Positions

Overview

  • Dr. Curtiss attended the University of Nebraska-Lincoln as an undergraduate, receiving a BS in Biochemistry and BA in Biology and worked in the lab of John Osterman. She completed a postbaccalaureate year at NIH-NIAID (Laboratory of Immunogenetics) in the IRTA program working in the lab of Silvia Bolland on the immunophenotype of mice with the lupus accelerator gene Yaa (since identified as a TLR7 gene duplication). She then completed her MD/PhD at the University of Iowa with a Ph.D. in Immunology in the laboratory of Paul Rothman studying the role of the transmembrane protein Tim-1 (HAVCR-1) in a mouse model of allergic airway disease and studying the initial signaling events downstream of Tim-1 ligation in lymphocytes. She was accepted into the ABIM Research Track at UAB where she completed her residency and a dual fellowship training in Allergy/Immunology and Pulmonary.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 “Stick a Fork in Me; I’m Done”: Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell DeathAmerican Journal of Respiratory Cell and Molecular Biology.  66:593-595. 2022
    2021 Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammationAmerican Journal of Physiology: Lung Cellular and Molecular Physiology.  320:L615-L626. 2021
    2020 Airway Remodeling in AsthmaFrontiers in Medicine.  7. 2020
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of AsthmaticsScientific Reports.  8. 2018
    2012 Tim-1 regulates Th2 responses in an airway hypersensitivity modelEuropean Journal of Immunology.  42:651-661. 2012
    2011 Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1)Molecular Immunology.  48:1424-1431. 2011
    2010 The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systemsJournal of Leukocyte Biology.  87:691-701. 2010
    2007 The role of the T-cell costimulatory molecule Tim-1 in the immune responseImmunologic Research.  39:52-61. 2007

    Research Overview

  • Dr. Curtiss' research focuses primarily on pulmonary inflammation, asthma, and immunodeficiencies.
  • Teaching Overview

  • Dr. Curtiss has engaged in didactic teaching while at UAB, with specific lectures given on anaphylaxis.
  • Education And Training

  • University of Alabama Birmingham, Residency
  • Doctor of Medicine, University of Iowa 2012
  • Doctor of Philosophy in Immunology, University of Iowa 2012
  • Full Name

  • Miranda Curtiss