• Victor Darley-Usmar received his Ph.D. at the University of Essex in England and then moved to the University of Oregon as a Post-Doctoral Fellow to pursue his interests in the structure and function of mitochondrial proteins in human disease. After a period as a lecturer in Japan and ten years as a Research Scientist in Burroughs Wellcome in London he joined UAB to establish his own research group in the Department of Pathology in 1995. He has received multiple awards for training and mentoring and served as the Associate Dean for Post-Doctoral Education and the Pathology Graduate Program Director. He co-established the UAB Center for Free Radical Biology from 2006-2015 as an international center for research in redox biology. In his current role of Senior Associate Dean for Research Compliance and Administration he brings his experience in the commercial sector and career development programs to the strategic management of the School of Medicine Research. In his own research program he has been instrumental in defining how redox biology modifies mitochondrial function in pathology and in recognition of these achievements was awarded a Lifetime Achievement Award by the Society for Free Radical Biology and Medicine in 2012. He has been continuously funded by NIH for 25 years and has published over 300 articles with an H factor of over 100. At UAB his contribution to research in mitochondrial pathology was recognized by his appointment as the Foundation Faculty for the “Endowed Professorship in Mitochondrial Medicine and Pathology”. He is now developing a program to apply measures of bioenergetic health to personalized medicine. He was a recent recipient of the prestigious “Creativity is a Decision” and “Blue Sky” awards from UAB for the Bioenergetic Health Index concept. He was recently recognized as the 2017 UAB Distinguished Faculty Lecturer, which is is the highest honor bestowed by the Academic Medical Center on a faculty member who has advanced the frontiers of science and made outstanding contributions to education, research and public service.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Bioenergetic maladaptation and release of HMGB1 in calcineurin inhibitor-mediated nephrotoxicityAmerican Journal of Transplantation.  21:2964-2977. 2021
    2021 UAB-UCSD o'brien center for acute kidney injury research 2021
    2021 A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1 2021
    2021 Metabolic alterations mediated by STAT3 promotes drug persistence in CMLLeukemia2021
    2021 Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease 2021
    2021 University of Alabama at Birmingham Nathan Shock Center: comparative energetics of agingGeroscience2021
    2021 ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppressionLaboratory Investigation2021
    2020 Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic PropertiesJournal of Medicinal Chemistry.  63:10984-11011. 2020
    2020 Nuclear receptor binding factor 2 (NRBF2) is required for learning and memoryLaboratory Investigation.  100:1238-1251. 2020
    2020 A novel approach to measure mitochondrial respiration in frozen biological samples 2020
    2020 Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia 2020
    2020 Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic DysfunctionAntioxidants and Redox Signaling.  32:1293-1312. 2020
    2020 Differential effects of REV-ERB/ agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption 2020
    2020 Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage PolarizationCells.  9. 2020
    2020 Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in AutoimmunityImmunity.  52:650-667.e10. 2020
    2020 Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination TherapyCell Reports.  30:1798-1810.e4. 2020
    2020 Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T CellsCell Reports.  30:1898-1909.e4. 2020
    2020 A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human plateletsRedox Biology.  28. 2020
    2020 Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. 2020
    2020 The role of metabolic plasticity in blood and brain stem cell pathophysiologyCancer Research.  80:5-16. 2020
    2019 Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in miceRedox Biology.  27. 2019
    2019 Targeting glycolysis through inhibition of lactate dehydrogenase impairs tumor growth in preclinical models of Ewing sarcomaCancer Research.  79:5060-5073. 2019
    2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate DecisionBiophysical Journal.  117:631-645. 2019
    2019 Acute increases in O-glcNAc indirectly impair mitochondrial bioenergetics through dysregulation of lonp1-mediated mitochondrial protein complex turnover 2019
    2019 Feasibility of cellular bioenergetics as a biomarker in porphyria patientsMolecular Genetics and Metabolism Reports.  19. 2019
    2019 New quantitative approach reveals heterogeneity in mitochondrial structure–function relations in tumor-initiating cellsJournal of Cell Science.  132. 2019
    2019 Mitochondria in precision medicine; linking bioenergetics and metabolomics in plateletsRedox Biology.  22. 2019
    2019 Truncating PKHD1 and PKD2 mutations alter energy metabolism 2019
    2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in miceRedox Biology.  21. 2019
    2019 SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injuryJCI insight.  4. 2019
    2019 Bioenergetics and translational metabolism: Implications for genetics, physiology and precision medicine 2019
    2019 SIRT1 regulates metabolism and leukemogenic potential in CML stem cellsJournal of Clinical Investigation.  129:2685-2701. 2019
    2018 N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in miceAnnals of Neurology.  84:854-872. 2018
    2018 Erratum to: Metformin reverses established lung fibrosis in a bleomycin model (Nature Medicine, (2018), 24, 8, (1121-1127), 10.1038/s41591-018-0087-6)Nature Medicine.  24:1627. 2018
    2018 AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formationBlood.  132:1180-1192. 2018
    2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cellsRedox Biology.  18:54-64. 2018
