Positions

Overview

  • David Cooper studied medicine at Guy’s Hospital Medical School in London (now merged with King’s College London). He subsequently trained in general and cardiothoracic surgery in Cambridge and London, interrupting this training to carry out research for the PhD degree. He was present at the first heart transplant in the UK in 1968, and a member of the team that initiated the heart transplant program at Papworth Hospital in 1979. Between 1972 and 1980, he was a Fellow and Director of Studies in Medicine at Magdalene College, Cambridge.

    In 1980 he took up an appointment in cardiac surgery at Groote Schuur Hospital at the University of Cape Town where, under Professor Christiaan Barnard (who, in 1967 had carried out the world’s first heart transplant), he had responsibility for patients undergoing heart transplantation. With Winston Wicomb and Dimitri Novitzky, he developed a hypothermic perfusion device to store donor hearts, which was used clinically, and investigated the detrimental effects of brain death on donor organs before establishing thyroid hormone therapy in the management of potential organ donors.

    In 1987, he relocated to the Oklahoma Transplantation Institute in the USA where he continued to work in both the clinical and research fields. With colleagues, he identified the importance of the Gal antigen in xenotransplantation. After 17 years as a surgeon-scientist, he decided to concentrate on research, initially at the Massachusetts General Hospital/Harvard Medical School in Boston, subsequently at the Thomas E. Starzl Transplantation Institute at the University of Pittsburgh, and now at UAB. His major interest is the xenotransplantation of organs, islets, and corneas in pig-to-nonhuman primate models, with the aim of using genetically-engineered pigs as a solution to the organ shortage for clinical transplantation.

    The Royal College of Surgeons of England appointed him to a Hunterian Professorship (1983), Arris and Gale Lectureship (1988), Amott Lectureship (2002), and awarded him the 1997 Jacksonian Prize and Medal. Professor Cooper has published more than 850 medical and scientific papers and chapters, has authored or edited 11 books, and has given more than 300 invited presentations worldwide.

    Between 1994-7, he was Honorary Secretary/Treasurer of the International Society for Heart and Lung Transplantation. He was the Founding Honorary Secretary of the International Xenotransplantation Association IXA) in 1997, its President in 1999-2001, and the Editor-in-Chief of Xenotransplantation from 2001-7. In 2009, he was elected to Honorary Membership of the IXA.

    He has also received the American Society of Transplant Surgeons (ASTS)-Roche Presidential Travel Award (2007), The Transplantation Society-Roche Award for Excellence in Translational Science (2010), the American Society of Transplantation (AST) Basic Science Established Investigator Award (2014), and The Transplantation Society’s Award for Outstanding Achievement in Transplantation (Basic Science) (2016). In 2016 he was made a Fellow of his alma mater, King’s College London.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review article 2019
    2019 Life-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens 2019
    2019 The potential role of 3D-bioprinting in xenotransplantation 2019
    2019 Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article 2019
    2019 Isolation and Culture of Primary Aortic Endothelial Cells from Miniature Pigs 2019
    2019 In Search of the Ideal Valve: Optimizing Genetic Modifications to Prevent Bioprosthetic Degeneration 2019
    2019 TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression 2019
    2019 Circulating pig-specific DNA as a novel biomarker for monitoring xenograft rejection 2019
    2019 Justification of specific genetic modifications in pigs for clinical organ xenotransplantation 2019
    2019 The complex functioning of the complement system in xenotransplantation 2019
    2019 The “Baby Fae” baboon heart transplant—Potential cause of rejection 2019
    2019 Evidence for the important role of inflammation in xenotransplantation 2019
    2019 Biodistribution of strontium and barium in the developing and mature skeleton of rats 2019
    2019 A review of pig liver xenotransplantation: Current problems and recent progress 2019
    2019 Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation 2019
    2019 Financial support for xenotransplantation research 2019
    2019 Genetically-engineered pigs as sources for clinical red blood cell transfusion: What pathobiological barriers need to be overcome? 2019
    2019 Life-supporting porcine cardiac xenotransplantation: The Munich study 2019
    2019 Potential pathological role of pro-inflammatory cytokines (IL-6, TNF-α, and IL-17) in xenotransplantation 2019
    2019 Experimental Pig Heart Xenotransplantation—Recent Progress and Remaining Problems 2019
    2019 Incidence of Neoplasia in Pigs and Its Relevance to Clinical Organ Xenotransplantation 2019
    2019 Chronic dialysis in patients with end-stage renal disease: Relevance to kidney xenotransplantation 2019
    2019 Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance? 2019
    2019 Oscar Salvatierra, Jr, MD (1935-2019) 2019
    2019 Will donor-derived neoplasia be problematic after clinical pig organ or cell xenotransplantation? 2019
    2019 The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome? 2019
    2019 A New fossil species of pycnomerus erichson (coleoptera: Zopheridae) from baltic amber, and a replacement name for a recent North American congener 2019
    2019 A method for islet transplantation to the omentum in mouse 2019
    2019 A potential role of TLR2 in xenograft rejection of porcine iliac endothelial cells: An in vitro study 2019
    2019 Circulating miRNA or circulating DNA—Potential biomarkers for organ transplant rejection 2019
    2019 Downregulation of Gabarapl1 significantly attenuates antibody binding to porcine aortic endothelial cells 2019
    2019 Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation 2019
    2018 B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy 2018
    2018 Crossover artifact in X-ray focusing imaging systems: K-edge subtraction imaging 2018
    2018 Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation 2018
    2018 Serum amyloid a as an indicator of impending xenograft failure: Experimental studies 2018
    2018 An approach to induction of tolerance to pig cardiac xenografts in neonates 2018
    2018 Skin xenotransplantation: Historical review and clinical potential 2018
    2018 Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy 2018
    2018 Physiologic aspects of pig kidney transplantation in nonhuman primates 2018
    2018 The effect of growth rate on the three-dimensional orientation of vascular canals in the cortical bone of broiler chickens 2018
    2018 Transplant Tolerance: Current Insights and Strategies for Long-Term Survival of Xenografts 2018
    2018 Xenotransplantation research and the ‘International Journal of Surgery’ 2018
    2018 Porcine IL-6, IL-1β, and TNF-α regulate the expression of pro-inflammatory-related genes and tissue factor in human umbilical vein endothelial cells 2018
    2018 Franklin expedition lead exposure: New insights from high resolution confocal x-ray fluorescence imaging of skeletal microstructure 2018
    2018 Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates: Recent Progress 2018
    2018 Christiaan Barnard-The surgeon who dared: The story of the first human-to-human heart transplant. 2018
    2018 Interpreting the three-dimensional orientation of vascular canals and cross-sectional geometry of cortical bone in birds and bats 2018
    2018 20th Anniversary of IXA, 1998–2018 2018
    2018 Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells 2018
    2018 Is sensitization to pig antigens detrimental to subsequent allotransplantation? 2018
    2018 Jewish, Christian and Muslim theological perspectives about xenotransplantation 2018
    2018 Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH 2018
    2018 Christiaan Barnard's views on euthanasia 2018
    2018 Bringing Home the Bacon: Update on the State of Kidney Xenotransplantation 2018
    2018 The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation 2018
    2018 Xenotransplantation - The current status and prospects 2018
    2018 Corrigendum to "The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation" 2018
    2018 Expression and regulation profile of mature microRNA in the pig: Relevance to xenotransplantation 2018
    2017 Christiaan Barnard's defining moment: The epic first human heart transplant performed 50 years ago by Chris Barnard is discussed by David Cooper MD who was with Barnard at Groote Schuur Hospital in Cape Town 2017
    2017 Life's defining moment: Christiaan Barnard and the first human heart transplant 2017
    2017 Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model 2017
    2017 Xenotransplantation: Past, present, and future 2017
    2017 Contributions to the palaeofauna of Ptinidae (Coleptera) known from Baltic amber 2017
    2017 Low anti-pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient? 2017
    2017 Miscellaneous 2017
    2017 Occurrence of osteon banding in adult human cortical bone 2017
    2017 The forgotten French: The ‘heroic’ era of kidney transplantation 2017
    2017 An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation 2017
    2017 Encapsulation of Human Islets Using a Biomimetic Self-Assembled Nanomatrix Gel for Protection against Cellular Inflammatory Responses 2017
    2017 David J. G. White, PhD, FRCPath 2017
    2017 Regulation of Clinical Xenotransplantation-Time for a Reappraisal 2017
    2017 Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum—relevance to xenotransplantation 2017
