Positions

Overview

  • Dr. Chaplin completed his undergraduate education at Harvard University in 1973, then undertook graduate training in the MD/PhD program at Washington University, graduating in 1980. He completed two years of Internal Medicine Residency at U of Texas/Southwestern Medical School, Parkland Memorial Hospital. His post-doctoral research training was with Dr. J.G. Seidman in the Department of Genetics at Harvard Medical School, studying the genetics of the murine major histocompatibility complex. In 1984, he accepted a position as Associate Investigator of the Howard Hughes Medical Institute and Assistant Professor of Medicine, Molecular Microbiology, and Genetics at Washington University in St. Louis. He was promoted to Associate Professor in 1992, and Professor in 1995. He was Director of the Division of Allergy and Immunology from 1994-2001. In July 2001, he joined the faculty of UAB as Charles H. McCauley Professor and Chairman of the Department of Microbiology. In 2012, he stepped down from his position as Department Chair and assumed the position of Associate Dean for Faculty Development in the School of Medicine.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.Scientific Reports.  8:10340. 2018
    2017 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients.The Journal of heart transplantation2017
    2015 IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.Mucosal Immunology.  8:930-942. 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease.Journal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2014 Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.Journal of Immunology.  192:2010-2014. 2014
    2013 IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.Proceedings of the National Academy of Sciences.  110:12768-12773. 2013
    2013 A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism.Gene Therapy.  20:733-741. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice.British Journal of Pharmacology.  169:462-476. 2013
    2012 Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.American Journal of Respiratory Cell and Molecular Biology.  46:790-796. 2012
    2012 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism.Molecular Medicine.  18:659-668. 2012
    2012 Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells.Journal of Immunology.  188:3107-3115. 2012
    2012 Regulatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma.European Journal of Pharmacology.  677:154-162. 2012
    2011 AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils.Federation proceedings.  25:4358-4368. 2011
    2011 Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection.Infection and Immunity.  79:3966-3977. 2011
    2011 Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness.Mucosal Immunology.  4:503-518. 2011
    2011 Inhibition of neutrophil apoptosis by PAI-1.AJP - Lung Cellular and Molecular Physiology.  301:L247-L254. 2011
    2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.Arthritis and Rheumatism.  63:2038-2048. 2011
    2011 Important role of neutrophils in the late asthmatic response in mice.Life Sciences.  88:1127-1135. 2011
    2011 Elevated levels of NO are localized to distal airways in asthma.Free Radical Biology and Medicine.  50:1679-1688. 2011
    2010 Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae.PLoS ONE.  5:e14417. 2010
    2010 Follicular dendritic cell makes environmental sense.Immunity.  33:2-4. 2010
    2010 Immunology. Tumor immune evasion.Science.  328:697-698. 2010
    2010 Overview of the immune response.Journal of Allergy and Clinical Immunology.  125:S3-23. 2010
    2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity.Journal of Immunology.  184:442-451. 2010
    2009 MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways.European Journal of Immunology.  39:2281-2292. 2009
    2009 The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function.Immunity.  30:408-420. 2009
    2008 Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.Journal of Immunology.  181:6027-6037. 2008
    2008 Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.Proceedings of the National Academy of Sciences.  105:6720-6724. 2008
    2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.Nature Immunology.  9:166-175. 2008
    2006 Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice.American Journal of Pathology.  168:1425-1434. 2006
    2006 1. Overview of the human immune response.Journal of Allergy and Clinical Immunology.  117:S430-S435. 2006
    2006 Taking control of follicular dendritic cells.Immunity.  24:13-15. 2006
    2005 Induction of a late asthmatic response associated with airway inflammation in mice.European Journal of Pharmacology.  521:144-155. 2005
    2005 CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.Nature Immunology.  6:698-706. 2005
    2003 Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin.The Scientific World Journal.  3:484-496. 2003
    2003 Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph nodeAJP - Heart and Circulatory Physiology.  284. 2003
    2003 Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.AJP - Heart and Circulatory Physiology.  284:H2213-H2226. 2003
    2003 Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function.Journal of Immunology.  170:5475-5482. 2003
    2003 1. Overview of the immune response.Journal of Allergy and Clinical Immunology.  111:S442-S459. 2003
    2002 Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma.Journal of Immunology.  169:5458-5467. 2002
