Positions

Overview

  • Dr. Bennett received his A.B. from Howard College (Samford University) in 1954, and his M.D. (cum laude) from Harvard Medical School in Boston, Massachusetts in 1958. He served fellowships at the Massachusetts General Hospital (Rheumatology), the National Institutes of Health (Molecular biology) in Bethesda, Maryland and California Institute of Technology (Molecular Genetics) in Pasadena, California.He returned to Birmingham in 1965 to join the faculty at the University of Alabama at Birmingham (UAB). From 1970-82, he was Professor and Chair of the Department of Microbiology and Director of the Division of Clinical Immunology and Rheumatology. In 1982, he was named Professor and Chair of the Department of Medicine, and in 1992 was honored with the William and Evalina Spencer Chair in Medical Science Leadership. On October 1, 1993, he became the fourth President of the University of Alabama at Birmingham. In 1997, he was designated by the University Board of Trustees as Distinguished University Professor Emeritus and became President and Chief Operating Officer of BioCryst Pharmaceuticals, Inc. (1997-2008).

    Dr. Bennett has published over 200 scientific papers. He has been Editor, Cecil Textbook of Medicine, 19th, 20th, and 21st editions (1998-2000); Editor-in-Chief of Arthritis and Rheumatism (1975-1980); Editor-in-Chief of the American Journal of Medicine (1986-97).

    His contributions in research include the delineation of constant (C) and variable (V) regions of immunoglobulin molecules, based on peptide analyses of myeloma proteins. These studies resulted in a general hypothesis for the generation of antibody diversity. These studies also led to description of the phylogenetic development of the immune system and formed the basis for site attachment of complement in activation of the inflammatory pathway. His clinical research focused on the structures of rheumatoid factors and relationships to various infectious agents as initiators of the rheumatoid process.

    He has received awards from a number of distinguished organizations including the Seale Harris Award, Southern Medical Association (1987); Master, American College of Physicians (1990); Phillips Memorial Award, American College of Physicians (1993); Robert H. Williams Distinguished Chair of Medicine Award, Association of Professors of Medicine (1994); Francis Gilman Blake Award, Association of American Physicians (1997); Master, American College of Rheumatology (1998); Carol Nachman Medal, German Society of Rheumatology (2000); and the Kober Medal from the Association of American Physicians (2000). He has been awarded honorary degrees by the University of Alabama at Birmingham (D.Sc.1992), the University of Leipzig, Germany (Dr. Med [honoris causa] 1999), and the University of Zurich, Switzerland (Dr. Med [honoris causa] 2008).

    Dr. Bennett has been elected to membership in the American Academy of Microbiology, American Society for Clinical Investigation, the Association of American Physicians, the Institute of Medicine of the National Academy of Sciences, the American Academy of Arts and Sciences, and the Royal Society of Medicine, London, and an honorary member of the Ludwig Heilmeyer Society (Germany).

    His professional activities include President of the American College of Rheumatology (1981-1982); Chair, American Board of Internal Medicine (1994-1995); Chair, Board of Health Sciences Policy, Institute of Medicine, National Academy of Sciences (1988-1993); President, Association of Professors of Medicine (1991-1992); Chairman, Federated Council of Internal Medicine (1992-1993); NIH Director’s Panel on Clinical Research (1995-1998); President of the Association of American Physicians (1996-1997).

    Dr. Bennett has served on many scientific advisory boards, including the Scientific Advisory Committee for Massachusetts General Hospital (1983-1987; 2001-2005); Scientific Advisory Board Merck Sharp & Dohme Research Laboratories (1987-1989); Founding Board Deutsches RheumaForschungsZentrum, Berlin (1988-1998); Scientific Advisory Committee, Warren Alpert Foundation (1989-1997); Scientific Advisory Committee, Charles E. Culpepper Foundation, Inc. (1989-1995); Visiting Committee, Harvard Medical School (1992-1997); and Board of Governors of the Warren Grant Magnuson Clinical Center, at the National Institutes of Health (1996-1999).
  • Selected Publications