    2017 Angiopoietin-1 and angiopoietin-2 protect porcine iliac endothelial cells from human antibody-mediated complement-dependent cytotoxicity through phosphatidylinositide 3-kinase/AKT pathway activation 2017
    2017 Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans 2017
    2017 Financial aspects of organ procurement from deceased donors in the USA—Relevance to xenotransplantation 2017
    2017 La(III) biodistribution profiles from intravenous and oral dosing of two lanthanum complexes, La(dpp)3 and La(XT), and evaluation as treatments for bone resorption disorders 2017
    2017 Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation 2017
    2017 Skeletal Lead Burden of the British Royal Navy in Colonial Antigua 2017
    2017 The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells 2017
    2017 Renal Allograft Survival in Nonhuman Primates Infused With Donor Antigen-Pulsed Autologous Regulatory Dendritic Cells 2017
    2017 Evaluating differential nuclear DNA yield rates and osteocyte numbers among human bone tissue types: A synchrotron radiation micro-CT approach 2017
    2017 Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection 2017
    2017 Renal xenotransplantation: experimental progress and clinical prospects 2017
    2017 Early clinical xenotransplantation experiences—An interview with Thomas E. Starzl, MD, PhD 2017
    2017 Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells 2017
    2017 Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts 2017
    2017 Superior spatial resolution in confocal X-ray techniques using collimating channel array optics: Elemental mapping and speciation in archaeological human bone 2017
    2017 Therapeutic regulation of systemic inflammation in xenograft recipients 2017
    2017 Thomas E. Starzl, MD, PhD, 1926-2017 2017
    2017 Transplantation of hepatocytes from genetically engineered pigs into baboons 2017
    2017 The White House Organ Summit 2017
    2017 A method for measuring the three-dimensional orientation of cortical canals with implications for comparative analysis of bone microstructure in vertebrates 2017
    2017 Development of retrocorneal membrane following pig-to-monkey penetrating keratoplasty 2017
    2017 Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys 2017
    2017 Klotho attenuated antibody-mediated porcine endothelial cell activation and injury 2017
    2017 Pig-to-primate islet xenotransplantation: Past, present, and future 2017
    2017 Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning 2017
    2017 Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys 2017
    2017 The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation 2017
    2016 Spectral K-edge subtraction imaging of experimental non-radioactive barium uptake in bone 2016
    2016 Progress in Clinical Encapsulated Islet Xenotransplantation 2016
    2016 Clinical Islet Xenotransplantation: A Step Forward 2016
    2016 Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic 2016
    2016 Transplantation of the heart after circulatory death 2016
    2016 Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation 2016
    2016 Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? 2016
    2016 Psychosocial challenges of xenotransplantation: the need for a multidisciplinary, religious, and cultural dialogue 2016
    2016 Circulating organ-specific microRNAs serve as biomarkers in organ-specific diseases: Implications for organ allo- and xeno-transplantation 2016
    2016 Thyroid hormone therapy and procurement of livers from brain-dead donors 2016
    2016 Hormone resuscitation therapy for brain-dead donors – is insulin beneficial or detrimental? 2016
    2016 Is successful orthotopic heart transplantation in the pig-to-non-human primate model required before proceeding to a clinical trial? 2016
    2016 Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients 2016
    2016 Thyroid hormone: relevance to xenotransplantation 2016
    2016 Executive summary of IPITA-TTS opinion leaders report on the future of b-cell replacement 2016
    2016 Modifying the sugar icing on the transplantation cake 2016
    2016 Heart Xenotransplantation: Historical Background, Experimental Progress, and Clinical Prospects 2016
    2016 Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs 2016
    2016 The pathobiology of pig-to-primate xenotransplantation: A historical review 2016
    2016 Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs 2016
    2016 Eomesoderminlo CTLA4hi Alloreactive CD8+ Memory T Cells Are Associated with Prolonged Renal Transplant Survival Induced by Regulatory Dendritic Cell Infusion in CTLA4 Immunoglobulin-Treated Nonhuman Primates 2016
    2016 Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation 2016
    2016 First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 2b: Genetically modified source pigs 2016
    2016 First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial 2016
    2016 First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Executive summary 2016
    2016 Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants 2016
    2016 Report from IPITA-TTS opinion leaders meeting on the future of β-cell replacement 2016
    2016 The role of genetically engineered pigs in xenotransplantation research 2016
    2015 Recent advances in understanding xenotransplantation: Implications for the clinic 2015
    2015 A brief history of clinical xenotransplantation 2015
    2015 Cell-based immunosuppression in kidney transplantation: The value of non-human primate studies 2015
    2015 Immunobiological barriers to xenotransplantation 2015
    2015 In vitro testing of an anti-CD40 monoclonal antibody, clone 2C10, in primates and pigs 2015
    2015 Potential alternative approaches to xenotransplantation 2015
    2015 Progress toward clinical xenotransplantation 2015
    2015 Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation? 2015
    2015 The need for xenotransplantation as a source of organs and cells for clinical transplantation 2015
    2015 Transgenic expression of human CD46: Does it reduce the primate T-cell response to pig endothelial cells? 2015
    2015 Xenograft bioprosthetic heart valves: Past, present and future 2015
    2015 Further evidence for sustained systemic inflammation in xenograft recipients (SIXR) 2015
    2015 David K. C. Cooper, MD, PhD: Professor of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, PA 2015
    2015 Experimental hepatocyte xenotransplantation - A comprehensive review of the literature 2015
    2015 Pig kidney graft survival in a baboon for 136 days: Longest life-supporting organ graft survival to date 2015
    2015 Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature 2015
    2015 MYROIDES INFECTION IN A BABOON AFTER PROLONGED PIG KIDNEY GRAFT SURVIVAL. 2015
    2015 Sequential monitoring and stability of Ex vivo-expanded autologous and nonautologous regulatory t cells following infusion in nonhuman primates 2015
    2015 The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs 2015
    2015 Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs 2015
    2015 Increased Procurement of Thoracic Donor Organs After Thyroid Hormone Therapy 2015
    2015 Characterization of the cellular infiltrate in bioprosthetic heart valves explanted from patients with structural valve deterioration 2015
    2015 Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein 2015
    2015 Expression of NeuGc on pig heart valves 2015
    2015 Glucose metabolism in pigs expressing human genes under an insulin promoter 2015
    2015 In vitro exposure of pig neonatal isletlike cell clusters to human blood 2015
    2015 Islet xenotransplantation: What is the optimal age of the islet-source pig? 2015
    2015 Pig-to-baboon heterotopic heart transplantation - Exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens 2015
    2015 Systemic inflammation in xenograft recipients precedes activation of coagulation 2015
    2015 The case for xenotransplantation 2015
    2014 The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors 2014
    2014 Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells 2014
    2014 Potential for clinical pancreatic islet xenotransplantation 2014
    2014 Progress in pig-to-non-human primate transplantation models (1998-2013): A comprehensive review of the literature 2014
    2014 The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation 2014
    2014 Streptozotocin-associated lymphopenia in cynomolgus monkeys 2014
    2014 Increased soluble CD154 (CD40 Ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodies 2014
    2014 Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation Association 2014
    2014 The Potential Role of Genetically-Modified Pig Mesenchymal Stromal Cells in Xenotransplantation 2014
    2014 A comparison of three methods of decellularization of pig corneas to reduce immunogenicity. 2014
    2014 A milestone in xenotransplantation research 2014
    2014 Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models? 2014
    2014 Bioprosthetic heart valves of the future 2014
    2014 Characterization of porcine corneal endothelium for xenotransplantation 2014
    2014 Corneal blindness and xenotransplantation 2014
    2014 Distribution of non-gal antigens in pig cornea: Relevance to corneal xenotransplantation 2014
    2014 Hematopoietic chimerism following allotransplantation of the spleen, splenocytes or kidney in pigs 2014
    2014 Kidney xenotransplantation 2014
    2014 Pig-to-monkey islet xenotransplantation using multi-transgenic pigs 2014
    2014 Plasma free triiodothyronine (fT3) levels in baboons undergoing pig organ transplantation: Relevance to early recovery of organ function 2014
    2014 Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition 2014
    2014 Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells 2014
    2014 The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options 2014