    2018 Rust never sleeps: The continuing story of the Iron BoltFree Radical Biology and Medicine.  124:353-357. 2018
    2018 Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in VitroACS Chemical Biology.  13:2048-2057. 2018
    2018 Reply to bailey et al.: new perspectives on the novel role of the Poldip2/ ACSM1 axis in a functional mammalian lipoylation salvage pathway 2018
    2018 Metformin reverses established lung fibrosis in a bleomycin modelNature Medicine.  24:1121-1131. 2018
    2018 Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammationJournal of Experimental Medicine.  215:1803-1812. 2018
    2018 Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signalingRedox Biology.  17:158-170. 2018
    2018 Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell cultureRedox Biology.  17:59-69. 2018
    2018 An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clockFree Radical Biology and Medicine.  119:75-84. 2018
    2018 Temporal partitioning of adaptive responses of the murine heart to fastingLife Sciences.  197:30-39. 2018
    2018 Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's diseaseJournal of Neurochemistry.  144:691-709. 2018
    2018 Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer 2018
    2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activationJournal of Biological Chemistry.  293:1218-1228. 2018
    2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.Journal of Biological Chemistry.  293:1218-1228. 2018
    2017 Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)Journal of Medicinal Chemistry.  60:9184-9204. 2017
    2017 Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neuronsAutophagy.  13:1828-1840. 2017
    2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
    2017 Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardiumRedox Biology.  12:937-945. 2017
    2017 Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected womenRedox Biology.  12:648-656. 2017
    2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; Implications for Parkinson's diseaseMolecular Brain.  10. 2017
    2017 O-GlcNAcylation and neurodegenerationBrain Research Bulletin.  133:80-87. 2017
    2017 Autophagy and the redox connection: Virtual collection Vol 2Redox Biology.  11:620-621. 2017
    2017 Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stressThe FASEB Journal.  31:1608-1619. 2017
    2017 Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neuronsRedox Biology.  11:73-81. 2017
    2017 Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrilsRedox Biology.  11:429-437. 2017
    2017 NADPH Oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathwayJournal of Biological Chemistry.  292:3029-3038. 2017
    2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolismFree Radical Biology and Medicine.  100:94-107. 2016
    2016 A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytesRedox Biology.  9:77-89. 2016
    2016 Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophilsRedox Biology.  9:57-66. 2016
    2016 The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytesRedox Biology.  8:43-50. 2016
    2016 Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic ReviewAlcoholism: Clinical and Experimental Research.  40:1390-1402. 2016
    2016 Assessing Cardiac MetabolismCirculation Research.  118:1659-1701. 2016
    2016 Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A 2 as a Regulator of Mitochondrial Bioenergetics during ActivationCell Metabolism.  23:930-944. 2016
    2016 Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: A mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscleThe FASEB Journal.  30:1865-1879. 2016
    2016 Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stressJournal of Translational Medicine.  14. 2016
    2016 Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolismFree Radical Biology and Medicine.  91:143-153. 2016
    2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
    2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356Autophagy.  12:443. 2016
    2016 The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage: Implications for neurodegenerative diseasesAging and Disease.  7:150-162. 2016
    2015 Defining the effects of storage on platelet bioenergetics: The role of increased proton leak 2015
    2015 Erratum: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity (Biochemical Journal (2015) 469 (347-355))Biochemical Journal.  471:431. 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiationJournal of Biological Chemistry.  290:25427-25438. 2015
    2015 KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicityBiochemical Journal.  469:347-355. 2015
    2015 Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammationFree Radical Biology and Medicine.  85:83-94. 2015
    2015 Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinaseCellular Signalling.  27:1186-1197. 2015
    2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4FBiochemical Journal.  467:517-527. 2015
    2015 Metabolic plasticity in resting and thrombin activated plateletsPLoS ONE.  10. 2015
    2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
    2015 Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients 2015
    2015 Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genesMolecular and Cellular Biology.  35:831-846. 2015
    2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patientsLaboratory Investigation.  95:132-141. 2015
    2015 Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophilsClinical Science.  129:489-504. 2015
    2015 Regulation of autophagy by protein post-translational modificationLaboratory Investigation.  95:14-25. 2015
    2015 The emerging theme of redox bioenergetics in health and diseaseBiomedical Journal.  38:294-300. 2015
    2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
    2014 Bioenergetics and the oxidative burst: Protocols for the isolation and evaluation of human leukocytes and plateletsJournal of Visualized Experiments2014
    2014 A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetesFree Radical Biology and Medicine.  67:437-450. 2014
