Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Fundus Autofluorescence in Neovascular Age-Related Macular Degeneration: A Clinicopathologic Correlation Relevant to Macular AtrophyOphthalmology Retina.  5:1085-1096. 2021
2021 Imaging Features Associated with Progression to Geographic Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 5Ophthalmology Retina.  5:855-867. 2021
2021 Stages of Drusen-Associated Atrophy in Age-Related Macular Degeneration Visible via Histologically Validated Fundus AutofluorescenceOphthalmology Retina.  5:730-742. 2021
2021 PRESUMED FOVEAL BACILLARY LAYER DETACHMENT IN A PATIENT WITH TOXOPLASMOSIS CHORIORETINITIS AND PACHYCHOROID DISEASE 2021
2021 Nodular Epiretinal Gliosis in the FoveaOphthalmology Retina.  5:594-596. 2021
2021 Point-supervised segmentation of microscopy images and volumes via objectness regularization 2021
2021 Hyperspectral autofluorescence characterization of drusen and sub-RPE deposits in age-related macular degeneration 2021
2021 Neurodegeneration, gliosis, and resolution of haemorrhage in neovascular age-related macular degeneration, a clinicopathologic correlationEye.  35:548-558. 2021
2021 Topographic Distribution and Progression of Soft Drusen Volume in Age-Related Macular Degeneration Implicate Neurobiology of FoveaInvestigative Ophthalmology and Visual Science.  62. 2021
2021 Biometrics, impact, and significance of basal linear deposit and subretinal drusenoid deposit in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  62. 2021
2021 Double-layer sign in neovascular age-related macular degeneration – do we treat? 2021
2021 Erythropsia and Chromatopsia: Case Study and Brief ReviewNeuro-Ophthalmology.  45:56-60. 2021
2020 Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High-Resolution Imaging Mass SpectrometryJournal of The American Society for Mass Spectrometry.  31:2426-2436. 2020
2020 Hyperreflective Foci and Specks Are Associated with Delayed Rod-Mediated Dark Adaptation in Nonneovascular Age-Related Macular DegenerationOphthalmology Retina.  4:1059-1068. 2020
2020 Measuring the contributions of basal laminar deposit and bruch's membrane in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  61. 2020
2020 Novel Multimodal Imaging and Volume Rendering of Type 3 Macular Neovascularization 2020
2020 Fluorescence lifetimes and spectra of rpe and sub-rpe deposits in histology of control and AMD eyesInvestigative Ophthalmology and Visual Science.  61. 2020
2020 ABUNDANCE AND MULTIMODAL VISIBILITY OF SOFT DRUSEN IN EARLY AGE-RELATED MACULAR DEGENERATION: A Clinicopathologic Correlation 2020
2020 Atlas of human retinal pigment epithelium organelles significant for clinical imagingInvestigative Ophthalmology and Visual Science.  61. 2020
2020 Imaging of age-related macular degeneration by adaptive optics scanning laser ophthalmoscopy in eyes with aged lenses or intraocular lenses 2020
2020 Local abundance of macular xanthophyll pigment is associated with rod- A nd cone-mediated vision in aging and age-related macular degenerationInvestigative Ophthalmology and Visual Science.  61. 2020
2020 Nonexudative Macular Neovascularization Supporting Outer Retina in Age-Related Macular Degeneration: A Clinicopathologic Correlation 2020
2020 Recognizing atrophy and mixed-type neovascularization in age-related macular degeneration via clinicopathologic correlation 2020
2020 Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): Design and methodsBMC Ophthalmology.  20. 2020
2020 Autofluorescent granules of the human retinal pigment epithelium: phenotypes, intracellular distribution, and age-related topographyInvestigative Ophthalmology and Visual Science.  61. 2020
2020 SUBRETINAL DRUSENOID DEPOSIT IN AGE-RELATED MACULAR DEGENERATION: Histologic Insights Into Initiation, Progression to Atrophy, and Imaging 2020
2020 The role of Müller cells in tractional macular disorders: An optical coherence tomography study and physical model of mechanical force transmissionBritish Journal of Ophthalmology.  104:466-472. 2020
2020 Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4 2020
2020 Lifecycles of Individual Subretinal Drusenoid Deposits and Evolution of Outer Retinal Atrophy in Age-Related Macular DegenerationOphthalmology Retina.  4:274-283. 2020
2020 Linear and planar reflection artifacts on swept-source and spectral-domain optical coherence tomography due to hyperreflective crystalline deposits 2020
2020 Exploring a structural basis for delayed rod-mediated dark adaptation in age-related macular degeneration via deep learning 2020
