Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 The apoA-I mimetic peptide 4F protects apolipoprotein A-I from oxidative damageChemistry and Physics of Lipids.  219:28-35. 2019
2018 Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaquesJournal of Lipid Research.  59:2075-2083. 2018
2018 The apolipoprotein e mimetic peptide AEM-2 attenuates mitochondrial injury and apoptosis in human THP-1 macrophagesCurrent topics in peptide & protein research.  19:15-25. 2018
2017 Cholesterol reduction and macrophage function: Role of paraoxonasesCurrent Opinion in Lipidology.  28:397-402. 2017
2017 High-density lipoprotein regulation of mitochondrial functionAdvances in Experimental Medicine and Biology.  982:407-429. 2017
2016 Apolipoprotein mimetic peptides as modulators of lipoprotein functionProtein and Peptide Letters.  23:1024-1031. 2016
2016 High-density lipoprotein, mitochondrial dysfunction and cell survival mechanismsChemistry and Physics of Lipids.  199:161-169. 2016
2016 Independent effects of early-life experience and trait aggression on cardiovascular functionAJP - Regulatory, Integrative and Comparative Physiology.  311:R272-R286. 2016
2015 Recent developments in modulating atherogenic lipoproteinsCurrent Opinion in Lipidology.  26:369-375. 2015
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4FBiochemical Journal.  467:517-527. 2015
2015 Early changes in vascular reactivity in response to 56Fe irradiation in ApoE-/- miceActa Astronautica.  108:40-45. 2015
2014 Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: A reviewJournal of Lipid Research.  55:2007-2021. 2014
2014 Inhibitors of arachidonate-regulated calcium channel signaling suppress triggered activity induced by the late sodium currentEuropean Journal of Pharmacology.  724:92-101. 2014
2014 L-4F Inhibits Lipopolysaccharide-Mediated Activation of Primary Human NeutrophilsInflammation.  37:1401-1412. 2014
2013 Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to SepsisPLoS ONE.  8. 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4FArteriosclerosis, Thrombosis, and Vascular Biology.  32:2631-2639. 2012
2012 Preservation of biological function despite oxidative modification of the apolipoprotein A-I mimetic peptide 4FJournal of Lipid Research.  53:1576-1587. 2012
2011 HDL Mimetic Peptide Administration Improves Left Ventricular Filling and Cardiac output in Lipopolysaccharide-Treated Rats.Journal of Clinical and Experimental Cardiology.  2. 2011
2011 Acyloxy nitroso compounds as nitroxyl (HNO) donors: Kinetics, reactions with thiols, and vasodilation propertiesJournal of Medicinal Chemistry.  54:1059-1070. 2011
2010 ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activityAdvances in Experimental Medicine and Biology.  660:1-4. 2010
2010 The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic ratsJournal of Lipid Research.  51:2695-2705. 2010
2010 Dietary flavonoid quercetin stimulates vasorelaxation in aortic vesselsFree Radical Biology and Medicine.  49:339-347. 2010
2010 Potential for chlorine gas-induced injury in the extrapulmonary vasculatureProceedings of the American Thoracic Society.  7:290-293. 2010
2010 Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophagesAmerican Journal of Physiology - Cell Physiology.  298. 2010
2010 Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH2Atherosclerosis.  208:134-141. 2010
2009 Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic ratsAJP - Heart and Circulatory Physiology.  297. 2009
2009 Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesisAJP - Lung Cellular and Molecular Physiology.  297. 2009
2009 Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular systemAJP - Heart and Circulatory Physiology.  296. 2009
2009 Vasculoprotective Effects of Apolipoprotein Mimetic Peptides: An Evolving Paradigm In Hdl Therapy (Vascular Disease Prevention, In Press.).Vascular Disease Prevention.  6:122-130. 2009
2008 HDL therapy for cardiovascular diseases: The road to HDL mimeticsCurrent Atherosclerosis Reports.  10:405-412. 2008
2006 Atherosclerosis and vascular disease: Effects of peptide mimetics of apolilpoproteinsCurrent Pharmaceutical Biotechnology.  7:235-240. 2006
2006 Synthetic peptides: Managing lipid disordersCurrent Opinion in Lipidology.  17:233-237. 2006
2005 Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive ratsAJP - Regulatory, Integrative and Comparative Physiology.  289. 2005
2005 Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxideFree Radical Biology and Medicine.  39:540-548. 2005
2005 Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptideCirculation Research.  97:236-243. 2005
2005 Apolipoprotein E mimetic peptide dramatically lowers plasma cholesterol and restores endothelial function in Watanabe heritable hyperlipidemic rabbitsCirculation.  111:3112-3118. 2005
