Selected Publications

Academic Article

Year Title Altmetric
2018 The Border of Macular Atrophy in Age-Related Macular Degeneration: A Clinicopathologic CorrelationAmerican Journal of Ophthalmology.  193:166-177. 2018
2018 Choroidal and Sub-Retinal Pigment Epithelium Caverns: Multimodal Imaging and Correspondence with Friedman Lipid GlobulesOphthalmology: Journal of The American Academy of Ophthalmology.  125:1287-1301. 2018
2018 Re: Cuenca et al.: Cellular characterization of OCT and outer retinal bands using specific immunohistochemistry markers and clinical implications (Ophthalmology. 2018;125;407-422)Ophthalmology: Journal of The American Academy of Ophthalmology.  125:e47-e48. 2018
2018 Visualizing melanosomes, lipofuscin, and melanolipofuscin in human retinal pigment epithelium using serial block face scanning electron microscopyExperimental Eye Research.  166:131-139. 2018
2017 Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular DegenerationOphthalmology: Journal of The American Academy of Ophthalmology.  124:644-656. 2017
2017 ReplyOphthalmology: Journal of The American Academy of Ophthalmology.  124:e20-e21. 2017
2016 Macrophages or retinal pigment epithelium expressing macrophage markers in age-related macular degeneration? Comment on Lad et al. 2015Graefe's Archive for Clinical and Experimental Ophthalmology.  254:1237-1238. 2016
2016 Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal ImagingOphthalmology: Journal of The American Academy of Ophthalmology.  123:1090-1100. 2016
2015 The Onion Sign in Neovascular Age-Related Macular Degeneration Represents Cholesterol CrystalsOphthalmology: Journal of The American Academy of Ophthalmology.  122:2316-2326. 2015
2015 OUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to HistologyRETINA2015
2015 Clinicopathological correlation of outer retinal tubulationinage-related macular degenerationJAMA Ophthalmology.  133:609-612. 2015
2015 CorrespondenceRETINA.  35:e13-e14. 2015
2015 Inner segment Remodeling and mitochondrial translocation in cone photoreceptors in age-related macular degeneration with outer retinal tubulationInvestigative Ophthalmology & Visual Science.  56:2243-2253. 2015
2015 Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degenerationInvestigative Ophthalmology & Visual Science.  56:3242-3252. 2015
2015 Refractile drusen: Clinical imaging and candidate histologyRETINA.  35:859-865. 2015
2014 7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusenExperimental Eye Research.  128:151-155. 2014
2014 Correspondence.RETINA.  34:e36-e37. 2014
2014 Transcriptome of the human retina, retinal pigmented epithelium and choroidGenomics2014
2014 Quantitative autofluorescence and cell density maps of the human retinal pigment epitheliumInvestigative Ophthalmology & Visual Science.  55:4832-4841. 2014
2014 In Vivo Imaging of Human Cone Photoreceptor Inner SegmentsInvestigative Ophthalmology & Visual Science.  55:4244-4251. 2014
2014 Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular healthInvestigative Ophthalmology & Visual Science.  55:4776-4789. 2014
2014 Assessing the cone photoreceptor mosaic in eyes with pseudodrusen and soft drusen in vivo using adaptive optics imagingOphthalmology: Journal of The American Academy of Ophthalmology.  121:545-551. 2014
2014 Age-related macular degeneration: Genetics and biology coming togetherAnnual Review of Genomics and Human Genetics.  15:151-171. 2014
2014 Author response: Relationship between foveal cone specialization and pit morphology in albinismInvestigative Ophthalmology & Visual Science.  55:5923. 2014
2014 Cholesterol in the retina: The best is yet to comeProgress in Retinal and Eye Research2014
2014 Cholesterol in the retina: The best is yet to comeProgress in Retinal and Eye Research.  41:64-89. 2014
2014 Comprehensive analysis of gene expression in human retina and supporting tissuesHuman Molecular Genetics.  23:4001-4014. 2014
2014 Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterolBritish Journal of Ophthalmology.  98:698-702. 2014