    2002 IgE cross-linking or lipopolysaccharide treatment induces recruitment of Th2 cells to the lung in the absence of specific antigen.Journal of Immunology.  169:5468-5476. 2002
    2002 Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation.Journal of Immunology.  168:2475-2482. 2002
    2002 T helper type 1 cells in asthma: friend or foe?Current Opinion in Allergy and Clinical Immunology.  2:31-37. 2002
    2002 Cell cooperation in development of eosinophil-predominant inflammation in airways.Immunologic Research.  26:55-62. 2002
    2002 Regulation of spleen white pulp structure and function by lymphotoxin.Advances in Experimental Medicine and Biology.  512:49-56. 2002
    2001 Visualization of early APC/T cell interactions in the mouse lung following intranasal challenge.Journal of Immunology.  167:6756-6764. 2001
    2001 Confocal fluorescent intravital microscopy of the murine spleen.Journal of Immunological Methods.  256:55-63. 2001
    2001 Interleukin-1beta promotes repair of the CNS.Journal of Neuroscience.  21:7046-7052. 2001
    2001 A role for IL-1 alpha in inducing pathologic inflammation during bacterial infection.Proceedings of the National Academy of Sciences.  98:10880-10885. 2001
    2001 Signaling through TNF receptor p55 in TNF-alpha-deficient mice alters the CXCL13/CCL19/CCL21 ratio in the spleen and induces maturation and migration of anergic B cells into the B cell follicle.Journal of Immunology.  167:1920-1928. 2001
    2001 IL-1beta is essential for langerhans cell activation and antigen delivery to the lymph nodes during contact sensitization: evidence for a dermal source of IL-1beta.Cellular Immunology.  211:105-112. 2001
    2001 Induction, distribution and modulation of upper airway allergic inflammation in mice.Clinical and Experimental Allergy.  31:1048-1059. 2001
    2001 Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.Journal of Experimental Medicine.  193:1227-1238. 2001
    2000 Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin.European Journal of Immunology.  30:2226-2234. 2000
    2000 Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation.Journal of Immunology.  164:2508-2514. 2000
    2000 Could asthma be worsened by stimulating the T-helper type 1 immune response?American Journal of Respiratory Cell and Molecular Biology.  22:143-146. 2000
    1999 The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo.Science.  286:2159-2162. 1999
    1999 Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation.Journal of Clinical Investigation.  104:1021-1029. 1999
    1999 Dysregulated myelopoiesis in mice lacking Jak3.Blood.  94:932-939. 1999
    1999 Requirement for membrane lymphotoxin in natural killer cell development.Proceedings of the National Academy of Sciences.  96:6336-6340. 1999
    1999 Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma.Journal of Immunology.  162:2375-2383. 1999
    1999 Development and maturation of secondary lymphoid tissues.Annual Review of Immunology.  17:399-433. 1999
    1998 Cytokine regulation of secondary lymphoid organ development.Current Opinion in Immunology.  10:289-297. 1998
    1998 B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion.Journal of Experimental Medicine.  187:1009-1018. 1998
    1998 B lymphocytes deliver lymphotoxin-dependent signals for the development of follicular dendritic cell clustersFederation proceedings.  12. 1998
    1998 Modulation of allergic airway inflammation by transferred Th1 and Th2 cellsFederation proceedings.  12. 1998
    1998 Targets in cytokine activation.Agents and actions. Supplements.  49:1-3. 1998
    1997 Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells.Journal of Experimental Medicine.  186:1997-2004. 1997
    1997 Abrogation of the alternative complement pathway by targeted deletion of murine factor B.Proceedings of the National Academy of Sciences.  94:8720-8725. 1997
    1997 Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses.Journal of Experimental Medicine.  185:2111-2120. 1997
    1997 Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node.Proceedings of the National Academy of Sciences.  94:5739-5743. 1997
    1997 Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers.Immunological Reviews.  156:137-144. 1997
    1996 Affinity maturation in the absence of germinal centers in lymphotoxin-α deficient miceFederation proceedings.  10. 1996
    1996 Mean multidimentional functionДоклады Академии Наук / Doklady Biological Sciences.  351:558-560. 1996
    1996 Polymorphic marker from there tumor necrosis factor receptor p75 gene: Application for the disease association studiesДоклады Академии Наук / Doklady Biological Sciences.  351:558-560. 1996
    1996 [A polymorphic markers for the p75 tumor necrosis factor receptor gene: use for analyzing disease linkage].Доклады Академии Наук / Doklady Biological Sciences.  351:558-560. 1996
    1996 Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.Nature.  382:462-466. 1996
    1996 Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.Proceedings of the National Academy of Sciences.  93:3357-3361. 1996
    1996 Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.Journal of Experimental Medicine.  183:1427-1436. 1996
    1996 Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.Science.  271:1289-1291. 1996
    1995 Macrophage apoptosis in the absence of active interleukin-1 beta-converting enzyme.Journal of Leukocyte Biology.  58:717-724. 1995
    1995 A novel Creb family gene telomeric of HLA-DRA in the HLA complex.Genomics.  30:149-156. 1995
