Browse
Browse
Home
People
Organizations
Research
Events
Capability Map
Lynn Dobrunz
Professor
Close
E-mail
dobrunz@uab.edu
Visualizations
Co-author Network
Map of Science
Co-investigator Network
Lynn Dobrunz
Professor
Positions
Senior Scientist (C)
,
Integrative Center for Aging Research
,
School of Medicine
Senior Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
Associate Scientist (C)
,
Civitan International Research Center
,
Academic Joint Departments
Associate Scientist (C)
,
Center for Glial Biology in Medicine
,
Academic Joint Departments
Professor (P)
,
Neurobiology
,
Academic Joint Departments
Professor (S)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2022
Bicuculline restores frequency-dependent hippocampal I/E ratio and circuit function in PGC-1ɑ null mice
.
Neuroscience Research
. 184:9-18.
2022
2021
A novel mouse model to evaluate neuropeptide Y–mediated melanocyte pathology
.
Experimental Dermatology
. 30:1800-1806.
2021
2021
Feasibility of cerium-doped LSO particles as a scintillator for x-ray induced optogenetics
.
Journal of Neural Engineering
. 18.
2021
2021
Differences between adult and adolescent male mice in approach/avoidance and expression of hippocampal NPY in response to acute footshock
2021
2020
Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control
.
Journal of Controlled Release
. 324:172-180.
2020
2020
A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons
.
Neuroscience
. 435:73-94.
2020
2020
Overexpression of neuropeptide Y decreases responsiveness to neuropeptide Y
.
Neuropeptides
. 79.
2020
2019
LITE-1 Dependent X-Ray Sensitivity in C. elegans
2019
2019
LSO:Ce Inorganic Scintillators Are Biocompatible With Neuronal and Circuit Function
.
Frontiers in Synaptic Neuroscience
. 11.
2019
2019
LSO:Ce Inorganic Scintillators are Biocompatible with Neuronal and Circuit Function
2019
2019
Organic Fluorophore Coated Polycrystalline Ceramic LSO:Ce Scintillators for X-ray Bioimaging
2019
2018
Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains
.
Neuroscience
. 388:430-447.
2018
2018
Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons
.
PLoS One
. 13.
2018
2018
Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus
.
Neuropsychopharmacology
. 43:1445-1456.
2018
2017
Klotho regulates CA1 hippocampal synaptic plasticity
.
Neuroscience
. 347:123-133.
2017
2017
Endogenously released neuropeptide Y suppresses hippocampal short-term facilitation and is impaired by stress-induced anxiety
2017
2016
Transcriptional dysregulation causes altered modulation of inhibition by haloperidol
.
Neuropharmacology
. 111:304-313.
2016
2015
Interneuron transcriptional dysregulation causes frequency-dependent alterations in the balance of inhibition and excitation in hippocampus
2015
2015
Short-term plasticity regulates the excitation/inhibition ratio and the temporal window for spike integration in CA1 pyramidal cells
.
European Journal of Neuroscience
. 41:1402-1415.
2015
2014
PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons
2014
2014
Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex
.
Neuroscience
. 271:137-148.
2014
2014
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number
2014
2013
Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (Usp14)
.
PLoS One
. 8.
2013
2012
Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits
.
PLoS One
. 7.
2012
2009
Calcium-permeable presynaptic kainate receptors involved in excitatory short-term facilitation onto somatostatin interneurons during natural stimulus patterns
.
Journal of Neurophysiology
. 101:1043-1055.
2009
2009
Developmental changes in short-term facilitation are opposite at temporoammonic synapses compared to schaffer collateral synapses onto CA1 pyramidal cells
2009
2008
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity
.
Molecular and Cellular Neuroscience
. 39:539-548.
2008
2008
Coactivation of M
1
muscarinic and α1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus
2008
2008
Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive
.
Journal of Neurophysiology
. 99:799-813.
2008
2006
Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses
.
Journal of Neurophysiology
. 96:3114-3121.
2006
2006
Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14
2006
2006
Presynaptic kainate receptor activation is a novel mechanism for target cell-specific short-term facilitation at Schaffer collateral synapses
2006
2006
Responses of excitatory hippocampal synapses to natural stimulus patterns reveal a decrease in short-term facilitation and increase in short-term depression during postnatal development
2006
2006
Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses
2006
2005
Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats
2005
2004
Novel Form of Long-Term Synaptic Depression in Rat Hippocampus Induced by Activation of α1 Adrenergic Receptors
.
