Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.Journal of Experimental Medicine.  215:1823-1838. 2018
2017 Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity.Mucosal Immunology.  10:1108-1117. 2017
2017 T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.Journal of Immunology.  199:613-623. 2017
2017 Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.Journal of Immunology.  199:312-322. 2017
2016 Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.PLoS Pathogens.  12:e1006050. 2016
2016 IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.Journal of Experimental Medicine.  213:2281-2291. 2016
2016 A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease.Journal of Clinical Investigation.  126:3541-3555. 2016
2016 Regulation of Effector Treg Cells in Murine Lupus.Arthritis and Rheumatology.  68:1454-1466. 2016
2016 Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile.BMC Microbiology.  16:5. 2016
2016 Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination.Journal of Visualized Experiments2016
2015 Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection.Journal of Experimental Medicine.  212:1405-1414. 2015
2015 Daughter's Tolerance of Mom Matters in Mate Choice.Cell.  162:467-469. 2015
2015 Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.Journal of Immunology.  195:450-463. 2015
2015 Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.Nature.  523:221-225. 2015
2015 T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine.Cancer Immunology Research.  3:806-814. 2015
2015 Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis.Proceedings of the National Academy of Sciences.  112:7061-7066. 2015
2015 Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.European Journal of Immunology.  45:1842-1854. 2015
2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.Nature Immunology.  16:286-295. 2015
2015 PD-L1hi B cells are critical regulators of humoral immunity.Nature Communications.  6:5997. 2015
2015 IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus.PLoS ONE.  10:e0141927. 2015
2014 Development and survival of Th17 cells within the intestines: the influence of microbiome- and diet-derived signals.Journal of Immunology.  193:4769-4777. 2014
2014 Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.Journal of Clinical Investigation.  124:3455-3468. 2014
2014 The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.Immunity.  40:355-366. 2014
2014 Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription.PLoS Genetics.  10:e1003969. 2014
2013 IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.Journal of Leukocyte Biology.  94:1103-1112. 2013
2013 IL-2 coordinates IL-2-producing and regulatory T cell interplay.Journal of Experimental Medicine.  210:2707-2720. 2013
2013 Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.Cancer Research.  73:5905-5913. 2013
2013 Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.Nature Immunology.  14:959-965. 2013
2013 Linking vitamin d deficiency to inflammatory bowel disease.Inflammatory Bowel Diseases.  19:2245-2256. 2013
2013 Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.Journal of Immunology.  191:2780-2795. 2013
2013 IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.Proceedings of the National Academy of Sciences.  110:12768-12773. 2013
2013 Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.Immunity.  39:148-159. 2013
2013 Allogeneic Th1 cells home to host bone marrow and spleen and mediate IFNγ-dependent aplasia.Biology of Blood and Marrow Transplantation.  19:876-887. 2013
2013 Dwelling on T cell fate decisions.Cell.  153:739-741. 2013
2013 Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants.Journal of Immunology.  190:2603-2613. 2013
2013 The Th17 family: flexibility follows function.Immunological Reviews.  252:89-103. 2013
2013 The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin.Annual Review of Pathology: Mechanisms of Disease.  8:477-512. 2013
2013 Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.Journal of Leukocyte Biology.  93:21-31. 2013
2012 Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria.Immunity.  37:1061-1075. 2012
2012 The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22.Journal of Immunology.  189:3653-3660. 2012
2012 γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.Immunity.  37:524-534. 2012
2012 Reciprocal interactions of the intestinal microbiota and immune system.Nature.  489:231-241. 2012
2012 Noninvasive bioluminescence imaging in small animalsILAR news.  53:103-115. 2012
2012 Stem-cell-like qualities of immune memory; CD4+ T cells join the party.Cell Stem Cell.  10:107-108. 2012
2012 Developmental regulation of Th17-cell capacity in human neonates.European Journal of Immunology.  42:311-319. 2012
2012 Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.Journal of Immunology.  188:1036-1048. 2012
2012 Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.Proceedings of the National Academy of Sciences.  109:1210-1215. 2012
2012 B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.Journal of Immunology.  188:678-685. 2012
2012 Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.Infection and Immunity.  80:410-417. 2012