    1995 Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes.Genomics.  30:53-58. 1995
    1995 Restriction map of a 35-kb HLA fragment constructed by nested deletion 'drop-out' mapping.Gene.  164:335-339. 1995
    1995 Molecular Dissection of the Murine IL-1beta Promoter.American Journal of Therapeutics.  2:677-686. 1995
    1995 Construction of a genomic DNA 'feature map' by sequencing from nested deletions: application to the HLA class I region.Nucleic Acids Research.  23:117-122. 1995
    1995 A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene.Molecular and Cellular Biology.  15:112-119. 1995
    1995 Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration.Journal of inflammation.  45:72-78. 1995
    1994 Fluorescent automated sequencing of supercoiled high molecular weight double-stranded DNA.BioTechniques.  17:854-857. 1994
    1994 Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1 beta gene.Journal of Immunology.  153:143-152. 1994
    1994 An NFIL-6 sequence near the transcriptional initiation site is necessary for the lipopolysaccharide induction of murine interleukin-1 beta.DNA (Mary Ann Liebert, Inc.).  13:561-569. 1994
    1994 Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin.Science.  264:703-707. 1994
    1994 P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.Immunogenetics.  39:48-55. 1994
    1993 Genes in one megabase of the HLA class I region.Proceedings of the National Academy of Sciences.  90:11870-11874. 1993
    1993 Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation.Proceedings of the National Academy of Sciences.  90:9470-9474. 1993
    1993 Regulation of IL-1 gene expression: differential responsiveness of murine macrophage lines.Cytokine.  5:327-335. 1993
    1993 Simultaneous transfer of four functional genes from the HLA class II region into mammalian cells by fusion with yeast spheroplasts carrying an artificial chromosome.Journal of Immunology.  150:5371-5378. 1993
    1993 Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78.Genomics.  16:193-198. 1993
    1993 Highly informative typing of the human TNF locus using six adjacent polymorphic markers.Genomics.  16:180-186. 1993
    1993 IDENTIFICATION IN THE HLA CLASS-I REGION OF A NOVEL GENE EXPRESSED IN TERMINALLY DIFFERENTIATING KERATINOCYTESJournal of Investigative Dermatology.  100:501-501. 1993
    1993 IDENTIFICATION IN THE HLA CLASS-I REGION OF A NOVEL GENE EXPRESSED IN TERMINALLY DIFFERENTIATING KERATINOCYTESClinical research.  41:A487-A487. 1993
    1993 RELEASE OF INTERLEUKIN-1 FROM ACTIVATED MOUSE MACROPHAGES BY ANTIGEN-SPECIFIC HELPER T-LYMPHOCYTE CLONESClinical research.  41:A184-A184. 1993
    1993 Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. I. Development and initial characterisation of the model.Agents and actions.  38:247-254. 1993
    1993 Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. II. Identification of (tissue) macrophages as the IL-1 producing cells and the effect of anti-inflammatory drugs.Agents and actions.  38:255-264. 1993
    1993 CHARACTERIZATION AND ACTIVATION OF THE MURINE INTERLEUKIN-1-BETA (IL-1-BETA) CONVERTING ENZYMEJournal of Cellular Biochemistry.  117-117. 1993
    1992 Molecular cloning of the murine IL-1 beta converting enzyme cDNA.Journal of Immunology.  149:3254-3259. 1992
    1992 Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomes.Proceedings of the National Academy of Sciences.  89:2669-2673. 1992
    1991 Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.Molecular Endocrinology -Baltimore-.  5:1853-1861. 1991
    1991 IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.Journal of Immunology.  147:2964-2969. 1991
    1991 Molecular linkage of the HLA-DR, HLA-DQ, and HLA-DO genes in yeast artificial chromosomes.Genomics.  11:577-586. 1991
    1991 cDNA selection: efficient PCR approach for the selection of cDNAs encoded in large chromosomal DNA fragments.Proceedings of the National Academy of Sciences.  88:9623-9627. 1991
    1991 Interleukin 1 is processed and released during apoptosis.Proceedings of the National Academy of Sciences.  88:8485-8489. 1991
    1991 Release of IL-1 from mononuclear phagocytes.Journal of Immunology.  147:2181-2186. 1991
    1991 Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo.Journal of Immunology.  146:1534-1540. 1991
    1991 Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci.Proceedings of the National Academy of Sciences.  88:1676-1680. 1991
    1990 Genetic variability at the human tumor necrosis factor loci.Journal of Immunology.  145:1278-1285. 1990
    1990 Compartmentalization of mammalian proteins produced in Escherichia coli.Journal of Biological Chemistry.  265:13066-13073. 1990
    1990 A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.Genes and Development.  4:978-992. 1990
    1990 Genomic organization of mouse Fc gamma receptor genes.Proceedings of the National Academy of Sciences.  87:2856-2860. 1990
    1990 Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.Journal of Biological Chemistry.  265:3193-3201. 1990
    1990 Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene.Biochemistry.  29:1226-1232. 1990
    1990 Factor H.Current Topics in Microbiology and Immunology.  153:147-162. 1990
    1990 The B144-H-2Db interval and the location of a mouse homologue of the human D6S81E locus.Immunogenetics.  32:200-204. 1990
    1989 Molecular analysis of the murine C4b-binding protein gene. Chromosome assignment and partial gene organization.Biochemistry.  28:8312-8317. 1989
