Selected Publications

Academic Article

Year Title Altmetric
2019 Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and metastasis in breast cancer.Cancer Research2019
2019 Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection.International Journal of Radiation Oncology - Biology - Physics.  103:453-459. 2019
2018 Adjuvant anti-angiogenic therapy enhances chemotherapeutic uptake in a murine model of head and neck cancer.Journal of Drug Targeting.  1-8. 2018
2018 Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions.Scientific Reports.  8:8412. 2018
2018 Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease.Journal of Clinical Neuroscience.  49:48-55. 2018
2018 Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.Journal of Ovarian Research.  11:12. 2018
2018 Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose.Biomarker Research.  6:22. 2018
2018 Kinomics toolbox-A web platform for analysis and viewing of kinomic peptide array data.PLoS ONE.  13:e0202139. 2018
2017 Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.Kidney International Reports.  2:1194-1207. 2017
2017 Fractionated stereotactic radiation therapy for intact brain metastases.Advances in Radiation Oncology.  2:564-571. 2017
2017 Management of Metastatic Spinal Cord Compression.Southern Medical Journal.  110:586-593. 2017
2017 Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma.Oncotarget.  8:29220-29232. 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets.Oncotarget.  8:21710-21718. 2017
2017 Creation of an Analytical Platform for Integrative Molecular Profiling of Glioblastoma Xenolines.American Journal of Clinical Pathology.  147:S171-S172. 2017
2017 MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines.Oncology Letters.  13:1216-1222. 2017
2017 Hepatitis C Virus Genie: A Web 2.0 Interpretation and Analytics Platform for the Versant Hepatitis C Virus Genotype Line Probe Assay Version 2.0.Journal of Pathology Informatics.  8:41. 2017
2016 Primary Sellar Rhabdomyosarcoma Arising in Association With a Pituitary Adenoma.International Journal of Surgical Pathology.  24:753-756. 2016
2016 Stereotactic Hypofractionated Radiation Therapy for Intact Brain Metastases.International Journal of Radiation Oncology - Biology - Physics.  96:E120-E121. 2016
2016 Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays.Journal of Proteomics and Bioinformatics.  9:151-157. 2016
2016 Correction: Kinomic Profiling of Electromagnetic Navigational Bronchoscopy Specimens: A New Approach for Personalized Medicine.PLoS ONE.  11:e0161986. 2016
2016 Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing.Journal of Visualized Experiments2016
2016 Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome.SpringerPlus.  5:229. 2016
2015 A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium.Journal of Cellular Biochemistry.  116:2793-2803. 2015
2015 Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition.BMC Cancer.  15:673. 2015
2015 Patient-Derived Xenografts as a Model System for Radiation Research.Seminars in Radiation Oncology.  25:273-280. 2015
2015 KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA.Medical research archives.  2015. 2015
2015 Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.Journal of Virology.  89:6656-6672. 2015
2015 The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampens tumor invasion-integrated analysis of expression and kinomics pathways.Modern Pathology.  28:631-653. 2015
2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity.International Journal of Oncology.  46:1079-1088. 2015
2015 High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes.PLoS ONE.  10:e0139267. 2015
2015 The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization.PLoS ONE.  10:e0140870. 2015
2014 Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: the University of Alabama at Birmingham experience.Neuro Oncology Practice.  1:172-177. 2014
2014 Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines.Radiotherapy and Oncology.  111:468-474. 2014
2014 Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma.Expert Opinion on Investigational Drugs.  23:305-315. 2014
2014 Cellular signaling and production of galactose-deficient IgA1 in IgA nephropathy, an autoimmune disease.Journal of Immunology Research.  2014:197548. 2014
2014 Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation.Journal of Virology.  88:364-376. 2014
2014 Kinomic profiling of electromagnetic navigational bronchoscopy specimens: a new approach for personalized medicine.PLoS ONE.  9:e116388. 2014
2013 Mini-review: bmx kinase inhibitors for cancer therapy.Recent Patents on Anti-Cancer Drug Discovery.  8:228-238. 2013
2012 Kinomic profiling approach identifies Trk as a novel radiation modulator.Radiotherapy and Oncology.  103:380-387. 2012
2012 MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma.Clinical Cancer Research.  18:3030-3041. 2012
2012 Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner.PLoS ONE.  7:e29653. 2012
2011 Treatment of small cell lung cancer with TRA-8 in combination with cisplatin and radiation.Radiotherapy and Oncology.  101:183-189. 2011
2011 Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma.Radiotherapy and Oncology.  99:339-343. 2011
2010 Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation.International Journal of Radiation Oncology - Biology - Physics.  77:1518-1526. 2010
2009 Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma.Radiotherapy and Oncology.  92:339-344. 2009
2009 Refractory lympho-epithelial carcinoma of the nasopharynx: a case report illustrating a protracted clinical course.Head and Neck Oncology.  1:18. 2009
2009 Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor.Molecular Cancer Therapeutics.  8:1270-1279. 2009
2008 Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium (Cancer Research (2008) 68, (2861-2869))Cancer Research.  68:8189. 2008
2008 STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMX.International Journal of Biological Sciences.  4:184-199. 2008
2008 Differential efficacy of combined therapy with radiation and AEE788 in high and low EGFR-expressing androgen-independent prostate tumor models.International Journal of Radiation Oncology - Biology - Physics.  71:237-246. 2008
2008 Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium.Cancer Research.  68:2861-2869. 2008
2007 Expression of protein kinase C isoforms in cultured human retinal pigment epithelial cells.Graefe's Archive for Clinical and Experimental Ophthalmology.  245:993-999. 2007
2007 HIV protease inhibitors enhance the efficacy of irradiation.Cancer Research.  67:4886-4893. 2007
2007 Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models.Clinical Cancer Research.  13:3033-3042. 2007
2007 A Phase II multi-institutional trial of chemoradiation using weekly docetaxel and erythropoietin for high-risk postoperative head and neck cancer patients.International Journal of Radiation Oncology - Biology - Physics.  67:1323-1331. 2007
2007 Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests.International Journal of Radiation Oncology - Biology - Physics.  67:1519-1525. 2007
2006 Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases.Journal of Molecular and Cellular Cardiology.  41:669-679. 2006
2003 Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src.Journal of Molecular and Cellular Cardiology.  35:671-683. 2003
2002 c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.Journal of Biological Chemistry.  277:23065-23075. 2002
2000 Integrin activation and focal complex formation in cardiac hypertrophy.Journal of Biological Chemistry.  275:35624-35630. 2000


