Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.Neuroscience.  388:430-447. 2018
2017 Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.Neuropsychopharmacology.  43:1445-1456. 2017
2017 Klotho regulates CA1 hippocampal synaptic plasticity.Neuroscience.  347:123-133. 2017
2017 Endogenously Released Neuropeptide Y Suppresses Hippocampal Short-Term Facilitation and Is Impaired by Stress-Induced Anxiety.Journal of Neuroscience.  37:23-37. 2017
2016 Transcriptional dysregulation causes altered modulation of inhibition by haloperidol.Neuropharmacology.  111:304-313. 2016
2015 Interneuron Transcriptional Dysregulation Causes Frequency-Dependent Alterations in the Balance of Inhibition and Excitation in Hippocampus.Journal of Neuroscience.  35:15276-15290. 2015
2015 Short-term plasticity regulates the excitation/inhibition ratio and the temporal window for spike integration in CA1 pyramidal cells.European Journal of Neuroscience.  41:1402-1415. 2015
2014 PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.Journal of Neuroscience.  34:14375-14387. 2014
2014 Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.Neuroscience.  271:137-148. 2014
2014 A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.Journal of Physiology.  592:571-586. 2014
2013 Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14).PLoS ONE.  8:e84042. 2013
2012 Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits.PLoS ONE.  7:e47884. 2012
2009 Calcium-permeable presynaptic kainate receptors involved in excitatory short-term facilitation onto somatostatin interneurons during natural stimulus patterns.Journal of Neurophysiology.  101:1043-1055. 2009
2009 Developmental changes in short-term facilitation are opposite at temporoammonic synapses compared to Schaffer collateral synapses onto CA1 pyramidal cells.Hippocampus.  19:187-204. 2009
2008 Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.Molecular and Cellular Neuroscience.  39:539-548. 2008
2008 Coactivation of M(1) muscarinic and alpha1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus.Journal of Neuroscience.  28:5350-5358. 2008
2008 Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive.Journal of Neurophysiology.  99:799-813. 2008
2006 Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.Journal of Neurophysiology.  96:3114-3121. 2006
2006 Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14.Journal of Neuroscience.  26:11423-11431. 2006
2006 Presynaptic kainate receptor activation is a novel mechanism for target cell-specific short-term facilitation at Schaffer collateral synapses.Journal of Neuroscience.  26:10796-10807. 2006
2006 Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses.Journal of Neuroscience.  26:3745-3756. 2006
2006 Responses of excitatory hippocampal synapses to natural stimulus patterns reveal a decrease in short-term facilitation and increase in short-term depression during postnatal development.Hippocampus.  16:66-79. 2006
2005 Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats.Journal of Physiology.  568:815-840. 2005
2004 Novel form of long-term synaptic depression in rat hippocampus induced by activation of alpha 1 adrenergic receptors.Journal of Neurophysiology.  91:1071-1077. 2004
2002 Release probability is regulated by the size of the readily releasable vesicle pool at excitatory synapses in hippocampus.International Journal of Developmental Neuroscience.  20:225-236. 2002
2002 Priming plasticity.Nature.  415:277-278. 2002
1999 Response of hippocampal synapses to natural stimulation patterns.Neuron.  22:157-166. 1999
1998 Long-term potentiation and the computational synapse.Proceedings of the National Academy of Sciences.  95:4086-4088. 1998
1997 Very short-term plasticity in hippocampal synapses.Proceedings of the National Academy of Sciences.  94:14843-14847. 1997
1997 Dynamic synapses in the cortex.Neuron.  19:1-4. 1997
1997 Heterogeneity of release probability, facilitation, and depletion at central synapses.Neuron.  18:995-1008. 1997
1995 Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998.Biophysical Journal.  69:189-201. 1995
1994 Effect of temperature on Ca(2+)-dependent and mechanical modulators of relaxation in mammalian myocardium.Journal of Molecular and Cellular Cardiology.  26:243-250. 1994
1990 Muscle stiffness measured under conditions simulating natural sound production.Biophysical Journal.  58:557-565. 1990
1987 The mechanism of low-frequency sound production in muscle.Biophysical Journal.  51:775-783. 1987

Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Johns Hopkins University
  • Full Name

  • Lynn Dobrunz
  • Blazerid

  • dobrunz