    2014 Thyroid hormone and the stunned myocardium 2014
    2014 Thyroid hormone therapy in the management of 63,593 brain-dead organ donors: A retrospective analysis 2014
    2014 Thyroid hormone therapy in the management of 63,593 brain-dead organ donors: A retrospective analysis 2014
    2013 Technique of endoscopic biopsy of islet allografts transplanted into the gastric submucosal space in pigs 2013
    2013 New concepts of immune modulation in xenotransplantation 2013
    2013 Islet xenotransplantation from genetically engineered pigs 2013
    2013 Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: A pilot study 2013
    2013 Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection 2013
    2013 Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells 2013
    2013 Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status 2013
    2013 Is there a correlation between anti-pig antibody levels in humans and geographic location during childhood? 2013
    2013 Ex vivo-expanded cynomolgus macaque regulatory T cells are resistant to Alemtuzumab-mediated cytotoxicity 2013
    2013 Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates 2013
    2013 Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells 2013
    2013 Toward clinical islet xenotransplantation - Are revisions to the IXA guidelines warranted? 2013
    2013 Commentary: Limitations of the pig-to-non-human primate islet transplantation model 2013
    2013 Post-transplant repopulation of naïve and memory T cells in blood and lymphoid tissue after alemtuzumab-mediated depletion in heart-transplanted cynomolgus monkeys 2013
    2013 The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation 2013
    2012 A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis 2012
    2012 John Collins Warren (1778-1856): An American surgeon in London 2012
    2012 Clinical islet xenotransplantation: How close are we? 2012
    2012 Early islet damage after direct exposure of pig islets to blood: Has humoral immunity been underestimated? 2012
    2012 Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm 2012
    2012 Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species 2012
    2012 Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs 2012
    2012 Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation 2012
    2012 Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells 2012
    2012 Immunobiology of liver xenotransplantation 2012
    2012 Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation 2012
    2012 Potential benefits and risks of clinical xenotransplantation 2012
    2012 Collagenous colitis-like condition in immunosuppressed infant baboons 2012
    2012 Costimulation blockade in pig artery patch xenotransplantation - A simple model to monitor the adaptive immune response in nonhuman primates 2012
    2012 Platelet aggregation in humans and nonhuman primates: Relevance to xenotransplantation 2012
    2012 The value of xenotransplantation. 2012
    2012 Clinical lung xenotransplantation - What donor genetic modifications may be necessary? 2012
    2012 Partial improvement of dupuytren contracture following a wasp sting 2012
    2012 T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons 2012
    2012 Induced regulatory T cells: Mechanisms of conversion and suppressive potential 2012
    2012 Clinical xenotransplantation: The next medical revolution? 2012
    2012 T-lymphocyte homeostasis and function in infant baboons: Implications for transplantation 2012
    2012 The future of bioprosthetic heart valves 2012
    2012 Genetically-engineered pig-to-baboon liver xenotransplantation: Histopathology of xenografts and native organs 2012
    2012 A brief history of cross-species organ transplantation. 2012
    2012 Adipose-derived mesenchymal stromal cells from genetically modified pigs: Immunogenicity and immune modulatory properties 2012
    2012 Porcine alanine transaminase after liver allo-and xenotransplantation 2012
    2012 Porcine bioprosthetic heart valves: The next generation 2012
    2012 The effect of Gal expression on pig cells on the human T-cell xenoresponse 2012
    2011 Edward gerjuoy: From physics to law and back again 2011
    2011 Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4 + T-cell responses co-stimulated by porcine and human B7 molecules 2011
    2011 Thrombocytopenia after pig-to-baboon liver xenotransplantation: Where do platelets go? 2011
    2011 A record of international meetings on xenotransplantation 1988-2010 2011
    2011 Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves 2011
    2011 Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs 2011
    2011 Clinical pig liver xenotransplantation: How far do we have to go? 2011
    2011 Genetically-modified pig mesenchymal stromal cells: Xenoantigenicity and effect on human T-cell xenoresponses 2011
    2011 Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates 2011
    2011 Xenotransplantation-the future of corneal transplantation? 2011
    2011 Attempted depletion of passenger leukocytes by irradiation in pigs. 2011
    2011 Giant gallstone: A case report 2011
    2011 The immense potential of xenotransplantation in surgery 2011
    2010 The spleen as a site for hematopoiesis 2010
    2010 Multivisceral xenotransplantation-does it have a future? 2010
    2010 Non-human primate regulatory T cells: Current biology and implications for transplantation 2010
    2010 Hepatic function after genetically engineered pig liver transplantation in baboons 2010
    2010 An in vitro model of pig liver xenotransplantation-pig complement is associated with reduced lysis of wild-type and genetically modified pig cells 2010
    2010 Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells 2010
    2010 The immunology of corneal xenotransplantation: A review of the literature 2010
    2010 Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation 2010
    2010 Genetically Engineered Pigs as a Source for Clinical Red Blood Cell Transfusion 2010
    2010 Outwitting evolution: Honorary Fellowship Lecture 2010
    2010 Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys 2010
    2010 Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs 2010
    2010 Overcoming the barriers to xenotransplantation: Prospects for the future 2010
    2010 Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants 2010
    2010 Investigation of potential carbohydrate antigen targets for human and baboon antibodies 2010
    2010 Pig heart xenotransplantation as a bridge to allotransplantation 2010
    2010 The potential of genetically-modified pig mesenchymal stromal cells in xenotransplantation 2010
    2009 Cyclophosphamide dosage in pigs 2009
    2009 Effect of the αgal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model 2009
    2009 Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets 2009
    2009 Genetically engineered pig red blood cells for clinical transfusion: Initial in vitro studies 2009
    2009 Commentary: How important is the anti-gal antibody response following the implantation of a porcine bioprosthesis? 2009
    2009 Endoscopic gastric submucosal transplantation of islets (ENDO-STI): Technique and initial results in diabetic pigs 2009
    2009 How important is the anti-Gal antibody response following the implantation of a porcine bioprosthesis? 2009
    2009 Monitoring of porcine and baboon cytomegalovirus infection in xenotransplantation 2009
    2009 Pig liver xenotransplantation as a bridge to allotransplantation: Which patients might benefit? 2009
    2009 Production and characterization of transgenic pigs expressing porcine CTLA4-Ig 2009
    2009 Current status of xenotransplantation and prospects for clinical application 2009
    2009 The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial 2009
    2009 The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Executive summary 2009
    2009 Coagulation dysregulation as a barrier to xenotransplantation in the primate 2009
    2009 Xenotransplantation of solid organs in the pig-to-primate model 2009
    2009 Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation 2009
    2009 The innate immune response and activation of coagulation in ±1,3-galactosyltransferase gene-knockout xenograft recipients 2009
    2009 Invited commentary 2009
    2009 A review of studies relating to thyroid hormone therapy in brain-dead organ donors 2009
    2009 Identification of αgal as the major target for human anti-pig antibodies 2009
    2008 Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation 2008
    2008 In vitro investigation of pig cells for resistance to human antibody-mediated rejection 2008
    2008 Rejection of cardiac xenografts transplanted from α1,3- galactosyltransferase gene-knockout (GalT-KO) pigs to baboons 2008
    2008 The choice of anatomical site for islet transplantation 2008
    2008 Hormonal therapy to the brain-dead potential organ donor: The misnomer of the "papworth cocktail" 2008
    2008 Suppressive efficacy and proliferative capacity of human regulatory t cells in allogeneic and xenogeneic responses 2008
    2008 Update: Cardiac xenotransplantation 2008
    2008 Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro 2008
    2008 Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells 2008
    2008 The Choice of Anatomical Site for Islet Transplantation. 2008
    2008 Of HIV, grief and TOP 2008
    2008 Erratum: Safe induction of diabetes by high-dose streptozotocin in pigs (Pancreas (2008) 36, 3, (328)) 2008
    2008 Liver xenografts for the treatment of acute liver failure: Clinical and experimental experience and remaining immunologic barriers 2008
    2008 High-Throughput Screening of Glycan-Binding Proteins Using Miniature Pig Kidney N-Glycan-Immobilized Beads 2008
    2008 Islet xenotransplantation: The pig-to-non-human primate model 2008
    2008 Hormonal resuscitation therapy in the management of the brain-dead potential organ donor 2008
