Selected Publications

Academic Article

Year Title Altmetric
2022 Exploring the Effects of Six Weeks of Resistance Training on the Fecal Microbiome of Older Adult Males: Secondary Analysis of a Peanut Protein Supplemented Randomized Controlled TrialSports.  10. 2022
2022 Erratum: Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition (Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition (2010) 142(2) (309–319), (S0092867410006203), (10.1016/j.cell.2010.06.002))Cell.  185:746. 2022
2021 An open-label, pilot study of veliparib and lapatinib in patients with metastatic, triple-negative breast cancerBreast Cancer Research.  23. 2021
2021 Erratum: Host bioenergetic parameters reveal cytotoxicity of antituberculosis drugs undetected using conventional viability assays (Antimicrobial Agents and Chemotherapy (2021) 65:10 (e00932-21) DOI: 10.1128/AAC.00932-21)Antimicrobial Agents and Chemotherapy.  65. 2021
2021 Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophagesCancer Research.  81:5425-5437. 2021
2021 Host bioenergetic parameters reveal cytotoxicity of antituberculosis drugs undetected using conventional viability assaysAntimicrobial Agents and Chemotherapy.  65. 2021
2021 Nuclear Aurora-A kinase-induced hypoxia signaling drives early dissemination and metastasis in breast cancer: implications for detection of metastatic tumorsOncogene.  40:5651-5664. 2021
2021 The bet inhibitor JQ1 augments the antitumor efficacy of gemcitabine in preclinical models of pancreatic cancerCancers.  13. 2021
2021 Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumorsOncogenesis.  10. 2021
2021 Associations between dna damage and pd-l1 expression in ovarian cancer, a potential biomarker for clinical responseBiology.  10. 2021
2021 Merlin deficiency alters the redox management program in breast cancerMolecular Oncology.  15:942-956. 2021
2021 Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancerCell Death and Disease.  12. 2021
2021 A system for phenotype harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) programAmerican Journal of Epidemiology.  190:1977-1992. 2021
2020 CHD7 regulates cardiovascular development through ATP-dependent and -independent activities 2020
2020 Erratum: Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 (Journal of Clinical Investigation (2017) 127:8 (3075-3089) DOI: 10.1172/JCI89092)Journal of Clinical Investigation.  130:6187. 2020
2020 Hedgehog signaling enables repair of ribosomal DNA double-strand breaksNucleic Acids Research.  48:10342-10352. 2020
2020 Erratum: Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 (The Journal of clinical investigation PII: 142404)Journal of Clinical Investigation.  130:5027. 2020
2020 Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV InfectionFrontiers in Immunology.  11. 2020
2020 Erratum: Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection (BMC Infectious Diseases (2019) 19 (1046) DOI: 10.1186/s12879-019-4681-0)BMC Infectious Diseases.  20. 2020
2019 Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infectionBMC Infectious Diseases.  19. 2019
2019 MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancerOncogene.  38:4820-4834. 2019
2019 Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influxEBioMedicine.  44:209-224. 2019
2019 Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancerOncoImmunology.  8. 2019
2019 Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing RadiationCell Reports.  26:1893-1905.e7. 2019
2018 Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 ExpressionScientific Reports.  8. 2018
2018 Gene Expression Profiling of Advanced Penile Squamous Cell Carcinoma Receiving Cisplatin-based Chemotherapy Improves Prognostication and Identifies Potential Therapeutic TargetsEuropean urology focus.  4:733-736. 2018
2018 Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) studyHuman Molecular Genetics.  27:2940-2953. 2018
2018 Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing FactorsCancer Cell.  34:119-135.e10. 2018
2018 Composition and richness of the serum microbiome differ by age and link to systemic inflammationGeroscience.  40:257-268. 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumorsOncogene.  37:1610-1623. 2018
2017 Targeting RNA-polymerase I in both chemosensitive and chemoresistant populations in epithelial ovarian cancerClinical Cancer Research.  23:6529-6540. 2017
2017 The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metalActa Crystallographica. Section d, Structural Biology.  73:921-939. 2017
2017 The assembly competence domain is essential for inv(16)-associated acute myeloid leukemiaLeukemia.  31:2267-2271. 2017
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and InvasionJournal of Cellular Biochemistry.  118:2968-2976. 2017
