyotrophic lateral sclerosisJournal of Biological Chemistry.  289:31792-31804. 2014
2014 Differences in the composition of the human antibody repertoire by b cell subsets in the bloodFrontiers in Immunology.  5. 2014
2014 Single Molecule Investigation of RNA Polymerase I using Multiplexed Tethered Particle MotionBiophysical Journal.  106:489a-489a. 2014
2013 Divergent contributions of conserved active site residues to transcription by Eukaryotic RNA polymerases I and IICell Reports.  4:974-984. 2013
2013 DNA binding by the ribosomal DNA transcription factor Rrn3 is essential for ribosomal DNA transcriptionJournal of Biological Chemistry.  288:9135-9144. 2013
2013 Single Molecule Characterization of RNA Polymerase I: Force Free Kinetic MeasurementsBiophysical Journal.  104:585a-585a. 2013
2013 Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progressionCell Cycle.  12:3408-3416. 2013
2012 RNA polymerase I activity is regulated at multiple steps in the transcription cycle: Recent insights into factors that influence transcription elongationGene.  493:176-184. 2012
2012 Efficient transcription by RNA polymerase I using recombinant core factorGene.  492:94-99. 2012
2011 The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negativelyJournal of Biological Chemistry.  286:18816-18824. 2011
2011 Yeast transcription elongation factor Spt5 associates with RNA polymerase I and RNA polymerase II directlyJournal of Biological Chemistry.  286:18825-18833. 2011
2010 The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesisJournal of Biological Chemistry.  285:14152-14159. 2010
2004 DksA: A critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTPCell.  118:311-322. 2004
2004 Relationship between growth rate and ATP concentration in escherichia coli: A bioassay for available cellular ATPJournal of Biological Chemistry.  279:8262-8268. 2004
2003 Changes in Escherichia coli rRNA promoter activity correlate with changes in initiating nucleoside triphosphate and guanosine 5′ diphosphate 3′-diphosphate concentrations after induction of feedback control of ribosome synthesisJournal of Bacteriology.  185:6185-6191. 2003
2003 Changes in the concentrations of guanosine 5′-diphosphate 3′-diphosphate and the initiating nucleoside triphosphate account for inhibition of rRNA transcription in fructose-1,6-diphosphate aldolase (fda) mutantsJournal of Bacteriology.  185:6192-6194. 2003
2003 An intersubunit contact stimulating transcription initiation by E. coli RNA polymerase: Interaction of the α C-terminal domain and σ region 4Genes and Development.  17:1293-1307. 2003
2003 Control of rRNA expression in Escherichia coliCurrent Opinion in Microbiology.  6:151-156. 2003

Teaching Activities

  • GBS794 - Lab Rotation 4 (Summer Term 2020) 2020
  • GBS796 - Lab Rotation 2 (Summer Term 2020) 2020
  • GBS798 - Non dissertation Research (Summer Term 2020) 2020
  • GBS799 - Dissertation Research (Summer Term 2020) 2020
  • GBSC737 - Independent Study (Summer Term 2020) 2020
  • GBS783 - Advanced RNA Biology (Spring Term 2020) 2020
  • GBS794 - Lab Rotation 4 (Spring Term 2020) 2020
  • GBS795 - Lab Rotation 1 (Spring Term 2020) 2020
  • GBS797 - Lab Rotation 3 (Spring Term 2020) 2020
  • GBS798 - Non dissertation Research (Spring Term 2020) 2020
  • GBS799 - Dissertation Research (Spring Term 2020) 2020
  • GBSC700 - Journal Clubs (Spring Term 2020) 2020
  • GBSC737 - Independent Study (Spring Term 2020) 2020
  • GBSC737 - Independent Study (Spring Term 2020) 2020
  • GBSC737 - Independent Study (Spring Term 2020) 2020
