Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.Clinical and Experimental Metastasis.  34:443-447. 2017
2016 SIN3A and SIN3B differentially regulate breast cancer metastasis.Oncotarget.  7:78713-78725. 2016
2016 Increased autophagic response in a population of metastatic breast cancer cells.Oncology Letters.  12:523-529. 2016
2016 Globular adiponectin enhances invasion in human breast cancer cells.Oncology Letters.  11:633-641. 2016
2015 SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.Cancer Immunology Research.  3:727-740. 2015
2015 Promising oncolytic agents for metastatic breast cancer treatment.Oncolytic Virotherapy.  4:63-73. 2015
2014 Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.Molecular Carcinogenesis.  53:1011-1026. 2014
2014 Linking adiponectin and autophagy in the regulation of breast cancer metastasis.The Clinical investigator.  92:1015-1023. 2014
2014 Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells.PLoS ONE.  9:e92919. 2014
2014 Linking adiponectin and autophagy in the regulation of breast cancer metastasisThe Clinical investigator.  92:1015-1023. 2014
2013 Unraveling the 'TGF-β paradox' one metastamir at a time.Breast Cancer Research.  15:305. 2013
2013 Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.PLoS ONE.  8:e68348. 2013
2013 The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.PLoS ONE.  8:e55966. 2013
2012 Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes.Cancer and Metastasis Reviews.  31:641-651. 2012
2012 Clinical significance of KISS1 protein expression for brain invasion and metastasis.Cancer.  118:2096-2105. 2012
2012 Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.Clinical and Experimental Metastasis.  29:315-325. 2012
2012 The influence of the cancer microenvironment on the process of metastasis.International Journal of Breast Cancer.  2012:756257. 2012
2011 Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression.FEBS Letters.  585:3185-3190. 2011
2011 Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype.Journal of Biological Chemistry.  286:30377-30383. 2011
2011 Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines.Clinical and Experimental Metastasis.  28:437-449. 2011
2011 Metastasis suppressors and the tumor microenvironment.Seminars in Cancer Biology.  21:113-122. 2011
2011 Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.Journal of Cancer.  2:165-176. 2011
2011 Metastasis suppressor genes at the interface between the environment and tumor cell growth.International Review of Cell and Molecular Biology.  286:107-180. 2011
2010 Linking metastasis suppression with metastamir regulationChinese Journal of Lung Cancer.  13:140-143. 2010
2009 Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression.International Journal of Cancer.  125:1778-1785. 2009
2009 Metastamir: the field of metastasis-regulatory microRNA is spreading.Cancer Research.  69:7495-7498. 2009
2009 Linking metastasis suppression with metastamiR regulation.Cell Cycle.  8:2673-2675. 2009
2009 Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells.Cancer Letters.  276:32-37. 2009
2009 Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone.Oncology Reports.  21:761-767. 2009
2009 Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.Cancer Research.  69:1279-1283. 2009
2009 Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression model.Clinical and Experimental Metastasis.  26:89-96. 2009
2009 Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution.Clinical and Experimental Metastasis.  26:527-533. 2009
2008 Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling.Journal of Biological Chemistry.  283:28354-28360. 2008
2008 Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.Journal of Biological Chemistry.  283:7438-7444. 2008
2008 BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process.American Journal of Pathology.  172:809-817. 2008
2007 A MSC-ing link in metastasis?Nature Medicine.  13:1289-1291. 2007
2007 Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy.JNCI: Journal of the National Cancer Institute.  99:309-321. 2007
2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.Biochemical and Biophysical Research Communications.  348:1429-1435. 2006
2006 Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1).Cancer Letters.  235:260-265. 2006
2006 Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases.Current Topics in Medicinal Chemistry.  6:289-316. 2006
2005 Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors.Biochemical Journal.  392:527-536. 2005
2004 Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activitiesBiochemical Journal.  377:775-779. 2004
2004 Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities.Biochemical Journal.  377:775-779. 2004
2003 The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling.Journal of Biological Chemistry.  278:51646-51653. 2003
2002 Protein engineering and properties of human metalloproteinase and thrombospondin 1.Biochemical and Biophysical Research Communications.  293:478-488. 2002
2001 Development and characterization of a new polyclonal antibody specifically against tissue inhibitor of metalloproteinases 4 in human breast cancer.Biochemical and Biophysical Research Communications.  281:166-171. 2001
2001 Preparation of 2-phenyl-4-(1h-pyrazol-5-yl)quinolinesOrganic Preparations and Procedures International: The New Journal for Organic Synthesis.  33:91-95. 2001
1999 A new series of proton/charge transfer molecules: Synthesis and spectral studies of 2-(5-Aryl-1-carbomethoxy-1H-pyrazol-3-yl)phenolsPhotochemistry and Photobiology.  70:176-183. 1999
1999 Preparation of N-aryl-4-oxo-4H-1-benzothiopyran-2-acetamides from trilithiated acetoacetanilides and lithiated methyl thiosalicylateCanadian Journal of Chemistry.  77:94-97. 1999
1999 The preparation of 2-(1-phenyl-5-phenyl or 5-substituted phenyl-1H- pyrazol-3-yl)phenols from trilithiated 2'-hydroxyacetophenone phenylhydrazone and aromatic estersSynthetic Communications.  29:495-506. 1999
1999 The preparation of 2-[4,5-dihydro-3-aryl-5-isoxazolyl]-phenols from C(α),O-dilithiooximes and lithiated hydroxyaryl aldehydesSynthetic Communications.  29:1977-1988. 1999
1999 The preparation of 4,5-dihydro-2H-benz[e]indazoles from dilithiated 2- tetralone phenylhydrazone and aromatic estersJournal of Heterocyclic Chemistry.  36:1231-1233. 1999
1998 Hydroxyaryl-isoxazoles: Synthesis and related studiesChemist.  75:7-11. 1998
1998 A New Preparation of Substituted 4H-1-Benzothiopyran-4-ones from C(α),N-Benzoylhydrazones or C(α),N-Carboalkoxyhydrazones and Methyl ThiosalicylateJournal of Heterocyclic Chemistry.  35:45-48. 1998
1998 The preparation of 2-(4-oxo-4h-1-benzopyran-2-yl)- 1-phenylethanones by the condensation/cyclization of dilithiated 1-benzoylacetone with lithiated methyl salicylatesSynthetic Communications.  28:1547-1554. 1998
1998 The preparation of 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides by the condensation/cyclization of trilithiated acetoacetanilides with lithiated methyl salicylatesJournal of Heterocyclic Chemistry.  35:1357-1359. 1998

Chapter

Year Title Altmetric
2016 Beyond the primary tumor: Progression, invasion, and metastasis.  203-216. 2016
2016 Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action..  111-137. 2016

Education And Training

  • Bachelor of Science or Mathematics in Biochemistry, College of Charleston
  • Doctor of Philosophy in Biochemistry, Florida State University
  • Full Name

  • Douglas Hurst
  • Blazerid

  • dhurst