2019 Cell-Type-Specific Complement Expression in the Healthy and Diseased RetinaCell Reports.  29:2835-2848.e4. 2019
2019 Calcium, Diet, Imaging, and Age-Related Macular DegenerationJAMA Ophthalmology.  137:1333-1334. 2019
2019 Standardizing the assessment of macular pigment using a dual-wavelength autofluorescence technique 2019
2019 Speckled Hypoautofluorescence as a Sign of Resolved Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration 2019
2019 Retinal Pathologic Features on OCT among Eyes of Older Adults Judged Healthy by Color Fundus PhotographyOphthalmology Retina.  3:670-680. 2019
2019 Tensor decomposition of hyperspectral images to study autofluorescence in age-related macular degenerationMedical Image Analysis.  56:96-109. 2019
2019 The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular DegenerationInternational Journal of Molecular Sciences.  20. 2019
2019 Reply 2019
2019 The fate and prognostic implications of hyperreflective crystalline deposits in nonneovascular age-related macular degenerationInvestigative Ophthalmology and Visual Science.  60:3100-3109. 2019
2019 Quantifying retinal pigment epithelium dysmorphia and loss of histologic auto fluorescence in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  60:2481-2493. 2019
2019 Rod-Mediated Dark Adaptation as a Suitable Outcome for Early and Intermediate Age-Related Macular Degeneration 2019
2019 CLINICOPATHOLOGIC CORRELATION OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION 2019
2019 The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration 2019
2019 Apolipoprotein A-I mimetic peptide l-4f removes bruch’s membrane lipids in aged nonhuman primatesInvestigative Ophthalmology and Visual Science.  60:461-472. 2019
2019 Clinicopathologic Correlation of Aneurysmal Type 1 Neovascularization in Age-Related Macular DegenerationOphthalmology Retina.  3:99-111. 2019
2019 Commentary on Lavia et al: Progress of optical coherence tomography angiography for visualizing human retinal vasculature 2019
2019 Obituary: Anita Hendrickson, PhDJournal of Comparative Neurology.  527:11-12. 2019
2019 The clinical relevance of visualising the peripheral retinaProgress in Retinal and Eye Research.  68:83-109. 2019
2018 Ex vivo hyperspectral autofluorescence imaging and localization of fluorophores in human eyes with age-related macular degeneration 2018
2018 Calcified nodules in retinal drusen are associated with disease progression in age-related macular degenerationScience Translational Medicine.  10. 2018
2018 Subretinal drusenoid deposits AKA pseudodrusenSurvey of Ophthalmology.  63:782-815. 2018
2018 Viewing Retinal Vasculature in Alzheimer DiseaseJAMA Ophthalmology.  136:1249-1250. 2018
2018 A new online portal will match eye banks with researchers seeking human ocular tissuesInvestigative Ophthalmology and Visual Science.  59:4796-4797. 2018
2018 The Border of Macular Atrophy in Age-Related Macular Degeneration: A Clinicopathologic CorrelationAmerican Journal of Ophthalmology.  193:166-177. 2018
2018 Choroidal and Sub-Retinal Pigment Epithelium Caverns: Multimodal Imaging and Correspondence with Friedman Lipid Globules 2018
2018 Rod-Mediated Dark Adaptation and Macular Pigment Optical Density in Older Adults with Normal MaculasCurrent Eye Research.  43:913-920. 2018
2018 Re: Cuenca et al.: Cellular characterization of OCT and outer retinal bands using specific immunohistochemistry markers and clinical implications (Ophthalmology. 2018;125;407-422) 2018
2018 Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3 2018
2018 Antecedents of soft drusen, the specific deposits of age-related macular degeneration, in the biology of human maculaInvestigative Ophthalmology and Visual Science.  59:AMD182-AMD194. 2018
2018 Optical coherence tomography and histology of age-related macular degeneration support mitochondria as reflectivity sources 2018
2018 Soft drusen in age-related macular degeneration: Biology and targeting via the oil spill strategiesInvestigative Ophthalmology and Visual Science.  59:AMD160-AMD181. 2018
2018 Dynamism of dot subretinal drusenoid deposits in age-related macular degeneration demonstrated with adaptive optics imaging 2018
2018 Clinicopathologic Correlation of Anti–Vascular Endothelial Growth Factor–Treated Type 3 Neovascularization in Age-Related Macular Degeneration 2018
2018 ApoA-I Mimetic Peptide 4F Reduces Age-Related Lipid Deposition in Murine Bruch’s Membrane and Causes Its Structural RemodelingCurrent Eye Research.  43:135-146. 2018
2018 Cuticular Drusen: Clinical Phenotypes and Natural History Defined Using Multimodal Imaging 2018