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2019) 2019
  • GBS794 - Lab Rotation 4 (Fall Term 2019) 2019
  • GBS795 - Lab Rotation 1 (Fall Term 2019) 2019
  • GBS796 - Lab Rotation 2 (Fall Term 2019) 2019
  • GBS797 - Lab Rotation 3 (Fall Term 2019) 2019
  • GBS798 - Non dissertation Research (Fall Term 2019) 2019
  • GBS799 - Dissertation Research (Fall Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2019) 2019
  • GBSC737 - Independent Study (Fall Term 2019) 2019
  • GBSC737 - Independent Study (Fall Term 2019) 2019
  • GBSC737 - Independent Study (Fall Term 2019) 2019
  • GBS794 - Lab Rotation 4 (Summer Term 2019) 2019
  • GBS795 - Lab Rotation 1 (Summer Term 2019) 2019
  • GBS798 - Non dissertation Research (Summer Term 2019) 2019
  • GBS799 - Dissertation Research (Summer Term 2019) 2019
  • GBSC737 - Independent Study (Summer Term 2019) 2019
  • GBS783 - Advanced RNA Biology (Spring Term 2019) 2019
  • GBS794 - Lab Rotation 4 (Spring Term 2019) 2019
  • GBS797 - Lab Rotation 3 (Spring Term 2019) 2019
  • GBS798 - Non dissertation Research (Spring Term 2019) 2019
  • GBS799 - Dissertation Research (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC737 - Independent Study (Spring Term 2019) 2019
  • GBSC737 - Independent Study (Spring Term 2019) 2019
  • GBSC737 - Independent Study (Spring Term 2019) 2019
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2018) 2018
  • GBS725 - Crafting a Research Proposal (Fall Term 2018) 2018
  • GBS795 - Lab Rotation 1 (Fall Term 2018) 2018
  • GBS796 - Lab Rotation 2 (Fall Term 2018) 2018
  • GBS797 - Lab Rotation 3 (Fall Term 2018) 2018
  • GBS798 - Non dissertation Research (Fall Term 2018) 2018
  • GBS799 - Dissertation Research (Fall Term 2018) 2018
  • GBSC700 - Journal Clubs (Fall Term 2018) 2018
  • GBSC737 - Independent Study (Fall Term 2018) 2018
  • GBSC737 - Independent Study (Fall Term 2018) 2018
  • GBSC737 - Independent Study (Fall Term 2018) 2018
  • GBS794 - Lab Rotation 4 (Summer Term 2018) 2018
  • GBS795 - Lab Rotation 1 (Summer Term 2018) 2018
  • GBS798 - Non dissertation Research (Summer Term 2018) 2018
  • GBS799 - Dissertation Research (Summer Term 2018) 2018
  • GBS746 - Special Topics (Spring Term 2018) 2018
  • GBS783 - RNA Biology (Spring Term 2018) 2018
  • GBS794 - Lab Rotation 4 (Spring Term 2018) 2018
  • GBS797 - Lab Rotation 3 (Spring Term 2018) 2018
  • GBS798 - Non dissertation Research (Spring Term 2018) 2018
  • GBS799 - Dissertation Research (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Spring Term 2018) 2018
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2017) 2017
  • GBS795 - Lab Rotation 1 (Fall Term 2017) 2017
  • GBS796 - Lab Rotation 2 (Fall Term 2017) 2017
  • GBS797 - Lab Rotation 3 (Fall Term 2017) 2017
  • GBS798 - Non dissertation Research (Fall Term 2017) 2017
  • GBS799 - Dissertation Research (Fall Term 2017) 2017
  • GBSC700 - Journal Clubs (Fall Term 2017) 2017
  • GBS794 - Lab Rotation 4 (Summer Term 2017) 2017
  • GBS795 - Lab Rotation 1 (Summer Term 2017) 2017
  • GBS798 - Non dissertation Research (Summer Term 2017) 2017
  • GBS799 - Dissertation Research (Summer Term 2017) 2017
  • GBS783 - RNA Biology (Spring Term 2017) 2017
  • GBS794 - Lab Rotation 4 (Spring Term 2017) 2017
  • GBS797 - Lab Rotation 3 (Spring Term 2017) 2017
  • GBS798 - Non dissertation Research (Spring Term 2017) 2017
  • GBS799 - Dissertation Research (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Spring Term 2017) 2017
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2016) 2016
  • GBS795 - Lab Rotation 1 (Fall Term 2016) 2016
