Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 The Border of Macular Atrophy in Age-Related Macular Degeneration: A Clinicopathologic Correlation 2018
2018 Choroidal and Sub-Retinal Pigment Epithelium Caverns: Multimodal Imaging and Correspondence with Friedman Lipid Globules 2018
2018 Re: Cuenca et al.: Cellular characterization of OCT and outer retinal bands using specific immunohistochemistry markers and clinical implications (Ophthalmology. 2018;125;407-422) 2018
2018 Visualizing melanosomes, lipofuscin, and melanolipofuscin in human retinal pigment epithelium using serial block face scanning electron microscopy 2018
2017 Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular Degeneration 2017
2017 Reply 2017
2016 Macrophages or retinal pigment epithelium expressing macrophage markers in age-related macular degeneration? Comment on Lad et al. 2015 2016
2016 Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal Imaging 2016
2015 The Onion Sign in Neovascular Age-Related Macular Degeneration Represents Cholesterol Crystals 2015
2015 OUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to Histology 2015
2015 Clinicopathological correlation of outer retinal tubulationinage-related macular degeneration 2015
2015 Correspondence 2015
2015 Inner segment Remodeling and mitochondrial translocation in cone photoreceptors in age-related macular degeneration with outer retinal tubulation 2015
2015 Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration 2015
2015 Refractile drusen: Clinical imaging and candidate histology 2015
2014 7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen 2014
2014 Correspondence. 2014
2014 Transcriptome of the human retina, retinal pigmented epithelium and choroid 2014
2014 Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium 2014
2014 In Vivo Imaging of Human Cone Photoreceptor Inner Segments 2014
2014 Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health 2014
2014 Assessing the cone photoreceptor mosaic in eyes with pseudodrusen and soft drusen in vivo using adaptive optics imaging 2014
2014 Age-related macular degeneration: Genetics and biology coming together 2014
2014 Author response: Relationship between foveal cone specialization and pit morphology in albinism 2014
2014 Cholesterol in the retina: The best is yet to come 2014
2014 Cholesterol in the retina: The best is yet to come 2014
2014 Comprehensive analysis of gene expression in human retina and supporting tissues 2014
2014 Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterol 2014
2014 Mice with cholesterol in bruch’s membrane: Have we arrived? 2014
2014 Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging 2014
2014 Outcomes of shunt tube coverage with glycerol preserved cornea versus pericardium 2014
2014 Outer retinal corrugations in age-related macular degeneration 2014
2014 Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy 2014
2014 Photoreceptor perturbation around subretinal drusenoid deposits as revealed by adaptive optics scanning laser ophthalmoscopy 2014
2014 Relationship between foveal cone specialization and pit morphology in Albinism 2014
2014 Simultaneous decomposition of multiple hyperspectral data sets: Signal recovery of unknown fluorophores in the retinal pigment epithelium 2014
2014 Subretinal drusenoid deposits: Further characterization by lipid histochemistry 2014
2013 In vivo optical coherence tomography of light-driven melanosome translocation in retinal pigment epithelium 2013
2013 Inner macular hyperreflectivity demonstrated by optical coherence tomography in niemann-pick disease 2013
2013 Rethinking A2E 2013
2013 Quantifying drusen in AMD 2013
2013 Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy 2013
2013 Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. 2013
2012 In vivo confocal intrinsic optical signal identification of localized retinal dysfunction 2012
2012 Comparison of different methods of glycerol preservation for deep anterior lamellar keratoplasty eligible corneas 2012
2012 Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina 2012
2012 Spatial distribution of the pathways of cholesterol homeostasis in human retina 2012
2012 Quantification of fluorescein-stained drusen associated with age-related macular degeneration 2012
2011 The oil spill in ageing Bruch membrane 2011
2011 Complementing apolipoprotein secretion by cultured retinal pigment epithelium 2011
2011 Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy 2011
2011 Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: Literature review and model 2011
2011 Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections 2011
2011 Two-photon excited autofluorescence imaging of freshly isolated frog retinas 2011
2010 Drusen characterization with multimodal imaging 2010
2010 Abundant lipid and protein components of drusen 2010
2010 Editorial: Drusen, an old but new frontier 2010
2010 Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina 2010
2010 Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration 2010
2010 Reticular Pseudodrusen Are Subretinal Drusenoid Deposits 2010
2009 Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins 2009
2009 Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroid 2009
2009 Lipoprotein particles of intraocular origin in human bruch membrane: An unusual lipid profile 2009
2009 Histochemistry and lipid profiling combine for insights into aging and age-related maculopathy. 2009
2008 Sub-retinal drusenoid deposits in human retina: Organization and composition 2008
2008 Effects of particulates and lipids on the hydraulic conductivity of Matrigel 2008
2008 Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membrane 2008
2008 Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy 2008
2007 Comparison of morphology of human macular and peripheral Bruch's membrane in older eyes 2007
2007 Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etch 2007
2007 Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen 2007
2007 The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field 2007
2006 Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina 2006
2006 Plasma apolipoproteins and risk for age related maculopathy 2006
2006 Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression 2006
2006 Declining availability of human eye tissues for research 2006
2006 Drusen and lipid-filled retinal pigment epithelium cells in a rhesus macula 2006
