Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.Clinical Cancer Research.  24:6433-6446. 2018
2018 New microbe genomic variants in patients fecal community following surgical disruption of the upper human gastrointestinal tractHuman Microbiome Journal.  10:37-42. 2018
2018 PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells.Scientific Reports.  8:16431. 2018
2018 Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats.Mechanisms of Development.  155:15-26. 2018
2018 Differential and Overlapping Effects of 20,23(OH)₂D3 and 1,25(OH)₂D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)₂D3.International Journal of Molecular Sciences.  19. 2018
2018 Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.Laboratory Investigation2018
2018 Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells.Scientific Reports.  8:11339. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance.Molecular Metabolism.  12:48-61. 2018
2018 Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis.Neurobiology of Disease.  114:85-94. 2018
2018 Cell-Specific Deletion of PGC-1α from Medium Spiny Neurons Causes Transcriptional Alterations and Age-Related Motor Impairment.Journal of Neuroscience.  38:3273-3286. 2018
2018 Molecular Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma.Cell Growth and Differentiation.  16:813-824. 2018
2018 Gene-Expression Analysis Identifies IGFBP2 Dysregulation in Dental Pulp Cells From Human Cleidocranial Dysplasia.Frontiers in Genetics.  9:178. 2018
2018 High-Throughput Tabular Data Processor - Platform independent graphical tool for processing large data sets.PLoS ONE.  13:e0192858. 2018
2017 Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors.Scientific Reports.  7:17787. 2017
2017 The Human Blood-Nerve Barrier Transcriptome.Scientific Reports.  7:17477. 2017
2017 β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.Journal of Virology2017
2017 Identification of transcriptome signature for myocardial reductive stress.Redox Biology.  13:568-580. 2017
2017 CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs.Immunity.  47:251-267.e7. 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets.Oncotarget.  8:21710-21718. 2017
2017 HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases.Glia.  65:945-963. 2017
2017 Erratum: Author Correction: Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile.npj Biofilms and Microbiomes.  3:29. 2017
2017 Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile.npj Biofilms and Microbiomes.  3:12. 2017
2017 RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome.Molecular Autism.  8:56. 2017
2016 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis.Scientific Reports.  6:37445. 2016
2016 Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy.Journal of the American Society of Nephrology.  27:3278-3284. 2016
2016 Burkholderia pseudomallei Capsule Exacerbates Respiratory Melioidosis but Does Not Afford Protection against Antimicrobial Signaling or Bacterial Killing in Human Olfactory Ensheathing Cells.Infection and Immunity.  84:1941-1956. 2016
2016 Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing.Developmental Biology.  426:429-441. 2016
2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.AJP - Heart and Circulatory Physiology.  311:H64-H75. 2016
2016 Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.Human Molecular Genetics.  25:1619-1636. 2016
2016 The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis.Nature Communications.  7:10869. 2016
2016 Uropathogenic Escherichia coli Engages CD14-Dependent Signaling to Enable Bladder-Macrophage-Dependent Control of Acute Urinary Tract Infection.Journal of Infectious Diseases.  213:659-668. 2016
2016 Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile.BMC Microbiology.  16:5. 2016
2015 Hypomagnesemia due to two novel TRPM6 mutations.Journal of Pediatric Endocrinology and Metabolism.  28:1373-1378. 2015
2015 Alterations in gene expression and DNA methylation during murine and human lung alveolar septation.American Journal of Respiratory Cell and Molecular Biology.  53:60-73. 2015
2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.Journal of Clinical Investigation.  125:2877-2890. 2015
2015 Analysis of the Human Proteome in Subcutaneous and Visceral Fat Depots in Diabetic and Non-diabetic Patients with Morbid Obesity.Journal of Proteomics and Bioinformatics.  8:133-141. 2015
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F.Biochemical Journal.  467:517-527. 2015
2015 Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction.AJP - Heart and Circulatory Physiology.  308:H269-H280. 2015
2014 Getting started with microbiome analysis: sample acquisition to bioinformatics.Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.].  82:18.8.1-18.829. 2014
2014 Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas.Nature Genetics.  46:182-187. 2014
2014 Differential Gene Expression Landscape of Co-Existing Cervical Pre-Cancer Lesions Using RNA-seq.Frontiers in Oncology.  4:339. 2014
2013 Real-time methylomic aberrations during initiation and progression of induced human mammary epithelial cell tumorigenesis.Epigenomics.  5:155-165. 2013
2013 WNT5A inhibits metastasis and alters splicing of Cd44 in breast cancer cells.PLoS ONE.  8:e58329. 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F.Arteriosclerosis, Thrombosis, and Vascular Biology.  32:2631-2639. 2012
2012 Altered DNA methylation profile in idiopathic pulmonary fibrosis.American Journal of Respiratory and Critical Care Medicine.  186:525-535. 2012
2012 Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function.Kidney International.  82:304-313. 2012
2011 The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.Journal of Biological Chemistry.  286:41862-41870. 2011
2011 Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.Medical and Pediatric Oncology.  57:930-938. 2011
2010 Abundant lipid and protein components of drusen.PLoS ONE.  5:e10329. 2010
2010 Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.Journal of Bacteriology.  192:326-335. 2010
2009 Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.PLoS Pathogens.  5:e1000545. 2009
2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.Journal of Biological Chemistry.  283:18032-18039. 2008
2000 High color-vision sensitivity in macaque and humans.Visual Neuroscience.  17:119-125. 2000

Investigator On

  • Mechanism of Ultraviolet Radiation Induced Immune Tolerance  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • Mechanism of Action and Function of Novel Secosteroid 20(OH)D3 in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • Significance of Metabolic Activation of Lumisterol in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Histone H4 Lysine16 Acetylation in Aging and Lung Fibrosis  awarded by National Institute on Aging/NIH/DHHS 2016 - 2021
  • Cervical Cancer Derived Xenografts (PDX) and Organoid Raft Cultures to Evaluate Pathway Specific Therapeutic Agents.  awarded by National Cancer Institute/NIH/DHHS 2019 - 2020
  • Canine Immuno Neurotherapeutics  awarded by National Cancer Institute/NIH/DHHS 2017 - 2020
  • Network Medicine Approaches to Cachexia in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Transcriptional Regulation of Metabolism in Neurons  awarded by SOUTHERN RESEARCH INSTITUTE 2017 - 2019
  • Chromatin Remodeling Mechanisms of Gene Transcription in Memory  awarded by National Institute of Mental Health/NIH/DHHS 2012 - 2018
  • Transcriptional Regulation of Metabolism in Neurons  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017
  • DHA Mechanisms in Obesity-Mediated Cardiac Remodeling Post-Myocardial Infarction  awarded by NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH/NIH/DHHS 2013 - 2016
  • Completed - Comprehensive Genomics Shared Facility - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Completed - Comprehensive Cancer Center Core Support Grant - Micro Array SF  awarded by National Cancer Institute/NIH/DHHS 2011 - 2013
  • Education And Training

  • Bachelor of Science or Mathematics in Biology, Samford University
  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham
  • Full Name

  • David Crossman