    2014 A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkersRedox Biology.  2:206-210. 2014
    2014 Autophagy as an essential cellular antioxidant pathway in neurodegenerative diseaseRedox Biology.  2:82-90. 2014
    2014 Bioenergetic adaptation in response to autophagy regulators during rotenone exposureJournal of Neurochemistry.  131:625-633. 2014
    2014 Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets.Journal of Visualized Experiments2014
    2014 Measuring bioenergetic health index (BHI)Ddw Drug Discovery World.  16:63. 2014
    2014 Mitochondria in monocytes and macrophages-implications for translational and basic research 2014
    2014 Mitophagy mechanisms and role in human diseases 2014
    2014 Redox Biology celebrates its first anniversary with over 100 articles, Listing In PubMedand 120,000 downloadswith over230 citations!Redox Biology.  2:640-641. 2014
    2014 Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeuticsFree Radical Biology and Medicine.  71:196-207. 2014
    2014 The Bioenergetic Health Index: a new concept in mitochondrial translational research.Clinical Science.  127:367-373. 2014
    2014 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cellsAutophagy.  10:986-1003. 2014
    2013 Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cellsAutophagy.  9:1996-2008. 2013
    2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))Biochemical Journal.  456:147. 2013
    2013 Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload 2013
    2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overloadBiochemical Journal.  455:157-167. 2013
    2013 Lipid Metabolites Enhance Secretion Acting on SNARE Microdomains and Altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin CellsPLoS ONE.  8. 2013
    2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells 2013
    2013 Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosisJournal of Biological Chemistry.  288:26013-26026. 2013
    2013 Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblastsBiochemical Journal.  454:249-257. 2013
    2013 Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells 2013
    2013 Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1αPLoS ONE.  8. 2013
    2013 Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human bloodLaboratory Investigation.  93:690-700. 2013
    2013 Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeuticsBiochemical Society Transactions.  41:127-133. 2013
    2013 Cellular metabolic and autophagic pathways: Traffic control by redox signalingFree Radical Biology and Medicine.  63:207-221. 2013
    2013 Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neuronsFree Radical Biology and Medicine.  65:1215-1228. 2013
    2013 Mitochondrially targeted compounds and their impact on cellular bioenergeticsRedox Biology.  1:86-93. 2013
    2013 Off to a good start and a promising future in communicating cutting edge developments in redox biologyRedox Biology.  1:446-447. 2013
    2013 Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouseRedox Biology.  1:381-386. 2013
    2013 Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation productsFree Radical Biology and Medicine.  59:56-68. 2013
    2012 Integration of cellular bioenergetics with mitochondrial quality control and autophagy 2012
    2012 Controlling radicals in the powerhouse: Development of mitoSOD 2012
    2012 Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell DeathPLoS ONE.  7. 2012
    2012 Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy 2012
    2012 Cell signalling by reactive lipid species: New concepts and molecular mechanismsBiochemical Journal.  442:453-464. 2012
    2012 Metabolic syndrome and mitochondrial dysfunction: Insights from preclinical studies with a mitochondrially targeted antioxidantFree Radical Biology and Medicine.  52:838-840. 2012
    2012 Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and functionJournal of Molecular and Cellular Cardiology.  52:538-549. 2012
    2012 The electrophile responsive proteome: Integrating proteomics and lipidomics with cellular functionAntioxidants and Redox Signaling.  17:1580-1589. 2012
    2012 Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitationsFree Radical Biology and Medicine.  52:1-6. 2012
    2011 Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stressFree Radical Biology and Medicine.  51:2007-2017. 2011
    2011 Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes 2011
    2011 Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overloadFree Radical Biology and Medicine.  51:1975-1984. 2011
    2011 Assessing bioenergetic function in response to oxidative stress by metabolic profilingFree Radical Biology and Medicine.  51:1621-1635. 2011
    2011 Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signalingFree Radical Biology and Medicine.  51:1271-1288. 2011
    2011 Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells 2011
    2011 Oxidative stress and myocardial remodeling in chronic mitral regurgitationAmerican Journal of the Medical Sciences.  342:114-119. 2011
    2011 Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosisHepatology.  54:153-163. 2011
    2011 PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation 2011
    2011 Role of iPLA2 in the regulation of Src trafficking and microglia chemotaxisTraffic.  12:878-889. 2011
    2011 Bioenergetic function in cardiovascular cells: The importance of the reserve capacity and its biological regulationChemico-Biological Interactions.  191:288-295. 2011
    2011 Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overloadJournal of Molecular and Cellular Cardiology.  50:147-156. 2011
    2010 Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chainJournal of Biological Chemistry.  285:39759-39767. 2010
    2010 Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy MitoQBiochemical Journal.  432:9-19. 2010
    2010 What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biologyJournal of Biological Chemistry.  285:19699-19704. 2010