2018 Histology of geographic atrophy secondary to age-related macular degeneration a multilayer approach 2018
2018 Re: Monés et al. Drusen Ooze: A Novel Hypothesis in Geographic Atrophy (Ophthalmol Retina. 2017;1:461–473)Ophthalmology Retina.  2:e1. 2018
2018 Visualizing melanosomes, lipofuscin, and melanolipofuscin in human retinal pigment epithelium using serial block face scanning electron microscopyExperimental Eye Research.  166:131-139. 2018
2017 Author response: The evolution of the plateau, an optical coherence tomography signature seen in geographic atrophyInvestigative Ophthalmology and Visual Science.  58:6196. 2017
2017 Tractional Abnormalities of the Central Foveal Bouquet in Epiretinal Membranes: Clinical Spectrum and Pathophysiological PerspectivesAmerican Journal of Ophthalmology.  184:167-180. 2017
2017 The Evolution of Outer Retinal Tubulation, a Neurodegeneration and Gliosis Prominent in Macular Diseases 2017
2017 Probing the role of inflammation in age-related macular degenerationJAMA Ophthalmology.  135:843-844. 2017
2017 RNA expression in human retinaHuman Molecular Genetics.  26:R68-R74. 2017
2017 ASSOCIATION between VISUAL FUNCTION and SUBRETINAL DRUSENOID DEPOSITS in NORMAL and EARLY AGE-RELATED MACULAR DEGENERATION EYES 2017
2017 Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular DegenerationInvestigative Ophthalmology and Visual Science.  58:BIO211-BIO226. 2017
2017 Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular Degeneration 2017
2017 Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings 2017
2017 The evolution of the plateau, an optical coherence tomography signature seen in geographic atrophyInvestigative Ophthalmology and Visual Science.  58:2349-2358. 2017
2017 Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits 2017
2017 Evaluation of segmentation of the superficial and deep vascular layers of the retina by optical coherence tomography angiography instruments in normal eyesJAMA Ophthalmology.  135:259-262. 2017
2017 Retinal Pigment Epithelium Degeneration Associated With Subretinal Drusenoid Deposits in Age-Related Macular DegenerationAmerican Journal of Ophthalmology.  175:87-98. 2017
2017 Clinical and Histopathologic Ocular Findings in Disseminated Mycobacterium chimaera Infection after Cardiothoracic Surgery 2017
2017 Reply 2017
2017 Subretinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture modelInvestigative Ophthalmology and Visual Science.  58:708-719. 2017
2017 Exploring photoreceptor reflectivity through multimodal imaging of outer retinal tubulation in advanced agerelated macular degeneration 2017
2016 Clinical Characteristics, Choroidal Neovascularization, and Predictors of Visual Outcomes in Acquired Vitelliform LesionsAmerican Journal of Ophthalmology.  172:28-38. 2016
2016 HYPERSPECTRAL AUTOFLUORESCENCE IMAGING OF DRUSEN AND RETINAL PIGMENT EPITHELIUM IN DONOR EYES WITH AGE-RELATED MACULAR DEGENERATION. 2016
2016 VISUALIZING RETINAL PIGMENT EPITHELIUM PHENOTYPES IN THE TRANSITION TO ATROPHY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. 2016
2016 VISUALIZING RETINAL PIGMENT EPITHELIUM PHENOTYPES IN THE TRANSITION TO GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION. 2016
2016 Coronary Artery Disease and Reticular Macular Disease, a Subphenotype of Early Age-Related Macular DegenerationCurrent Eye Research.  41:1482-1488. 2016
2016 Associations between retinal pigment epithelium and drusen volume changes during the lifecycle of large drusenoid pigment epithelial detachmentsInvestigative Ophthalmology and Visual Science.  57:5479-5489. 2016
2016 Macrophages or retinal pigment epithelium expressing macrophage markers in age-related macular degeneration? Comment on Lad et al. 2015 2016
2016 Optic neuropathy in late-onset neurodegenerative Chédiak-Higashi syndromeBritish Journal of Ophthalmology.  100:704-707. 2016
2016 Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal Imaging 2016
2016 Quantitative analysis of outer retinal tubulation in age-related macular degeneration from spectral-domain optical coherence tomography and histologyInvestigative Ophthalmology and Visual Science.  57:2647-2656. 2016
2016 Relating Retinal Morphology and Function in Aging and Early to Intermediate Age-related Macular Degeneration SubjectsAmerican Journal of Ophthalmology.  165:65-77. 2016
2016 Sequence and expression of complement factor H gene cluster variants and their roles in age-related macular degeneration riskInvestigative Ophthalmology and Visual Science.  57:2763-2769. 2016