2014 Mice with cholesterol in bruch’s membrane: Have we arrived?Investigative Ophthalmology & Visual Science.  55:7296. 2014
2014 Microstructure of subretinal drusenoid deposits revealed by adaptive optics imagingBiomedical Optics Express.  5:713-727. 2014
2014 Outcomes of shunt tube coverage with glycerol preserved cornea versus pericardiumJournal of Glaucoma.  23:258-261. 2014
2014 Outer retinal corrugations in age-related macular degenerationJAMA Ophthalmology.  132:806-813. 2014
2014 Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser OphthalmoscopyAmerican Journal of Ophthalmology2014
2014 Photoreceptor perturbation around subretinal drusenoid deposits as revealed by adaptive optics scanning laser ophthalmoscopyAmerican Journal of Ophthalmology.  158. 2014
2014 Relationship between foveal cone specialization and pit morphology in AlbinismInvestigative Ophthalmology & Visual Science.  55:4186-4198. 2014
2014 Simultaneous decomposition of multiple hyperspectral data sets: Signal recovery of unknown fluorophores in the retinal pigment epitheliumBiomedical Optics Express.  5:4171-4185. 2014
2014 Subretinal drusenoid deposits: Further characterization by lipid histochemistryRETINA.  34:825-826. 2014
2013 In vivo optical coherence tomography of light-driven melanosome translocation in retinal pigment epitheliumScientific Reports.  3. 2013
2013 Inner macular hyperreflectivity demonstrated by optical coherence tomography in niemann-pick diseaseJAMA Ophthalmology.  131:1244-1246. 2013
2013 Rethinking A2EInvestigative Ophthalmology & Visual Science.  54:5543. 2013
2013 Quantifying drusen in AMDRetina Today.  MAY. 2013
2013 Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophyOphthalmology: Journal of The American Academy of Ophthalmology.  120:821-828. 2013
2013 Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model.RETINA.  33:265-276. 2013
2012 In vivo confocal intrinsic optical signal identification of localized retinal dysfunctionInvestigative Ophthalmology & Visual Science.  53:8139-8145. 2012
2012 Comparison of different methods of glycerol preservation for deep anterior lamellar keratoplasty eligible corneasInvestigative Ophthalmology & Visual Science.  53:5675-5685. 2012
2012 Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retinaJournal of Biomedical Optics.  17. 2012
2012 Spatial distribution of the pathways of cholesterol homeostasis in human retinaPLoS ONE.  7. 2012
2012 Quantification of fluorescein-stained drusen associated with age-related macular degenerationRETINA.  32:19-24. 2012
2011 The oil spill in ageing Bruch membraneBritish Journal of Ophthalmology.  95:1638-1645. 2011
2011 Complementing apolipoprotein secretion by cultured retinal pigment epitheliumProceedings of the National Academy of Sciences.  108:18569-18570. 2011
2011 Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophyExperimental Eye Research.  93:413-423. 2011
2011 Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: Literature review and modelRETINA.  31:1609-1619. 2011
2011 Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sectionsInvestigative Ophthalmology & Visual Science.  52:3943-3954. 2011
2011 Two-photon excited autofluorescence imaging of freshly isolated frog retinasBiomedical Optics Express.  2:1494-1503. 2011
2010 Drusen characterization with multimodal imagingRETINA.  30:1441-1454. 2010
2010 Abundant lipid and protein components of drusenPLoS ONE.  5. 2010
2010 Editorial: Drusen, an old but new frontierRETINA.  30:1163-1165. 2010
2010 Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retinaMolecular Vision.  16:1317-1323. 2010
2010 Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degenerationJournal of Lipid Research.  51:451-467. 2010
2010 Reticular Pseudodrusen Are Subretinal Drusenoid DepositsOphthalmology: Journal of The American Academy of Ophthalmology.  117. 2010
2009 Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteinsProgress in Retinal and Eye Research.  28:393-422. 2009
2009 Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroidJournal of Histochemistry and Cytochemistry.  57:731-739. 2009