    Academic Article

    Year Title Altmetric
    1993 Interactions of cell-surface galactosyltransferase with immunoglobulins.Molecular Immunology.  30:265-275. 1993
    1993 Interactions of galactosyltransferase with serum and secretory immunoglobulins and their component chains.Molecular Immunology.  30:277-286. 1993
    1992 Development of a didactic curriculum in science related to internal medicine.Annals of Internal Medicine.  116:1088-1090. 1992
    1989 Analysis of the spectrin binding domains of globin.Biochemical and Biophysical Research Communications.  164:894-902. 1989
    1988 Conversion of the beckman liquid phase sequencer to a gas-liquid phase sequencer.Analytical Biochemistry.  175:39-51. 1988
    1988 Interactions between surface molecules and the cytoskeleton in the lymphocyte.Transactions- American Clinical and Climatological Association.  99:119-125. 1988
    1987 Heterogeneity of binding of monoclonal IgA to staphylococcal protein A is related to the IgA polymerization state.Immunology Letters.  16:11-14. 1987
    1987 The infectious etiology of chronic rheumatic diseases.Seminars in Arthritis and Rheumatism.  17:1-23. 1987
    1986 Simple device for high-performance liquid chromatographic separation on microbore columns.J Chromatogr.  370:508-512. 1986
    1986 Purification of spectrin and its subunits by high-performance liquid chromatography.J Chromatogr.  369:159-164. 1986
    1986 Interleukin 1-like factor produced by a hybrid of an adherent mouse spleen cell and a thymoma cell.Immunology Letters.  13:143-149. 1986
    1986 Biochemical characterization of Fc gamma receptors of mouse DCH-5 cell line.Immunobiology.  172:81-91. 1986
    1986 The stoichiometry of J chain in human secretory dimeric IgA.Molecular Immunology.  23:541-544. 1986
    1985 Secondary structure of the immunoglobulin J chain. (circular dichroism/hydrophobicity profile/tertiary structure/antiparallel β-barrel)Proceedings of the National Academy of Sciences.  82:5905-5909. 1985
    1985 A modified system for thiazolinone conversion to thiohydantoin derivatives and their separation by high-pressure liquid chromatography.Analytical Biochemistry.  150:457-462. 1985
    1985 Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil elastase from normal donors.Analytical Biochemistry.  149:153-162. 1985
    1984 Identification of phenylthiohydantoin derivatives of substituted amino acids encountered during amino acid sequence analysis by high-performance liquid chromatography.J Chromatogr.  314:467-470. 1984
    1984 Amino acid sequence of human D of the alternative complement pathway.Biochemistry.  23:2482-2486. 1984
    1984 Use of mini-octadecylsilane ultrasphere column in high-pressure liquid chromatography for protein structural studies.Analytical Biochemistry.  137:256-260. 1984
    1984 Partial characterisation of the high and low molecular weight forms of P388D1-derived interleukin 1.Journal of Cellular Biochemistry.  26:65-73. 1984
    1983 A comparison of fluorescamine and o-phthaldialdehyde as effective blocking reagents in protein sequence analyses by the Beckman sequencer.Analytical Biochemistry.  131:337-340. 1983
    1983 American rheumatology: markings. Presidential address to the American Rheumatism Association, June 1982.Arthritis and Rheumatism.  26:548-552. 1983
    1983 Amino-terminal amino acid sequence of p10, the fifth major gag polypeptide of avian sarcoma and leukemia viruses.Journal of Virology.  45:885-888. 1983
    1983 Exclusive Use of High Pressure Liquid Chromatography for The Determination of the Complete Amino Acid Sequence of The 12K Fragment of Avian Sarcoma Virus Structural Protein p27Journal of liquid chromatography.  6:249-258. 1983
    1982 Selective dansylation of M protein within intact influenza virions.Journal of Virology.  44:871-876. 1982
    1982 Buffer electrofocusing of Interleukin I.Bioscience Reports.  2:241-246. 1982
    1982 The H-2Kk antigen: isolation using monoclonal immunoadsorbent chromatography and sequence analysis without radioisotopes.Molecular Immunology.  19:1-11. 1982
    1981 Purification and characterization of the gag gene products of avian-type C retroviruses by high-pressure liquid chromatography.Analytical Biochemistry.  112:128-134. 1981
