Positions

Overview

  • Dennis Pillion has been a diabetes researcher and educator at UAB since 1979. In 2011 he retired from full-time work to assume a position as a part-time Professor. He currently lectures on Pharmacology to first and second year students in the schools of Medicine, Dentistry and Optometry. He also teaches a course to undergraduate students in the Science and Technology Honors Program. As a volunteer, he serves as an advisor to the Alabama camp for children with diabetes and he is the Chairman of the Board of Directors of the international Diabetes Education and Camping Association.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2013 High efficiency intranasal drug delivery using IntravailĀ® alkylsaccharide absorption enhancers.Drug Delivery and Translational Research.  3:16-25. 2013
    2010 Reestablishment of the nasal permeability barrier to several peptides following exposure to the absorption enhancer tetradecyl-beta-D-maltoside.Journal of Pharmaceutical Sciences.  99:1912-1920. 2010
    2010 Nasal absorption of mixtures of fast-acting and long-acting insulins.International Journal of Pharmaceutics.  388:202-208. 2010
    2010 Highly bioavailable nasal calcitonin - Potential for expanded use in analgesiaDrug Delivery Technology.  10:58-63. 2010
    2006 Oral ddAVP for nighttime urinary incontinence in characterized nursing home residents: a pilot study.Journal of the American Medical Directors Association.  7:6-11. 2006
    2004 Correlation of tetradecylmaltoside induced increases in nasal peptide drug delivery with morphological changes in nasal epithelial cells.Journal of Pharmaceutical Sciences.  93:2205-2213. 2004
    2004 Obstructive sleep apnea, nocturia and polyuria in older adults.Sleep.  27:139-144. 2004
    2003 Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-beta-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-).European Journal of Pharmaceutical Sciences.  20:27-34. 2003
    2003 Arginine vasopressin and nocturnal polyuria in older adults with frequent nighttime voidingJournal of Urology, The.  170:480-484. 2003
    2003 Arginine vasopressin and nocturnal polyuria in older adults with frequent nighttime voiding.Journal of Urology, The.  170:480-484. 2003
    2003 Sucrose cocoate, a component of cosmetic preparations, enhances nasal and ocular peptide absorption.International Journal of Pharmaceutics.  251:195-203. 2003
    2002 Nasal administration of low molecular weight heparin.Journal of Pharmaceutical Sciences.  91:1707-1714. 2002
    2002 Synthetic long-chain alkyl maltosides and alkyl sucrose esters as enhancers of nasal insulin absorption.Journal of Pharmaceutical Sciences.  91:1456-1462. 2002
    2002 Nocturnal polyuria in type 2 diabetes: a symptom of obstructive sleep apnea.Diabetes Educator.  28:424-434. 2002
    2001 Enhanced bioavailability of calcitonin formulated with alkylglycosides following nasal and ocular administration in rats.Pharmaceutical Research.  18:1742-1746. 2001
    2001 Mutual inhibition of the insulin absorption-enhancing properties of dodecylmaltoside and dimethyl-beta-cyclodextrin following nasal administration.Pharmaceutical Research.  18:608-614. 2001
    2000 Sleep apnea symptoms, nocturia, and diabetes in African-American community dwelling older adults.Journal- National Black Nurses Association.  11:25-33. 2000
    1998 Dodecylmaltoside-mediated nasal and ocular absorption of lyspro-insulin: independence of surfactant action from multimer dissociation.Pharmaceutical Research.  15:1637-1639. 1998
    1996 Structure-function relationship among Quillaja saponins serving as excipients for nasal and ocular delivery of insulin.Journal of Pharmaceutical Sciences.  85:518-524. 1996
    1995 DS-1, a modified Quillaja saponin, enhances ocular and nasal absorption of insulin.Journal of Pharmaceutical Sciences.  84:1276-1279. 1995
    1995 Misoprostol Modulation of Dendritic Cell Function in Immune Responses.American Journal of Therapeutics.  2:626-629. 1995
    1995 Systemic absorption of insulin and glucagon applied topically to the eyes of rats and a diabetic dog.Journal of Ocular Pharmacology and Therapeutics.  11:283-295. 1995
    1994 Alkylglycosides enhance systemic absorption of insulin applied topically to the rat eye.Journal of Pharmacology and Experimental Therapeutics.  271:1274-1280. 1994
    1994 Insulin delivery in nosedrops: new formulations containing alkylglycosides.Endocrinology.  135:2386-2391. 1994
    1994 Protein crystal growth in microgravity-temperature induced large scale crystallization of insulin.Microgravity Science and Technology.  7:196-202. 1994
    1994 Xylosyl transfer to an endogenous renal acceptor. Characteristics of the reaction and properties of the product.Journal of Biological Chemistry.  269:11503-11508. 1994
    1994 Efficacy of insulin eyedrops.Journal of ocular pharmacology.  10:461-470. 1994
