Positions

Selected Publications

Academic Article

Year Title Altmetric
2013 Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouseRedox Biology.  1:381-386. 2013
2011 PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in miceThorax.  66:788-796. 2011
2010 Dietary flavonoid quercetin stimulates vasorelaxation in aortic vesselsFree Radical Biology and Medicine.  49:339-347. 2010
2009 Alcohol in moderation, cardioprotection, and neuroprotection: Epidemiological considerations and mechanistic studiesAlcoholism: Clinical and Experimental Research.  33:206-219. 2009
2008 Mechanical circulatory device thrombosis: A new paradigm linking hypercoagulation and hypofibrinolysisASAIO Journal.  54:351-358. 2008
2007 Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexesFree Radical Research.  41:127-134. 2007
2007 Ethanol and red wine polyphenols induce the short-term downregulation of PAI-1 gene expression in vivo in rat aortic endotheliumJournal of the Science of Food and Agriculture.  87:1794-1798. 2007
2007 Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjectsAIDS.  21:1373-1375. 2007
2007 Mechanism by which Alcohol and Wine Polyphenols Affect Coronary Heart Disease RiskAnnals of Epidemiology.  17. 2007
2006 Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive ratMicrocirculation.  13:551-566. 2006
2005 Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxideFree Radical Biology and Medicine.  39:540-548. 2005
2005 Revealing anti-inflammatory mechanisms of soy isoflavones by flow: Modulation of leukocyte-endothelial cell interactionsAJP - Heart and Circulatory Physiology.  289. 2005
2004 L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemiaFEBS Letters.  561:94-98. 2004
2004 Peroxynitrite Inactivates Tissue Plasminogen ActivatorAnesthesia and Analgesia.  98:1312-1317. 2004
2004 Peroxynitrite decreases hemostasis in Human plasma in vitroAnesthesia and Analgesia.  99:21-26. 2004
2003 Xanthine oxidase activity in the dexamethasone-induced hypertensive ratMicrovascular Research.  66:30-37. 2003
2002 Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitrationFree Radical Biology and Medicine.  33:1243-1249. 2002
2002 Iron regulates xanthine oxidase activity in the lungAJP - Lung Cellular and Molecular Physiology.  283. 2002
2002 Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetinFree Radical Biology and Medicine.  32:1220-1228. 2002
2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell diseaseProceedings of the National Academy of Sciences.  98:15215-15220. 2001
2001 Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavengingFree Radical Biology and Medicine.  31:1570-1581. 2001
2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acidAJP - Heart and Circulatory Physiology.  281. 2001
2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid.AJP - Heart and Circulatory Physiology.  281:H1469-H1475. 2001
2001 Moderate wine and alcohol consumption: Beneficial effects on cardiovascular diseaseThrombosis and Haemostasis.  86:517-528. 2001
2001 L-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide ProductionJournal of Biological Chemistry.  276:27159-27165. 2001
2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-444. 2001
2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
2001 Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophyJournal of Molecular and Cellular Cardiology.  33:69-82. 2001
2000 Evaluation of low-dose endotoxin administration during pregnancy as a model of preeclampsiaAnesthesiology.  93:1446-1455. 2000
1999 Preserving brain function during neonatal asphyxiaClinics in Perinatology.  26:733-747. 1999
1999 Binding of xanthine oxidase to vascular endothelium: Kinetic characterization and oxidative impairment of nitric oxide-dependent signalingJournal of Biological Chemistry.  274:4985-4994. 1999
1999 A mechanism of oxygen free radical production in the Dahl hypertensive ratMicrocirculation.  6:179-187. 1999
1999 Increased injury following intermittent fetal hypoxia-reoxygenation is associated with increased free radical production in fetal rabbit brainJournal of Neuropathology and Experimental Neurology.  58:972-981. 1999
1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