2011 Th17 cells mediate clade-specific, serotype-independent mucosal immunity.Immunity.  35:997-1009. 2011
2011 Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection.Infection and Immunity.  79:3966-3977. 2011
2011 Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness.Mucosal Immunology.  4:503-518. 2011
2011 Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.Gastroenterology.  140:2031-2043. 2011
2011 Immunology: Context is key in the gut.Nature.  471:169-170. 2011
2011 Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.Journal of Biological Chemistry.  286:997-1004. 2011
2011 IL-12 converts Foxp3(+) regulatory T cells to Foxp3(+)IFN-γ(+) T cells with inhibitory functions during induction of colitisGastroenterology.  140:2031-43. 2011
2010 Regulation of the Ifng locus in the context of T-lineage specification and plasticity.Immunological Reviews.  238:216-232. 2010
2010 Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels.Journal of Immunology.  185:3643-3651. 2010
2010 Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.Immunity.  33:35-47. 2010
2010 Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.Immunity.  32:616-627. 2010
2010 Autoimmunity: increasing suspects in the CD4+ T cell lineup.Nature Immunology.  11:36-40. 2010
2009 Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective.Nature Reviews Immunology.  9:883-889. 2009
2009 Intestinal effector T cells in health and disease.Immunity.  31:389-400. 2009
2009 Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic model.BMC Immunology.  10:44. 2009
2009 IL-9 as a mediator of Th17-driven inflammatory disease.Journal of Experimental Medicine.  206:1653-1660. 2009
2009 MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways.European Journal of Immunology.  39:2281-2292. 2009
2009 The AP-1 transcription factor Batf controls T(H)17 differentiation.Nature.  460:405-409. 2009
2009 TGF-beta promotes Th17 cell development through inhibition of SOCS3.Journal of Immunology.  183:97-105. 2009
2009 Developmental plasticity of Th17 and Treg cells.Current Opinion in Immunology.  21:274-280. 2009
2009 Editorial overview: lymphocyte development.Current Opinion in Immunology.  21:119-120. 2009
2009 Th17: The ascent of a new effector T-cell subset. Preface.European Journal of Immunology.  39:634-636. 2009
2009 Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells.Journal of Experimental Medicine.  206:343-357. 2009
2009 Duality in the Th17-Treg developmental decision.F1000 biology reports.  1:5. 2009
2009 Late developmental plasticity in the T helper 17 lineage.Immunity.  30:92-107. 2009
2009 Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis.Journal of Neuroimmunology.  206:22-27. 2009
2008 Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation.Immunological Reviews.  226:219-233. 2008
2008 Memory CD4 T cells emerge from effector T-cell progenitors.Nature.  452:356-360. 2008
2008 Emergence of the Th17 pathway and its role in host defense.Advances in Immunology.  99:115-163. 2008
2008 Noninvasive bioluminescence imaging in small animals.ILAR news.  49:103-115. 2008
2007 The central role of the Th17 lineage in regulating the inflammatory/autoimmune axis.Seminars in Immunology.  19:351-352. 2007
2007 Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter.International Immunology.  19:1165-1173. 2007
2007 The genetics of inflammatory bowel disease.Gastroenterology.  133:1327-1339. 2007
2007 Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10.Nature Immunology.  8:931-941. 2007
2007 Immunology: narcissistic helpers.Nature.  448:416-418. 2007
2007 Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.Gastroenterology.  132:2359-2370. 2007
2007 T-cell subsets: the more the merrier.Current Biology.  17:R61-R63. 2007
2007 IL-17 family cytokines and the expanding diversity of effector T cell lineages.Annual Review of Immunology.  25:821-852. 2007
2006 A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.Immunity.  25:717-729. 2006
2006 Expanding the effector CD4 T-cell repertoire: the Th17 lineage.Current Opinion in Immunology.  18:349-356. 2006
2006 Th17: an effector CD4 T cell lineage with regulatory T cell ties.Immunity.  24:677-688. 2006
2006 Transforming growth factor-beta induces development of the T(H)17 lineage.Nature.  441:231-234. 2006
2006 Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice.American Journal of Pathology.  168:1425-1434. 2006
2006 Alterations of T lymphocytes in inflammatory bowel diseases.Advances in Experimental Medicine and Biology.  579:133-148. 2006
2005 Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium.American Journal of Pathology.  167:1661-1675. 2005
2005 P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculature.American Journal of Pathology.  167:1647-1660. 2005
2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.Nature Immunology.  6:1123-1132. 2005
2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota.Immunological Reviews.  206:260-276. 2005
2005 Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function.Journal of Immunology.  174:2787-2795. 2005
2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-76. 2005
2004 Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells.Journal of Immunology.  173:7249-7258. 2004