  • GBS796 - Lab Rotation 2 (Fall Term 2016) 2016
  • GBS797 - Lab Rotation 3 (Fall Term 2016) 2016
  • GBS798 - Non dissertation Research (Fall Term 2016) 2016
  • GBS799 - Dissertation Research (Fall Term 2016) 2016
  • GBSC700 - Journal Clubs (Fall Term 2016) 2016
  • GBS794 - Lab Rotation 4 (Summer Term 2016) 2016
  • GBS795 - Lab Rotation 1 (Summer Term 2016) 2016
  • GBS797 - Lab Rotation 3 (Summer Term 2016) 2016
  • GBS798 - Non dissertation Research (Summer Term 2016) 2016
  • GBS799 - Dissertation Research (Summer Term 2016) 2016
  • GBS783 - RNA Biology (Spring Term 2016) 2016
  • GBS794 - Lab Rotation 4 (Spring Term 2016) 2016
  • GBS796 - Lab Rotation 2 (Spring Term 2016) 2016
  • GBS797 - Lab Rotation 3 (Spring Term 2016) 2016
  • GBS798 - Non dissertation Research (Spring Term 2016) 2016
  • GBS799 - Dissertation Research (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Spring Term 2016) 2016
  • GBSC701 - Seminars (Spring Term 2016) 2016
  • GBSC701 - Seminars (Spring Term 2016) 2016
  • GBS783 - RNA BIOLOGY (Spring Term 2016) 2016
  • GBS795 - Lab Rotation 1 (Fall Term 2015) 2015
  • GBS796 - Lab Rotation 2 (Fall Term 2015) 2015
  • GBS798 - Non dissertation Research (Fall Term 2015) 2015
  • GBS799 - Dissertation Research (Fall Term 2015) 2015
  • GBSC700 - Journal Clubs (Fall Term 2015) 2015
  • GBSC700 - Journal Clubs (Fall Term 2015) 2015
  • GBSC701 - Seminars (Fall Term 2015) 2015
  • GBSC701 - Seminars (Fall Term 2015) 2015
  • GBS783 - RNA Biology (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Spring Term 2015) 2015
  • GBSC701 - Seminars (Spring Term 2015) 2015
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2014) 2014
  • GBS780 - BSB Lab Methods (Fall Term 2014) 2014
  • GBSC700 - Journal Clubs (Fall Term 2014) 2014
  • GBSC701 - Seminars (Fall Term 2014) 2014
  • GBSC701 - Seminars (Fall Term 2014) 2014
  • BMG769 - Graduate Student Research Mtg (Spring Term 2014) 2014
  • BMG786 - Jour Club in Transcription (Spring Term 2014) 2014
  • BMG798 - Non-Dissertation Research (Spring Term 2014) 2014
  • BMG799 - Dissertation Research (Spring Term 2014) 2014
  • GBS783 - RNA Biology (Spring Term 2014) 2014
  • BMG769 - Graduate Student Research Mtg (Fall Term 2013) 2013
  • BMG786 - Jour Club in Transcription (Fall Term 2013) 2013
  • BMG798 - Non-Dissertation Research (Fall Term 2013) 2013
  • BMG799 - Dissertation Research (Fall Term 2013) 2013
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2013) 2013
  • GBS780 - BSB Lab Methods (Fall Term 2013) 2013
  • BMG786 - Jour Club in Transcription (Spring Term 2013) 2013
  • GBS783 - RNA Biology (Spring Term 2013) 2013
  • GBS783 - RNA BIOLOGY (Spring Term 2013) 2013
  • BMG786 - Jour Club in Transcription (Fall Term 2012) 2012
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2012) 2012
  • BMG786 - Jour Club in Transcription (Spring Term 2012) 2012
  • GBS783 - 98 (Spring Term 2012) 2012
  • BMG786 - Jour Club in Transcription (Fall Term 2011) 2011
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • BMG786 - Jour Club in Transcription (Spring Term 2011) 2011
  • GBS761 - Eukaryotic Molecular Biology (Spring Term 2011) 2011
  • GBS783 - 98 (Spring Term 2011) 2011
  • BMG786 - Jour Club in Transcription (Fall Term 2010) 2010
  • BMG706 - RNA Bio:Metabolism & Action (Spring Term 2010) 2010
  • Education And Training

  • Doctor of Philosophy in Microbiology, University of Wisconsin System : Madison 2003
  • University of California, Irvine Biological Chemistry, Postdoctoral Fellowship 2007
  • Full Name

  • David Schneider