2006 The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration 2006
2005 Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy 2005
2005 Imaging maculopathy in post-mortem human eyes 2005
2005 Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterization 2005
2005 Retina expresses microsomal triglyceride transfer protein: Implications for age-related maculopathy 2005
2005 Basal deposits and drusen in eyes with age-related maculopathy: Evidence for solid lipid particles 2005
2005 Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaques 2005
2005 Lipoprotein-like particles (LLP) in human Bruch's membrane: Isolation and initial characterization 2005
2005 The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration 2005
2005 Ultrastructure of age-related changes in human Bruch's membrane as seen by quick-freeze/deep-etch (QFDE) 2005
2004 Cultured human retinal pigment epithelium (RPE) contains, synthesizes, and secretes neutral lipid 2004
2004 Distribution of complement proteins and receptors in normal human retina 2004
2004 Membranous debris (MemD) in Drusen and basal linear deposit (BlinD) of eyes with age-related maculopathy (ARM): Evidence for solid particles 2004
2003 The association between statin use and age related maculopathy 2003
2003 Genes for apolipoprotein B (Apo B) and microsomal triglyceride transfer protein (MTP) are expressed in human retina and retinal pigment epithelium (RPE) 2003
2003 Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membrane 2003
2003 Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy 2003
2002 Photoreceptor inner segments in monkey and human retina: Mitochondrial density, optics, and regional variation 2002
2002 Photoreceptor degeneration and dysfunction in aging and age-related maculopathy 2002
2002 A local source for esterified cholesterol (EC) in human Bruch's membrane (BrM) 2002
2002 Absence of Bruch's membrane (BrM) cholesterol deposition in rabbits consuming atherogenic diets 2002
2002 An age related lipid wall' in human Bruch's membrane 2002
2002 Localization of apolipoproteins and cholesterol in macular and peripheral Bruch's membrane, basal deposits (BD) and drusen of normal and age-related maculopathy (ARM) eyes 2002
2002 Phenotypic variation of retinal pigment epithelium in age-related macular degeneration 2002
2001 Preservation of ganglion cell layer neurons in age-related macular degeneration 2001
2001 Cholesterol in basel deposits and drusen of eyes with age-related maculopathy (ARM): filipin histochemistry. 2001
2001 Accumulation of cholesterol with age in human Bruch's membrane 2001
2001 Murine high-fat diet and laser photochemical model of basal deposits in bruch membrane 2001
2001 Photoreceptor topography in ageing and age-related maculopathy 2001
2000 Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration 2000
2000 Spare the rods, save the cones in aging and age-related maculopathy 2000
2000 Ultrastructural changes in Bruch's membrane of apolipoprotein E- deficient mice 2000
2000 Cholesterol accumulates with age in human Bruch's membrane 2000
2000 Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss 2000
1999 Lipids in human Bruch's membrane: Histochemistry and ultrastructure 1999
1999 Subpopulations of human blue cones identified by immunocytochemistry for calcium-binding proteins 1999
1999 Thick sub-RPE deposits spare the macula in a family with late-onset retinal degeneration. 1999
1999 Basal linear deposit and large drusen are specific for early age- related maculopathy 1999
1998 The alabama age-related macular degeneration grading system for donor eyes 1998
1997 Loss of neurons in the ganglion cell layer (gcl) of eyes with age-related maculopathy (arm) and macular degeneration (amd) 1997
1997 Rpe/bruch's membrane pathology and photoreceptor loss in age-related maculopathy (arm) 1997
1996 Photoreceptor loss in age-related macular degeneration 1996
1996 Peripapillary Chorioretinal Atrophy (PPCRA) in normal eyes: Histopathology and photoreceptor loss 1996
1995 PHOTORECEPTOR DEGENERATION AND LOSS IN NON-EXUDATIVE AGE-RELATED MACULAR DEGENERATION (NE-AMD) 1995
1995 PHOTORECEPTOR LOSS IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION (EX-AMD) 1995
1994 AGING AND PHOTORECEPTORS - REPLY 1994
1994 Aging and photoreceptors [2] 1994
1993 TOPOGRAPHY OF RETINAL CELLS AND VISUAL SENSITIVITY IN THE SAME HUMAN EYES 1993
1993 Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retina 1993
1993 Retinal ganglion cells in Alzheimer's disease and aging 1993
1992 Packing geometry of human cone photoreceptors: Variation with eccentricity and evidence for local anisotropy 1992
1991 PACKING GEOMETRY OF HUMAN CONE PHOTORECEPTORS 1991
1991 Chapter 5 Organization and development of the primate photoreceptor mosaic 1991
1991 Distribution and morphology of human cone photoreceptors stained with anti‐blue opsin 1991
1990 Developmental redistribution of photoreceptors across the Macaca nemestrina (pigtail macaque) retina 1990
1990 Human photoreceptor topography 1990
1990 Topography of ganglion cells in human retina 1990
1989 Computer methods for sampling, reconstruction, display and analysis of retinal whole mounts 1989
1989 Photoreceptor topography of the retina in the adult pigtail macaque (Macaca nemestrina) 1989
1989 The spatial resolution capacity of human foveal retina 1989
1987 A whole mount method for sequential analysis of photoreceptor and ganglion cell topography in a single retina 1987
1987 Distribution of cones in human and monkey retina: Individual variability and radial asymmetry 1987
1986 Computer‐assisted morphometry using video‐mixed microscopic images and computer graphics 1986
1986 Stability of dendrites in cortical barrels of C57BL/6N mice between 4 and 45 months 1986
1985 Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epithelium 1985
1984 Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II 1984
1984 Nucleus raphe dorsalis in dementia of the alzheimer type: Neurofibrillary changes and neuronal packing density 1984
1984 Variation in longevity of rats: Evidence for a systematic increase in lifespan over time 1984
1983 Stability of synaptic density and spine volume in dentate gyrus of aged rats 1983
1982 Stability of neuron number in cortical barrels of aging mice 1982
1981 A computer system for combined neuronal mapping and morphometry 1981
1978 Organization of pulvinar afferents to area 18 in the squirrel monkey: evidence for stripes 1978