2017 Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2Journal of Clinical Investigation.  127:3075-3089. 2017
2017 MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancerBreast Cancer Research.  19. 2017
2017 Pdgfrb is a direct regulatory target of TGFβ signaling in atrioventricular cushion mesenchymal cellsPLoS ONE.  12. 2017
2017 Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic ProgenySTEM CELLS.  35:473-484. 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targetsOncotarget.  8:21710-21718. 2017
2017 Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinomaOncotarget.  8:29220-29232. 2017
2016 Kinase gene expression profiling of metastatic clear cell renal cell carcinoma tissue identifies potential new therapeutic targetsPLoS ONE.  11. 2016
2016 A microscopic landscape of the invasive breast cancer genomeScientific Reports.  6. 2016
2016 Targeting TGF-β1 and AKT signal on growth and metastasis of anaplastic thyroid cancer cell in vivo 2016
2016 Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cellsClinical Cancer Research.  22:2545-2554. 2016
2016 Expression of the MHC class II pathway in triple-negative breast cancer tumor cells is associated with a good prognosis and infiltrating lymphocytesCancer Immunology Research.  4:390-399. 2016
2016 The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft modelsOncogene.  35:833-845. 2016
2016 Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancerProteomics.  16:516-531. 2016
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2016 ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breastOncotarget.  7:80655-80663. 2016
2015 Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicingeLife.  4. 2015
2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypesPLoS ONE.  10. 2015
2015 KIFC1 is a novel potential therapeutic target for breast cancerCancer Biology and Therapy.  16:1316-1322. 2015
2015 KAP1 promotes proliferation and metastatic progression of breast cancer cellsCancer Research.  75:344-355. 2015
2015 N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cellsScientific Reports.  5. 2015
2015 Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survivalOncogenesis.  4. 2015
2015 A Genomic Profile of the Immune Response to Stroke With Implications for Stroke RecoveryBiological Research for Nursing.  17:248-256. 2015
2015 FOXP3 controls an MIR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cellsCancer Research.  75:1703-1713. 2015
2015 S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinaseScientific Reports.  5. 2015
2015 Altered blood proteome in girls with high urine concentrations of bisphenol a, genistein, mono-ethyl hexylphthalate and mono-benzyl phthalate.MOJ Proteom Bioinform.  2:44-57. 2015
2015 Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubesNanoscale Research Letters.  10:1-12. 2015
2015 SEMA6D expression and patient survival in breast invasive carcinomaInternational Journal of Breast Cancer.  2015. 2015
2014 Altered serine/threonine kinase activity in schizophreniaBrain Research.  1568:42-54. 2014
2014 Transient knockdown of SULT4A1 induces upregulation of phototransduction proteinsThe FASEB Journal.  28:1064.19-1064.19. 2014
2014 Alterations in the rat serum proteome induced by prepubertal exposure to bisphenol A and genisteinJournal of Proteome Research.  13:1502-1514. 2014
2014 Comprehensive kinase profiling to classify clear cell (cc)-renal cell carcinoma (RCC).Journal of Clinical Oncology.  32:409-409. 2014
2014 Integrated comprehensive high-throughput kinomics profiling and whole exome sequencing of penile squamous cell cancer (PSCC).Journal of Clinical Oncology.  32:383-383. 2014
2014 Inhibition of sult4a1 expression induces up-regulation of phototransduction gene expression in 72-hour postfertilization zebrafish larvaeDrug Metabolism and Disposition.  42:947-953. 2014
2014 MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1Oncotarget.  5:3512-3525. 2014
2014 Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancerOncotarget.  5:8750-8764. 2014
2013 DNA from dead cancer cells induces TLR9-mediated invasion and inflammation in living cancer cellsBreast Cancer Research and Treatment.  142:477-487. 2013
2013 LRRK2 secretion in exosomes is regulated by 14-3-3Human Molecular Genetics.  22:4988-5000. 2013
2013 RNA-seq analyses of gene expression in the microsclerotia of Verticillium dahliaeBMC Genomics.  14. 2013
2013 Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis 2013
2012 A cloud computing system to quickly implement new microarray data pre-processing methodsOpen Bioinformatics Journal.  6:37-42. 2012
2012 Low TLR9 expression defines an aggressive subtype of triple-negative breast cancerBreast Cancer Research and Treatment.  135:481-493. 2012