2016 Spatial and spectral characterization of human retinal pigment epithelium fluorophore families by ex vivo hyperspectral autofluorescence imaging 2016
2016 Intraretinal Hyperreflective Foci in Acquired Vitelliform Lesions of the Macula: Clinical and Histologic StudyAmerican Journal of Ophthalmology.  164:89-98. 2016
2016 Visual function in older eyes in normal macular health: Association with incident early age-related macular degeneration 3 years laterInvestigative Ophthalmology and Visual Science.  57:1782-1789. 2016
2016 A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variantsNature Genetics.  48:134-143. 2016
2016 Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration 2016
2016 Hyperspectral autofluorescence imaging of drusen and retinal pigment epithelium in donor eyes with age-related macular degeneration 2016
2016 Multi-nucleate retinal pigment epithelium cells of the human macula exhibit a characteristic and highly specific distributionVisual Neuroscience.  33:e001. 2016
2016 The association between subretinal drusenoid deposits in older adults in normal macular health and incident age-related macular degenerationInvestigative Ophthalmology and Visual Science.  57:739-745. 2016
2016 Visualizing retinal pigment epithelium phenotypes in the transition to atrophy in neovascular age-related macular degeneration 2016
2016 Visualizing retinal pigment epithelium phenotypes in the transition to geographic atrophy in age-related macular degeneration 2016
2015 Correlation of type 1 neovascularization associated with acquired vitelliform lesion in the setting of age-related macular degenerationAmerican Journal of Ophthalmology.  160:1024-1033.e3. 2015
2015 The Onion Sign in Neovascular Age-Related Macular Degeneration Represents Cholesterol Crystals 2015
2015 Variability in Human Cone Topography Assessed by Adaptive Optics Scanning Laser OphthalmoscopyAmerican Journal of Ophthalmology.  160:290-300.e1. 2015
2015 Refractile drusen: Clinical imaging and candidate histology 2015
2015 Clinicopathological correlation of outer retinal tubulationinage-related macular degenerationJAMA Ophthalmology.  133:609-612. 2015
2015 Transcriptome of the human retina, retinal pigmented epithelium and choroidGenomics.  105:253-264. 2015
2015 Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptorsScientific Reports.  5. 2015
2015 Correspondence 2015
2015 Dark-adapted visual function with retinal structural changes in patients with Stargardt disease 2015
2015 Inner segment Remodeling and mitochondrial translocation in cone photoreceptors in age-related macular degeneration with outer retinal tubulationInvestigative Ophthalmology and Visual Science.  56:2243-2253. 2015
2015 Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degenerationInvestigative Ophthalmology and Visual Science.  56:3242-3252. 2015
2015 Outer retinal tubulation in advanced age-related macular degeneration optical coherence tomographic findings correspond to histology 2015
2015 RefMoB, a reflectivity feature model-based automated method for measuring four outer retinal hyperreflective bands in optical coherence tomographyInvestigative Ophthalmology and Visual Science.  56:4166-4176. 2015
2015 Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epitheliumInvestigative Ophthalmology and Visual Science.  56:3269-3278. 2015
2015 The project macula retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  56:3253-3268. 2015
2014 7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusenExperimental Eye Research.  128:151-155. 2014
2014 Correspondence. 2014
2014 Quantitative autofluorescence and cell density maps of the human retinal pigment epitheliumInvestigative Ophthalmology and Visual Science.  55:4832-4841. 2014
2014 In Vivo Imaging of Human Cone Photoreceptor Inner SegmentsInvestigative Ophthalmology and Visual Science.  55:4244-4251. 2014
2014 Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular healthInvestigative Ophthalmology and Visual Science.  55:4776-4789. 2014
2014 Assessing the cone photoreceptor mosaic in eyes with pseudodrusen and soft drusen in vivo using adaptive optics imaging 2014
2014 Age-related macular degeneration: Genetics and biology coming togetherAnnual Review of Genomics and Human Genetics.  15:151-171. 2014
2014 Author response: Relationship between foveal cone specialization and pit morphology in albinismInvestigative Ophthalmology and Visual Science.  55:5923. 2014
2014 Cholesterol in the retina: The best is yet to comeProgress in Retinal and Eye Research.  41:64-89. 2014