    2010 Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factorBiochemical Journal.  428:255-267. 2010
    2010 Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen speciesFree Radical Biology and Medicine.  48:905-914. 2010
    2010 Mitochondrial targeting of the electrophilic lipid 15-deoxy-Δ12,14- prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanismsBiochemical Journal.  426:31-41. 2010
    2010 Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation 2010
    2010 Bioenergetic profile experiment using C2C12 myoblast cellsJournal of Visualized Experiments2010
    2009 Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenalBiochemical Journal.  424:99-107. 2009
    2009 Methods for imaging and detecting modification of proteins by reactive lipid speciesFree Radical Biology and Medicine.  47:201-212. 2009
    2009 High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivoBiochemical Journal.  417:183-193. 2009
    2009 Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system 2009
    2008 Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signalingJournal of Biological Chemistry.  283:15319-15327. 2008
    2008 Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease.Methods in Molecular Biology.  447:369-380. 2008
    2008 Accumulation of 15-deoxy-Δ12,14-prostaglandin J 2 adduct formation with Keap1 over time: Effects on potency for intracellular antioxidant defence inductionBiochemical Journal.  411:297-306. 2008
    2008 Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenalJournal of Lipid Research.  49:282-294. 2008
    2008 Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver diseaseMethods in Molecular Biology.  447:369-380. 2008
    2008 S-nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning.Biochemical Journal.  412. 2008
    2007 Hydrogen sulfide mediates the vasoactivity of garlic 2007
    2007 Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver diseaseWorld Journal of Gastroenterology.  13:4967-4973. 2007
    2007 Methods for Measuring the Regulation of Respiration by Nitric OxideMethods in Cell Biology.  80:395-416. 2007
    2007 Is the soluble guanylate cyclase pathway the only one available for nitric oxide (NO) signaling? 2007
    2007 Hydrogen sulfide mediates vasoactivity in an O2-dependent manner 2007
    2007 Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respirationCirculation Research.  100:654-661. 2007
    2007 Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide.Biochemical Journal.  405. 2007
    2007 Mechanism by which Alcohol and Wine Polyphenols Affect Coronary Heart Disease RiskAnnals of Epidemiology.  17. 2007
    2006 S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver 2006
    2006 Free radicals, mitochondria, and oxidized lipids: The emerging role in signal transduction in vascular cellsCirculation Research.  99:924-932. 2006
    2006 Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species 2006
    2006 Induction of the permeability transition and cytochrome c release by 15-deoxy-Δ12,14-prostaglandin J2 in mitochondriaBiochemical Journal.  394:185-195. 2006
    2006 A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stressFree Radical Biology and Medicine.  40:459-468. 2006
    2006 Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilationBlood.  107:566-574. 2006
    2006 Activation of mitogen-activated protein kinases by lysophosphatidylcholine- induced mitochondrial reactive oxygen species generation in endothelial cellsAmerican Journal of Pathology.  168:1737-1748. 2006
    2005 Cell signalling by oxidized lipids and the role of reactive oxygen species in the endotheliumBiochemical Society Transactions.  33:1385-1389. 2005
    2005 Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxideFree Radical Biology and Medicine.  39:540-548. 2005
    2005 Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells 2005
    2005 Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissuesAnalytical Biochemistry.  341:40-51. 2005
    2005 Nitric oxide signaling gone awry: Nitration of glutamine synthetase and hyperammonemia in sepsisHepatology.  41:980-982. 2005
    2005 Nitroxia: The pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathwayFree Radical Biology and Medicine.  38:297-306. 2005
    2005 Mitochondrial proteomics in free radical researchFree Radical Biology and Medicine.  38:175-188. 2005
    2005 Metabolism of phytoestrogen conjugatesMethods in Enzymology.  400:316-342. 2005
    2004 Human glutamate cysteine ligase gene regulation through the electrophile response elementFree Radical Biology and Medicine.  37:1152-1159. 2004
    2004 The powerhouse takes control of the cell; The role of mitochondria in signal transductionFree Radical Biology and Medicine.  37:753-754. 2004
    2004 The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in miceHepatology.  40:565-573. 2004
    2004 Weight loss and race modulate nitric oxide metabolism in overweight womenFree Radical Biology and Medicine.  37:695-702. 2004
    2004 Modification of cytochrome c by 4-hydroxy-2-nonenal: Evidence for histidine, lysine, and arginine-aldehyde adductsJournal of The American Society for Mass Spectrometry.  15:1136-1147. 2004
    2004 Regulation of endothelial glutathione by ICAM-1: Implications for inflammationThe FASEB Journal.  18:1321-1323. 2004
    2004 Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicityJournal of Biological Chemistry.  279:22092-22101. 2004
    2004 Mechanisms of the interaction of nitroxyl with mitochondriaBiochemical Journal.  379:359-366. 2004
    2004 L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemiaFEBS Letters.  561:94-98. 2004
    2004 Cellular mechanisms of redox cell signalling: Role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation productsBiochemical Journal.  378:373-382. 2004
    2004 Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins 2004
    2004 Oxidative modification of hepatic mitochondria protein thiols: Effect of chronic alcohol consumption 2004
    2004 Redox signalling: From nitric oxide to oxidized lipidsBiochemical Society Symposia.  71:107-120. 2004
