Selected Publications

Academic Article

Year Title Altmetric
2017 TβRIII is induced by TCR signaling and downregulated in FoxP3+ regulatory T cells.Biochemical and Biophysical Research Communications.  494:82-87. 2017
2016 A Potential Structural Switch for Regulating DNA-Binding by TEAD Transcription Factors.Journal of Molecular Biology.  428:2557-2568. 2016
2016 Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions.Journal of Neuroimmune Pharmacology.  11:36-47. 2016
2016 CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.PLoS ONE.  11:e0168155. 2016
2015 Functional requirement of tyrosine residue 429 within CD5 cytoplasmic domain for regulation of T cell activation and survival.Biochemical and Biophysical Research Communications.  466:381-387. 2015
2015 Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.Journal of Immunology.  195:450-463. 2015
2015 Expression of Interferon-γ Receptor Genes in Peripheral Blood Mononuclear Cells Is Associated With Rheumatoid Arthritis and Its Radiographic Severity in African Americans.Arthritis and Rheumatology.  67:1165-1170. 2015
2015 MAT2A mutations predispose individuals to thoracic aortic aneurysms.American Journal of Human Genetics.  96:170-177. 2015
2014 CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization.European Journal of Immunology.  44:1137-1142. 2014
2014 Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.Journal of Immunology.  192:59-72. 2014
2014 Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses.PLoS ONE.  9:e84895. 2014
2013 The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis.Journal of Immunology.  191:2967-2977. 2013
2013 MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.Journal of Neuroscience.  33:9592-9600. 2013
2013 Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity.Clinical Reviews in Allergy and Immunology.  44:114-120. 2013
2013 The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes.Biochemical and Biophysical Research Communications.  432:52-59. 2013
2012 Picosecond to second dynamics reveals a structural transition in Clostridium botulinum NO-sensor triggered by the activator BAY-41-2272.ACS Chemical Biology.  7:2046-2054. 2012
2012 CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.Journal of Immunology.  189:2918-2930. 2012
2012 Janus-like effects of type I interferon in autoimmune diseases.Immunological Reviews.  248:23-35. 2012
2012 Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation.Proceedings of the National Academy of Sciences.  109:5004-5009. 2012
2012 Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis.PLoS ONE.  7:e44217. 2012
2012 Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling.PLoS ONE.  7:e52658. 2012
2012 Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.Journal of Leukocyte Biology.  91:97-103. 2012
2011 Green tea: a new option for the prevention or control of osteoarthritis.Arthritis Research.  13:121. 2011
2011 Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.Journal of Immunology.  187:102-109. 2011
2011 Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.Proceedings of the National Academy of Sciences.  108:10644-10649. 2011
2011 Interferon-β exacerbates Th17-mediated inflammatory disease.Immunology Today.  32:272-277. 2011
2011 The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease.Current Opinion in Immunology.  23:310-318. 2011
2011 The reaction mechanism of allene oxide synthase: Interplay of theoretical QM/MM calculations and experimental investigations.Archives of Biochemistry and Biophysics.  507:14-25. 2011
2010 Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression.Immunology and Cell Biology.  88:451-460. 2010
2010 T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.Nature Medicine.  16:406-412. 2010
2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity.Journal of Immunology.  184:442-451. 2010
2009 The structures of indazolin-3-one (=1,2-dihydro-3H-indazol-3-one) and 7-nitroindazolin-3-oneHelvetica Chimica Acta.  92:1952-1962. 2009
2009 Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling.European Journal of Immunology.  39:2233-2247. 2009
2009 Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.American Journal of Human Genetics.  84:617-627. 2009
2008 Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes.Nature.  455:363-368. 2008
2008 CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells.Immunology Letters.  119:103-113. 2008
2008 Lithium prevents and ameliorates experimental autoimmune encephalomyelitis.Journal of Immunology.  181:338-345. 2008
2008 Corrigendum: Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections (Nature Genetics (2007) 39, (1488-1493))Nature Genetics.  40:255. 2008
2008 Erratum: MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor1 and angiotensin II (Human Molecular Genetics (2007) vol. 16 (20) (2453-2462) 10.1093/hmg/ddm201)Human Molecular Genetics.  17:158. 2008
2007 Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.Nature Genetics.  39:1488-1493. 2007
2007 MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.Human Molecular Genetics.  16:2453-2462. 2007
2007 Efficient synthesis of 7-substituted or 3,7-disubstituted 1H-indazolesSYNLETT.  1203-1206. 2007
2007 A new mutation within the porphobilinogen deaminase gene leading to a truncated protein as a cause of acute intermittent porphyria in an extended Indian family.Folia Biologica.  53:194-201. 2007
2006 CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system.Journal of Immunology.  177:8542-8549. 2006
2006 Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.Journal of Inorganic Biochemistry.  100:2024-2033. 2006
2006 Dynamics of NO rebinding to the heme domain of NO synthase-like proteins from bacterial pathogens.Nitric Oxide: Biology and Chemistry.  15:312-327. 2006