    2008 Frankenswine, or bringing home the bacon: How close are we to clinical trials in xenotransplantation? 2008
    2008 Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: Implications for translation into clinical practice 2008
    2008 Recent advances in pig-to-human organ and cell transplantation 2008
    2008 Safe induction of diabetes by high-dose streptozotocin in pigs 2008
    2008 Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from α1,3-galactosyltransferase gene-knockout pigs in baboons 2008
    2007 Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: Implications for xenotransplantation in infants 2007
    2007 Response to commentaries on "α1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: Where do we go from here?" 2007
    2007 Knowledge and use of emergency contraception among women in the Western Cape province of South Africa: A cross-sectional study 2007
    2007 Erratum: Babesia as a complication of immunosuppression following pig-to-baboon heart transplantation (Xenotransplantation (2007) 14,2, (162-165) DOI: 10.1111/j.1399-3089.2007.00375.x) 2007
    2007 Erratum: The potential of statins in xenotransplantation (Xenotransplantation (2007) 14,2, (100-103) DOI: 10.1111/j.1399-3089.2007.00389. x) 2007
    2007 Rapid loss of intraportally transplanted islets: An overview of pathophysiology and preventive strategies 2007
    2007 α1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: Where do we go from here? 2007
    2007 Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - Case history and review of the literature 2007
    2007 The pig-to-primate immune response: Relevance for xenotransplantation 2007
    2007 Using α1,3-galactosyltransferase gene-knockout pig organs in nonhuman primates 2007
    2007 Pig-to-Non-human Primate Heart Transplantation: Immunologic Progress Over 20 Years 2007
    2007 The potential of statins in xenotransplantation: Commentary 2007
    2007 Progress in xenotransplantation following the introduction of gene-knockout technology 2007
    2007 Babesia as a complication of immunosuppression following pig-to-baboon heart transplantation 2007
    2007 Gene expression of porcine lymphotrophic herpesvirus-1 in miniature swine with posttransplant lymphoproliferative disorder 2007
    2007 Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies 2007
    2007 Reduction of early graft loss after intraportal porcine islet transplantation in monkeys 2007
    2007 Rene Kuss's clinical experience with pig kidney transplantation in 1966 [4] 2007
    2006 Hormonal therapy of the brain-dead organ donor: Experimental and clinical studies 2006
    2006 Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart grafts 2006
    2006 Measurement of anti-CD154 monoclonal antibody in primate sera by competitive inhibition ELISA 2006
    2006 Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human 2006
    2006 Selected physiologic compatibilities and incompatibilities between human and porcine organ systems 2006
    2006 Community attitudes towards sexual activity and childbearing by HIV-positive people in South Africa 2006
    2006 Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: Adverse effects and early responses 2006
    2006 The status of legal termination of pregnancy in South Africa 2006
    2006 Xenotransplantation - Will tolerance be essential? [6] 2006
    2006 ABO-incompatible allotransplantation as a basis for clinical xenotransplantation 2006
    2006 Antibodies directed to pig non-Gal antigens in naïve and sensitized baboons 2006
    2006 Allosensitization does not increase the risk of xenoreactivity to α1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists 2006
    2006 Engraftment potential of adult spleen cells in vitro and in vivo 2006
    2006 Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans 2006
    2006 Islet xenotransplantation: Are we really ready for clinical trials? 2006
    2006 Pig-to-nonhuman primate islet xenotransplantation: A review of current problems 2006
    2006 Immunologic benefits of spleen transplantation in the absence of graft-versus-host disease [7] 2006
    2006 PERV methodology 2006
    2006 Editorial introductions 2006
    2006 Elicited antibodies in baboons exposed to tissues from α1,3-galactosyltransferase gene-knockout pigs 2006
    2006 Xenotransplantation: The road ahead 2006
    2006 The IJS welcomes two great pioneers 2006
    2006 Facilitating physiologic self-regeneration: A step beyond islet cell replacement 2006
    2006 Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models 2006
    2006 Buccal mucosal cell immunohistochemistry: A simple method of determining the ABH phenotype of baboons, monkeys, and pigs 2006
    2006 Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system: the initial clinical experience. 2006
    2006 Journal requirements for manuscripts on clinical trials of xenotransplantation 2006
    2006 Letter from the Editors 2006
    2005 Lack of cardiac differentiation in c-kit-enriched porcine bone marrow and spleen hematopoietic cell cultures using 5-azacytidine 2005
    2005 Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys 2005
    2005 Immunological unresponsiveness in chimeric miniature swine following MHC-mismatched spleen transplantation 2005
    2005 alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. 2005
    2005 Localized myocardial infarction following pig-to-baboon heart transplantation 2005
    2005 α1,3-galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months 2005
    2005 Preformed antibodies to α1,3-galactosyltransferase gene-knockout (GT-KO) pig cells in humans, baboons, and monkeys: Implications for xenotransplantation 2005
    2005 Pig-to-nonhuman primate organ xenotransplantation 2005
    2005 Carbohydrates in xenotransplantation 2005
    2005 Heart transplantation: The contributions of Christiaan Barnard and the University of Cape Town/Groote Schuur Hospital 2005
    2005 Reducing Gal expression on the pig organ - A retrospective review 2005
    2005 Porcine red blood cells express a polyagglutinable red blood cell phenotype [1] (multiple letters) 2005
    2005 Which patients first? Planning the first clinical trial of xenotransplantation: A case for cardiac bridging 2005
    2005 The ethics debate in relation to xenotransplantation 2005
    2005 How strong is the T cell response in the pig-to-primate model? 2005
    2005 HIV-infected women in ART programmes [5] 2005
    2005 Histopathology of spleen allograft rejection in miniature swine 2005
    2005 Porcine hematopoietic progenitor cell transplantation in nonhuman primates: A review of progress 2005
    2005 Draft reports for public comment from the US Secretary's Advisory Committee on Xenotransplantation. 2005
    2005 Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus 2005
    2005 Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience 2005
    2005 Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue 2005
    2005 Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons 2005
    2005 Troponin T levels in baboons with pig heterotopic heart transplants 2005
    2004 T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model 2004
    2004 Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation 2004
    2004 Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons 2004
    2004 Failed contraception? [2] 2004
    2004 Bone marrow transplantation from α1,3-galactosyltransferase gene-knockout pigs in baboons 2004
    2004 Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation 2004
    2004 Investigation of red blood cells from α1,3-galactosyltransferase- knockout pigs for human blood transfusion 2004
    2004 Letter to the editor [3] 2004
    2004 Letter to the editor [4] 2004
    2004 α1-3-galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-gal antobodies 2004
    2004 Acute vascular rejection of xenografts: Roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity 2004
    2004 Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation 2004
    2004 Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: Implications for xenotransplantation 2004
    2004 Pig spleen transplantation induces transient hematopoietic cell chimerism in baboons [2] 2004
    2004 Transfusion of pig red blood cells into baboons [1] 2004
    2004 The Surgical Anatomy of Experimental and Clinical Thoracic Organ Transplantation 2004
    2004 Reduction of anti-Galα1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly-L-lysine 2004
    2004 Suppression of Natural and Elicited Antibodies in Pig-to-Baboon Heart Transplantation Using a Human Anti-Human CD154 mAb-Based Regimen 2004
    2004 Xenotransplantation Manuscripts Now Published OnlineEarly 2004
    2004 Alloantibody and xenoantibody cross-reactivity in transplantation 2004
    2004 Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens 2004
    2004 Galα1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus 2004
    2004 In vitro and in vivo investigation of a novel monoclonal antibody to plasma cells (W5 mAb) 2004
    2004 Initial investigation of the potential of modified porcine erythrocytes for transfusion in primates 2004
    2004 Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine. 2004
    2004 Relative effects of GAL+ and GALlow/- porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: Implications for the induction of mixed hematopoietic chimerism in the pig-to-primate model 2004
    2004 Statement on allogeneic and xenogeneic transplantation by Fifty-Seventh World Health Assembly, 22 May 2004. 2004
    2004 Xenotransplantation: Letter from the Editors 2004
    2003 Correlation of Biochemical and Hematological Changes with Graft Failure Following Pig Heart and Kidney Transplantation in Baboons 2003
    2003 Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galα1-3Gal conjugate 2003
    2003 An investigation of the effect of thalidomide on anti-gal antibody production in baboons 2003