    1994 Insulin administration to the eyes of normoglycemic human volunteers.Journal of ocular pharmacology.  10:683-690. 1994
    1994 Insulin delivery in nosedrops: New formulations containing alkylglycosidesEndocrinology.  135:2386-2391. 1994
    1994 Toxicity of insulin administered chronically to human eye in vivo.Journal of ocular pharmacology.  10:101-107. 1994
    1993 Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cells.American Journal of Physiology.  264:R1101-R1110. 1993
    1993 Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cellsAmerican Journal of Physiology.  264. 1993
    1992 Glucagon administration to the rat via eye drops.Journal of ocular pharmacology.  8:349-358. 1992
    1992 Insulin signal transduction: the role of protein phosphorylation.American Journal of the Medical Sciences.  303:40-52. 1992
    1991 Identification of macrophage cell-surface binding sites for cationized bovine serum albumin.Biochemical and Biophysical Research Communications.  181:787-796. 1991
    1991 Apolipoprotein A-I decreases neutrophil degranulation and superoxide production.Journal of Lipid Research.  32:1911-1918. 1991
    1991 Systemic absorption of insulin delivered topically to the rat eye.Investigative Ophthalmology & Visual Science.  32:3021-3027. 1991
    1991 Insulin-sensitive myelin basic protein phosphorylation on tyrosine residues.Biochemical and Biophysical Research Communications.  179:392-400. 1991
    1991 Glomerular development in intraocular and intrarenal grafts of fetal kidneys.Laboratory Investigation.  64:629-639. 1991
    1991 Increased sensitivity of 32P and 125I counted in the presence of a solid scintillator: detection of protein bands separated by polyacrylamide gel electrophoresis.Journal of Biochemical and Biophysical Methods.  22:89-92. 1991
    1990 Angiotensin II and bradykinin stimulate phosphoinositide breakdown in intact rat kidney glomeruli but not in proximal tubules: glomerular response modulated by phorbol ester.Biochemical and Biophysical Research Communications.  166:373-379. 1990
    1990 Renal glomerular and tubular insulin and insulin-like growth factor receptors.Contributions to Nephrology.  83:60-66. 1990
    1989 Receptors for insulin and insulin-like growth factor-I in the human adrenal gland.Biochemical and Biophysical Research Communications.  165:204-211. 1989
    1989 Receptors for IGF-I, but not for IGF-II, on proximal colon epithelial cell apical membranes.American Journal of Physiology.  257:E27-E34. 1989
    1989 Insulin receptor overexpression in a human pre-B acute lymphocytic leukemia cell line with a t(1;19) chromosome translocation near the INSR locus.Biochemical and Biophysical Research Communications.  159:1275-1282. 1989
    1989 Colonic absorption of insulin: an in vitro and in vivo evaluation.Journal of Pharmacology and Experimental Therapeutics.  248:567-572. 1989
    1989 Evidence for vasoactive intestinal peptide receptors in apical membranes from tracheal epithelium.Life Sciences.  44:1037-1042. 1989
    1988 Binding and degradation of 125I-insulin by isolated rat renal brush border membranes: evidence for low affinity, high capacity insulin recognition sites.Journal of Membrane Biology.  105:113-129. 1988
    1988 Distinct receptors for insulin-like growth factor I in rat renal glomeruli and tubules.American Journal of Physiology.  255:E504-E512. 1988
    1988 Specific, high affinity receptors for insulin-like growth factor II in the rat kidney glomerulus.Endocrinology.  123:774-780. 1988
    1988 Distribution of receptors for insulin and insulin-like growth factor I (somatomedin C) in the adrenal gland.Biochemical and Biophysical Research Communications.  154:138-145. 1988
    1988 Effect of haemolysis on radioimmunoassay for insulin.Diabetologia.  31:403-404. 1988
    1988 Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats.American Journal of Physiology.  254:E749-E755. 1988
    1988 Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats.American Journal of Physiology.  254:E749-E755. 1988
    1988 Isolation and characterization of insulin receptors from rat kidney glomeruli and tubules.Biochemical and Biophysical Research Communications.  151:370-381. 1988
    1987 Enantiomeric composition analysis of amphetamine and methamphetamine by chiral phase high-performance liquid chromatography-mass spectrometry.J Chromatogr.  398:239-246. 1987
    1987 Chloride measurement by microelectrode in cystic fibrosis and normal sweat.Mineral and Electrolyte Metabolism.  13:196-200. 1987
    1986 Comparison of insulin receptors from bovine retinal blood vessels and nonvascular retinal tissue.Investigative Ophthalmology & Visual Science.  27:1681-1690. 1986
    1985 Differential effects of insulin, antibodies against rat adipocyte plasma membranes, and other agents that mimic insulin action in rat adipocytes.Metabolism.  34:1012-1019. 1985
    1985 Sulfate transport in human lung fibroblasts (IMR-90).Journal of Cellular Physiology.  125:243-250. 1985