    1981 Use of fluorescamine as an effective blocking reagent to reduce the background in protein sequence analyses by the Beckman automated sequencer.Analytical Biochemistry.  112:158-162. 1981
    1981 An improved procedure for high-sensitivity microsequencing: use of aminoethyl aminopropyl glass beads in the Beckman sequencer and the ultrasphere ODS column for PTH amino acid identification.Analytical Biochemistry.  110:355-359. 1981
    1981 Interleukin 1: production by P388D1 cells attached to microcarrier beads.Journal of Immunological Methods.  46:197-204. 1981
    1981 Reverse phase ion pair high performance liquid chromatography of viral tryptic glycopeptidesJournal of liquid chromatography.  4:587-598. 1981
    1980 Monoclonal and allospecific H-2Kk antisera precipitate a high molecular weight protein.Journal of Immunology.  125:2295-2298. 1980
    1980 Alignment of the peptides derived from acid-catalyzed cleavage of an aspartylprolyl bond in the major internal structural polypeptide of avian retroviruses.Journal of Biological Chemistry.  255:6962-6965. 1980
    1980 Separation of influenza hemagglutinin tryptic glycopeptides by ion-pair reverse-phase high-performance liquid chromatography (HPLC).Journal of Biochemical and Biophysical Methods.  3:61-63. 1980
    1980 A simple modification on the vacuum system of the Beckman automated sequencer to improve the efficiency of Edman degradation.Analytical Biochemistry.  102:35-38. 1980
    1980 Partial amino acid sequence of human factor D:homology with serine proteases.Proceedings of the National Academy of Sciences.  77:1116-1119. 1980
    1979 Structure of the membrane protein of influenza virus. I. Isolation and characterization of cyanogen bromide cleavage products.Journal of Virology.  30:759-766. 1979
    1979 Reverse phase ion‐pair chromatography of viral glycopeptidesHrc -Heidelberg-.  2:149-150. 1979
    1978 Computer-Assisted high-pressure liquid chromatography of radio-labelled phenylthiohydantoin amino acidsChromatographic reviews.  156:35-41. 1978
    1978 Amino-terminal amino acid sequence of the major structural polypeptides of avian retroviruses: sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses.Proceedings of the National Academy of Sciences.  75:2708-2712. 1978
    1978 The infectious etiology of rheumatoid arthritis. New considerations.Arthritis and Rheumatism.  21:531-538. 1978
    1978 Methanol solvent system for rapid analysis of phenylthiohydantoin amino acids by high-pressure liquid chromatographyChromatographic reviews.  148:532-535. 1978
    1978 Quantitative yields of underivatized peptides by HPLCHrc -Heidelberg-.  1:177-178. 1978
    1978 The molecular structure and interrelationships of murine T lymphoid cell-surface antigens.Contemporary topics in molecular immunology.  7:283-317. 1978
    1977 Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.Biochemistry.  16:3507-3513. 1977
    1977 Primary structure of human J chain: isolation and characterization of tryptic and chymotryptic peptides of human J chain.Biochemistry.  16:3501-3507. 1977
    1977 A preliminary study using electron capture detection of pentafluorophenylthiohydantoin amino acid derivatives.Proceedings of the Society for Experimental Biology and Medicine.  155:287-289. 1977
    1977 Structural analysis of the peptides derived from specific acid-catalyzed hydrolysis at aspartylprolyl peptide bonds in human J chain.Journal of Immunology.  118:67-70. 1977
    1976 Sequence analysis of human J chain. Amino terminal location of a disulfide bond linking the immunoglobulin heavy chain.Biochemical and Biophysical Research Communications.  73:92-97. 1976
    1976 Antibodies to human native and denatured collagens in synovial fluids of patients with rheumatoid arthritis.Clinical immunology and immunopathology.  6:209-212. 1976
    1976 A comparative analysis of the C1-binding ability of fragments derived from complement-fixing and noncomplement-fixing IgM proteins.Journal of Clinical Investigation.  58:16-21. 1976
    1976 Quantitative isolation of mouse thymus leukemia antigen, TL.Tissue Antigens.  7:158-164. 1976
    1976 Isolation and properties of the CNBr peptides of influenza viral membrane proteinFederation proceedings.  35. 1976