    2003 Porcine red blood cells as a source of blood transfusion in humans 2003
    2003 Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation 2003
    2003 Clinical xenotransplantion - How close are we? 2003
    2003 Can spleen transplantation induce tolerance? A review of the literature 2003
    2003 Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons 2003
    2003 Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene 2003
    2003 Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation 2003
    2003 Spleen transplantation in miniature swine: Surgical technique and results in major histocompatibility complex-matched donor and recipient pairs 2003
    2003 Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness 2003
    2003 ABO-incompatible organ and bone marrow transplantation: Current status 2003
    2003 Xenogeneic thymus transplantation in a pig-to-baboon model 2003
    2003 6th Congress of the International Xenotransplantation Association 2003
    2003 An exploratory investigation of the effect of arsenic trioxide on anti-Gal antibody production in baboons 2003
    2003 An investigation of the specificity of induced anti-pig antibodies in baboons 2003
    2003 Clinical xenotransplantation: The next great surgical revolution? 2003
    2003 Models of xenotransplantation tolerance 2003
    2003 Neurotoxicity of leflunomide in baboons [2] 2003
    2003 Outwitting evolution - Progress towards clinical xenotransplantation 2003
    2003 Primates as models for xenotransplantation 2003
    2002 Therapeutic interventions in xenotransplantation 2002
    2002 Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model 2002
    2002 Promotion of xenogeneic hematopoietic chimerism in rodents by mononuclear phagocyte depletion 2002
    2002 Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells 2002
    2002 Gene therapy - Its potential in surgery 2002
    2002 Xenotransplant cardiac chimera: Immune tolerance of adult stem cells: Invited commentary 2002
    2002 Differential expression of Galα1,3Gal epitopes on fetal and adult porcine hematopoietic cells 2002
    2002 Xenotransplantation trials [10] (multiple letters) 2002
    2002 Activation of cytomegalovirus in pig-to-primate organ xenotransplantation 2002
    2002 Activation of human endothelial cells by mobilized porcine leukocytes in vitro: Implications for mixed chimerism in xenotransplantation 2002
    2002 Will the pig solve the transplantation backlog? 2002
    2002 Anti-Galα1-3Gal IgM and IgG antibody levels in sera of humans and old world non-human primates 2002
    2002 Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies 2002
    2002 Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to Gal oligosaccharides 2002
    2002 Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade 2002
    2002 Xenotransplantation so close, but yet so far 2002
    2002 Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade 2002
    2002 Anti-CD154 monoclonal antibody and thromboembolism revisited [2] 2002
    2002 Xenotransplantation - How far have we come? 2002
    2002 Xenotransplantation and tolerance. 2002
    2001 Transplantation of islets of Langerhans: New developments 2001
    2001 CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons 2001
    2001 Pig kidney transplantation in baboons: Anti-galα1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation 2001
    2001 Assessment of methotrexate as a potential immunosuppressive agent in baboons 2001
    2001 Xenotransplantation: Letter from the editor 2001
    2001 Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons 2001
    2001 Modulation of platelet aggregation in baboons: Implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells 2001
    2001 Modulation of platelet aggregation in baboons: Implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation 2001
    2001 Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: Depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-αGal antibody 2001
    2001 Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy 2001
    2001 Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation 2001
    2001 Xenotransplantation: Letter from the editor 2001
    2001 Effects of xenogeneic thymic transplantation in baboons 2001
    2001 The potential role of xenotransplantation in treating endstage cardiac disease: A summary of the report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation 2001
    2001 Report: International Xenotransplantation Association 2001
    2001 Xenotransplantation: Editorial 2001
    2001 Anti-CD154 monoclonal antibody and thromboembolism 2001
    2001 Cardiac hyperacute rejection: A new look or a skewed look at an old problem? [1] 2001
    2001 Total depletion and suppression of natural and induced anti-pig antibodies in baboons. 2001
    2001 Christiaan Barnard and his contributions to heart transplantation 2001
    2001 Christiaan Neethling Barnard. 2001
    2001 Immunosuppression for pig-to-nonhuman primate organ grafting 2001
    2001 Letter to Editor 2001
    2001 Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade 2001
    2001 The pig as a source of cardiac xenografts 2001
    2001 Xenotransplantation 2001
    2000 Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates 2000
    2000 Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation 2000; 70:1323 2000
    2000 Inhibition of platelet aggregation in baboons: Therapeutic implications for xenotransplantation 2000
    2000 Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: Experience with 320 aphereses in baboons 2000
    2000 Are pigs transgenic for human complement regulatory proteins necessary for xenotransplantation 2000
    2000 A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons 2000
    2000 Coagulation/thrombotic disorders associated with organ and cell xenotransplantation 2000
    2000 Effect of B cell/plasma cell depletion or suppression on Anti-Gal antibody in the baboon 2000
    2000 Experience with porcine thymic transplantation in baboons 2000
    2000 Increases in autologous hematopoietic progenitors in the blood of baboons following irradiation and treatment with porcine stem cell factor and interleukin-3 2000
    2000 Induction of mixed hematopoietic chimerism in the pig-to-baboon model 2000
    2000 Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon 2000
    2000 Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: Experience with 275 aphereses in baboons 2000
    2000 Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation 2000
    2000 Human immunodeficiency virus type 1 RNA level and CD4 count as prognostic markers and surrogate end points: A meta-analysis 2000
    2000 Oesophageal syncope 2000
    2000 High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response 2000
    2000 Gene therapy and transplantation 2000
    2000 An approach to the control of disease transmission in pig-to-human xenotransplantation 2000
    2000 Xenotransplantation (multiple letters) 2000
    2000 Anti-Galα1-3Gal antibody levels in organ transplant recipients receiving immunosuppressive therapy 2000
    2000 Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA Class II DR gene transfer in baboons 2000
    2000 Venular thrombosis is the key event in the pathogenesis of antibody- mediated cardiac rejection 2000
    2000 Acute humoral xenograft rejection: Destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts 2000
    2000 Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment 2000
    2000 Disordered regulation of coagulation and platelet activation in xenotransplantation 2000
    2000 Pharmacotherapeutic agents in xenotransplantation 2000
    2000 Report of the xenotransplantation advisory committee of the international society for heart and lung transplantation: The present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases 2000
    2000 Xenotransplantation. This new form of treatment might benefit millions. 2000
    2000 Xenotransplantation: The challenge to current psychosocial attitudes 2000
    1999 Peripheral blood progenitor cell mobilization and leukapheresis in pigs 1999
    1999 Xenoreactive natural antibodies 1999
    1999 Pig xenogeneic antigen modification with green coffee bean α- galactosidase 1999
    1999 Different responses of human anti-HLA and anti-αgal antibody to long- term intravenous immunoglobulin therapy 1999
    1999 The problem of anti-pig antibodies in pig-to-primate xenografting: Current and novel methods of depletion and/or suppression of production of anti-pig antibodies 1999
    1999 Major carbohydrate epitopes in tissues of domestic and African wild animals of potential interest for xenotransplantation research 1999
    1999 Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers 1999
    1999 David Kempton Cartwright Cooper, MD: A conversation with the editor 1999
    1999 Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors 1999
    1999 Serum cytotoxicity to pig cells and anti-αGal antibody level and specificity in humans and baboons 1999
    1999 Brain death and its influence on donor organ quality and outcome after transplantation 1999
    1999 Effect of pig-specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons 1999
    1999 Intravenous synthetic αgal saccharides delay hyperacute rejection following pig-to-baboon heart transplantation 1999
    1999 Lack of variation in αgal expression on lymphocytes in miniature swine of different genotypes 1999
    1999 Physiologic changes following brain death 1999
    1999 Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption 1999
    1999 A reliable, rapid and inexpensive two-color fluorescence assay to monitor serum cytotoxicity in xenotransplantation 1999
    1999 Anti-Gal, alpha-Gal epitopes, and xenotransplantation. 1999
    1999 Xenogeneic thymic transplantation in a pig-to-nonhuman primate model 1999
    1999 Xenotransplantation--state of the art--update 1999. 1999