2012 Sex hormone-dependent attenuation of EAE in a transgenic mouse with astrocytic expression of the RNA regulator HuRJournal of Neuroimmunology.  246:34-37. 2012
2012 Gene profiling of muscle specific VEGF deficient mice: Linking angiogenesis to metabolism?The FASEB Journal.  26:1144.16-1144.16. 2012
2012 Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable Stage III colorectal adenocarcinomasPLoS ONE.  7. 2012
2011 Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the fras-1-related extracellular matrix protein (FREM2) gene 2011
2011 Influence of aging and hemorrhage injury on Sirt1 expression: Possible role of myc-Sirt1 regulation in mitochondrial function 2011
2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injuryMolecular Medicine.  17:542-549. 2011
2011 GenDrux: A biomedical literature search system to identify gene expression-based drug sensitivity in breast cancerBMC Medical Informatics and Decision Making.  11. 2011
2011 Gene expression profiling in soybean under aluminum stress: genes differentially expressed between Al-tolerant and Al-sensitive genotypesAmerican Journal of Molecular Biology.  01:156-173. 2011
2010 Identification of aluminum responsive genes in Al-tolerant soybean line PI 416937International Journal of Plant Genomics.  2010. 2010
2010 Mechanisms of magnesium amelioration of aluminum toxicity in soybean at the gene expression level 2010
2010 A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: In vitro and in vivo activity and mechanisms of actionBreast Cancer Research and Treatment.  123:321-331. 2010
2010 Molecular profiling of the developing mouse axial skeleton: A role for Tgfbr2 in the development of the intervertebral discBMC Developmental Biology.  10. 2010
2010 Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: Role of Bnip3 and Pdk1Shock.  34:169-175. 2010
2010 Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body CompositionCell.  142:309-319. 2010
2010 Upregulation of chemokine (C-C motif) ligand 20 in adult epidermal keratinocytes in direct current electric fieldsArchives of Dermatological Research.  302:211-220. 2010
2009 Turning access™ into a web-enabled secure information system for clinical trialsClinical Trials.  6:378-385. 2009
2009 Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expressionInternational Journal of Cancer.  125:1778-1785. 2009
2009 The prolyl isomerase Pin1 regulates the NF-B signaling pathway and interleukin-8 expression in glioblastomaOncogene.  28:3735-3745. 2009
2009 Tumoristatic effects of endostatin in prostate cancer is dependent on androgen receptor status 2009
2009 Late Developmental Plasticity in the T Helper 17 LineageImmunity.  30:92-107. 2009
2008 Transcriptional response of dermal fibroblasts in direct current electric fieldsBioelectromagnetics.  29:394-405. 2008
2008 Level of expression of the nonmutant Ferrochelatase allele is a determinant of biochemical phenotype in a mouse model of erythropoietic protoporphyria.Gene Regulation and Systems Biology.  2:233-241. 2008
2008 A guided approach for personalized information search and visualizationInterdisciplinary Journal of Information, Knowledge, and Management.  3:11-21. 2008
2006 Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity 2006
2006 Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agentsCancer Gene Therapy.  13:606-618. 2006
2005 Personalized online information search and visualizationBMC Medical Informatics and Decision Making.  5. 2005
2005 Development and analyses of CPT-11 resistant sublines of human colorectal adenocarcinoma cell line, SW-948Proceedings of the American Association of Cancer Research.  46:350-350. 2005
2004 Wireless local area network in a prehospital environmentBMC Medical Informatics and Decision Making.  4. 2004
1997 Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6Immunity.  6:47-56. 1997
1993 Potentials for Targeting Hepatoma with Anti-Ferritin (IgG)-Daunomycin Immunoconjugate: In Vitro and In Vivo StudiesChinese Journal of Cancer Research.  3:34-38. 1993
1991 Specific Experimental Radioimmunotherapy and Chemoimmunotherapy of Hepatoma Grafts in Nude MiceClinical Research of the Infectious Disease.  4:7-10. 1991
1991 The Biodistribution and (gamma-image of 131-I-Labeled Anti-Ferritin-Daunomycin Immunoconjugate in the Engrafted Nude MiceThe Chinese Journal of Microbiology and Immunology.  13:117-117. 1991
1991 The Biodistribution of 125-I-Labeled Anti-Ferritin (IgG) Daunomycin Immunoconjugate in Hepatoma Engrafted Nude MiceZhongguo mian yi xue za zhi = Chinese journal of immunology.  7:306-308. 1991
1990 The Spleen PFC Changes Induced by Tritiated-Water in LACA MiceChinese Journal of Radiation Medicine and Radiological Protection.  10:20-22. 1990