2009 Lipoprotein particles of intraocular origin in human bruch membrane: An unusual lipid profileInvestigative Ophthalmology & Visual Science.  50:870-877. 2009
2009 Histochemistry and lipid profiling combine for insights into aging and age-related maculopathy.Methods in Molecular Biology.  580:267-281. 2009
2008 Sub-retinal drusenoid deposits in human retina: Organization and compositionExperimental Eye Research.  87:402-408. 2008
2008 Effects of particulates and lipids on the hydraulic conductivity of MatrigelJournal of applied physiology: respiratory, environmental and exercise physiology.  105:621-628. 2008
2008 Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membraneInvestigative Ophthalmology & Visual Science.  49:2721-2727. 2008
2008 Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathyInvestigative Ophthalmology & Visual Science.  49:1200-1209. 2008
2007 Comparison of morphology of human macular and peripheral Bruch's membrane in older eyesCurrent Eye Research.  32:791-799. 2007
2007 Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etchExperimental Eye Research.  85:202-218. 2007
2007 Distribution and composition of esterified and unesterified cholesterol in extra-macular drusenExperimental Eye Research.  85:192-201. 2007
2007 The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual fieldVision Research.  47:2901-2911. 2007
2006 Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retinaExperimental Eye Research.  83:834-840. 2006
2006 Plasma apolipoproteins and risk for age related maculopathyBritish Journal of Ophthalmology.  90:1028-1033. 2006
2006 Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expressionInvestigative Ophthalmology & Visual Science.  47:3119-3128. 2006
2006 Declining availability of human eye tissues for researchInvestigative Ophthalmology & Visual Science.  47:2747-2749. 2006
2006 Drusen and lipid-filled retinal pigment epithelium cells in a rhesus maculaVeterinary Ophthalmology.  9:201-207. 2006
2006 The iron carrier transferrin is upregulated in retinas from patients with age-related macular degenerationInvestigative Ophthalmology & Visual Science.  47:2135-2140. 2006
2005 Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathyExperimental Eye Research.  81:731-741. 2005
2005 Imaging maculopathy in post-mortem human eyesVision Research.  45:3496-3503. 2005
2005 Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterizationInvestigative Ophthalmology & Visual Science.  46:2576-2586. 2005
2005 Retina expresses microsomal triglyceride transfer protein: Implications for age-related maculopathyJournal of Lipid Research.  46:628-640. 2005
2005 Basal deposits and drusen in eyes with age-related maculopathy: Evidence for solid lipid particlesExperimental Eye Research.  80:761-775. 2005
2005 Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaquesBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1733:76-89. 2005
2005 Lipoprotein-like particles (LLP) in human Bruch's membrane: Isolation and initial characterizationInvestigative Ophthalmology & Visual Science.  46. 2005
2005 The iron carrier transferrin is upregulated in retinas from patients with age-related macular degenerationInvestigative Ophthalmology & Visual Science.  46. 2005
2005 Ultrastructure of age-related changes in human Bruch's membrane as seen by quick-freeze/deep-etch (QFDE)Investigative Ophthalmology & Visual Science.  46. 2005
2004 Cultured human retinal pigment epithelium (RPE) contains, synthesizes, and secretes neutral lipidInvestigative Ophthalmology & Visual Science.  45:U722-U722. 2004
2004 Distribution of complement proteins and receptors in normal human retinaInvestigative Ophthalmology & Visual Science.  45:U324-U324. 2004
2004 Membranous debris (MemD) in Drusen and basal linear deposit (BlinD) of eyes with age-related maculopathy (ARM): Evidence for solid particlesInvestigative Ophthalmology & Visual Science.  45:U718-U718. 2004
2003 The association between statin use and age related maculopathyBritish Journal of Ophthalmology.  87:1121-1125. 2003