2014 Comprehensive analysis of gene expression in human retina and supporting tissuesHuman Molecular Genetics.  23:4001-4014. 2014
2014 Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterolBritish Journal of Ophthalmology.  98:698-702. 2014
2014 Mice with cholesterol in bruch’s membrane: Have we arrived?Investigative Ophthalmology and Visual Science.  55:7296. 2014
2014 Microstructure of subretinal drusenoid deposits revealed by adaptive optics imagingBiomedical Optics Express.  5:713-727. 2014
2014 Outcomes of shunt tube coverage with glycerol preserved cornea versus pericardiumJournal of Glaucoma.  23:258-261. 2014
2014 Outer retinal corrugations in age-related macular degenerationJAMA Ophthalmology.  132:806-813. 2014
2014 Photoreceptor perturbation around subretinal drusenoid deposits as revealed by adaptive optics scanning laser ophthalmoscopyAmerican Journal of Ophthalmology.  158. 2014
2014 Relationship between foveal cone specialization and pit morphology in AlbinismInvestigative Ophthalmology and Visual Science.  55:4186-4198. 2014
2014 Simultaneous decomposition of multiple hyperspectral data sets: Signal recovery of unknown fluorophores in the retinal pigment epitheliumBiomedical Optics Express.  5:4171-4185. 2014
2014 Subretinal drusenoid deposits: Further characterization by lipid histochemistry 2014
2013 In vivo optical coherence tomography of light-driven melanosome translocation in retinal pigment epitheliumScientific Reports.  3. 2013
2013 Inner macular hyperreflectivity demonstrated by optical coherence tomography in niemann-pick diseaseJAMA Ophthalmology.  131:1244-1246. 2013
2013 Rethinking A2EInvestigative Ophthalmology and Visual Science.  54:5543. 2013
2013 Quantifying drusen in AMDRetina Today.  MAY. 2013
2013 Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy 2013
2013 Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. 2013
2013 Quantifying drusen in AMDRetina Today.  MAY/JUNE. 2013
2012 In vivo confocal intrinsic optical signal identification of localized retinal dysfunctionInvestigative Ophthalmology and Visual Science.  53:8139-8145. 2012
2012 Comparison of different methods of glycerol preservation for deep anterior lamellar keratoplasty eligible corneasInvestigative Ophthalmology and Visual Science.  53:5675-5685. 2012
2012 Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retinaJournal of Biomedical Optics.  17. 2012
2012 Spatial distribution of the pathways of cholesterol homeostasis in human retinaPLoS ONE.  7. 2012
2012 Quantification of fluorescein-stained drusen associated with age-related macular degeneration 2012
2011 The oil spill in ageing Bruch membraneBritish Journal of Ophthalmology.  95:1638-1645. 2011
2011 Complementing apolipoprotein secretion by cultured retinal pigment epithelium 2011
2011 Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophyExperimental Eye Research.  93:413-423. 2011
2011 Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: Literature review and model 2011
2011 Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sectionsInvestigative Ophthalmology and Visual Science.  52:3943-3954. 2011
2011 Two-photon excited autofluorescence imaging of freshly isolated frog retinasBiomedical Optics Express.  2:1494-1503. 2011
2010 Drusen characterization with multimodal imaging 2010
2010 Abundant lipid and protein components of drusenPLoS ONE.  5. 2010
2010 Editorial: Drusen, an old but new frontier 2010
2010 Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retinaMolecular Vision.  16:1317-1323. 2010
2010 Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degenerationJournal of Lipid Research.  51:451-467. 2010
2010 Reticular Pseudodrusen Are Subretinal Drusenoid Deposits 2010
2009 Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteinsProgress in Retinal and Eye Research.  28:393-422. 2009
2009 Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroid 2009
2009 Lipoprotein particles of intraocular origin in human bruch membrane: An unusual lipid profileInvestigative Ophthalmology and Visual Science.  50:870-877. 2009
2009 Histochemistry and lipid profiling combine for insights into aging and age-related maculopathy.Methods in Molecular Biology.  580:267-281. 2009
2008 Sub-retinal drusenoid deposits in human retina: Organization and compositionExperimental Eye Research.  87:402-408. 2008
2008 Effects of particulates and lipids on the hydraulic conductivity of Matrigel 2008
2008 Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membraneInvestigative Ophthalmology and Visual Science.  49:2721-2727. 2008