Journal of Neurophysiology
. 91:1071-1077.
2004
2002
Release probability is regulated by the size of the readily releasable vesicle pool at excitatory synapses in hippocampus
.
International Journal of Developmental Neuroscience
. 20:225-236.
2002
2002
Priming plasticity
.
Nature
. 415:277-278.
2002
1999
Response of hippocampal synapses to natural stimulation patterns
.
Neuron
. 22:157-166.
1999
1998
Long-term potentiation and the computational synapse
1998
1997
Very short-term plasticity in hippocampal synapses
1997
1997
Dynamic synapses in the cortex
.
Neuron
. 19:1-4.
1997
1997
Heterogeneity of release probability, facilitation, and depletion at central synapses
.
Neuron
. 18:995-1008.
1997
1995
Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998
.
Biophysical Journal
. 69:189-201.
1995
1994
Effect of temperature on Ca
2+
-dependent and mechanical modulators of relaxation in mammalian myocardium
.
Journal of Molecular and Cellular Cardiology
. 26:243-250.
1994
1990
Muscle stiffness measured under conditions simulating natural sound production
.
Biophysical Journal
. 58:557-565.
1990
1987
The mechanism of low-frequency sound production in muscle
.
Biophysical Journal
. 51:775-783.
1987
Research
Principal Investigator On
Development and Validation of an NPY-Sensitive Microelectrode for Measuring NPY Release from Hippocampal
awarded by
UNIVERSIDAD ANA G MENDEZ - GURABO CAMPUS
Effects of NPY on Hippocampal Circuit Function
awarded by
National Institute of Mental Health/NIH/DHHS
Effects of NPY on Hippocampal Circuit Function
awarded by
National Institute of Mental Health/NIH/DHHS
Frequency Dependence of Excitatory Synaptic Transmission
awarded by
National Institute of Mental Health/NIH/DHHS
Interneuron Dysfunction Alters the Dynamics of the Inhibition-Excitation Balance
awarded by
National Institute of Mental Health/NIH/DHHS
REU Site: Neuroscience Research for Undergraduates at UAB
awarded by
NSF - National Science Foundation
The Impact of Normative Aging and Alzheimers Disease on Fear based Disorders and Amygdala Dysfunction
awarded by
National Institute on Aging/NIH/DHHS
Investigator On
Frequency-dependent Modulation of Synaptic Transmission and Plasticity by pH
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson’s Disease
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Private Grant
awarded by
BOSTON SCIENTIFIC CORPORATION
RII Track-2 FEC: The Creation of Next Generation Tools for Neuroscience - Noninvasive Radioluminescence Approaches to Optogenetics
awarded by
Clemson University
Training Program in the Neurobiology of Cognition and Cognitive Disorders
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Teaching
Teaching Activities
EGR790 - Special Topics (Fall Term 2020)
EGR790 - Special Topics (Spring Term 2021)
GBS731 - Principles of Cell Neuroscie (Fall Term 2010)
GBS731 - Principles of Cell Neuroscie (Fall Term 2011)
IDNE701 - Topics in Neuroengineering I (Fall Term 2021)
IDNE701 - Topics in Neuroengineering I (Fall Term 2022)
IDNE702 - Topics in Neuroengineering II (Spring Term 2022)
IDNE796 - Neuroengineering Journal Club (Fall Term 2021)
IDNE796 - Neuroengineering Journal Club (Fall Term 2022)
IDNE796 - Neuroengineering Journal Club (Spring Term 2022)
NBL703 - Neurobiology Seminar Series (Fall Term 2007)
NBL703 - Neurobiology Seminar Series (Fall Term 2008)
NBL703 - Neurobiology Seminar Series (Spring Term 2008)
NBL703 - Neurobiology Seminar Series (Spring Term 2009)
NEUR713 - Princ of Cell Neurosci Mod 2&3 (Fall Term 2009)
NEUR713 - Princ of Cell Neurosci Mod III (Fall Term 2008)
Background
Education And Training
Doctor of Philosophy in Biomedical / Medical Engineering,
Johns Hopkins University
1994
Contact
Full Name
Lynn
Dobrunz