Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 A novel mouse model to evaluate neuropeptide Y–mediated melanocyte pathology.  Experimental Dermatology.  30:1800-1806. 2021
2021 Feasibility of cerium-doped LSO particles as a scintillator for x-ray induced optogenetics 2021
2021 Differences between adult and adolescent male mice in approach/avoidance and expression of hippocampal NPY in response to acute footshock 2021
2020 Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control.  Journal of Controlled Release.  324:172-180. 2020
2020 A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons.  Neuroscience.  435:73-94. 2020
2020 Overexpression of neuropeptide Y decreases responsiveness to neuropeptide Y.  Neuropeptides.  79. 2020
2019 LITE-1 Dependent X-Ray Sensitivity in C. elegans 2019
2019 LSO:Ce Inorganic Scintillators Are Biocompatible With Neuronal and Circuit Function.  Frontiers in Synaptic Neuroscience.  11. 2019
2019 Organic Fluorophore Coated Polycrystalline Ceramic LSO:Ce Scintillators for X-ray Bioimaging 2019
2018 Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.  Neuroscience.  388:430-447. 2018
2018 Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons.  PLoS ONE.  13. 2018
2018 Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.  Neuropsychopharmacology.  43:1445-1456. 2018
2017 Klotho regulates CA1 hippocampal synaptic plasticity.  Neuroscience.  347:123-133. 2017
2017 Endogenously released neuropeptide Y suppresses hippocampal short-term facilitation and is impaired by stress-induced anxiety 2017
2016 Transcriptional dysregulation causes altered modulation of inhibition by haloperidol.  Neuropharmacology.  111:304-313. 2016
2015 Interneuron transcriptional dysregulation causes frequency-dependent alterations in the balance of inhibition and excitation in hippocampus 2015
2015 Short-term plasticity regulates the excitation/inhibition ratio and the temporal window for spike integration in CA1 pyramidal cells.  European Journal of Neuroscience.  41:1402-1415. 2015
2014 PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons 2014
2014 Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.  Neuroscience.  271:137-148. 2014
2014 A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number 2014
2013 Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (Usp14).  PLoS ONE.  8. 2013
2012 Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits.  PLoS ONE.  7. 2012
2009 Calcium-permeable presynaptic kainate receptors involved in excitatory short-term facilitation onto somatostatin interneurons during natural stimulus patterns.  Journal of Neurophysiology.  101:1043-1055. 2009
2009 Developmental changes in short-term facilitation are opposite at temporoammonic synapses compared to schaffer collateral synapses onto CA1 pyramidal cells 2009
2008 Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.  Molecular and Cellular Neuroscience.  39:539-548. 2008
2008 Coactivation of M1 muscarinic and α1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus 2008
2008 Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive.  Journal of Neurophysiology.  99:799-813. 2008
2006 Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.  Journal of Neurophysiology.  96:3114-3121. 2006
2006 Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14 2006
2006 Presynaptic kainate receptor activation is a novel mechanism for target cell-specific short-term facilitation at Schaffer collateral synapses 2006
2006 Responses of excitatory hippocampal synapses to natural stimulus patterns reveal a decrease in short-term facilitation and increase in short-term depression during postnatal development 2006
2006 Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses 2006
2005 Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats 2005
2004 Novel Form of Long-Term Synaptic Depression in Rat Hippocampus Induced by Activation of α1 Adrenergic Receptors.  Journal of Neurophysiology.  91:1071-1077. 2004
2002 Release probability is regulated by the size of the readily releasable vesicle pool at excitatory synapses in hippocampus.  International Journal of Developmental Neuroscience.  20:225-236. 2002
2002 Priming plasticity.  Nature.  415:277-278. 2002
1999 Response of hippocampal synapses to natural stimulation patterns.  Neuron.  22:157-166. 1999
1998 Long-term potentiation and the computational synapse 1998
1997 Very short-term plasticity in hippocampal synapses 1997
1997 Dynamic synapses in the cortex.  Neuron.  19:1-4. 1997
1997 Heterogeneity of release probability, facilitation, and depletion at central synapses.  Neuron.  18:995-1008. 1997
1995 Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998.  Biophysical Journal.  69:189-201. 1995
1994 Effect of temperature on Ca2+-dependent and mechanical modulators of relaxation in mammalian myocardium.  Journal of Molecular and Cellular Cardiology.  26:243-250. 1994
1990 Muscle stiffness measured under conditions simulating natural sound production.  Biophysical Journal.  58:557-565. 1990
1987 The mechanism of low-frequency sound production in muscle.  Biophysical Journal.  51:775-783. 1987
LSO:Ce Inorganic Scintillators are Biocompatible with Neuronal and Circuit Function

Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Johns Hopkins University 1994

    • Full Name

  • Lynn Dobrunz