2008 Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathyInvestigative Ophthalmology and Visual Science.  49:1200-1209. 2008
2007 Comparison of morphology of human macular and peripheral Bruch's membrane in older eyesCurrent Eye Research.  32:791-799. 2007
2007 Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etchExperimental Eye Research.  85:202-218. 2007
2007 Distribution and composition of esterified and unesterified cholesterol in extra-macular drusenExperimental Eye Research.  85:192-201. 2007
2007 The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual fieldVision Research.  47:2901-2911. 2007
2006 Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retinaExperimental Eye Research.  83:834-840. 2006
2006 Plasma apolipoproteins and risk for age related maculopathyBritish Journal of Ophthalmology.  90:1028-1033. 2006
2006 Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expressionInvestigative Ophthalmology and Visual Science.  47:3119-3128. 2006
2006 Declining availability of human eye tissues for researchInvestigative Ophthalmology and Visual Science.  47:2747-2749. 2006
2006 Drusen and lipid-filled retinal pigment epithelium cells in a rhesus maculaVeterinary Ophthalmology.  9:201-207. 2006
2006 The iron carrier transferrin is upregulated in retinas from patients with age-related macular degenerationInvestigative Ophthalmology and Visual Science.  47:2135-2140. 2006
2005 Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathyExperimental Eye Research.  81:731-741. 2005
2005 Imaging maculopathy in post-mortem human eyesVision Research.  45:3496-3503. 2005
2005 Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterizationInvestigative Ophthalmology and Visual Science.  46:2576-2586. 2005
2005 Retina expresses microsomal triglyceride transfer protein: Implications for age-related maculopathyJournal of Lipid Research.  46:628-640. 2005
2005 Basal deposits and drusen in eyes with age-related maculopathy: Evidence for solid lipid particlesExperimental Eye Research.  80:761-775. 2005
2005 Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaques 2005
2005 Lipoprotein-like particles (LLP) in human Bruch's membrane: Isolation and initial characterizationInvestigative Ophthalmology and Visual Science.  46. 2005
2005 The iron carrier transferrin is upregulated in retinas from patients with age-related macular degenerationInvestigative Ophthalmology and Visual Science.  46. 2005
2005 Ultrastructure of age-related changes in human Bruch's membrane as seen by quick-freeze/deep-etch (QFDE)Investigative Ophthalmology and Visual Science.  46. 2005
2004 Cultured human retinal pigment epithelium (RPE) contains, synthesizes, and secretes neutral lipidInvestigative Ophthalmology and Visual Science.  45:U722-U722. 2004
2004 Distribution of complement proteins and receptors in normal human retinaInvestigative Ophthalmology and Visual Science.  45:U324-U324. 2004
2004 Membranous debris (MemD) in Drusen and basal linear deposit (BlinD) of eyes with age-related maculopathy (ARM): Evidence for solid particlesInvestigative Ophthalmology and Visual Science.  45:U718-U718. 2004
2003 The association between statin use and age related maculopathyBritish Journal of Ophthalmology.  87:1121-1125. 2003
2003 Genes for apolipoprotein B (Apo B) and microsomal triglyceride transfer protein (MTP) are expressed in human retina and retinal pigment epithelium (RPE)Investigative Ophthalmology and Visual Science.  44:U393-U393. 2003
2003 Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membraneInvestigative Ophthalmology and Visual Science.  44:1753-1759. 2003
2003 Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathyAmerican Journal of Pathology.  162:413-425. 2003
2002 Photoreceptor inner segments in monkey and human retina: Mitochondrial density, optics, and regional variationVisual Neuroscience.  19:395-407. 2002
2002 Photoreceptor degeneration and dysfunction in aging and age-related maculopathyAgeing Research Reviews.  1:381-396. 2002
2002 A local source for esterified cholesterol (EC) in human Bruch's membrane (BrM)Investigative Ophthalmology and Visual Science.  43:U187-U187. 2002
2002 Absence of Bruch's membrane (BrM) cholesterol deposition in rabbits consuming atherogenic dietsInvestigative Ophthalmology and Visual Science.  43:U656-U656. 2002
2002 An age related lipid wall' in human Bruch's membraneInvestigative Ophthalmology and Visual Science.  43:U651-U651. 2002
2002 Localization of apolipoproteins and cholesterol in macular and peripheral Bruch's membrane, basal deposits (BD) and drusen of normal and age-related maculopathy (ARM) eyesInvestigative Ophthalmology and Visual Science.  43:U652-U652. 2002
