• Dr. Datta earned his Bachelor of Science (BS), Honors in Chemistry; Physics and Mathematics, and his Master of Science (MS), Organic Chemistry from The University of Burdwan, India.  He erned his Ph.D. in Organic Chemistry, from the Bose Institute, Calcutta, India.  His thesis title was Studies on Natural Carbocyclic Compounds. He worked as a research associate with Dr. Srilata Bagchi at the University of Illinois in Chicago and with Dr. Harold L. Moses at The Vanderbilt-Ingram Cancer Center in Nashville. He began work as assistant professor in Surgical Oncology Cancer Biology at Vanderbilt University in 2000. Dr. Datta also served as a research scientist at the Veterans Affairs Medical Center in Nasvhille. In 2012, Dr. Datta joined the faculty at UAB, where he is Professor and Director of Research in the Division of Hematology/Oncology. He is also leader of the Colon and Lung Cancer Basic Research Program. He is senior scientist in the Cancer Cell Biology Program at the UAB Comprehensive Cancer Center. In addition, Dr. Datta also serves as Research Scientist at the Veterans Affairs Medical Center in Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis 2018
    2017 Regulation of EMT in colorectal cancer: A culprit in metastasis 2017
    2017 STRAP promotes stemness of human colorectal cancer via epigenetic regulation of the NOTCH pathwaya 2017
    2017 Molecular characterization of pro-metastatic functions of β4- integrin in colorectal cancer 2017
    2016 Role of TGF-β-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer 2016
    2016 Effect of Cigarette Smoking on Epithelial to Mesenchymal Transition (EMT) in Lung Cancer. 2016
    2016 Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling 2016
    2016 Activin a-smad signaling mediates connective tissue growth factor synthesis in liver progenitor cells 2016
    2015 An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC 2015
    2014 Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21Cip1 by modulating the transcription factor Sp1 2014
    2014 Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway 2014
    2014 Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma 2014
    2014 Smad6 suppresses the growth and self-renewal of hepatic progenitor cells 2014
    2013 Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer 2013
    2013 Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling 2013
    2012 Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress 2012
    2012 Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin 2012
    2012 Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer 2012
    2012 Alterations in the Smad pathway in human cancers 2012
    2012 Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer 2012
    2011 Role of STRAP in regulating GSK3β function and Notch3 stabilization 2011
    2011 STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation 2011
    2011 Elucidating the mechanism of regulation of transforming growth factor β type II receptor expression in human lung cancer cell lines 2011
    2011 TGF-beta-dependent and -independent roles of STRAP in cancer 2011
    2010 Increased cell migration and plasticity in Nrf2-deficient cancer cell lines 2010
    2010 Antimetastatic Role of Smad4 Signaling in Colorectal Cancer 2010
    2010 Serine Threonine Receptor-Associated Protein (STRAP) plays a role in the maintenance of mesenchymal morphology 2010
    2010 Targeting the transforming growth factor-β signaling pathway in human cancer 2010
    2009 Targeting transforming growth factor-β signaling in liver metastasis of colon cancer 2009
    2008 Smad7 induces hepatic metastasis in colorectal cancer 2008
    2007 Smad4 regulates claudin-1 expression in a transforming growth factor-β-independent manner in colon cancer cells 2007
    2006 Oncogenic serine-threonine kinase receptor-associated protein modulates the function of ewing sarcoma protein through a novel mechanism 2006
    2006 Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-β 2006
    2006 Role of Smad proteins in the regulation of NF-κB by TGF-β in colon cancer cells 2006
    2006 Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis 2006
    2005 Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells 2005
    2005 Smad7 induces tumorigenicity by blocking TGF-β-induced growth inhibition and apoptosis 2005
    2005 A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers 2005
    2004 Smad3 has a critical role in TGF-β-mediated growth inhibition and apoptosis in colonic epithelial cells 2004
    2003 Over-expression of cyclin D1 regulates Cdk4 protein synthesis 2003
    2003 Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites 2003
    2001 Oncogenic Ras Represses Transforming Growth Factor-β/Smad Signaling by Degrading Tumor Suppressor Smad4 2001
    2000 Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-β-induced physical and functional interactions between Smads and Sp1 2000
    2000 STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling 2000
    1999 Synergistic Induction of Cyclooxygenase-2 by Transforming Growth Factor-β1 and Epidermal Growth Factor Inhibits Apoptosis in Epithelial Cells 1999
    1998 Identification of STRAP, a novel WD domain protein in transforming growth factor-β signaling 1998
    1998 Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation 1998
    1998 RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activation 1998
    1998 Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation. 1998
    1995 Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription 1995
    1994 Repression of transforming growth factor β1 promoter by the adenovirus oncogene E1A: Identification of a unique GC-rich sequence as a target for E1A repression 1994

    Full Name

  • Pran Datta