    1998 Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts 1998
    1998 Comparison of Bile Chemistry between Humans, Baboons, and Pigs: Implications for Clinical and Experimental Liver Xenotransplantation 1998
    1998 Discordant organ xenotransplantation in primates: World experience and current status 1998
    1998 The safety of xenotransplantation 1998
    1998 Anti-Galα1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction 1998
    1998 Intravenous infusion of Galα1-3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts 1998
    1998 Hepatitis C status of heart transplant recipients 1998
    1998 Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galα1-3Galβ1-4βGlc-X immunoaffinity column 1998
    1998 Comparative histopathology of hepatic allografts and xenografts in the nonhuman primate 1998
    1998 Depletion of anti-Galα1-3Gal antibody in baboons by specific α-Gal immunoaffinity columns 1998
    1998 Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti-αGal antibody in the baboon 1998
    1998 Xenoantigens and xenoantibodies 1998
    1998 Xenostransplantation of cells and tissues: Application to a range of diseases, from diabetes to Alzheimer's 1998
    1997 Review of literature on heart transplant recipients' return to work: predictors and outcomes. 1997
    1997 Letter to the Editor 1997
    1997 Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy 1997
    1997 Xenoantigens and xenoantibodies: Their modification 1997
    1997 Primary bronchogenic carcinoma in recipients of heart transplants 1997
    1997 Women's health status and use of health services in a rapidly growing peri-urban area of South Africa 1997
    1997 Clinical xenotransplantation: Past, present and future 1997
    1997 Anti-GAL IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation 1997
    1997 Legal implications of xenotransplantation 1997
    1997 Returning to work after heart transplantation: A replication 1997
    1997 Ultrastructure changes associated with brain death in the human donor heart 1997
    1997 Xenotransplantation. 1997
    1996 Manipulation of the anti-αGal antibody-αGal epitope system in experimental discordant xenotransplantation 1996
    1996 In vivo immunoadsorption of antipig antibodies in baboons using a specific Galα1-3Gal column 1996
    1996 Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-α-galactosyl antibodies in vitro and after intravenous infusion in baboons 1996
    1996 Monoclonal antiidiotypic antibodies neutralize cytotoxic effects of anti-αGal antibodies 1996
    1996 A histopathologic grading system of hyperacute (humoral, antibody- mediated) cardiac xenograft and allograft rejection 1996
    1996 Cobra venom factor stimulates anti-α-galactose antibody production in baboons: Implications for pig-to-human xenotransplantation 1996
    1996 A comparison of transplant patient and social worker attitudes in regard to transplant patient psychosocial selection criteria, role expectations, and communication style 1996
    1996 How many endomyocardial biopsies are necessary in the first year after heart transplantation? 1996
    1996 Characterization of baboon class I major histocompatibility molecules: Implications for baboon-to-human xenotransplantation 1996
    1996 Xenotransplantation: Benefits, risks and regulation 1996
    1996 The existence of coronary artery disease in a potential heart donor. 1996
    1996 The reducing end of αGal oligosaccharides contributes to their efficiency in blocking natural antibodies of human and baboon sera 1996
    1996 Cardiac transplantation in patients aged 60 years or older. 1996
    1996 Cervical cytology screening--knowledge, attitudes and practice in a peri-urban settlement. 1996
    1996 Ethical aspects of xenotransplantation of current importance 1996
    1996 Investigation of the anti-complement agents, FUT-175 and K76COOH, in discordant xenotransplantation 1996
    1996 Organ transplants [1] 1996
    1996 Ratites (ostrich, emu) as potential heart donors for humans: Immunologic, anatomic, and physiologic considerations 1996
    1996 The potential role of thyroid hormone substitutes in cardiac surgery and transplantation 1996
    1996 Xenotransplantation--state of the art. 1996
    1995 Newborn baboon serum anti-αgalactosyl antibody levels and cytotoxicity to cultured pig kidney (PK15) cells 1995
    1995 Secondary organ allografting after a primary “bridging” xenotransplant 1995
    1995 A comparison of organ transplant patient and professional staff attitudes 1995
    1995 Auxiliary liver allografting and xenografting in the nonhuman primate 1995
    1995 Alternatives to human heart replacement 1995
    1995 Atypical clostridium difficile colitis in a heart transplant recipient 1995
    1995 Detection, immunoabsorption, and inhibition of cytotoxic activity of anti‐αGal antibodies using newly developed substances with synthetic Gal α1–3Gal disaccharide epitopes 1995
    1995 Failure of intrathymic inoculation of donor-specific splenocytes to prolong cardiac or renal allograft survival in dogs 1995
    1995 Induction therapy with cyclosporine without cytolytic agents results in a low incidence of acute rejection without significant renal impairment in heart transplant patients 1995
    1995 Inhibition of human anti‐αGal IgG by oligosaccharides derived from porcine stomach mucin 1995
    1995 Screening of baboons as potential liver donors for humans 1995
    1995 Vladimir Demikhov 1995
    1994 Cardiac allotransplantation across the ABO-blood group barrier by the neutralization of preformed antibodies: The baboon as a model for the human 1994
    1994 Monomorphic and polymorphic carbohydrate antigens on pig tissues: implications for organ xenotransplantation in the pig-to-human model 1994
    1994 Evidence that intravenously administered a-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (pk15) and transplanted pig hearts 1994
    1994 Heart transplantation for giant cell myocarditis [1] 1994
    1994 Medication noncompliance and its relationship to financial factors after heart transplantation [2] 1994
    1994 Oligosaccharides and Discordant Xenotransplantation 1994
    1994 Protection of pig kidney (pk15) cells from the cytotoxic effect of anti-pig antibodies by α-galactosyl oligosaccharides 1994
    1994 Study of the relative incidences of psychosocial factors before and after heart transplantation and the influence of posttransplantation psychosocial factors on heart transplantation outcome 1994
    1994 Survival following organ transplantation in an Oklahoma institution, 1985-1993. 1994
    1994 The pig as a potential organ donor for man: A study of potentially transferable disease from donor pig to recipient man 1994
    1994 Variability of anti‐αGal antibodies in human serum and their relation to serum cytotoxicity against pig cells 1994
    1993 Binding and specificity of major immunoglobulin classes of preformed human anti-pig heart antibodies 1993
    1993 Genetically engineered pigs 1993
    1993 A successful regimen to reduce cytomegalovirus disease in heart transplant patients 1993
    1993 A suggested technique for 'orthotopic' heart transplantation in a patient with situs inversus 1993
    1993 Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation 1993
    1993 Early detection of de novo hepatitis C infection in patients after liver transplantation by reverse transcriptase polymerase chain reaction 1993
    1993 Identification of α-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man 1993
    1993 Methyl methacrylate plate to prevent compression after heart transplantation 1993
    1993 Returning to work after heart transplantation 1993
    1993 Specific intravenous carbohydrate therapy: A new concept in inhibiting antibody-mediated rejection - Experience with ABO-incompatible cardiac allografting in the baboon 1993
    1993 Task force 6: Future developments 1993
    1993 Transplantation using donor hearts from patients with circulatory arrest 1993
    1992 Is xenotransplantation a realistic clinical option? 1992
    1992 Angina pectoris in patients with cardiac transplants [1] 1992
    1992 Cytomegalovirus disease in heart transplant patients 1992
    1992 Donor organ availability. 1992
    1992 Donor-heart evaluation by monitoring the left ventricular pressure-volume relationship: Clinical observations 1992
    1992 Enzyme‐linked immunosorbent assay for the detection of substances that carry blood group A specificity 1992
    1992 Invited letter concerning: Changes in plasma-free thyroid hormones during cardiopulmonary bypass [1] 1992
    1992 Nonhemic prime in cardiopulmonary bypass 1992
    1992 Organ transplantation in India. 1992
    1992 Prevention of loss of vertebral bone density in heart transplant patients 1992
    1992 Social rehabilitation and return to work after cardiac transplantation—a multicenter survey 1992
    1992 The assessment of the results of heart transplantation. 1992
    1992 The chacma baboon as an organ donor for man 1992
    1991 Risk of endocarditis in donor hearts. 1991
    1991 Histopathology of hyperacute rejection of the heart: Experimental and clinical observations in allografts and xenografts 1991
    1991 Human cancer prostaglandins and patient survival. 1991
    1991 Successful management of symptomatic cytomegalovirus disease with ganciclovir after heart transplantation 1991
    1991 The gastrointestinal management of patients undergoing heart transplantation. 1991
    1991 Triiodothyronine in the recovery of stunned myocardium in dogs 1991
    1990 Accelerated cardiac allograft rejection associated with administration of liver cell extract in the baboon 1990
    1990 Changes in triiodothyronine during cardiopulmonary bypass: A clinical problem? (I: Reply) 1990
    1990 Clinical survey of heart transplantation between ABO blood group - incompatible recipients and donors 1990