Chapter

Year Title Altmetric
2012 Structure, Function, and Pathology of Bruch's Membrane.  465-481. 2012
2005 Photoreceptor degeneration in aging and age-related maculopathy.  45-62. 2005

Principal Investigator On

  • A Hyperspectral Approach to RPE Fluorophores in AMD  awarded by National Eye Institute/NIH/DHHS 2017 - 2021
  • Validated Autofluorescence in Age-Related Macular Degeneration  awarded by Mount Sinai School of Medicine 2018 - 2020
  • Single Cell Sequencing of Retinal Cells  awarded by University of Pennsylvania 2017 - 2019
  • Validated Autofluorescence in Age-Related Macular Degeneration  awarded by New York University 2015 - 2019
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2016 - 2019
  • Visualizing Aging in the Eye: A Personalized Strategy for Preserving Vision in the Aging Population in Europe  awarded by MEDICAL UNIVERSITY OF VIENNA 2015 - 2019
  • Visualizing Organelles in Human Retinal Pigment Epithelium by 3-Dimensional Electron Microscopy  awarded by MACULA SOCIETY 2016 - 2019
  • Hyperspectral Imaging of the Normal and Age-Related Macular Degeneration  awarded by NEW YORK UNIVERSITY SCHOOL OF MEDICINE 2013 - 2016
  • Private Grant  awarded by Genentech 2013 - 2015
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2012 - 2014
  • Quantitative Analysis of Aging Retina  awarded by National Eye Institute/NIH/DHHS 2010 - 2014
  • 2013 Summer Student Fellowship for Allen Oak, "The Characterization of Cholesterol Content in Subretinal Drusenoid Deposits"  awarded by Fight for Sight, Inc. 2013
  • Synergy Between Gene Experssion and Histological Phenotype in Atrophic Age-Related Macular Degeneration  awarded by Beckman (Arnold and Mable) Foundation 2011 - 2012
  • Clinical Imaging in Age-Related Macular Degeneration: Histological Validation and a Nonline Resource  awarded by International Retinal Research Foundation, Inc. 2010 - 2011
  • Improved Anatomical Endpoints for Treatments of Age-Related Macular Degeneration  awarded by EDWARD N & DELLA L THOME MEMORIAL FOUNDATION 2009 - 2011
  • Full Name

  • Christine Curcio