• Dr. Datta earned his Bachelor of Science (BS), Honors in Chemistry; Physics and Mathematics, and his Master of Science (MS), Organic Chemistry from The University of Burdwan, India.  He erned his Ph.D. in Organic Chemistry, from the Bose Institute, Calcutta, India.  His thesis title was Studies on Natural Carbocyclic Compounds. He worked as a research associate with Dr. Srilata Bagchi at the University of Illinois in Chicago and with Dr. Harold L. Moses at The Vanderbilt-Ingram Cancer Center in Nashville. He began work as assistant professor in Surgical Oncology Cancer Biology at Vanderbilt University in 2000. Dr. Datta also served as a research scientist at the Veterans Affairs Medical Center in Nasvhille. In 2012, Dr. Datta joined the faculty at UAB, where he is Professor and Director of Research in the Division of Hematology/Oncology. He is also leader of the Colon and Lung Cancer Basic Research Program. He is senior scientist in the Cancer Cell Biology Program at the UAB Comprehensive Cancer Center. In addition, Dr. Datta also serves as Research Scientist at the Veterans Affairs Medical Center in Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis.STEM CELLS.  36:1368-1379. 2018
    2017 Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis.Cancers.  9. 2017
    2017 Molecular characterization of pro-metastatic functions of β4-integrin in colorectal cancer.Oncotarget.  8:92333-92345. 2017
    2017 STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.Cancer Research.  77:5464-5478. 2017
    2016 Role of TGF-β-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer.Cellular Signalling.  28:1537-1544. 2016
    2016 Effect of Cigarette Smoking on Epithelial to Mesenchymal Transition (EMT) in Lung Cancer.Journal of Clinical Medicine.  5. 2016
    2016 Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.Oncotarget.  7:16023-16037. 2016
    2016 Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells.International Journal of Molecular Sciences.  17:408. 2016
    2015 An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC.Oncotarget.  6:33237-33252. 2015
    2014 Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.Hepatology.  60:1620-1636. 2014
    2014 Smad6 suppresses the growth and self-renewal of hepatic progenitor cells.Journal of Cellular Physiology.  229:651-660. 2014
    2014 Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.British Journal of Cancer.  110:946-957. 2014
    2014 Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1.Cell Cycle.  13:3909-3920. 2014
    2013 Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer.Cancer Biology and Therapy.  14:1059-1067. 2013
    2013 Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling.Cellular Signalling.  25:1981-1992. 2013
    2012 Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.Nucleic Acids Research.  40:11404-11415. 2012
    2012 Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin.Molecular Cancer Therapeutics.  11:2362-2372. 2012
    2012 Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer.Neoplasia : An International Journal for Oncology Research.  14:644-655. 2012
    2012 Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer.Cancer Prevention Research.  5:453-463. 2012
    2012 Alterations in the Smad pathway in human cancers.Frontiers in Bioscience.  17:1281-1293. 2012
    2011 Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines.Neoplasia : An International Journal for Oncology Research.  13:912-922. 2011
    2011 Role of STRAP in regulating GSK3β function and Notch3 stabilization.Cell Cycle.  10:1639-1654. 2011
    2011 STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation.Biochemical and Biophysical Research Communications.  407:372-377. 2011
    2011 TGF-beta-dependent and -independent roles of STRAP in cancer.Frontiers in Bioscience.  16:105-115. 2011
    2010 Increased cell migration and plasticity in Nrf2-deficient cancer cell lines.Oncogene.  29:3703-3714. 2010
    2010 Antimetastatic role of Smad4 signaling in colorectal cancer.Gastroenterology.  138:969-80.e1-3. 2010
    2010 Serine threonine receptor-associated protein (STRAP) plays a role in the maintenance of mesenchymal morphology.Cellular Signalling.  22:138-149. 2010
    2010 Targeting the transforming growth factor-beta signaling pathway in human cancer.Expert Opinion on Investigational Drugs.  19:77-91. 2010
    2009 Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.Cancer Letters.  277:114-120. 2009
    2008 Smad7 induces hepatic metastasis in colorectal cancer.British Journal of Cancer.  99:957-965. 2008
    2007 Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells.Cancer Research.  67:1571-1579. 2007
    2006 Oncogenic serine-threonine kinase receptor-associated protein modulates the function of Ewing sarcoma protein through a novel mechanism.Cancer Research.  66:10824-10832. 2006
    2006 Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta.Journal of Biological Chemistry.  281:33971-33981. 2006
    2006 Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells.Cellular Signalling.  18:1041-1050. 2006
    2006 Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis.Cancer Research.  66:6156-6166. 2006
    2005 Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells.British Journal of Cancer.  93:1157-1167. 2005
    2005 Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.Experimental Cell Research.  307:231-246. 2005
    2005 A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.Neoplasia : An International Journal for Oncology Research.  7:509-521. 2005
    2004 Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.Journal of Surgical Research.  117:296-305. 2004
    2003 Over-expression of cyclin D1 regulates Cdk4 protein synthesis.Cell Proliferation.  36:347-360. 2003
    2003 Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites.Nucleic Acids Research.  31:5368-5376. 2003
    2001 Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.Journal of Biological Chemistry.  276:29531-29537. 2001
    2000 Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1.Journal of Biological Chemistry.  275:40014-40019. 2000
    2000 STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.Molecular and Cellular Biology.  20:3157-3167. 2000
    1999 Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells.Neoplasia : An International Journal for Oncology Research.  1:508-517. 1999
    1998 Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling.Journal of Biological Chemistry.  273:34671-34674. 1998
    1998 RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation.Journal of Biological Chemistry.  273:9921-9926. 1998
    1998 Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation.Journal of Cellular Biochemistry -Supplement-.  30-31:111-122. 1998
    1998 Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation.Journal of Cellular Biochemistry.  72 Suppl 30-31:111-122. 1998
    1995 Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription.Molecular and Cellular Biology.  15:5444-5452. 1995
    1994 Repression of transforming growth factor beta 1 promoter by the adenovirus oncogene E1A. Identification of a unique GC-rich sequence as a target for E1A repression.Journal of Biological Chemistry.  269:25392-25399. 1994

    Education And Training

  • Bachelor of Science or Mathematics in Chemistry, University of Burdwan
  • Doctor of Philosophy in Organic Chemistry, Jadavpur University
  • Master of Sciences or Mathematics in Organic Chemistry, University of Burdwan
  • Full Name

  • Pran Datta