1998 Hypoxia-reoxygenation is as damaging as ischemia-reperfusion in the rat liverCritical Care Medicine.  26:1089-1095. 1998
1998 Multiple organ dysfunction syndrome: Role of xanthine oxidase and nitric oxidePathophysiology.  5:49-66. 1998
1998 Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive ratsProceedings of the National Academy of Sciences.  95:4754-4759. 1998
1998 Endothelial injury from a circulating mediator following rat liver ischemiaFree Radical Biology and Medicine.  24:427-434. 1998
1998 Sustained hypoxia-ischemia results in reactive nitrogen and oxygen species production and injury in the premature fetal rabbit brainJournal of Neuropathology and Experimental Neurology.  57:544-553. 1998
1998 Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia: Role in acute lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  158:299-305. 1998
1997 Halothane and xanthine oxidase increase hepatocellular enzyme release and circulating lactate after ischemia - Reperfusion in rabbitsAnesthesiology.  87:908-917. 1997
1997 Hextend® (hetastarch solution) decreases multiple organ injury and xanthine oxidase release after hepatoenteric ischemia-reperfusion in rabbitsCritical Care Medicine.  25:1565-1574. 1997
1997 Free and protein-associated nitrotyrosine formation following rat liver preservation and transplantationArchives of Biochemistry and Biophysics.  342:282-288. 1997
1997 Xanthine oxidase mediates myocardial injury after hepatoenteric ischemia-reperfusionCritical Care Medicine.  25:1044-1050. 1997
1996 Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbitsProceedings of the National Academy of Sciences.  93:8745-8749. 1996
1996 Gastric intramucosal pH and multiple organ injury: Impact of ischemia- reperfusion and xanthine oxidaseCritical Care Medicine.  24:1339-1344. 1996
1996 Lung injury after hepatoenteric ischemia-reperfusion: Role of xanthine oxidaseAmerican Journal of Respiratory and Critical Care Medicine.  154:1364-1369. 1996
1996 Maternal infusion of antioxidants (Trolox and ascorbic acid) protects the fetal heart in rabbit fetal hypoxiaPediatric Research.  39:499-503. 1996
1995 Circulating xanthine oxidase in human ischemia reperfusionSouthern Medical Journal.  88:479-482. 1995
1995 Liver ischemia-reperfusion increases pulmonary permeability in rat: Role of circulating xanthine oxidaseAJP - Gastrointestinal and Liver Physiology.  268. 1995
1995 Xanthine oxidase inactivation attenuates postocclusion shock after descending thoracic aorta occlusion and reperfusion in rabbitsJournal of Thoracic and Cardiovascular Surgery.  110:715-722. 1995
1994 Xanthine oxidoreductase release after descending thoracic aorta occlusion and reperfusion in rabbitsJournal of Thoracic and Cardiovascular Surgery.  107:1222-1227. 1994
1993 Physiologic levels of uric acid inhibit xanthine oxidase in human plasmaPediatric Research.  34:303-307. 1993
1993 Role of angiotensin and adrenoceptors in hemodynamic response to aortic cross-clampingAmerican Journal of Physiology.  264. 1993
1993 Role of angiotensin and adrenoceptors in hemodynamic response to aortic cross-clamping.American Journal of Physiology.  264:H14-H20. 1993
1993 Xanthine oxidase activity in the circulation of rats following hemorrhagic shockFree Radical Biology and Medicine.  15:407-414. 1993
1992 Haemodynamic changes and oxygen uptake during crossclamping of the thoracic aorta in dexmedetomidine pretreated dogsCanadian Journal of Anesthesia / Journal canadien d'anesthésie.  39:731-741. 1992
1992 Inhibition of xanthine oxidase by uric acid and its influence on superoxide radical productionBBA - Proteins and Proteomics.  1122:178-182. 1992
1992 Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-αArchives of Biochemistry and Biophysics.  294:686-694. 1992
1991 Role of xanthine dehydrogenase and oxidase in focal cerebral ischemic injury to ratAmerican Journal of Physiology.  261. 1991
1991 Role of xanthine dehydrogenase and oxidase in focal cerebral ischemic injury to rat.American Journal of Physiology.  261:H2051-H2057. 1991
1991 H1 and H2 receptor antagonists and hepatic oxygen supply-demand relationship in pigsCanadian Journal of Anesthesia / Journal canadien d'anesthésie.  38:121-128. 1991