    1989 Molecular biology and genetics of interleukin-1.The Year in immunology.  5:21-37. 1989
    1989 Regulation of the human chorionic gonadotrophin beta subunit genes.Journal of Reproduction and Fertility -Supplement-.  37:1-10. 1989
    1988 Structure of the murine complement factor H gene.Journal of Biological Chemistry.  263:16720-16724. 1988
    1988 Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.Journal of Immunology.  141:2643-2650. 1988
    1988 Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.Proceedings of the National Academy of Sciences.  85:5649-5653. 1988
    1988 Identification of a promoter region in the CG beta gene cluster.Journal of Biological Chemistry.  263:7322-7329. 1988
    1988 The major histocompatibility complex and autoimmunity.The Year in immunology.  3:179-198. 1988
    1987 Germline organization of the murine T cell receptor beta-chain genes.Science.  238:545-548. 1987
    1987 Anaphylaxis to intravenous furosemide.Journal of Allergy and Clinical Immunology.  80:538-541. 1987
    1987 Deletion of C4A genes in patients with systemic lupus erythematosus.Arthritis and Rheumatism.  30:1015-1022. 1987
    1987 Cosmid mapping of the human chorionic gonadotropin beta subunit genes by field-inversion gel electrophoresis.Nucleic Acids Research.  15:4437-4448. 1987
    1987 Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.Journal of Immunology.  138:3799-3802. 1987
    1987 Membrane IL-1: a key protein in antigen presentation.Annales de l'Institut Pasteur. Immunology.  138:489-492. 1987
    1987 Human complement C3b/C4b receptor (CR1) mRNA polymorphism that correlates with the CR1 allelic molecular weight polymorphism.Proceedings of the National Academy of Sciences.  84:2459-2463. 1987
    1987 Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse.Immunogenetics.  26:339-343. 1987
    1986 Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression.Proceedings of the National Academy of Sciences.  83:9601-9605. 1986
    1986 Characterization of a regulatory region of the steroid 21-hydroxylase gene.Journal of Biological Chemistry.  261:15353-15355. 1986
    1986 Molecular analysis of 21-hydroxylase gene expression in mouse adrenal cells.Endocrine Research.  12:409-427. 1986
    1985 Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells.Proceedings of the National Academy of Sciences.  82:7860-7864. 1985
    1985 Expression of complement proteins C2 and factor B in transfected L cells.Journal of Clinical Investigation.  76:1449-1454. 1985
    1985 Molecular organization and in vitro expression of murine class III genes.Immunological Reviews.  87:61-80. 1985
    1985 Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats.Journal of Experimental Medicine.  162:444-458. 1985
    1985 Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.Proceedings of the National Academy of Sciences.  82:1089-1093. 1985
    1985 Molecular linkage of the genes encoding adrenal steroid 21-hydroxylase to the S region of the murine major histocompatibility complex (MHC)Federation proceedings.  44. 1985
    1984 Two steroid 21-hydroxylase genes are located in the murine S region.Nature.  312:465-467. 1984
    1984 Eukaryotic chromosome transfer: linkage of the murine major histocompatibility complex to an inserted dominant selectable marker.Proceedings of the National Academy of Sciences.  81:4879-4883. 1984
    1984 Class I, II and III major histocompatibility complex gene polymorphisms in BB rats.Diabetologia.  27 Suppl:77-79. 1984
    1984 Expression of hemolytically active murine fourth component of complement in transfected L cells.Cell.  37:569-576. 1984
    1984 Eukaryotic chromosome transfer: Linkage of the murine major histocompatibility complex to an inserted dominant selectable markerProceedings of the National Academy of Sciences.  81:4879-4883. 1984
    1983 Molecular map of the murine S region.Proceedings of the National Academy of Sciences.  80:6947-6951. 1983
    1983 Molecular map of the murine S regionProceedings of the National Academy of Sciences.  80:6947-6951. 1983
    1980 Early activation events in lectin-stimulated human lymphocytes: evidence that wheat germ agglutinin and mitogenic lectins cause similar early changes in lymphocyte metabolism.Journal of Immunology.  125:1544-1550. 1980
    1980 Protein phosphorylation in human peripheral blood lymphocytes: mitogen-induced increases in protein phosphorylation in intact lymphocytes.Journal of Immunology.  124:2390-2398. 1980
    1979 Protein phosphorlyation in human peripheral blood lymphocytes. Phosphorylation of endogenous plasma membrane and cytoplasmic proteins.Biochemical Journal.  182:537-546. 1979
    1979 Protein phosphorylation in human peripheral blood lymphocytes. Subcellular distribution and partial characterization of adenosine 3':5'-cyclic monophosphate-dependent protein kinase.Biochemical Journal.  182:525-536. 1979
    1979 Stimulation by mitogens of phosphorylation of a 65,000 MW protein in intact human lymphocytesFederation proceedings.  38. 1979
    1978 Inhibition of lectin-induced lymphocyte activation by diamide and other sulfhydryl reagents.Cellular Immunology.  36:303-311. 1978
    1977 Sulfhydryl compounds potentiate lectin induced increases in cyclic AMP in human peripheral lymphocytesCellular Immunology.  28:338. 1977
    1974 The effects of thrombin on phytohemagglutinin receptor sites in human platelets.Journal of Cell Biology.  60:541-553. 1974