2002 Phenotypic variation of retinal pigment epithelium in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  43:267-273. 2002
2001 Preservation of ganglion cell layer neurons in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  42:795-803. 2001
2001 Cholesterol in basel deposits and drusen of eyes with age-related maculopathy (ARM): filipin histochemistry.Investigative Ophthalmology and Visual Science.  42:S944-S944. 2001
2001 Accumulation of cholesterol with age in human Bruch's membraneInvestigative Ophthalmology and Visual Science.  42:265-274. 2001
2001 Murine high-fat diet and laser photochemical model of basal deposits in bruch membraneJAMA Ophthalmology.  119:1643-1649. 2001
2001 Photoreceptor topography in ageing and age-related maculopathyEye.  15:376-383. 2001
2000 Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration 2000
2000 Spare the rods, save the cones in aging and age-related maculopathyInvestigative Ophthalmology and Visual Science.  41:2015-2018. 2000
2000 Ultrastructural changes in Bruch's membrane of apolipoprotein E- deficient miceInvestigative Ophthalmology and Visual Science.  41:2035-2042. 2000
2000 Cholesterol accumulates with age in human Bruch's membraneInvestigative Ophthalmology and Visual Science.  41:S115-S115. 2000
2000 Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss 2000
1999 Lipids in human Bruch's membrane: Histochemistry and ultrastructureInvestigative Ophthalmology and Visual Science.  40:S921-S921. 1999
1999 Subpopulations of human blue cones identified by immunocytochemistry for calcium-binding proteinsInvestigative Ophthalmology and Visual Science.  40:S158-S158. 1999
1999 Thick sub-RPE deposits spare the macula in a family with late-onset retinal degeneration.Investigative Ophthalmology and Visual Science.  40:S223-S223. 1999
1999 Basal linear deposit and large drusen are specific for early age- related maculopathyJAMA Ophthalmology.  117:329-339. 1999
1998 The alabama age-related macular degeneration grading system for donor eyesInvestigative Ophthalmology and Visual Science.  39:1085-1096. 1998
1997 Loss of neurons in the ganglion cell layer (gcl) of eyes with age-related maculopathy (arm) and macular degeneration (amd)Investigative Ophthalmology and Visual Science.  38. 1997
1997 Rpe/bruch's membrane pathology and photoreceptor loss in age-related maculopathy (arm)Investigative Ophthalmology and Visual Science.  38. 1997
1996 Photoreceptor loss in age-related macular degenerationInvestigative Ophthalmology and Visual Science.  37:1236-1249. 1996
1996 Peripapillary Chorioretinal Atrophy (PPCRA) in normal eyes: Histopathology and photoreceptor lossInvestigative Ophthalmology and Visual Science.  37. 1996
1995 PHOTORECEPTOR DEGENERATION AND LOSS IN NON-EXUDATIVE AGE-RELATED MACULAR DEGENERATION (NE-AMD)Investigative Ophthalmology and Visual Science.  36:S237-S237. 1995
1995 PHOTORECEPTOR LOSS IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION (EX-AMD)Investigative Ophthalmology and Visual Science.  36:S432-S432. 1995
1994 AGING AND PHOTORECEPTORS - REPLYInvestigative Ophthalmology and Visual Science.  35:783-784. 1994
1994 Aging and photoreceptors [2]Investigative Ophthalmology and Visual Science.  35:783-784. 1994
1993 TOPOGRAPHY OF RETINAL CELLS AND VISUAL SENSITIVITY IN THE SAME HUMAN EYESInvestigative Ophthalmology and Visual Science.  34:777-777. 1993
1993 Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retinaInvestigative Ophthalmology and Visual Science.  34:3278-3296. 1993
1993 Retinal ganglion cells in Alzheimer's disease and agingAnnals of Neurology.  33:248-257. 1993
1992 Packing geometry of human cone photoreceptors: Variation with eccentricity and evidence for local anisotropyVisual Neuroscience.  9:169-180. 1992
1991 PACKING GEOMETRY OF HUMAN CONE PHOTORECEPTORSInvestigative Ophthalmology and Visual Science.  32:1128-1128. 1991
1991 Chapter 5 Organization and development of the primate photoreceptor mosaicProgress in Retinal and Eye Research.  10:89-120. 1991
1991 Distribution and morphology of human cone photoreceptors stained with anti‐blue opsinJournal of Comparative Neurology.  312:610-624. 1991
1990 Developmental redistribution of photoreceptors across the Macaca nemestrina (pigtail macaque) retinaJournal of Comparative Neurology.  298:472-493. 1990
1990 Human photoreceptor topographyJournal of Comparative Neurology.  292:497-523. 1990
1990 Topography of ganglion cells in human retinaJournal of Comparative Neurology.  300:5-25. 1990