2003 Genes for apolipoprotein B (Apo B) and microsomal triglyceride transfer protein (MTP) are expressed in human retina and retinal pigment epithelium (RPE)Investigative Ophthalmology & Visual Science.  44:U393-U393. 2003
2003 Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membraneInvestigative Ophthalmology & Visual Science.  44:1753-1759. 2003
2003 Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathyAmerican Journal of Pathology.  162:413-425. 2003
2002 Photoreceptor inner segments in monkey and human retina: Mitochondrial density, optics, and regional variationVisual Neuroscience.  19:395-407. 2002
2002 Photoreceptor degeneration and dysfunction in aging and age-related maculopathyAgeing Research Reviews.  1:381-396. 2002
2002 A local source for esterified cholesterol (EC) in human Bruch's membrane (BrM)Investigative Ophthalmology & Visual Science.  43:U187-U187. 2002
2002 Absence of Bruch's membrane (BrM) cholesterol deposition in rabbits consuming atherogenic dietsInvestigative Ophthalmology & Visual Science.  43:U656-U656. 2002
2002 An age related lipid wall' in human Bruch's membraneInvestigative Ophthalmology & Visual Science.  43:U651-U651. 2002
2002 Localization of apolipoproteins and cholesterol in macular and peripheral Bruch's membrane, basal deposits (BD) and drusen of normal and age-related maculopathy (ARM) eyesInvestigative Ophthalmology & Visual Science.  43:U652-U652. 2002
2002 Phenotypic variation of retinal pigment epithelium in age-related macular degenerationInvestigative Ophthalmology & Visual Science.  43:267-273. 2002
2001 Preservation of ganglion cell layer neurons in age-related macular degenerationInvestigative Ophthalmology & Visual Science.  42:795-803. 2001
2001 Cholesterol in basel deposits and drusen of eyes with age-related maculopathy (ARM): filipin histochemistry.Investigative Ophthalmology & Visual Science.  42:S944-S944. 2001
2001 Accumulation of cholesterol with age in human Bruch's membraneInvestigative Ophthalmology & Visual Science.  42:265-274. 2001
2001 Murine high-fat diet and laser photochemical model of basal deposits in bruch membraneArchives of Ophthalmology -New Series-.  119:1643-1649. 2001
2001 Photoreceptor topography in ageing and age-related maculopathyEye.  15:376-383. 2001
2000 Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degenerationOphthalmology: Journal of The American Academy of Ophthalmology.  107:2256-2266. 2000
2000 Spare the rods, save the cones in aging and age-related maculopathyInvestigative Ophthalmology & Visual Science.  41:2015-2018. 2000
2000 Ultrastructural changes in Bruch's membrane of apolipoprotein E- deficient miceInvestigative Ophthalmology & Visual Science.  41:2035-2042. 2000
2000 Cholesterol accumulates with age in human Bruch's membraneInvestigative Ophthalmology & Visual Science.  41:S115-S115. 2000
2000 Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor lossOphthalmology: Journal of The American Academy of Ophthalmology.  107:334-343. 2000
1999 Lipids in human Bruch's membrane: Histochemistry and ultrastructureInvestigative Ophthalmology & Visual Science.  40:S921-S921. 1999
1999 Subpopulations of human blue cones identified by immunocytochemistry for calcium-binding proteinsInvestigative Ophthalmology & Visual Science.  40:S158-S158. 1999
1999 Thick sub-RPE deposits spare the macula in a family with late-onset retinal degeneration.Investigative Ophthalmology & Visual Science.  40:S223-S223. 1999
1999 Basal linear deposit and large drusen are specific for early age- related maculopathyArchives of Ophthalmology -New Series-.  117:329-339. 1999
1998 The alabama age-related macular degeneration grading system for donor eyesInvestigative Ophthalmology & Visual Science.  39:1085-1096. 1998
1997 Loss of neurons in the ganglion cell layer (gcl) of eyes with age-related maculopathy (arm) and macular degeneration (amd)Investigative Ophthalmology & Visual Science.  38. 1997
1997 Rpe/bruch's membrane pathology and photoreceptor loss in age-related maculopathy (arm)Investigative Ophthalmology & Visual Science.  38. 1997