2004 Early upregulation of T cell IL-10 production plays an important role in oral tolerance induction.Annals of the New York Academy of Sciences.  1029:319-320. 2004
2004 New developments in experimental models of inflammatory bowel disease.Current Opinion in Gastroenterology.  20:360-367. 2004
2004 Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes.International Immunology.  16:345-351. 2004
2004 Gene disruption and immunity in experimental colitis.Inflammatory Bowel Diseases.  10 Suppl 1:S25-S28. 2004
2004 Early upregulation of T cell IL-10 production plays an important role in oral tolerance inductionAnnals of the New York Academy of Sciences.  1029:319-20. 2004
2003 Immunology. T-bet or not T-bet.Science.  302:993-994. 2003
2003 IFN-gamma-inducible chemokines enhance adaptive immunity and colitis.Journal of Interferon and Cytokine Research.  23:591-600. 2003
2003 Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells.Journal of Experimental Medicine.  198:123-132. 2003
2003 Psoriasiform dermatitis susceptibility in Itgb2(tm1Bay) PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease.American Journal of Pathology.  163:197-202. 2003
2003 Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene.Arthritis and Rheumatism.  48:1602-1611. 2003
2003 Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation.Journal of Experimental Medicine.  197:751-762. 2003
2002 Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora.Journal of Immunology.  169:6112-6119. 2002
2002 Cutting-edge technology IV. Genomic engineering for studies of the gastrointestinal tract in miceAJP - Gastrointestinal and Liver Physiology.  283. 2002
2002 Cutting-edge technology: IV. Genomic engineering for studies of the gastrointestinal tract in mice.AJP - Gastrointestinal and Liver Physiology.  283:G1232-G1237. 2002
2002 Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigens.Journal of Immunology.  169:2337-2345. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic modelBMC Immunology.  3. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model.BMC Immunology.  3:4. 2002
2002 Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway.Journal of Immunology.  168:4495-4503. 2002
2002 T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis.Journal of Experimental Medicine.  195:71-84. 2002
2002 Gene delivery into primary T cells: overview and characterization of a transgenic model for efficient adenoviral transduction.Immunologic Research.  26:131-141. 2002
2002 Inhibition of T cell responses by transferrin-coupled competitor peptides.Immunologic Research.  26:77-85. 2002
2001 Unexpected characteristics of the IFN-gamma reporters in nontransformed T cells.Journal of Immunology.  167:855-865. 2001
2001 Immuno-bacterial homeostasis in the gut: new insights into an old enigma.Seminars in Immunology.  13:187-194. 2001
2001 Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members.Journal of Immunology.  166:4534-4542. 2001
2000 Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12.Journal of Immunology.  165:2173-2182. 2000
1999 Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function.Immunity.  11:271-280. 1999
1999 Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR.International Immunology.  11:1253-1264. 1999
1998 Experimental models to study molecular mechanisms underlying intestinal inflammation.Annals of the New York Academy of Sciences.  859:85-95. 1998
1998 Regional differences in L-selectin expression in murine intestinal lymphocytes.Gastroenterology.  114:965-974. 1998
1998 Heterogeneity in the clonal T cell response. Implications for models of T cell activation and cytokine phenotype development.Immunologic Research.  17:279-302. 1998
1997 Evaluation of pathologic criteria for acute renal allograft rejection: reproducibility, sensitivity, and clinical correlation.Journal of the American Society of Nephrology.  8:1930-1941. 1997
1997 The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective up-regulation of B7.2 expression.Journal of Immunology.  159:5301-5308. 1997
1997 Single-cell analyses of CD4+ T cells from alpha beta T cell receptor-transgenic mice: a distinct mucosal cytokine phenotype in the absence of transgene-specific antigen.European Journal of Immunology.  27:1774-1781. 1997
1997 Visualization of antigen-specific T cell activation and cytokine expression in vivo.Journal of Immunology.  158:649-657. 1997
1996 Anti-LFA-1 mAb drives naive CD4 T cells to A TH2-like phenotypeFederation proceedings.  10. 1996
1996 Differences in phenotypes and activation markers in different compartments of the intestineFederation proceedings.  10. 1996
1996 Direct alloantigen stimulation of T cells in vitro (MLR) shows inhibition characteristics of low TCR avidity responsesFederation proceedings.  10. 1996
1996 Heterogenity of fas-ligand expression during CD4+ T cell phenotype development detected by single-cell analysisFederation proceedings.  10. 1996
1996 In vivo analysis of CD4+T cell responses to oral immunizationFederation proceedings.  10. 1996
1996 In vivo cytokine production and antibody isotype profiles reflect the TR1 or TN2 phenotype of adoptivley transferred αβ-tcr transgenic cellsFederation proceedings.  10. 1996