    2004 Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition. 2004
    2003 Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant propertiesFree Radical Biology and Medicine.  35:1417-1430. 2003
    2003 Nitric oxide and cell signaling; modulation of redox tone and protein modificationAmino Acids.  25:313-321. 2003
    2003 Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. 2003
    2003 Control of the Nitric Oxide-Cytochrome c Oxidase Signaling Pathway under Pathological and Physiological Conditions 2003
    2003 Control of mitochondrial respiration by NO., Effects of low oxygen and respiratory stateJournal of Biological Chemistry.  278:31603-31609. 2003
    2003 Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxideJournal of Biological Chemistry.  278:27520-27524. 2003
    2003 Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxideHepatology.  38:141-147. 2003
    2003 Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: A novel class of biological metabolitesJournal of Mass Spectrometry.  38:764-771. 2003
    2003 S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation 2003
    2003 S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation. 2003
    2003 Cytoprotection against oxidative stress and the regulation of glutathione synthesis 2003
    2003 Oxidized low-density lipoprotein and 15-deoxy-Δ 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells 2003
    2002 Mitochondria, nitric oxide, and cardiovascular dysfunctionFree Radical Biology and Medicine.  33:1465-1474. 2002
    2002 Nanotransducers in cellular redox signaling: Modification of thiols by reactive oxygen and nitrogen speciesTrends in Biochemical Sciences.  27:489-492. 2002
    2002 Mitochondria: Regulators of signal transduction by reactive oxygen and nitrogen speciesFree Radical Biology and Medicine.  33:755-764. 2002
    2002 High throughput two-dimensional blue-native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexesProteomics.  2:969-977. 2002
    2002 High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes.Proteomics.  2:969-977. 2002
    2002 A novel microchip nitric oxide sensor with sub-nM detection limitElectroanalysis.  14:697-703. 2002
    2002 Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetinFree Radical Biology and Medicine.  32:1220-1228. 2002
    2002 Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide 2002
    2002 Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis 2002
    2002 Specific modification of mitochondrial protein thiols in response to oxidative stress. A proteomics approachJournal of Biological Chemistry.  277:17048-17056. 2002
    2002 Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-β activation in mesangial cellsJournal of Biological Chemistry.  277:9880-9888. 2002
    2002 Hypothesis: The mitochondrial NO· signaling pathway, and the transduction of nitrosative to oxidative cell signals: An alternative function for cytochrome c oxidaseFree Radical Biology and Medicine.  32:370-374. 2002
    2002 Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: Protection against quinone-mediated oxidative stressBiochemical Journal.  362:51-59. 2002
    2002 Bromination, Chlorination, and Nitration of IsoflavonoidsACS Symposium Series.  807:251-261. 2002
    2002 Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxideMethods in Enzymology.  359:305-319. 2002
    2002 Obesity, aerobic exercise, and vascular disease: The role of oxidant stress 2002
    2001 Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavengingFree Radical Biology and Medicine.  31:1570-1581. 2001
    2001 Bioenergetics in cardiac hypertrophy: Mitochondrial respiration as a pathological target of NO·American Journal of Physiology.  281. 2001
    2001 Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO*. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoprotein 2001
    2001 Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxideFree Radical Biology and Medicine.  31:688-696. 2001
    2001 Soy isoflavonoids and cancer - Metabolism at the target siteMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  480-481:121-127. 2001
    2001 L-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide ProductionJournal of Biological Chemistry.  276:27159-27165. 2001
    2001 Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase 2001
    2001 Bioenergetics in cardiac hypertrophy: Mitochondrial respiration as a pathological target of NO· 2001
    2001 Biphasic effects of 15-deoxy-Δ12,14-prostaglandin J2 on glutathione induction and apoptosis in human endothelial cells 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoprotein 2001
    2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid 2001
    2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-443. 2001
    2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
    2001 Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophyJournal of Molecular and Cellular Cardiology.  33:69-82. 2001
    2001 Mechanisms of cell signaling by nitric oxide and peroxynitrite: From mitochondria to MAP kinasesAntioxidants and Redox Signaling.  3:215-229. 2001
    2001 Protein kinase B/Akt activates c-Jun NH2-terminal kinase by increasing NO production in response to shear stress 2001
    2000 Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosisCardiovascular Research.  47:465-474. 2000
    2000 Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c releaseJournal of Biological Chemistry.  275:20474-20479. 2000
    2000 Cell signaling by reactive nitrogen and oxygen species in atherosclerosisFree Radical Biology and Medicine.  28:1780-1794. 2000
    2000 Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cellsAntimicrobial Agents and Chemotherapy.  44:496-503. 2000
    2000 Antioxidants: Strategies for interventions in aging and age-related diseases: A workshop sponsored by the National Institute on Aging and by the Office of Dietary SupplementsAntioxidants and Redox Signaling.  2:375-377. 2000
    2000 Beyond ERα and ERβ: Estrogen receptor binding is only part of the isoflavone story 2000
