Stijn De Langhe Ph.D.

Stijn De Langhe Ph.D.
Associate Professor

Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Scientist, Cancer Cell Biology , O'Neal Comprehensive Cancer Center
Associate Professor (P), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine

Overview

Dr. De Langhe is an Associate Professor of Medicine at the University of Alabama at Birmingham (UAB). Following his training at Ghent University and the USC Keck School of Medicine , he has held faculty positions at National Jewish Health's Department of Pediatrics and the University of Colorado's Division of Pulmonary Sciences and Critical Care Medicine.

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells.. eLife. 10. 2021
2020	Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration. Frontiers in Pharmacology. 11. 2020
2020	The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Theranostics. 10:4422-4436. 2020
2019	FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury. Stem Cell Reports. 12:1041-1055. 2019
2019	Developmental pathways in the pathogenesis of lung fibrosis. Molecular Aspects of Medicine. 65:56-69. 2019
2019	Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling 2019
2018	Protein tyrosine phosphatase-N13 promotes myofibroblast resistance to apoptosis in idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 198:914-927. 2018
2018	Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury.. Frontiers in Genetics. 9:418. 2018
2017	Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Developmental Cell. 43:48-59.e5. 2017
2017	Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. Journal of Clinical Investigation. 127:2262-2276. 2017
2017	Erratum: Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis (Cell Stem Cell (2017) 20(2) (261–273) (S1934590916303447) (10.1016/j.stem.2016.10.004)). Cell Stem Cell. 20:571. 2017
2017	Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. Cell Stem Cell. 20:261-273.e3. 2017
2016	Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis. Scientific Reports. 6. 2016
2015	Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development 2015
2015	Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. STEM CELLS. 33:999-1012. 2015
2015	Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development. Developmental Dynamics. 244:342-366. 2015
2014	General parity between trio and pairwise breeding of laboratory mice in static caging. Journal of Immunology. 193:4757-4760. 2014
2014	miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development 2014
2014	Lung epithelial stem cells and their niches: Fgf10 takes center stage 2014
2013	Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors 2013
2013	c-Myc Regulates Proliferation and Fgf10 Expression in Airway Smooth Muscle after Airway Epithelial Injury in Mouse. PLoS ONE. 8. 2013
2013	Erratum: Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner (Endocrine-Related Cancer 19 (111-122) DOI:10.1530/ERC-10-0327). Endocrine-Related Cancer. 20. 2013
2012	Mesodermal Pten inactivation leads to alveolar capillary dysplasia-like phenotype. Journal of Clinical Investigation. 122:3862-3872. 2012
2012	Characterization of a novel Fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. PLoS ONE. 7. 2012
2012	Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocrine-Related Cancer. 19:111-122. 2012
2011	Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. Journal of Clinical Investigation. 121:4409-4419. 2011
2011	Neutrophil transmigration triggers repair of the lung epithelium via β-catenin signaling 2011
2011	FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium 2011
2011	Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo. STEM CELLS. 29:206-216. 2011
2010	β-Catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis. Journal of Surgical Research. 164:276-285. 2010
2010	Corrigendum to "Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis" [Mol. Cell. Neurosci. 37 (2008) 857-868] (DOI:10.1016/j.mcn.2008.01.008). Molecular and Cellular Neuroscience. 43:259. 2010
2010	Lung organogenesis. Current Topics in Developmental Biology. 90:73-158. 2010
2009	Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of apert syndrome. Pediatric Research. 66:386-390. 2009
2009	Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. American Journal of Respiratory and Critical Care Medicine. 180:701-712. 2009
2009	Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease. Anatomical Record. 292:1045-1061. 2009
2009	miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Developmental Biology. 333:238-250. 2009
2008	Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. STEM CELLS. 26:2902-2911. 2008
2008	Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Developmental Biology. 317:121-131. 2008
2008	Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by β-catenin signaling. PLoS ONE. 3. 2008
2008	Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Molecular and Cellular Neuroscience. 37:857-868. 2008
2008	Wnt signaling in lung organogenesis. Organogenesis. 4:100-108. 2008
2007	Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via β-catenin activation. Hepatology. 46:1187-1197. 2007
2007	Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Developmental Biology. 307:237-247. 2007
2006	Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Developmental Biology. 299:52-62. 2006
2006	Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Developmental Biology. 293:77-89. 2006
2006	The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. Journal of Pediatric Surgery. 41:132-136. 2006
2005	Wnt5a regulates Shh and Fgf10 signaling during lung development. Developmental Biology. 287:86-97. 2005
2005	A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Developmental Biology. 282:422-431. 2005
2005	Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage 2005
2005	Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Developmental Biology. 277:316-331. 2005
2005	Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. Journal of Pediatric Surgery. 40:390-396. 2005
2005	Fibroblast growth factor-10 serves a regulatory role in duodenal development. Journal of Pediatric Surgery. 40:313-316. 2005
2005	Molecular Mechanisms of Early Lung Specification and Branching Morphogenesis. Pediatric Research. 57:26R-37R. 2005
2004	A genetic mechanism for cecal atresia: The role of the Fgf10 signaling pathway. Journal of Surgical Research. 120:201-209. 2004
2004	Fibroblast growth factor receptor 2 IIIb invalidation - A potential cause of familial duodenal atresia. Journal of Pediatric Surgery. 39:872-874. 2004
2004	Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Developmental Biology. 265:61-74. 2004
2002	Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.. International Journal of Molecular Medicine. 9:451-459. 2002

Research Overview

Dr. De Langhe's research focuses on lung development, lung regeneration and lung stem cells. He is especially interested in how Wnt and FGF signaling pathways between stem cells and their niche control the differentiation, proliferation and maintenance of several mesenchymally and epithelial cell lineages.