1996 Photoreceptor loss in age-related macular degenerationInvestigative Ophthalmology & Visual Science.  37:1236-1249. 1996
1996 Peripapillary Chorioretinal Atrophy (PPCRA) in normal eyes: Histopathology and photoreceptor lossInvestigative Ophthalmology & Visual Science.  37. 1996
1995 PHOTORECEPTOR LOSS IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION (EX-AMD)Investigative Ophthalmology & Visual Science.  36:S432-S432. 1995
1994 AGING AND PHOTORECEPTORS - REPLYInvestigative Ophthalmology & Visual Science.  35:783-784. 1994
1994 Aging and photoreceptors [2]Investigative Ophthalmology & Visual Science.  35:783-784. 1994
1993 TOPOGRAPHY OF RETINAL CELLS AND VISUAL SENSITIVITY IN THE SAME HUMAN EYESInvestigative Ophthalmology & Visual Science.  34:777-777. 1993
1993 Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retinaInvestigative Ophthalmology & Visual Science.  34:3278-3296. 1993
1993 Retinal ganglion cells in Alzheimer's disease and agingAnnals of Neurology.  33:248-257. 1993
1992 Packing geometry of human cone photoreceptors: Variation with eccentricity and evidence for local anisotropyVisual Neuroscience.  9:169-180. 1992
1991 PACKING GEOMETRY OF HUMAN CONE PHOTORECEPTORSInvestigative Ophthalmology & Visual Science.  32:1128-1128. 1991
1991 Chapter 5 Organization and development of the primate photoreceptor mosaicProgress in Retinal and Eye Research.  10:89-120. 1991
1991 Distribution and morphology of human cone photoreceptors stained with anti‐blue opsinJournal of Comparative Neurology.  312:610-624. 1991
1990 Developmental redistribution of photoreceptors across the Macaca nemestrina (pigtail macaque) retinaJournal of Comparative Neurology.  298:472-493. 1990
1990 Human photoreceptor topographyJournal of Comparative Neurology.  292:497-523. 1990
1990 Topography of ganglion cells in human retinaJournal of Comparative Neurology.  300:5-25. 1990
1989 Computer methods for sampling, reconstruction, display and analysis of retinal whole mountsVision Research.  29:529-540. 1989
1989 Photoreceptor topography of the retina in the adult pigtail macaque (Macaca nemestrina)Journal of Comparative Neurology.  288:165-183. 1989
1989 The spatial resolution capacity of human foveal retinaVision Research.  29:1095-1101. 1989
1987 A whole mount method for sequential analysis of photoreceptor and ganglion cell topography in a single retinaVision Research.  27:9-15. 1987
1987 Distribution of cones in human and monkey retina: Individual variability and radial asymmetryScience.  236:579-582. 1987
1986 Computer‐assisted morphometry using video‐mixed microscopic images and computer graphicsAnatomical Record.  214:329-337. 1986
1986 Stability of dendrites in cortical barrels of C57BL/6N mice between 4 and 45 monthsNeurobiology of Aging.  7:101-105. 1986
1985 Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epitheliumJournal of Comparative Neurology.  235:519-528. 1985
1984 Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer IIAnatomical Record.  210:657-662. 1984
1984 Nucleus raphe dorsalis in dementia of the alzheimer type: Neurofibrillary changes and neuronal packing densityJournal of Neuropathology and Experimental Neurology.  43:359-368. 1984
1984 Variation in longevity of rats: Evidence for a systematic increase in lifespan over timeExperimental Aging Research.  10:137-140. 1984
1983 Stability of synaptic density and spine volume in dentate gyrus of aged ratsNeurobiology of Aging.  4:77-87. 1983
1982 Stability of neuron number in cortical barrels of aging miceJournal of Comparative Neurology.  212:158-172. 1982
1981 A computer system for combined neuronal mapping and morphometryJournal of Neuroscience Methods.  4:267-276. 1981
1978 Organization of pulvinar afferents to area 18 in the squirrel monkey: evidence for stripesBrain Research.  143:155-161. 1978


Year Title Altmetric
2012 Structure, Function, and Pathology of Bruch's Membrane.  465-481. 2012
2005 Photoreceptor degeneration in aging and age-related maculopathy.  45-62. 2005

Education And Training

  • Doctor of Philosophy in Anatomy, University of Rochester 1982
  • Full Name

  • Christine Curcio