    2000 Glucose stimulation of transforming growth factor-β bioactivity in mesangial cells is mediated by thrombospondin-1American Journal of Pathology.  157:1353-1363. 2000
    2000 Isoflavonoids and chronic disease: Mechanisms of actionBioFactors.  12:209-215. 2000
    2000 Therapeutic applications of reactive oxygen and nitrogen species in human diseaseFree Radical Biology and Medicine.  28:1449-1450. 2000
    1999 Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscleFree Radical Biology and Medicine.  27:1386-1392. 1999
    1999 A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failureJournal of Biological Chemistry.  273:31731-31737. 1999
    1999 Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase.American Journal of Physiology.  277:H1647-H1653. 1999
    1999 Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH2-terminal kinase 1999
    1999 Chlorination and nitration of soy isoflavonesArchives of Biochemistry and Biophysics.  368:265-275. 1999
    1999 15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclaseJournal of Biological Chemistry.  274:20083-20091. 1999
    1999 Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosationJournal of Biological Chemistry.  274:15487-15492. 1999
    1999 Biological aspects of reactive nitrogen species 1999
    1999 Effects of pyrrolidine dithiocarbamate on endothelial cells: Protection against oxidative stressFree Radical Biology and Medicine.  26:1138-1145. 1999
    1999 The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: A role for γ-glutamylcysteine synthetase and γ-glutamyl transpeptidaseFEBS Letters.  448:292-296. 1999
    1999 Antioxidant properties of phytoestrogensJournal of Medicinal Food.  2:163-166. 1999
    1999 Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH2-terminal kinase 1999
    1999 Molecular mechanisms of the copper dependent oxidation of low-density lipoproteinFree Radical Research.  30:1-9. 1999
    1999 Molecular mechanisms of the copper dependent oxidation of low-density lipoprotein - Invited commentaryFree Radical Research.  30:1-9. 1999
    1999 Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ionChemical Research in Toxicology.  12:83-92. 1999
    1999 Nitration of unsaturated fatty acids by nitric oxide-derived reactive speciesMethods in Enzymology.  301:454-470. 1999
    1999 Nitric oxide donor generation from reactions of peroxynitriteMethods in Enzymology.  301:288-298. 1999
    1998 Nitric oxide-dependent and independent effects on human platelets treated with peroxynitriteCardiovascular Research.  40:380-388. 1998
    1998 Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells.American Journal of Physiology.  275:H1898-H1904. 1998
    1998 Phosphatidylinositol 3-kinase γ mediates shear stress-dependent activation of JNK in endothelial cells 1998
    1998 Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetaseArchives of Biochemistry and Biophysics.  358:74-82. 1998
    1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
    1998 Making and working with peroxynitrite.Methods in Molecular Biology.  100:215-230. 1998
    1998 Phosphatidylinositol 3-kinase γ mediates shear stress-dependent activation of JNK in endothelial cells 1998
    1997 Nitric oxide inhibition of lipid peroxidation: Kinetics of reaction with lipid peroxyl radicals and comparison with α-tocopherolBiochemistry.  36:15216-15223. 1997
    1997 No role for NO in estrogen-mediated vasoprotection?Circulation.  96:2769-2771. 1997
    1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
    1997 Estrogen restores endothelial cell function in an experimental model of vascular injuryCirculation.  96:1624-1630. 1997
    1997 The inhibition of cytochrome c oxidase by nitric oxide using S-nitrosoglutathioneJournal of Inorganic Biochemistry.  66:207-212. 1997
    1997 Reduction of Cu(II) by lipid hydroperoxides: Implications for the copper-dependent oxidation of low-density lipoproteinBiochemical Journal.  322:425-433. 1997
    1997 Disruption of vascular signalling by the reaction of nitric oxide with superoxide: Implications for cardiovascular diseaseExperimental Physiology.  82:305-316. 1997
    1997 Gender and cardiovascular disease: Recent insightsTrends in Cardiovascular Medicine.  7:94-100. 1997
    1997 Nitric oxide, free radicals and cell signalling in cardiovascular diseaseBiochemical Society Transactions.  25. 1997
    1997 The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for diseaseSeminars in Perinatology.  21:351-366. 1997
    1996 Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits 1996
    1996 Role of lipid hydroperoxides in the activation of 15-lipoxygenaseBiochemistry.  35:7197-7203. 1996
    1996 Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucoseBiochemical Journal.  314:877-880. 1996
    1996 cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase 1996
    1996 The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapyAtherosclerosis.  119:169-179. 1996
    1996 Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copperJournal of Lipid Research.  37:2361-2371. 1996
    1996 Nitric oxide regulation of tissue free radical injuryChemical Research in Toxicology.  9:809-820. 1996
    1996 Oxidation of human low-density lipoprotein by soybean 15-lipoxygenase in combination with copper (II) or met-myoglobinFree Radical Biology and Medicine.  20:525-532. 1996
    1996 Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular systemPharmaceutical Research.  13:649-662. 1996
    1996 Redox cycling of human methaemoglobin by H2O2 yields persistent ferryl iron and protein based radicalsFree Radical Research.  25:117-123. 1996
    1996 Stimulation of mitochondrial oxygen consumption in isolated cardiomyocytes after hypoxia-reoxygenationFree Radical Research.  24:159-166. 1996
    1996 Using peroxynitrite as oxidant with low-density lipoproteinMethods in Enzymology.  269:375-384. 1996
    1995 Nitric oxide and oxygen radicals: a question of balanceFEBS Letters.  369:131-135. 1995
    1995 Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.FEBS Letters.  360:271-276. 1995