2005 Assessing NO-dependent vasodilatation using vessel bioassays at defined oxygen tensionsMethods in Enzymology.  396:553-568. 2005
2004 L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemiaFEBS Letters.  561:94-98. 2004
2003 Vasoactivity of S-nitrosohemoglobin: Role of oxygen, heme, and NO oxidation statesBlood.  101:4408-4415. 2003
2003 The neointimal response ot endovascular injury is increased in obese Zucker ratsDiabetes, Obesity and Metabolism.  5:415-423. 2003
2002 Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activityProceedings of the National Academy of Sciences.  99:15941-15946. 2002
2002 Myeloperoxidase, a leukocyte-derived vascular NO oxidaseScience.  296:2391-2394. 2002
2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell diseaseProceedings of the National Academy of Sciences.  98:15215-15220. 2001
2001 Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration.Journal of Clinical Investigation.  108:1759-1770. 2001
2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acidAJP - Heart and Circulatory Physiology.  281. 2001
2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid.AJP - Heart and Circulatory Physiology.  281:H1469-H1475. 2001
2001 L-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide ProductionJournal of Biological Chemistry.  276:27159-27165. 2001
2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-444. 2001
2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
2001 Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinctMolecular Endocrinology -Baltimore-.  15:281-293. 2001
2000 Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats.Hypertension.  35:403-408. 2000
1999 Chemiluminescent detection of oxidants in vascular tissue: Lucigenin but not coelenterazine enhances superoxide formationCirculation Research.  84:1203-1211. 1999
1999 Biological aspects of reactive nitrogen speciesBBA - Bioenergetics.  1411:385-400. 1999
1999 Nitric oxide donor generation from reactions of peroxynitriteMethods in Enzymology.  301:288-298. 1999
1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
1998 Captopril treatment and its withdrawal prevents impairment of endothelium-dependent responses in the spontaneously hypertensive ratClinical and experimental hypertension.  20:847-866. 1998
1997 No role for NO in estrogen-mediated vasoprotection?Circulation.  96:2769-2771. 1997
1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
1997 Estrogen restores endothelial cell function in an experimental model of vascular injuryCirculation.  96:1624-1630. 1997
1997 Immunoglobulin light chain alters mesangial cell calcium homeostasisAJP - Renal Physiology.  272. 1997
1997 Immunoglobulin light chain alters mesangial cell calcium homeostasis.American Journal of Physiology.  272:F319-F324. 1997
1997 Gender and cardiovascular disease: Recent insightsTrends in Cardiovascular Medicine.  7:94-100. 1997
1997 Nitric oxide, free radicals and cell signalling in cardiovascular diseaseBiochemical Society Transactions.  25. 1997
1997 The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for diseaseSeminars in Perinatology.  21:351-366. 1997
1996 Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbitsProceedings of the National Academy of Sciences.  93:8745-8749. 1996
1995 A functional comparison of the rat type-1 angiotensin II receptors (AT1AR and AT1BR)Regulatory Peptides.  60:135-147. 1995
1995 Hyperglycemia alters cytoplasmic Ca2+ responses to capacitative Ca2+ influx in rat aortic smooth muscle cellsAmerican Journal of Physiology - Cell Physiology.  269. 1995
1995 Calcium-Sensitive Chloride Channels in Vascular Smooth Muscle CellsProceedings of the Society for Experimental Biology and Medicine.  208:255-262. 1995
1995 Oxygen Radical-Nitric Oxide Reactions in Vascular DiseasesAdvances in Pharmacology.  34:45-69. 1995
1994 Calcium-mobilizing agonists stimulate anion fluxes in cultured endothelial cells from human umbilical veinJournal of Membrane Biology.  142:171-179. 1994
1994 Superoxide and peroxynitrite in atherosclerosisProceedings of the National Academy of Sciences.  91:1044-1048. 1994
1994 Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.Biological chemistry Hoppe-Seyler.  375:81-88. 1994

Chapter

Year Title Altmetric
2010 HDL mimetic peptides: Novel therapeutic strategies for the treatment of inflammatory vascular disease.  179-197. 2010

Education And Training

  • Doctor of Philosophy in Physiology, Pathology, and Related Sciences, University of Illinois System : Urbana-Champaign 1989
  • Master of Life Sciences in Physiology, Pathology and Related Sciences, University of Illinois System : Urbana-Champaign 1985
  • Full Name

  • Charles White