1996 Tolerization of ovalbumin-specific αβ-tcr transgenic cells in adoptively transferred mice by the feeding of ovalbuminFederation proceedings.  10. 1996
1996 Visualization of T cell activation and cytokine expression in vivoFederation proceedings.  10. 1996
1996 Oral-antigen delivery by way of a multiple emulsion system enhances oral tolerance.Annals of the New York Academy of Sciences.  778:156-162. 1996
1996 Oral antigen delivery via a multiple emulsion system enhances oral toleranceAnnals of the New York Academy of Sciences.  778:156-62. 1996
1995 Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.Proceedings of the National Academy of Sciences.  92:7565-7569. 1995
1995 In situ hybridization for cytokine mRNA with digoxigenin-labeled riboprobes. Sensitivity of detection and double label applications.Journal of Immunological Methods.  182:93-106. 1995
1994 Heterogeneity of single cell cytokine gene expression in clonal T cell populations.Journal of Experimental Medicine.  180:1251-1262. 1994
1994 T cells of staphylococcal enterotoxin B-tolerized autoimmune MRL-lpr/lpr mice require co-stimulation through the B7-CD28/CTLA-4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co-stimulatory signal.European Journal of Immunology.  24:1019-1025. 1994
1993 Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.Proceedings of the National Academy of Sciences.  90:4409-4413. 1993
1993 Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell.Journal of Immunology.  150:3832-3842. 1993
1992 CD45: a transmembrane protein tyrosine phosphatase involved in the transduction of antigenic signals.Biochemical Society Transactions.  20:169-174. 1992
1991 CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.Molecular and Cellular Biology.  11:4415-4422. 1991
1991 CD8+T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuliMolecular and Cellular Biology.  11:4415-4422. 1991
1990 ReplyImmunology Today.  11:304. 1990
1990 The costimulatory function of antigen-presenting cellsImmunology Today.  11:55-59. 1990
1990 The costimulatory function of antigen-presenting cells.Immunology Today.  11:49-55. 1990
1990 Costimulatory function of APCs (I: Reply)Immunology Today (Reference Edition).  11:304. 1990
1990 ReplyImmunology Today.  11:304. 1990
1990 The costimulatory function of antigen-presenting cellsImmunology Today.  11:55-59. 1990
1989 Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.Proceedings of the National Academy of Sciences.  86:10034-10038. 1989
1989 Nonopiate active proenkephalin-derived peptides are secreted by T helper cells.Federation proceedings.  3:2401-2407. 1989
1989 A new murine CD4+ T cell subset with an unrestricted cytokine profile.Journal of Immunology.  143:518-525. 1989
1989 T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of TH1 and TH2 subsets.Journal of Immunology.  142:3469-3476. 1989
1988 T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.Proceedings of the National Academy of Sciences.  85:8181-8185. 1988
1987 Membrane IL-1: a key protein in antigen presentation.Annales de l'Institut Pasteur. Immunology.  138:489-492. 1987
1986 T cell induction of membrane IL 1 on macrophages.Journal of Immunology.  137:3868-3873. 1986
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.Science.  361.

Chapter

Year Title Altmetric
2015 Effector CD4+ T Cells in the Intestines.  721-732. 2015
2010 In Vivo Models of Inflammatory Bowel Disease.  25-51. 2010
2006 Experimental mouse models of inflammatory bowel disease: New insights into pathogenic mechanisms.  67-99. 2006
2005 Disease induction and prevention in experimental models of inflammatory bowel disease.  1237-1254. 2005
2004 Regulatory T cells in animal models: therapeutic potential.  100-6. 2004
2003 Are lessons from experimental models relevant for human IBD? 2003
2000 Aetiopathogenesis 1999- How to put it all together.  133-41. 2000
2000 Induced mutant mouse models of inflammatory bowel disease: new insights into disease pathogenesis.  47-55. 2000
1998 Animal models to study molecular mechanisms underlying intestinal disease 1998
1998 Cytokines and anti-cytokines in the therapy of inflammatory bowel disease.  232-8. 1998
1998 Experimental models of inflammatory bowel disease: Old hypotheses confirmed and new paradigms generated.  35-42. 1998
1998 What can we learn from animal models?.  65-72. 1998
1997 Genetic and chemical models of IBD. In Proc. of Falk Symposium No. 96.  21-6. 1997
1995 Regulation of mucosal immune responses - the missing link in IBD?.  81-81. 1995

Principal Investigator On

  • Specialization of Innate and Adaptive Immune Cells in Intestinal Barrier Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Mechanisms Controlling Regulatory T Cell Effector Function in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Private Grant  awarded by JT PHARMA INC. 2017 - 2020
  • Th17 Pathway Plasticity in the Pathogenesis of Inflammatory Bowel Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Role of Rorgt Positive Innate Lymphoid Cells in Neonatal Intestinal Barrier Development  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Acquisition of a Mainz COLOVIEW System for COLOVIEW Systems for Research Using Animal Models  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • IL-1-Mediated Regulation of the Th17 Developmental Program and Its Role in IBD  awarded by Crohn's & Colitis Foundation of America 2015 - 2018