    1995 α-Tocopherol mediated peroxidation in the copper (II) and met myoglobininduced oxidation of human low density lipoprotein: The influence of lipid hydroperoxidesFEBS Letters.  360:271-276. 1995
    1995 Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite.Advances in prostaglandin, thromboxane, and leukotriene research.  23:225-227. 1995
    1995 Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitriteCirculation Research.  77:335-341. 1995
    1995 Inhibition of cytochrome c oxidase in turnover by nitric oxide: Mechanism and implications for control of respirationBiochemical Journal.  312:169-173. 1995
    1995 Role of apolipoprotein b-derived radical and α-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoproteinJournal of Lipid Research.  36:1037-1045. 1995
    1995 The formation of nitric oxide donors from peroxynitriteBritish Journal of Pharmacology.  116:1999-2004. 1995
    1994 Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart 1994
    1994 The oxidation of cytochrome-c oxidase vesicles by hemoglobin 1994
    1994 Paradoxical fate and biological action of peroxynitrite on human platelets 1994
    1994 Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseasesFEBS Letters.  345:50-54. 1994
    1994 Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosisFEBS Letters.  342:49-52. 1994
    1994 Interactions of peroxynitrite with human plasma and its constituents: Oxidative damage and antioxidant depletionBiochemical Journal.  303:295-301. 1994
    1994 The role of lipid hydroperoxides in the myoglobin-dependent oxidation of LDLArchives of Biochemistry and Biophysics.  314:39-44. 1994
    1993 Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptorFEBS Letters.  330:181-185. 1993
    1993 The role of α-tocopherol as a peroxyl radical scavenger in human low density lipoproteinBiochemical Pharmacology.  45:2195-2201. 1993
    1993 Changes in mitochondrial matrix free calcium in perfused rat hearts subjected to hypoxia-reoxygenationJournal of Molecular and Cellular Cardiology.  25:949-958. 1993
    1993 Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophagesBiochemical Journal.  296:151-154. 1993
    1993 Peroxynitrite and atherosclerosisBiochemical Society Transactions.  21:358-362. 1993
    1993 The oxidation of α-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxideFEBS Letters.  326:199-203. 1993
    1992 Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigsPulmonary pharmacology.  5:39-50. 1992
    1992 Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoproteinBiochemical Journal.  282:631-634. 1992
    1992 Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxideBiochemical Journal.  281:419-424. 1992
    1992 Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoproteinJournal of Biological Chemistry.  267:6789-6795. 1992
    1992 The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoproteinFree Radical Research.  17:9-20. 1992
    1991 5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoproteinBiochemical Journal.  278:163-169. 1991
    1991 Mitochondria, oxygen and reperfusion damageAnnals of Medicine.  23:583-588. 1991
    1991 Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (Complex I) activity in the hypoxic/reoxygenated rat heartBiochemical Journal.  274:133-137. 1991
    1991 Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione contentBiochemical Journal.  278:429-434. 1991
    1990 Hypoxia-reoxygenation induced damage in the myocardium: The role of mitochondriaBiochemical Society Transactions.  18:526-528. 1990
    1990 Oxidation of low-density lipoprotein and macrophage derived foam cellsBiochemical Society Transactions.  18:1064-1066. 1990
    1990 Reoxygenation of the hypoxic myocardium causes a mitochondrial complex I defectBiochemical Society Transactions.  18:549. 1990
    1989 The exocrine secretions of the grafted pancreasTransplantation Proceedings.  21:3449-3451. 1989
    1989 A method for the comparative assessment of antioxidants as peroxyl radical scavengersBiochemical Pharmacology.  38:1465-1469. 1989
    1989 Fatal lactic acidosis in infancy with a defect of complex III of the respiratory chainPediatric Research.  25:553-559. 1989
    1989 Hypoxia-reoxygenation induced increase in cellular Ca2+ in myocytes and perfused hearts: the role of mitochondriaJournal of Molecular and Cellular Cardiology.  21:963-973. 1989
    1989 Oxygen and reperfusion damage: An overviewFree Radical Research.  7:247-254. 1989
    1989 The glutathione status of perfused rat hearts subjected to hypoxia and reoxygenation: The oxygen paradoxFree Radical Research.  6:261-267. 1989
    1989 The glutathione status of perfused rat hearts subjected to hypoxia and reoxygenation: The oxygen paradoxFree Radical Research.  5:283-289. 1989
    1987 The molecular aetiology of human mitochondrial myopathiesBiochemical Society Transactions.  15:102-103. 1987
    1986 Analysis of pure pancreatic juice proteins by two-dimensional gel electrophoresis in cases of pancreatic cancerGastroenterologia Japonica.  21:623-629. 1986
    1986 Mitochondrial myopathy: tissue-specific expression of a defect in ubiquinol-cytochrome c reductaseClinica Chimica Acta.  158:253-261. 1986
    1985 Analyses of muscle proteins in a patient with a mitochondrial myopathyJournal of Biochemistry.  97:1767-1775. 1985
    1985 The teaching of medical english in Japanese medical schools - A new appoachBiochemical Education.  13:119-121. 1985
    1984 31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle. 1984
    1984 Reaction of thionitrobenzoate-modified yeast cytochrome c with monomeric and dimeric forms of beef heart cytochrome c oxidaseFEBS Letters.  166:131-135. 1984
    1984 Lactic acidosis and mitochondrial myopathy associated with deficiency of several components of complex III of the respiratory chainPediatric Research.  18:991-999. 1984
    1983 Deficiency in ubiquinone cytochrome c reductase in a patient with mitochondrial myopathy and lactic acidosis. 1983
    1983 Structure of cytochrome c oxidaseBiochimica et Biophysica Acta - Reviews On Bioenergetics.  726:135-148. 1983
    1983 Electron Transfer in Monomeric Forms of Beef and Shark Heart Cytochrome c OxidaseBiochemistry.  22:1317-1322. 1983