2006 De Novo mutation found in the porphobilinogen deaminase gene in Slovak acute intermittent porphyria patient: molecular biochemical study.Physiological Research.  55 Suppl 2:S145-S154. 2006
2005 Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis.European Journal of Immunology.  35:3487-3492. 2005
2005 Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis.Journal of Immunology.  175:6327-6333. 2005
2005 Structural basis of hereditary coproporphyria.Proceedings of the National Academy of Sciences.  102:14232-14237. 2005
2005 Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections.Circulation.  112:513-520. 2005
2004 Femtomolar sensitivity of a NO sensor from Clostridium botulinum.Science.  306:1550-1553. 2004
2004 Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice.Journal of Immunology.  173:2928-2932. 2004
2004 Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease.American Journal of Pathology.  165:609-616. 2004
2004 A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.Journal of Biological Chemistry.  279:20186-20193. 2004
2003 The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.Journal of Immunology.  170:3534-3543. 2003
2002 AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells.Journal of Immunology.  168:5612-5620. 2002
2002 CD5, an important regulator of lymphocyte selection and immune tolerance.Immunologic Research.  26:255-263. 2002
2001 Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.Journal of Biological Chemistry.  276:49133-49141. 2001
2001 Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.Biochemistry.  40:13448-13455. 2001
2001 Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.Journal of Biological Chemistry.  276:26486-26491. 2001
2001 CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as a binding and phosphoacceptor site for casein kinase 2.Journal of Immunology.  166:7208-7218. 2001
2001 Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.Biochemistry.  40:5399-5406. 2001
2000 Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.Journal of Inorganic Biochemistry.  81:133-139. 2000
2000 Antibody-detected folding: kinetics of surface epitope formation are distinct from other folding phases.Protein Science.  9:129-137. 2000
1999 Factors determining the selectivity of protein tyrosine nitration.Archives of Biochemistry and Biophysics.  371:169-178. 1999
1999 Isothermal titration calorimetry of protein-protein interactions.Methods.  19:213-221. 1999
1999 Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase.Journal of Biological Chemistry.  274:21276-21284. 1999
1999 Zinc content of Escherichia coli-expressed constitutive isoforms of nitric-oxide synthase. Enzymatic activity and effect of pterin.Journal of Biological Chemistry.  274:14537-14540. 1999
1999 Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase.Current Opinion in Chemical Biology.  3:131-137. 1999
1998 The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.Journal of Biological Chemistry.  273:34799-34805. 1998
1998 Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.Cell.  95:939-950. 1998
1998 Cutting edge: Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: Implication on TCR/CD3-mediated activationJournal of Immunology.  161:5817-5820. 1998
1998 Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: implication on TCR/CD3-mediated activation.Journal of Immunology.  161:5817-5820. 1998
1998 Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5.Journal of Biological Chemistry.  273:19183-19189. 1998
1998 CD5 regulates Casein Kinase 2 (CK2) by direct interaction with the holoenzymeFederation proceedings.  12. 1998
1998 Interaction of AP50 with the cytoplasmic domain of murine CD22.2Federation proceedings.  12. 1998
1998 NO news is good news.Structure.  6:255-258. 1998
1997 CYS 331 of neuronal nitric oxide synthase is involved in L-arg binding rather than direct BH4 bindingFederation proceedings.  11. 1997
1997 Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences.International Immunology.  9:1503-1515. 1997
1997 Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein.Nucleic Acids Research.  25:814-821. 1997
1997 Human coproporphyrinogen oxidase. Biochemical characterization of recombinant normal and R231W mutated enzymes expressed in E. coli as soluble, catalytically active homodimers.Cellular and Molecular Biology.  43:47-58. 1997
1995 Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA.Gene.  163:325-326. 1995
1995 Enthalpy of antibody--cytochrome c binding.Biochemistry.  34:5831-5838. 1995
1995 High hydrostatic pressure induces the dissociation of cpn60 tetradecamers and reveals a plasticity of the monomers.Journal of Biological Chemistry.  270:2061-2066. 1995
1994 MPSA short communicationsJournal of Protein Chemistry.  13:431-512. 1994
1994 Preferential VH gene usage in rabbit Ig-secreting heterohybridomas.Journal of Immunology.  152:3935-3945. 1994
1992 CD5+ B cells predominate in peripheral tissues of rabbit.Journal of Immunology.  149:3858-3864. 1992
1992 Diffusion-limited rates for monoclonal antibody binding to cytochrome c.Biochemistry.  31:10370-10379. 1992
1992 Identification and cloning of rabbit CD5.Annals of the New York Academy of Sciences.  651:78-81. 1992
1990 Evaluation of an ELISA for the detection of anti-Histoplasma ribosomal and antihistoplasmin antibodies in histoplasmosis.Journal of Clinical Laboratory Analysis.  4:199-207. 1990


Year Title Altmetric
2000 Structures of gas-generating heme enzymes: Nitric oxide synthase and heme oxygenase.  Ed. 51.  2000

Education And Training

  • Doctor of Philosophy in Microbiology, Southern Illinois University System : Carbondale
  • Full Name

  • Chander Raman
  • Blazerid

  • craman