Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 The apoA-I mimetic peptide 4F protects apolipoprotein A-I from oxidative damageChemistry and Physics of Lipids.  219:28-35. 2019
2018 Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaquesJournal of Lipid Research.  59:2075-2083. 2018
2018 The apolipoprotein e mimetic peptide AEM-2 attenuates mitochondrial injury and apoptosis in human THP-1 macrophagesCurrent topics in peptide & protein research.  19:15-25. 2018
2017 Cholesterol reduction and macrophage function: Role of paraoxonasesCurrent Opinion in Lipidology.  28:397-402. 2017
2017 High-density lipoprotein regulation of mitochondrial functionAdvances in Experimental Medicine and Biology.  982:407-429. 2017
2016 Apolipoprotein mimetic peptides as modulators of lipoprotein function 2016
2016 High-density lipoprotein, mitochondrial dysfunction and cell survival mechanismsChemistry and Physics of Lipids.  199:161-169. 2016
2016 Independent effects of early-life experience and trait aggression on cardiovascular function 2016
2015 Recent developments in modulating atherogenic lipoproteinsCurrent Opinion in Lipidology.  26:369-375. 2015
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4FBiochemical Journal.  467:517-527. 2015
2015 Early changes in vascular reactivity in response to 56Fe irradiation in ApoE-/- miceActa Astronautica.  108:40-45. 2015
2014 Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: A reviewJournal of Lipid Research.  55:2007-2021. 2014
2014 Inhibitors of arachidonate-regulated calcium channel signaling suppress triggered activity induced by the late sodium current 2014
2014 L-4F Inhibits Lipopolysaccharide-Mediated Activation of Primary Human NeutrophilsInflammation.  37:1401-1412. 2014
2013 Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to SepsisPLoS ONE.  8. 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F 2012
2012 Preservation of biological function despite oxidative modification of the apolipoprotein A-I mimetic peptide 4FJournal of Lipid Research.  53:1576-1587. 2012
2011 HDL Mimetic Peptide Administration Improves Left Ventricular Filling and Cardiac output in Lipopolysaccharide-Treated Rats.Journal of Clinical and Experimental Cardiology.  2. 2011
2011 Acyloxy nitroso compounds as nitroxyl (HNO) donors: Kinetics, reactions with thiols, and vasodilation propertiesJournal of Medicinal Chemistry.  54:1059-1070. 2011
2010 ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activityAdvances in Experimental Medicine and Biology.  660:1-4. 2010
2010 The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic ratsJournal of Lipid Research.  51:2695-2705. 2010
2010 Dietary flavonoid quercetin stimulates vasorelaxation in aortic vesselsFree Radical Biology and Medicine.  49:339-347. 2010
2010 Potential for chlorine gas-induced injury in the extrapulmonary vasculatureAnnals of the American Thoracic Society.  7:290-293. 2010
2010 Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages 2010
2010 Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH2Atherosclerosis.  208:134-141. 2010
2009 Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats 2009
2009 Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis 2009
2009 Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system 2009
2009 Vasculoprotective Effects of Apolipoprotein Mimetic Peptides: An Evolving Paradigm In Hdl Therapy (Vascular Disease Prevention, In Press.).Vascular Disease Prevention.  6:122-130. 2009
2008 HDL therapy for cardiovascular diseases: The road to HDL mimeticsCurrent Atherosclerosis Reports.  10:405-412. 2008
2006 Atherosclerosis and vascular disease: Effects of peptide mimetics of apolilpoproteinsCurrent Pharmaceutical Biotechnology.  7:235-240. 2006
2006 Synthetic peptides: Managing lipid disordersCurrent Opinion in Lipidology.  17:233-237. 2006
2005 Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats 2005
2005 Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxideFree Radical Biology and Medicine.  39:540-548. 2005
2005 Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptideCirculation Research.  97:236-243. 2005
2005 Apolipoprotein E mimetic peptide dramatically lowers plasma cholesterol and restores endothelial function in Watanabe heritable hyperlipidemic rabbitsCirculation.  111:3112-3118. 2005
2005 Assessing NO-dependent vasodilatation using vessel bioassays at defined oxygen tensionsMethods in Enzymology.  396:553-568. 2005
2004 L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemiaFEBS Letters.  561:94-98. 2004
2003 Vasoactivity of S-nitrosohemoglobin: Role of oxygen, heme, and NO oxidation statesBlood.  101:4408-4415. 2003
2003 The neointimal response ot endovascular injury is increased in obese Zucker rats 2003
2002 Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity 2002
2002 Myeloperoxidase, a leukocyte-derived vascular NO oxidaseScience.  296:2391-2394. 2002
2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease 2001
2001 Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration.Journal of Clinical Investigation.  108:1759-1770. 2001
2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid. 2001
2001 L-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide ProductionJournal of Biological Chemistry.  276:27159-27165. 2001
2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid 2001
2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-443. 2001
2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
2001 Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct 2001
2000 Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats.Hypertension.  35:403-408. 2000
1999 Chemiluminescent detection of oxidants in vascular tissue: Lucigenin but not coelenterazine enhances superoxide formationCirculation Research.  84:1203-1211. 1999
1999 Biological aspects of reactive nitrogen species 1999
1999 Nitric oxide donor generation from reactions of peroxynitriteMethods in Enzymology.  301:288-298. 1999
1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
1998 Captopril treatment and its withdrawal prevents impairment of endothelium-dependent responses in the spontaneously hypertensive ratClinical and experimental hypertension.  20:847-866. 1998
1997 No role for NO in estrogen-mediated vasoprotection?Circulation.  96:2769-2771. 1997
1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
1997 Estrogen restores endothelial cell function in an experimental model of vascular injuryCirculation.  96:1624-1630. 1997
1997 Immunoglobulin light chain alters mesangial cell calcium homeostasis.American Journal of Physiology.  272:F319-F324. 1997
1997 Gender and cardiovascular disease: Recent insightsTrends in Cardiovascular Medicine.  7:94-100. 1997
1997 Immunoglobulin light chain alters mesangial cell calcium homeostasis 1997
1997 Nitric oxide, free radicals and cell signalling in cardiovascular diseaseBiochemical Society Transactions.  25. 1997
1997 The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for diseaseSeminars in Perinatology.  21:351-366. 1997
1996 Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits 1996
1995 A functional comparison of the rat type-1 angiotensin II receptors (AT1AR and AT1BR)Regulatory Peptides.  60:135-147. 1995
1995 Calcium-Sensitive Chloride Channels in Vascular Smooth Muscle Cells 1995
1995 Hyperglycemia alters cytoplasmic Ca2+ responses to capacitative Ca2+ influx in rat aortic smooth muscle cells 1995
1995 Oxygen Radical-Nitric Oxide Reactions in Vascular DiseasesAdvances in Pharmacology.  34:45-69. 1995
1994 Calcium-mobilizing agonists stimulate anion fluxes in cultured endothelial cells from human umbilical vein 1994
1994 Superoxide and peroxynitrite in atherosclerosis 1994
1994 Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.Biological chemistry Hoppe-Seyler.  375:81-88. 1994

Chapter

Year Title Altmetric
2010 HDL mimetic peptides: Novel therapeutic strategies for the treatment of inflammatory vascular disease.  179-197. 2010

Education And Training

  • Doctor of Philosophy in Physiology, Pathology, and Related Sciences, University of Illinois System : Urbana-Champaign 1989
  • Master of Life Sciences in Physiology, Pathology and Related Sciences, University of Illinois System : Urbana-Champaign 1985
  • Full Name

  • Charles White