1989 Computer methods for sampling, reconstruction, display and analysis of retinal whole mountsVision Research.  29:529-540. 1989
1989 Photoreceptor topography of the retina in the adult pigtail macaque (Macaca nemestrina)Journal of Comparative Neurology.  288:165-183. 1989
1989 The spatial resolution capacity of human foveal retinaVision Research.  29:1095-1101. 1989
1987 A whole mount method for sequential analysis of photoreceptor and ganglion cell topography in a single retinaVision Research.  27:9-15. 1987
1987 Distribution of cones in human and monkey retina: Individual variability and radial asymmetryScience.  236:579-582. 1987
1986 Computer‐assisted morphometry using video‐mixed microscopic images and computer graphicsAnatomical Record.  214:329-337. 1986
1986 Stability of dendrites in cortical barrels of C57BL/6N mice between 4 and 45 monthsNeurobiology of Aging.  7:101-105. 1986
1985 Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epitheliumJournal of Comparative Neurology.  235:519-528. 1985
1984 Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer IIAnatomical Record.  210:657-662. 1984
1984 Nucleus raphe dorsalis in dementia of the alzheimer type: Neurofibrillary changes and neuronal packing densityJournal of Neuropathology and Experimental Neurology.  43:359-368. 1984
1984 Variation in longevity of rats: Evidence for a systematic increase in lifespan over timeExperimental Aging Research.  10:137-140. 1984
1983 Stability of synaptic density and spine volume in dentate gyrus of aged ratsNeurobiology of Aging.  4:77-87. 1983
1982 Stability of neuron number in cortical barrels of aging miceJournal of Comparative Neurology.  212:158-172. 1982
1981 A computer system for combined neuronal mapping and morphometryJournal of Neuroscience Methods.  4:267-276. 1981
1978 Organization of pulvinar afferents to area 18 in the squirrel monkey: evidence for stripesBrain Research.  143:155-161. 1978
Hyperreflective foci, OCT progression indicators in age-related macular degeneration, include transdifferentiated retinal pigment epithelium

Chapter

Year Title Altmetric
2012 Structure, Function, and Pathology of Bruch's Membrane.  465-481. 2012
2005 Photoreceptor degeneration in aging and age-related maculopathy.  45-62. 2005

Principal Investigator On

  • 2013 Summer Student Fellowship for Allen Oak, "The Characterization of Cholesterol Content in Subretinal Drusenoid Deposits"  awarded by Fight for Sight, Inc.
  • A Hyperspectral Approach to RPE Fluorophores in AMD  awarded by National Eye Institute/NIH/DHHS
  • Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye  awarded by VANDERBILT UNIVERSITY
  • Clinical Imaging in Age-Related Macular Degeneration: Histological Validation and a Nonline Resource  awarded by International Retinal Research Foundation, Inc.
  • Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/Choroid  awarded by University of Pennsylvania
  • Hyperspectral Imaging of the Normal and Age-Related Macular Degeneration  awarded by NEW YORK UNIVERSITY SCHOOL OF MEDICINE
  • Improved Anatomical Endpoints for Treatments of Age-Related Macular Degeneration  awarded by EDWARD N & DELLA L THOME MEMORIAL FOUNDATION
  • In Vivo Ultrastructure of Chorioretinal Disease  awarded by DOHENY EYE INSTITUTE
  • Molecularly Informed OCT of AMD via Imaging Mass Spectrometry Fusion  awarded by VANDERBILT UNIVERSITY
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd.
  • Private Grant  awarded by REGENERON PHARMACEUTICALS, INC.
  • Private Grant  awarded by Genentech
  • Quantitative Analysis of Aging Retina  awarded by National Eye Institute/NIH/DHHS
  • Single Cell Sequencing of Retinal Cells  awarded by University of Pennsylvania
  • Synergy Between Gene Experssion and Histological Phenotype in Atrophic Age-Related Macular Degeneration  awarded by Beckman (Arnold and Mable) Foundation
  • The Human Foveal Connectome  awarded by UNIVERSITY OF WASHINGTON
  • Validated Autofluorescence in Age-Related Macular Degeneration  awarded by New York University
  • Validated Autofluorescence in Age-Related Macular Degeneration  awarded by Mount Sinai School of Medicine ^
  • Visualizing Aging in the Eye: A Personalized Strategy for Preserving Vision in the Aging Population in Europe  awarded by MEDICAL UNIVERSITY OF VIENNA
  • Visualizing Organelles in Human Retinal Pigment Epithelium by 3-Dimensional Electron Microscopy  awarded by MACULA SOCIETY
  • Education And Training

  • Doctor of Philosophy in Anatomy, University of Rochester 1982
  • Full Name

  • Christine Curcio