Research Overview

  • -Informatics services for high throughput data including microarray and next generation sequencing (NGS)
    -Integration of Medical Informatics and Bioinformatics through data mining and information system development
    -Application of gene expression profiles for personalized medicine
  • Investigator On

  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS
  • Active - Biostatistics and Bioinformatics - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Active - Proteomics - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • COMPLETED - Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Biostatistics/Bioinformatics Shared Resource  awarded by National Cancer Institute/NIH/DHHS
  • Collapsing the Tumor-Supportive Immune Portfolio of Breast Cancer to Achieve Durable Reduction of Metastasis  awarded by DOD - Department of Defense
  • Combinational Environmental Chemicals Altering Susceptibility for Mammary Cancer  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Coronary Artery Risk Development In Young Adults (CARDIA) Coordinating Center  awarded by NIH - National Institutes of Health/DHHS
  • Coronary Artery Risk Development In Young Adults (CARDIA) Study-Coordinating Center  awarded by NIH - National Institutes of Health/DHHS
  • Coronary Artery Risk Development In Young Adults (CARDIA) Study-Coordinating Center  awarded by NIH - National Institutes of Health/DHHS
  • Coronary Artery Risk Development in Young Adults (CARDIA) Study - Coordinating Center  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Critical Roles of CHD7 During Mouse Cardiogenesis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • DNA Damage as a Predictive Biomarker for Immunotherapy Response in Ovarian Cancer  awarded by DOD - Department of Defense
  • Developing Novel Combination Therapies for Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Dietary Intervention of Non-Classical Wnt Signaling  awarded by National Cancer Institute/NIH/DHHS
  • Elevated Uracil Glycosylase Coupled to Reduced Base Excision Repair Promotes AA PCa Progression  awarded by DOD - Department of Defense
  • Engineered HSV for the Treatment of Malignant Glioma  awarded by National Cancer Institute/NIH/DHHS
  • Engineered HSV for the Treatment of Malignant Glioma - Core A. Administrative Core  awarded by National Cancer Institute/NIH/DHHS
  • Epigenetic Regulation of Cardiac Neural Crest Cell Development  awarded by American Heart Association
  • Epigenome Editing for Targeted Reactivation of X- Linked FOXP3 to Treat Breast Cancers  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Evaluation pf Clinically-ready Oncolytic HSV in Pediatric Brain Tumors  awarded by HYUNDAI HOPE ON WHEELS
  • Functions of CHD7 in Regulating Cardiogenesis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Glycosylation-dependent Mechanisms Regulating Ovarian Tumor cell Phenotype  awarded by National Cancer Institute/NIH/DHHS
  • Longitudinal Studies of Coronary Heart Disease Risk Factors in Young Adults (CARDIA) - Coordinating Center  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mid-South Transdisciplinary Collaborative Center for Health Disparities Research  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Biostatistics/Bioinformatics Shared Resource  awarded by National Cancer Institute/NIH/DHHS
  • Ph1 of HSV G207 and Radiation to Treat Pediatric Brain Tumors IND 16294 (12/10/14)  awarded by Food & Drug Administration
  • Pilot Study of HSV G207 Alone or with Radiation in Children with Recurrent Brain Tumors  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE
  • RANK Signaling in Osteoclast Differentiation and Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination-Mediated Gene Silencing  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Role of O-GlcNAc-ylation on Tumor Progression  awarded by National Cancer Institute/NIH/DHHS
  • Roles of Semaphorin Signaling in Breast Cancer Racial Disparities  awarded by National Cancer Institute/NIH/DHHS
  • SULT4A1 in Zebrafish Development  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Targeting MELK-Mediated EZH2 Signaling in Glioma Stem Cells  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Targeting Pediatric Medulloblastoma with Engineered Herpes Simplex Virus  awarded by RALLY FOUNDATION
  • Trans-Omics for Precision Medicine (TOPMed) Data Coordinating Center (DCC)  awarded by UNIVERSITY OF WASHINGTON
  • UAB / UMN SPORE in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS
  • UAB / UMN SPORE in Pancreatic Cancer - Core C  awarded by National Cancer Institute/NIH/DHHS
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO
  • Education And Training

  • Master of Sciences or Mathematics in Informatics, University of Alabama at Birmingham 2002
  • Doctor of Philosophy in Biomedical Sciences, City University of New York System : Graduate School & University Center 1999
  • Bachelor of Science or Mathematics in Medicine, Jilin University 1986
  • Full Name

  • Dongquan Chen
  • Fax

  • 205-934-4262