Year Title Altmetric
2011 Interaction of Chemotherapy and Radiation.  65-82. 2011

Investigator On

  • RTOG Foundation Master Service Agreement for Participation in Foundation Research: RTOG 3501 Tryhard: A Phase II, Randomized, Double Blind, Placebo-Controlled Study of Lapatinib (Tykerb) for Non-HPV Locally Advanced Head and Neck Cancer with Concurrent Chemoradiation  awarded by American College of Radiology 2012 - 2022
  • Private Grant  awarded by NOVOCURE, INC. 2019 - 2022
  • Private Grant  awarded by PROSTATE CANCER CLINICAL TRIALS CONSORTIUM, LLC 2017 - 2019
  • Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2019
  • Private Grant  awarded by NOVOCURE, INC. 2017 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2015 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2014 - 2019
  • Private Grant  awarded by ELI LILLY AND COMPANY 2016 - 2019
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC. 2014 - 2017
  • Private Grant  awarded by VIVO BIOSCIENCES, INC. 2015 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Private Grant  awarded by SUCAMPO PHARMACEUTICALS 2016
  • Molecular Predictors of Post-Mastectomy Breast Cancer Loco-Regional Recurrence  awarded by National Cancer Institute/NIH/DHHS 2012 - 2016
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO 2014 - 2015
  • Private Grant  awarded by Pfizer Pharmaceuticals 2013 - 2015
  • Private Grant  awarded by ELI LILLY AND COMPANY 2012 - 2015
  • Integrated Pharmacogenomic/Pharmacokinomic Approach to Optimize GBM Therapy  awarded by National Brain Tumor Society 2011 - 2013
  • Education And Training

  • Bachelor of Science or Mathematics in Biomedical / Medical Engineering, Duke University
  • Doctor of Medicine, Medical University of South Carolina
  • Doctor of Philosophy in Medical Scientist, Medical University of South Carolina
  • Spartanburg Regional Medical Center, Internship 2004
  • Vanderbilt University Medical Center, Residency 2008
  • Full Name

  • Christopher Willey