  • Molecular Regulation of MS Susceptibility Genes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2018
  • HSF-GEF Scholar Award  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • Factors Controlling Effector T Cell Maintenance in the Pathogenesis of Colitis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2017
  • Interplay of T Cell Subsets in IBD Pathogenesis  awarded by Crohn's & Colitis Foundation of America 2014 - 2017
  • Private Grant  awarded by JT PHARMA INC. 2013 - 2017
  • Mechanistic Studies of Interleukin 10 Gene Regulation in Intestinal CD4 T Cells  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2017
  • Gene Regulatory Networks Controlling Effector and Regulatory T Cell Balance in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2016
  • Innate and Adaptive Immunity in IBD - Project 3  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Regulation of IL-10 Expression by Intestinal T Cells  awarded by Crohn's & Colitis Foundation of America 2012 - 2014
  • Regulation of IL-22 Induction from Th17 and Non-Th17 CD4 T Cells  awarded by Crohn's & Colitis Foundation of America 2012 - 2014
  • A Critical Role for T Cell-Derived IL-6 in the Pathogenesis of Colitis  awarded by Crohn's & Colitis Foundation of America 2011 - 2014
  • Control of Chromatin Landscapes in Effector T Cell Lineage Specifications  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Mechanisms of Vitamin D-Mediated Protection Against IBD  awarded by Crohn's & Colitis Foundation of America 2009 - 2012
  • Howard Hughes Medical Institute Fellows Award  awarded by Hughes (Howard) Medical Institute 2011 - 2012
  • Post-Thymic T-Cell Functional Repetoire Heterogeneity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2006 - 2012
  • Control of Effector Cytokine Gene Induction in Immunopathogenic T Cells  awarded by Crohn's & Colitis Foundation of America 2009 - 2011
  • Mechanisms Controlling IL-10 Producing Intestinal Regulatory T Cells  awarded by Crohn's & Colitis Foundation of America 2009 - 2011
  • CD4 T Cell Functional Heterogeneity During Multiple Sclerosis  awarded by National Multiple Sclerosis Society 2006 - 2011
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • UAB Autoimmunity Center for Excellence: Project 4 - Development and Maintenance of Intestinal Regulatory T Cells  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2009
  • Investigator On

  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Comprehensive Cancer Center Core Support Grant - Inflammation, Immunology and Immunotherapeutics Program  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Comprehensive Cancer Center Core Support Grant - Microbiome and Gnotobiotics Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Biology of Innate IL-22 During Lung Fungal Infection  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Regulation of T Cell Activity during Chronic Infections  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2019
  • Rheumatic Diseases Research Core Centers - Core C: Analytic Imaging and Immunoreagent Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core C: Analytic Imaging and Immunoreagent Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • The Thrombospondin1-TGF-Beta Axis in Multiple Myeloma  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Immunopathogenesis in Fungal Asthma  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2018
  • Pathological TNFR1 Expressing CD4+ T-Cells are Critical for HF Progression  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2018
  • Glycosylation-Dependent Mechanisms Regulating Ovarian Tumor Cell Survival  awarded by National Institute of General Medical Sciences/NIH/DHHS 2014 - 2018
  • Interactions Between AHR Ligands and the Gut Microbiota in Murine Arthritis  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2014 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Comprehensive Cancer Center Core Support Grant - Microbiome and Gnotobiotics Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Innate and Adaptive Immunity in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Innate and Adaptive Immunity in IBD - Animal Model Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Expansion of the UAB Gnotobiotic-Microbiome Research Facility  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2012 - 2016
  • Developing and Improving the UAB Gnotobiotic Facility  awarded by NIH - OFFICE OF THE DIRECTOR 2013 - 2015
  • New Animal Model for Studies of Mucosal Immunity and IgA Nephropathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2013
  • Mucosal HIV and Immunobiology Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • UAB Autoimmunity Center for Excellence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2009
  • Education And Training

  • Bachelor of Science or Mathematics in Biochemistry, University of Florida
  • Doctor of Medicine, University of Florida
  • Full Name

  • Casey Weaver
  • Blazerid

  • cweaver