1990 Circulating xanthine oxidase: potential mediator of ischemic injury.American Journal of Physiology.  258:G564-G570. 1990
1990 Circulating xanthine oxidase: Potential mediator of ischemic injuryAmerican Journal of Physiology.  258. 1990
1990 Dopamine and hepatic oxygen supply - Demand relationshipCanadian Journal of Physiology and Pharmacology.  68:1165-1169. 1990
1990 Hepatic circulation and oxygen supply-uptake relationships after hepatic ischemic insult during anesthesia with volatile anesthetics and fentanyl in miniature pigsAnesthesia and Analgesia.  70:53-62. 1990
1990 Hepatic oxygen supply-uptake relationship and metabolism during anesthesia in miniature pigsAnesthesiology.  72:902-910. 1990
1990 Hypothermia, hepatic oxygen supply-demand, and ischemia-reperfusion injury in pigsAmerican Journal of Physiology.  258. 1990
1989 A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissuesFree Radical Biology and Medicine.  6:607-615. 1989
1989 Oxygen radicals: Mediators of gastrointestinal pathophysiologyGut.  30:293-298. 1989
1988 Allopurinol does not enhance antioxidant properties of extracellular fluidAmerican Journal of Physiology.  255. 1988
1988 Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: A reevaluationAmerican Journal of Physiology.  254. 1988
1988 Ischemia‐reperfusion injury: A radical viewHepatology.  8:680-682. 1988
1987 Glucagon increases hepatic oxygen supply-demand ratio in pigsAJP - Gastrointestinal and Liver Physiology.  252. 1987
1986 Role of oxygen radicals in ischemic bowel disordersPediatric Surgery International.  1:15-20. 1986
1986 Contributions of ischemia and reperfusion to mucosal lesion formationAJP - Gastrointestinal and Liver Physiology.  250. 1986
1986 Incarcerate free radicalsHepatology.  6:536-537. 1986
1986 Ischemia-reperfusion injury: role of oxygen-derived free radicalsActa Physiologica Scandinavica.  126:47-63. 1986
1986 Role of oxygen radicals in ischemia-induced lesions in the cat stomachGastroenterology.  90:362-367. 1986
1986 Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestineGastroenterology.  90:80-84. 1986
1986 Xanthine oxidase: Biochemistry, distribution and physiologyActa Physiologica Scandinavica.  126:87-99. 1986
1985 Physiology of the Splanchnic CirculationArchives of Internal Medicine -New Series-.  145:1278-1281. 1985
1985 Relationship of blood flow and oxygen consumption to ischemic injury in the canine small intestineGastroenterology.  89:852-857. 1985
1985 Soybean trypsin inhibitor attenuates ischemic injury to the feline small intestineGastroenterology.  89:6-12. 1985
1985 Xanthine oxidase as a source of free radical damage in myocardial ischemiaJournal of Molecular and Cellular Cardiology.  17:145-152. 1985
1984 Oxygen radicals: Effects on intestinal vascular permeabilityAJP - Gastrointestinal and Liver Physiology.  10. 1984
1984 Reperfusion injury in the ischemic small intestineFederation proceedings.  43. 1984
1983 Role of oxygen radicals in the pathogenesis of intestinal ischemia.Physiologist.  26:159-164. 1983
1983 Intestinal blood flow: Relations to functionDigestive Diseases.  1:217-228. 1983
1983 Ischemia-induced vascular changes: Role of xanthine oxidase and hydroxyl radicalsAJP - Gastrointestinal and Liver Physiology.  8. 1983
1983 Role of oxygen free radicals in shock, ischemia, and organ preservationSurgery.  94:428-432. 1983
1983 Role of oxygen-derived free radicals in digestive tract diseasesSurgery.  94:415-422. 1983
1982 Comparison of partial and complete arterial occlusion models for studying intestinal ischemiaSurgery.  92:896-901. 1982
1982 Effects of ischemia and oxygen radicals on mucosal albumin clearance in intestineAJP - Gastrointestinal and Liver Physiology.  5. 1982
1982 Ischemic injury in the cat small intestine: Role of superoxide radicalsGastroenterology.  82:9-15. 1982
1981 Effects of intestinal blood flow reduction and superoxide radicals on mucosal albumin clearancePhysiologist.  24. 1981

Investigator On

  • Private Grant  awarded by TENAX THERAPEUTICS 2016 - 2019
  • Education And Training

  • Doctor of Philosophy in Medical Basic Sciences, University of South Alabama 1983
  • Full Name

  • Dale Parks