    Chapter

    Year Title Altmetric
    2007 Overview of Immunology in the Mouse: Molecular and Cellular Immunology.  1-55. 2007
    2001 Analysis of isolated YAC clones. 2001
    2001 Overview of strategies for screening YAC libraries and analyzing YAC clones. 2001

    Research Overview

  • Interplay between innate and adaptive immunity in asthmatic inflammation - Dr. Chaplin’s laboratory aims to define the ways innate immune stimuli modulate allergic inflammatory responses that are manifest in tissues through the action of the adaptive immune response. He has a special interest in the ways commensal and pathogenic microbes that are present in the lung alter allergic inflammatory responses such as those that underlie asthmatic inflammation. He is testing the hypothesis that airway microbes impact the quality and quantity of asthmatic inflammation largely through their induction of myeloid-derived regulatory cells (MDRC). Lung and airway MDRC, defined by Dr. Chaplin’s laboratory in 2011, constitute several discrete populations of cells that determine the overall inflammatory tone in the tissues through their production of cytokines, chemokines, and reactive nitrogen and oxygen free radical species. Dr. Chaplin’s laboratory demonstrated in studies using a mouse model that superoxide-producing MDRC dramatically accentuate airway hyperresponsiveness after exposure to aerosolized antigen. In contrast, populations of nitric oxide-producing MDRC blunt airway hyperresponsiveness, suggesting that the nitric oxide/superoxide axis may be a valuable target for future development of novel anti-asthmatic therapeutics.
  • Investigator On

  • Asthma Cohort Support Contract  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2013 - 2023
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2020
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • UAB Skin Disease Research Center - Administrative Core - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • Second-Hand Smoke and Myeloid Cells in Asthma  awarded by Flight Attendant Medical Research Institute 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) KL2 Component  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) T32 (TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Dental Academic Research Training - DART  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2012
  • Teaching Overview

  • Course Director for GBS 730-01 Respiratory Tract Pathogens 2010, 2012, 2015, 2017
    Course Co-Director for MIC 788 Primary Immunodeficiency Diseases 2008, 2011
    Course Director for EPI 680 Clinical and Translational Science Training Program 2015, 2016, 2017, 2018
  • Full Name

  • David Chaplin
  • Fax

  • 205-996-4008