    1990 Cytoimmunologic monitoring after heart and heart-lung transplantation 1990
    1990 Effect of pharmacologic immunosuppression on donor heart survival in a closely related nonhuman primate xenograft model 1990
    1990 Experience with cardiorespiratory support devices in patients undergoing heart and heart-lung transplantation. 1990
    1990 Improved cardiac allograft function following triiodothyronine therapy to both donor and recipient 1990
    1989 Xenotransplantation and AIDS: Retroviral prevalence in the non-human primate donor 1989
    1989 Optimalization of immunosuppression after xenogeneic heart transplantation in primates 1989
    1989 Can cardiac allografts and xenografts be transplanted across the ABO blood group barrier? 1989
    1989 The role of ABO blood group compatibility in heart transplantation between closely related animal species. An experimental study using the vervet monkey to baboon cardiac xenograft model 1989
    1989 Experience with endomyocardial biopsy in 23 patients with heart transplants. 1989
    1989 Can cardiac allografts and xenografts be transplanted across the ABO blood group barrier? 1989
    1989 Diagnosis of acute cardiac rejection by changes in left ventricular volumes. 1989
    1989 Diagnosis of acute cardiac rejection by changes in left ventricular volumes 1989
    1989 Does central nervous system toxicity occur in transplant patients with hypocholesterolemia receiving cyclosporine 1989
    1989 Early extranuclear effect of triiodothyronine (T3) on tissue slices: Relevance to organ donor viability 1989
    1989 Electrocardiographic and histopathologic changes developing during experimental brain death in the baboon 1989
    1989 Inotropic effect of triiodothyronine (T3) in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: An initial experience in patients undergoing open heart surgery 1989
    1989 Pituitary function in brain-dead patients 1989
    1989 Right ventricular assist by a heterotopic left ventricle 1989
    1989 The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart 1989
    1989 Xenograft transplantation 1989
    1989 Xenotransplantation 1989
    1988 Malignant fibrous histiocytoma of the heart. A case report 1988
    1988 Added effects of organ (heart) storage after brain death in the experimental animal 1988
    1988 Effects of hormonal therapy on subsequent organ (kidney) storage in the experimental animal 1988
    1988 Endocrine changes and metabolic responses 1988
    1988 Hemodynamic and electrocardiographic responses 1988
    1988 Hormonal therapy in the brain-dead experimental animal 1988
    1988 Myocardial and pulmonary histopathologic changes 1988
    1988 Results of hormonal therapy in human brain-dead potential organ donors 1988
    1988 Cardiac allotransplantation across major blood group barriers in the baboon 1988
    1988 Prediction of acute cardiac rejection by changes in left ventricular volumes 1988
    1988 Added effects of organ (heart) storage after brain death in the experimental animal. 1988
    1988 Effects of hormonal therapy on subsequent organ (kidney) storage in the experimental animal. 1988
    1988 Endocrine changes and metabolic responses. 1988
    1988 Hemodynamic and electrocardiographic responses. 1988
    1988 Hormonal therapy in the brain-dead experimental animal. 1988
    1988 Myocardial and pulmonary histopathologic changes. 1988
    1988 Results of hormonal therapy in human brain-dead potential organ donors. 1988
    1988 Indications for heterotopic heart transplantation and report on two patients. 1988
    1988 Assessment and selection of patients for heart transplantation. 1988
    1988 Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine therapy 1988
    1988 Effect of triiodothyronine (T3) on myocardial high energy phosphates and lactate after ischemia and cardiopulmonary bypass: An experimental study in baboons 1988
    1988 Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon 1988
    1988 Initial Experimental Experience with a “Replaceable” Cardiac Valve Prosthesis 1988
    1988 Initial experience with heart and lung transplantation 1988
    1988 Injury of myocardial conduction tissue and coronary artery smooth muscle following brain death in the baboon 1988
    1988 Inotropic Effect of Triiodothyronine Following Myocardial Ischemia and Cardiopulmonary Bypass: An Experimental Study in Pigs 1988
    1988 Surgical management of stab wounds of the chest. A 6-month prospective study of 45 consecutive cases requiring operation 1988
    1988 The effects of denervation and acute rejection on left ventricular volumes measured by radionuclide ventriculography following cardiac transplantation in the chacma baboon 1988
    1988 The physiological management of cardiac transplant donors and recipients using triiodothyronine 1988
    1988 The role of nuclear cardiology procedures in the evaluation of cardiac function following heart transplantation 1988
    1988 Thyroid function in human cardiac allograft donors 1988
    1988 Triiodothyronine therapy for heart donor and recipient 1988
    1988 Triiodothyronine therapy in the cardiac transplant recipient 1988
    1987 Brain death, triiodothyronine depletion, and inhibition of oxidative phosphorylation: Relevance to management of organ donors 1987
    1987 Heart transplantation at Groote Schuur Hospital, Cape Town. Twenty years' experience 1987
    1987 Is ABO compatibility essential in xenografting between closely related species? 1987
    1987 Prolongation of cardiac xenograft (vervet monkey to baboon) function by a combination of total lymphoid irradiation and immunosuppressive drug therapy 1987
    1987 Twenty years of heart transplantation at Groote Schuur Hospital 1987
    1987 Virological implications of the use of primates in xenotransplantation 1987
    1987 Cardiac allograft survival in ABO blood group incompatible baboons 1987
    1987 Cardiac transplantation using discordant xenografts in a nonhuman primate model 1987
    1987 Cardiac allograft survival in ABO blood group incompatible baboons. 1987
    1987 Cardiac transplantation using discordant xenografts in a nonhuman primate model. 1987
    1987 Are there indications for heterotopic heart transplantation today? 1987
    1987 Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors 1987
    1987 Improved cardiac function following hormonal therapy in brain dead pigs: Relevance to organ donation 1987
    1987 Is pulmonary ischemia a factor in the reperfusion response? An experimental study in the chacma baboon. 1987
    1987 Loss of myocardial viability following hypothermic perfusion storage from contaminating trace elements in the perfusate 1987
    1987 Pathophysiology of Pulmonary Edema Following Experimental Brain Death in the Chacma Baboon 1987
    1987 Prevention of myocardial injury by pretreatment with verapamil hydrochloride prior to experimental brain death: Efficacy in a baboon model 1987
    1987 Successful orthotopic heart-lung transplantation in the baboon after five hours of cold ischemia with cardioplegia and Collins' solution. 1987
    1987 The value of hormonal therapy in improving organ viability in the transplant donor. 1987
    1986 Acute pulmonary rejection precedes cardiac rejection following heart-lung transplantation in a primate model 1986
    1986 Hemodynamic and myocardial histologic and ultrastructural studies on baboons from 3 to 27 months following autotransplantation of hearts stored by hypothermic perfusion for 24 or 48 hours 1986
    1986 Hyperacute rejection in a discordant (pig to baboon) cardiac xenograft model 1986
    1986 Interpretation of endomyocardial biopsy after heart transplantation. Potentially confusing factors 1986
    1986 Regression of Kaposi's sarcoma after reduction of immunosuppressive therapy in a heart transplant patient 1986
    1986 Value of triiodothyronine (T3) therapy to brain-dead potential organ donors. 1986
    1986 Surgery in patients with heart transplants. Anaesthetic and operative considerations 1986
    1986 The effects of brain death and 24 hours' storage by hypothermic perfusion on donor heart function in the pig 1986
    1986 Acute Isolated Pulmonary Rejection Following Transplantation of the Heart and Both Lungs: Experimental and Clinical Observations 1986
    1986 Are there indications for heterotopic heart transplantation in 1986? A 2- to 11-year follow-up of 49 consecutive patients undergoing heterotopic heart transplantation 1986
    1986 Brain death-induced hemodynamic changes resulting in cardiac and pulmonary injury in the baboon 1986
    1986 Endomyocardial biopsy site morphology. An experimental study in baboons 1986
    1986 Evidence of myocardial and renal functional recovery following hormonal treatment after brain death 1986
    1986 Forty-eight hours hypothermic perfusion storage of pig and baboon hearts 1986
    1986 Hemodynamic changes, myocardial injury, and pulmonary edema induced by sympathetic activity during the development of brain death in the baboon 1986
    1986 Histopathologic changes at the site of endomyocardial biopsy: Potential for confusion with acute rejection 1986
    1986 Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy 1986
    1986 Improved function of stored hearts following hormonal therapy after brain death in pigs 1986
    1986 Prevention of Myocardial Injury During Brain Death by Total Cardiac Sympathectomy in the Chacma Baboon 1986
    1985 A successful method of administering cyclosporin A to the chacma baboon 1985
    1985 Does the electrocardiogram detect early acute heart rejection 1985
    1985 Physiopathological epidemiology of tumors after transplantation 1985
    1985 Transplantation of the heart and both lungs: Experimental and clinical experience and review of the literature 1985
    1985 An airlift pump device for low pressure perfusion storage of the isolated heart 1985
    1985 Effects of brain death and hypothermic perfusion storage on donor heart function: An experimental study 1985