    1983 Arrangement of Subunit IV in Beef Heart Cytochrome c Oxidase Probed by Chemical Labeling and Protease Digestion ExperimentsBiochemistry.  22:4405-4411. 1983
    1983 Deficiency in ubiquinone cytochrome c reductase in a patient with mitochondrial myopathy and lactic acidosis 1983
    1982 Structural and functional features of the interaction of cytochrome c with complex III and cytochrome c oxidaseFEBS Letters.  138:1-7. 1982
    1982 Cytochrome c Is Cross-Linked to Subunit II of Cytochrome c Oxidase by a Water-Soluble CarbodiimideBiochemistry.  21:3857-3862. 1982
    1981 Identification of cysteines in subunit II as ligands to the redox centers of bovine cytochrome c oxidaseBiochemical and Biophysical Research Communications.  103:1223-1230. 1981
    1981 Mr-values of mature subunits I and III of beef heart cytochrome c oxidase in relationship to nucleotide sequences of their genesFEBS Letters.  135:164-166. 1981
    1981 On the identification and nomenclature of the polypeptide subunits of bovine cytochrome C oxidaseBiochemical and Biophysical Research Communications.  99:51-57. 1981
    1981 A comparison of the structural and functional properties of cytochrome c oxidase isolated from beef (Bos tauros), camel (Camelus dromedarius), chicken (Gallus domesticus) and rat (Rattus norvegicus)Comparative Biochemistry and Physiology - B: Comparative Biochemistry.  68:445-456. 1981
    1981 A method for the preparation of low-pH dodecyl sulphate/polyacrylamide-gradient gels.Biochemical Journal.  193:1013-1015. 1981
    1981 Covalent Complex between Yeast Cytochrome c and Beef Heart Cytochrome c Oxidase Which Is Active in Electron TransferBiochemistry.  20:7046-7053. 1981
    1981 The electron transfer system of Pseudomonas aeruginosa: a study of the pH-dependent transitions between redox forms of azurin and cytochrome c551Journal of Inorganic Biochemistry.  14:327-338. 1981
    1980 Structural and functional properties of cytochrome c oxidases isolated from sharks.Journal of Biological Chemistry.  255:2722-2728. 1980


    Year Title Altmetric
    2013 Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology.  17-22. 2013
    2012 Mitochondrial dysfunction in neurodegenerative disease: Protein aggregation, autophagy, and oxidative stress.  95-111. 2012
    2006 The Covalent Advantage: A New Paradigm for Cell Signaling Mediated by Thiol Reactive Lipid Oxidation Products.  343-367. 2006
    2003 The importance of in vivo metabolism of polyphenols and their biological actions.  51-59. 2003
    2000 Cytoprotective mechanisms of nitric oxide: the role of cell signaling.  191-199. 2000

    Research Overview

  • Dr. Darley-Usmar's major research interests are in translating basic research in redox biology and bioenergetics to a clinical setting. His research is focused on the contribution of mitochondrial dysfunction to the pathophysiology of human disease. He recently developed the methods for the assessment of bioenergetic function in cells isolated from human blood which opens up the potential for using mitochondrial function in translational medicine (1). Deteriorating mitochondrial quality control is an important mechanism for understanding how bioenergetics changes in response to metabolic stress and the interface with autophagy was explore in the context of diabetes and heme toxicity (2,3). Recently he has shown how novel mitochondrial therapeutics can protect against metabolic stress (4,5).
    1. Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW, Ballinger SW, Darley-Usmar VM (2013) Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab Invest. 93(6):690-700.
    2. Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM (2013) Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells. American J of Physiology in press
    3. Higdon, A. N., Benavides, G. A., Chacko, B. K., Ouyang, X., Johnson, M. S., Landar, A., Zhang, J. and Darley-Usmar, V. M. (2012) Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. American journal of physiology. Heart and circulatory physiology. 302, H1394-1409
    4. Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM (2011) Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology 54(1):153-63.
    5. Chacko BK, Reily C, Srivastava A, Johnson MS, Ye Y, Ulasova E, Agarwal A, Zinn KR, Murphy MP, Kalyanaraman B, Darley-Usmar VM (2010) Prevention of diabetic nephropathy in Ins2(+/)(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J;432:9-19.
  • Teaching Overview

  • Since joining UAB in 1995, Dr. Darley-Usmar has actively engaged in graduate training and post-doctoral training. During his time at UAB he has mentored 16 graduate students, has served on over 25 student thesis committees and over this period mentored the transition to independence of 9 Post Docs to faculty (3, are Assistant Professors, 2 are now Associate Professors and 2 Full Professors). He has played an active role in developing educational programs at UAB at both the administrative and faculty level. He served as graduate program director for the Pathology Graduate Program (50-60 students) from 2003-2005 and as Associate Dean for Post-Doctoral Education from 2003-2007 (290-320 Post Doctoral Trainees). In 2009 he received the Deans award for Mentorship and most valued faculty member award from the Pathology graduate students on four occasions. He has served as a charter member of the Atherosclerosis and Inflammation study section in addition to reviewing program projects, training grants and the K99 training program. As a member of the Center for Free Radical Biology and member of the Clinical Nutrition Center Center, Comprehensive Diabetes and Cardiovascular Centers and Nephrology Research Training Center, Co-Director of a Core in the O’Brien AKI injury center, Dr. Darley-Usmar has contributed to the career development of the trainees in the program by offering mentoring guidance and expertise in metabolism and bioenergetics.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, University of Essex 1980
  • Full Name

  • Victor Darley-Usmar