    1985 Liquid-chromatographic determination of chloride in sweat from cystic fibrosis patients and normal persons.Clinical Chemistry.  31:1155-1157. 1985
    1985 Identification of insulin receptors on the mucosal surface of colon epithelial cells.Journal of Biological Chemistry.  260:5244-5247. 1985
    1985 Identification of the insulin receptor of cerebral microvessels.American Journal of Physiology.  248:E115-E125. 1985
    1984 Polyamines stimulate D-glucose transport in isolated renal brush-border membrane vesicles.BBA - Biochimica et Biophysica Acta.  777:1-8. 1984
    1984 Serum sulfate levels in patients with cystic fibrosis.Clinica Chimica Acta.  142:241-247. 1984
    1984 Identification and characterization of the insulin receptor of bovine retinal microvessels.Endocrinology.  115:698-704. 1984
    1984 Differential effects of insulin and agents that mimic insulin action on rat adipocyte glucose oxidation and lipogenesisFederation proceedings.  43. 1984
    1984 Immunofluorescent studies of the rat adipocyte cell surface.International Journal of Immunopharmacology.  6:193-204. 1984
    1984 Serum sulfate levels in patients with cystic fibrosisFederation proceedings.  43. 1984
    1984 Sulfate utilization in human lung fibroblasts (IMR-90)Federation proceedings.  43. 1984
    1982 Cerebral cortical microvessels: an insulin-sensitive tissue.Biochemical and Biophysical Research Communications.  104:686-692. 1982
    1982 Response of cyclic AMP phosphodiesterase to insulin in rat renal tissueFederation proceedings.  41:4107. 1982
    1982 Stimulation of glucose oxidation and cyclic-AMP phosphodiesterase activity by insulin in bovine retinal microvesselsFederation proceedings.  41:5596. 1982
    1982 Stimulation of microvascular cyclic-AMP phosphodiesterase activity by insulin, spermine and concanavalinDiabetes.  31. 1982
    1982 Utilization of antibodies against rat adipocyte membranes as a probe of insulin actionInternational Journal of Immunopharmacology.  4:292. 1982
    1980 Isolation of adipocyte plasma membrane antigens by immunoaffinity chromatography. Insulinomimetic antibodies do not bind directly to the insulin receptor or the glucose transport system.Journal of Biological Chemistry.  255:9168-9176. 1980
    1980 Reconstituted D-glucose transport from the adipocyte plasma membrane. Chromatographic resolution of transport activity from membrane glycoproteins using immobilized concanavalin A.Biochemistry.  19:2374-2385. 1980
    1979 Biological properties of antibodies against rat adipocyte intrinsic membrane proteins. Dependence on multivalency for insulin-like activity.Journal of Biological Chemistry.  254:3211-3220. 1979
    1979 alpha-Methyl-D-glucoside uptake in renal cortical slices of normal and alloxan diabetic rabbits.Archives internationales de physiologie et de biochimie.  87:245-252. 1979
    1979 Molecular basis of the insulin-like action of antibodies against the partially purified adipocyte hexose transport systemFederation proceedings.  38. 1979
    1978 Antibodies against intrinsic adipocyte plasma membrane proteins activate D-glucose transport independent of interaction with insulin binding sites.Journal of Biological Chemistry.  253:3761-3764. 1978
    1978 Resistance of the intact and reconstituted adipocyte hexose transport system to irreversible inhibition by sulfhydryl and amino reagents.Journal of supramolecular structure.  9:363-371. 1978
    1978 Retention of insulin-stimulated D-glucose transport activity by adipocyte plasma membranes following extraction of extrinsic proteins.Journal of supramolecular structure.  8:269-277. 1978
    1977 The role of glutathione in renal cortical tissue. Effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity.Enzymologia.  18:109-115. 1977
    1977 Selective extraction of an intrinsic fat-cell plasma-membrane glycoprotein by Triton X-100. Correlation with [3H]cytochalasin B binding activity.FEBS Letters.  83:71-75. 1977
    1977 Characterization of the insulin-sensitive d-glucose transport system in plasma membrane vesicles from rat adipocytesJournal of Supramolecular and Cellular Biochemistry.  6. 1977
    1976 Extraction of glutathione by the isolated perfused rabbit kidney.Journal of Surgical Research.  21:169-174. 1976
    1976 Gamma-glutamyl transpeptidase in the urine from an isolated rabbit kidney perfused with and without DMSO.Biochemical Pharmacology.  25:913-918. 1976
    1976 Inhibition of protein kinase activity and amino acid and alpha-methyl-D-glucoside transport by diamide.BBA - Biochimica et Biophysica Acta.  419:104-111. 1976
    1975 Specific inhibition of protein kinase by diazenedicarboxylic acid bis-(N,N-dimethylamide).Biochemical and Biophysical Research Communications.  64:433-440. 1975
    1975 The effect of diamide and glutathione on the uptake of alpha-methyl-D-glucoside by slices of rat kidney cortex.BBA - Biochimica et Biophysica Acta.  382:246-252. 1975