    1985 Failure of pretransplant third-party and preoperative donor-specific blood transfusion to improve heterotopic cardiac allograft survival in baboons 1985
    1985 Further Cardiac Transplant Procedures in Patients with Heterotopic Heart Transplants 1985
    1985 Prediction of acute cardiac rejection using radionuclide scanning to detect left ventricular volume changes 1985
    1984 Cyclosporin A in the management of patients with heart transplants. Initial experience at Groote Schuur Hospital 1984
    1984 Electrocardiographic, hemodynamic & endocrine changes occurring during experimental brain death in the Chacma baboon 1984
    1984 Preformed lymphocytotoxic antibodies disappear following cyclosporine therapy 1984
    1984 The significance of left ventricular volume measurement after heart transplantation using radionuclide techniques 1984
    1984 Heterotopic versus orthotopic heart transplantation 1984
    1984 Prediction of acute cardiac rejection using radionuclide techniques 1984
    1984 Cardiac Transplantation Following Storage of the Donor Heart by a Portable Hypothermic Perfusion System 1984
    1984 Circulatory Assistance with Allograft 1984
    1984 Comparison of patients with ischemic, myopathic, and rheumatic heart diseases as cardiac transplant recipients 1984
    1984 Immunosuppression in the baboon cardiac allograft model: Effects of splenectomy, bolus methylprednisolone, propranolol, high–dose azathioprine, cyclophosphamide, and a niridazole metabolite 1984
    1984 Lack of efficacy of high-dose verapamil in preventing brain damage in baboons and pigs after prolonged partial cerebral ischemia 1984
    1984 Noncompliance in heart transplant recipients: The Cape Town experience 1984
    1984 Orthotopic and heterotopic transplantation of the heart: The Cape Town experience 1984
    1984 Orthotopic heart transplantation in a patient with a heterotopic heart transplant 1984
    1984 Reversal of acute rejection by cyclosporine in a heterotopic heart transplant 1984
    1984 The value of recipient heart assistance during severe acute rejection following heterotopic cardiac transplantation 1984
    1984 Valve replacement in patients over 70 years of age 1984
    1983 Survival after cardiac transplantation. 1983
    1983 Toxoplasmosis of donor and recipient hearts after heterotopic cardiac transplantation 1983
    1983 Transplantation of heart 1983
    1983 Malignant neoplasms occurring after cardiac transplantation 1983
    1983 Malignant Neoplasms Occurring After Cardiac Transplantation 1983
    1983 Cryptic mediastinal masses causing airways obstruction 1983
    1983 Factors influencing survival following heart transplantation 1983
    1983 Infectious complications after heart transplantation 1983
    1983 Orthotopic allotransplantation and autotransplantation of the baboon heart following 24-hr storage by a portable hypothermic perfusion system 1983
    1983 Storage of the donor heart by a portable hypothermic perfusion system: Experimental development and clinical experience 1983
    1983 The Surgical Technique of Heterotopic Heart Transplantation 1983
    1983 The problem of the presensitized heart transplant recipient 1983
    1983 Trends in cardiac surgery at the University of Cape Town, 1971 - 1981 1983
    1982 Changes in indications for heart transplantation. An additional argument for the preservation of the recipient's own heart 1982
    1982 Medical, legal and administrative aspects of cadaveric organ donation in the RSA 1982
    1982 Transplantation of the heart 1982
    1982 Effect of ABO Blood-Group Antigens on Long-Term Survival after Cardiac Transplantation 1982
    1982 Orthotopic transplantation of the baboon heart after 20 to 24 hours' preservation by continuous hypothermic perfusion with an oxygenated hyperosmolar solution 1982
    1982 Donor heart morphology twelve and a half years after orthotopic transplantation 1982
    1982 Emergency open-heart surgery. Experience with 100 consecutive cases 1982
    1982 Heart transplantation: The South African experience 1982
    1982 Low-dose versus high-dose steroid therapy in the prevention of acute rejection in baboon heterotopic cardiac allografts 1982
    1982 Technique, complications, and climncal value of endomyocardial biopsy in patients with heterotopic heart transplants 1982
    1982 The assessment and selection of patients for heterotopic heart transplantation 1982
    1982 The results of orthotopic and heterotopic heart transplantation at Groote Schuur Hospital, Cape Town: 1967-1981 1982
    1982 Twenty-four-hour preservation of the pig heart by a portable hypothermic perfusion system 1982
    1981 Clinical transplantation of the heart: A review of 13 years' personal experience 1981
    1981 Ex vivo functional evaluation of pig hearts subjected to 24 hours' preservation by hypothermic perfusion 1981
    1981 The present status of heterotopic cardiac transplantation 1981
    1981 An investigation of the immunosuppressive effects of niridazole and metronidazole in rat and baboon heterotopic cardiac allograft models 1981
    1981 Management of oesophageal perforation associated with benign stricture and hiatus hernia by oesophagoplasty and fundoplication 1981
    1981 The incidence of postoperative infection and the role of antibiotic prophylaxis in pulmonary surgery. A review of 221 consecutive patients undergoing thoracotomy 1981
    1980 A comparison of two prophylactic antibiotic regimes for open-heart surgery 1980
    1980 Long-term survival after orthotopic and heterotopic cardiac transplantation 1980
    1980 Pharmacological and hypothermic inhibition of metabolism during myocardial ischaemia 1980
    1980 Recent experience with heart transplantation 1980
    1979 Factors contributing to the mortality associated with open-heart surgery in infants. 1979
    1979 Orthotopic heart transplantation after 16 hours ischaemia 1979
    1979 Results of surgical correction of persistent complete atrioventricular canal 1979
    1979 The surgical management of malignant tumours of the oesophagus and cardia: A review of the results in 292 patients treated over a 15‐year period (1961–75) 1979
    1978 Collagen diseases as a cause of constrictive pericarditis 1978
    1978 Incidence of postoperative infection and role of antibiotic prophylaxis in pulmonary surgery 1978
    1977 The Haematoxylin-basic Fuchsin-picric acid staining reaction as a test of myocardial viability in resuscitated and preserved hearts 1977
    1976 Acute massive mitral regurgitation from prosthetic valve dysfunction 1976
    1976 Conservative surgery for bronchial adenomata 1976
    1976 The donor heart: The present position with regard to resuscitation, storage, and assessment of viability 1976
    1975 A simple method of resuscitation and short term preservation of the canine cadaver heart 1975
    1975 Donor heart resuscitation and storage 1975
    1975 Haemodynamic studies during short-term preservation of the autoperfusing heart-lung preparation 1975
    1975 Observations on ischaemic contracture of the heart ('stone heart') 1975
    1974 Resuscitation of the cadaver donor heart in the dog. I. Haemodynamic, electrocardiographic, blood chemical and histopathological changes during and after death by asphyxia 1974
    1974 Resuscitation of the cadaver donor heart in the dog. II. A comparison of two simple techniques 1974
    1974 Resuscitation of the cadaver donor heart in the dog. III. The influence of the agonal period on the success of resuscitation 1974
    1974 Viability assessment of the preserved heart: a brief review of current experimental techniques 1974
    1973 Associated Carcinomata of Colon and Anus 1973
    1973 Electrocardiographic prediction of unmodified rejection in heterotopic canine cardiac allografts 1973
    1972 Transplantation of the heart. 1972
    1972 Accidents in agriculture 1972
    1971 Transplantation of the heart. 1971
    1969 Electrocardiographic studies in the rat in physiological and pathological states 1969
    1969 Measurement of pulmonary surfactant by du nuoy tensiometer in various physiopathological conditions 1969
    1969 Transplantation of the heart and both lungs. I. Historical review. 1969
    1969 Transplantation of the heart and both lungs. II. Experimental cardiopulmonary transplantation. 1969
    1968 Experimental Development of Cardiac Transplantation 1968

    Book

    Year Title Altmetric
    2018 Preface 2018
    2018 Recollections of pioneers in xenotransplantation research 2018
    2014 Preface 2014
    2013 Introduction.  Ed. 9781461443049.  2013

    Chapter

    Year Title Altmetric
    2018 The establishment of the International Xenotransplantation Association: The first section of The Transplantation Society.  409-418. 2018
    2018 The next great medical revolution: A cardiac surgeon's efforts to develop xenotransplantation.  27-62. 2018
    2018 Xenotransplantation: The official journal of the International Xenotransplantation Association.  401-408. 2018
    2018 Future directions in liver replacement therapy: Liver xenotransplantation.  347-378. 2018
    2014 Early clinical experience of hormonal therapy in the brain-dead potential organ donor.  191-207. 2014
    2013 Impact of brain death on storage of the heart.  283-288. 2013
    2013 Management of the brain-dead organ donor: Perspectives of the transplant coordinator.  251-261. 2013
    2013 Pathophysiology of brain death and effects of hormonal therapy in large animal models.  65-90. 2013
    2013 Thyroid hormone therapy to the recipient of a heart from a brain-dead donor.  321-331. 2013
    2012 Xenotransplantation.  391-402. 2012
    2012 Xenotransplantation of thoracic organs: Current status.  803-805. 2012

    Research Overview

  • organ transplantation, islet xenotransplantation, xenotransplantation
  • Full Name

  • David Cooper