• Dr. LaFon his completed his initial medical training at USF Health Morsani College of Medicine in Tampa, Florida. Following this training, Dr. LaFon completed his internship, residency, and fellowship at the University of Alabama at Birmingham. Following his fellowship, Dr. LaFon began work as an instructor in the UAB Division of Pulmonary, Allergy, and Critical Care Medicine, His current clinical and research interest is immunity in pneumococcal infections.

    Dr. LaFon has been first author on three peer-reviewed manuscripts written with Dr. Nahm that have been accepted or published. In addition to the manuscript accepted to Journal of Allergy and Clinical Immunology, one manuscript has been published in Journal of Immunological Methods, and another accepted for publication in Transfusion. He regularly attends pulmonary division didactic lectures and conferences. He is planning a K23 submission in middle of 2020.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Risk of exacerbation and pneumonia with single-inhaler triple versus dual therapy in IMPACTAnnals of the American Thoracic Society.  18:788-798. 2021
    2021 Pneumococcal Antibody Function for Immunologic Evaluation: Normal Results in Older Adults, and a Novel Analytical Model for Vaccine ResponseJournal of Clinical Immunology2021
    2020 Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-analysisChest.  158:1420-1430. 2020
    2020 Machine Learning and Prediction of All-Cause Mortality in COPDChest.  158:952-964. 2020
    2020 Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults 2020
    2020 Peripheral CD4 T follicular cells induced by a conjugated pneumococcal vaccine correlate with enhanced opsonophagocytic antibody responses in younger individualsVaccine.  38:1778-1786. 2020
    2020 Pulmonary artery enlargement and mortality risk in moderate to severe COPD: Results from COPDGeneEuropean Respiratory Journal.  55. 2020
    2019 Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial 2019
    2019 Interlaboratory variability in multiplexed pneumococcal antibody testingJournal of Allergy and Clinical Immunology.  143:1255-1257. 2019
    2018 Measuring quantity and function of pneumococcal antibodies in immunoglobulin productsTransfusion.  58:3114-3120. 2018
    2018 Measuring immune responses to pneumococcal vaccinesJournal of Immunological Methods.  461:37-43. 2018
    2017 A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill AdultsChest.  152:712-722. 2017
    2016 Indirect effects of pneumococcal conjugate vaccines in national immunization programs for children on adult pneumococcal diseaseInfection and Chemotherapy.  48:257-266. 2016
    2013 Parthenogenetic populations of the freshwater snail Campeloma limum occupy habitats with fewer environmental stressors than their sexual counterpartsFreshwater Biology.  58:655-663. 2013

    Research Overview

  • Dr. LaFon’s research is focused on measuring immune responses to pneumococcal vaccines in order to characterize the immune dysfunction associated with COPD. Since current methods for diagnosing immune dysfunction are inadequate, Dr. LaFon is interested in identifying novel means of evaluating vaccine responses in clinical populations, and applying these techniques to COPD. In particular, he plans to investigate the use of multiplexed opsonophagocytosis assays (MOPA) as an indicator of pneumococcal antibody function in individuals with COPD who experience frequent infections. He is working with Dr. Mark Dransfield to apply analytical techniques used in the Nahm Lab to study clinical populations. Dr. LaFon is currently a co-investigator in a multi-site study of immune parameters in COPD. He is also analyzing vaccine response data in COPD and initiating a study of pneumococcal antibodies in COPD sera. Dr. LaFon conducted a study demonstrating that different laboratories’ assays that measure pneumococcal antibodies generate different results, with the potential to affect clinical diagnosis. He is first-author on a manuscript describing these findings which has been accepted to the Journal of Allergy and Clinical Immunology.
  • Investigator On

    Education And Training

  • Doctor of Medicine, University of South Florida 2012
  • Full Name

  • David LaFon