    Research Overview

  • Dr. Pillion previously studied insulin binding, delivery and action. He has patented through the UAB Research Foundation a series of excipients that can be used to deliver drugs nasally. This patent is licensed to Aegis Therapeutics, LLC in San Diego, CA.
  • Teaching Activities

  • STH299 - Interdisciplinary Seminar (Fall Term 2018) 2018
  • STH299 - Interdisciplinary Seminar (Fall Term 2017) 2017
  • OBHS112 - Fundamentals Dent/Optometry II (Fall Term 2012) 2012
  • OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2011) 2011
  • OBHS221 - Sys 6 Hematology/Endocrine (Fall Term 2010) 2010
  • DENT2101 - Respiratory Systems (Fall Term 2010) 2010
  • DENT2102 - Musculoskeletal & GI Systems (Fall Term 2010) 2010
  • DENT2105 - Hematology-Endocrinology (Fall Term 2010) 2010
  • DENT2106 - Board Review (Fall Term 2010) 2010
  • OBHS211 - System 5 Musc/Skel/Skin/Gastro (Fall Term 2010) 2010
  • OBHS151 - System 5 Respiratory (Summer Term 2010) 2010
  • OBHS141 - System 3 Cardio/Renal/GU (Spring Term 2010) 2010
  • OBHS141L - Sys. 3 Cardio/Renal/GU Lab (Spring Term 2010) 2010
  • DENT1205 - Cardiovascular & Renal Systems (Spring Term 2010) 2010
  • OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2009) 2009
  • OBHS221 - Sys 8 Hematology/Endocrine (Fall Term 2009) 2009
  • OPVS121 - Basic Science/Clin Opt II (Fall Term 2009) 2009
  • DENT2101 - Respiratory Systems (Fall Term 2009) 2009
  • DENT2102 - Musculoskeletal Systems (Fall Term 2009) 2009
  • DENT2103 - GI Systems (Fall Term 2009) 2009
  • DENT2105 - Hematology-Endocrinology (Fall Term 2009) 2009
  • DENT2106 - Board Review (Fall Term 2009) 2009
  • PHR701 - Graduate Pharmacology I (Fall Term 2009) 2009
  • OBHS211 - System 6 Musc/Skel/Skin (Fall Term 2009) 2009
  • OBHS212 - System 7 Gastrointestinal (Fall Term 2009) 2009
  • OBHS151 - System 5 Respiratory (Summer Term 2009) 2009
  • DENT1203 - Neuroanatomy (Spring Term 2009) 2009
  • DENT1205 - Cardiovascular Systems (Spring Term 2009) 2009
  • DENT1206 - Renal Systems (Spring Term 2009) 2009
  • OBHS141 - System 3 Cardiovascular (Spring Term 2009) 2009
  • OBHS142 - System 4 Renal/GenU (Spring Term 2009) 2009
  • DENT2237 - Pharmacology (Spring Term 2009) 2009
  • OPT507 - Diabetes Eye and Health Care (Spring Term 2009) 2009
  • PHR200 - General Pharmacology (Winter Term 2009) 2008 - 2009
  • PHR701 - Graduate Pharmacology I (Fall Term 2008) 2008
  • PHR702 - Graduate Pharmacology II (Fall Term 2008) 2008
  • 01-723R - PHARMACOLOGY REMEDIATION (Spring Term 2008) 2008
  • OPT507 - Diabetes Eye and Health Care (Spring Term 2008) 2008
  • HON314 - Honors Prog: Sem in Medicine (Spring Term 2008) 2008
  • DENT2237 - Pharmacology (Winter Term 2008) 2007 - 2008
  • PHR200 - General Pharmacology (Winter Term 2008) 2007 - 2008
  • 01-723 - PHARMACOLOGY (Fall Term 2007) 2007
  • PHR701 - Graduate Pharmacology I (Fall Term 2007) 2007
  • PHR702 - Graduate Pharmacology II (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Medical College of Georgia
  • Brown University Physiological Chemistry, Postdoctoral Fellowship 1979
  • Full Name

  • Dennis Pillion
  • Blazerid

  • dpillion