    1975 Purification of murine thymus leukemia antigen (TL). A quantitative assessment of limited proteolysis.Biochemistry.  14:4792-4796. 1975
    1975 C1 fixation and classical complement pathway activation by a fragment of the Cmu4 domain of IgM.Journal of Experimental Medicine.  142:1322-1326. 1975
    1975 Subfragments of the papain solubilized TL antigen.Journal of Immunology.  115:1013-1017. 1975
    1975 The primary structure of J chain: sequence analyses of the major proteolytic fragmentsFederation proceedings.  34:4160. 1975
    1973 Characterization of a teleost immunoglobulin: the immune macroglobulin from the channel catfish, Ictalurus punctatus.Comparative Biochemistry and Physiology - B: Comparative Biochemistry.  46:187-197. 1973
    1973 Isolation of F(c)5mu and Fabmu fragments of human IgM.European Journal of Immunology.  3:415-419. 1973
    1973 Rheumatoid arthritis: an immune complex disease? A review of the reaction of antigen with antibody to form immune complexes and the mechanisms by which they mediate tissue injury.Geriatrics -Minnesota-.  28:84-91. 1973
    1973 Isolation and characterization of the glycopeptides from a human immunoglobulin M.Journal of Immunology.  110:840-847. 1973
    1972 The carbohydrate composition of immunoglobulins from diverse species of vertebrates.Journal of Immunology.  109:371-381. 1972
    1972 Purification and characterization of two classes of immunoglobulins from the marine toad, Bufo marinus.Biochemistry.  11:2751-2759. 1972
    1972 Studies of the component chains of human IgM by citraconylation.BBA - Biochimica et Biophysica Acta.  263:339-350. 1972
    1971 Isolation and characterization of the immune macroglobulin from the paddlefish, Polyodon spathula.Journal of Biological Chemistry.  246:6760-6769. 1971
    1971 Degradation of human IgM by pepsin: characterization of a high molecular weight fragment.Journal of Immunology.  107:870-880. 1971
    1971 Isolation and physico-chemical characterization of the "IgM-like" immunologlobulin from the stingray Dasyatis americana.Journal of Immunology.  107:782-793. 1971
    1971 The carbohydrate composition of immunoglobulins G.BBA - Biochimica et Biophysica Acta.  237:442-449. 1971
    1971 Phylogeny of immunoglobulins. Characterization of a 14S immunoglobulin from the gar, Lepisosteus osseus.Biochemistry.  10:2028-2036. 1971
    1971 Oxidative sulfitolysis of human IgM.Journal of Immunology.  106:1136-1138. 1971
    1971 Tetrameric immune macroglobulins in three orders of bony fishes.Proceedings of the National Academy of Sciences.  68:107-111. 1971
    1970 N-terminal sequences of immunoglobulin heavy and light chains from three species of lower vertebrates.Nature.  228:991-992. 1970
    1970 Studies of maleylated chains of human IgM.Journal of Immunology.  105:846-855. 1970
    1970 Antibodies to homologous RNA in the rabbit following stimulation by exogenous RNA.Proceedings of the Society for Experimental Biology and Medicine.  134:968-970. 1970
    1970 Antibodies to ribosomal ribonucleic acid (rRNA) in patients with systemic lupus erythematosus (SLE).Immunology.  19:439-442. 1970
    1970 Release of Fab- and Fc-like fragments from human IgM by reductive cleavage.Journal of Immunology.  104:518-521. 1970
    1969 Physical and chemical characterization of an oyster hemagglutinin.Journal of Biological Chemistry.  244:4128-4135. 1969
    1969 Studies on the structural variation of the H chain of immunoglobulin M(IgM).Archives of Biochemistry and Biophysics.  131:551-560. 1969
    1969 Immunological capabilities of the oyster Crassostrea virginica.Comparative Biochemistry and Physiology.  29:149-160. 1969
    1969 Management of rheumatoid arthritis.Southern Medical Journal.  62:307-314. 1969
    1969 Possible Usefulness of Azathioprine (Imuran) In Severe Rheumatoid ArthritisThe Journal of clinical pharmacology and the journal of new drugs.  9:251-258. 1969
    1968 The amino-terminal sequence of the heavy chain of human immunoglobulin M.Biochemistry.  7:3340-3344. 1968
    1967 [36] Paper chromatography and electrophoresis; special procedure for peptide mapsMethods in Enzymology.  11:330-339. 1967
    1966 Concluding remarks: the regulation of hemoglobin and immunoglobulin synthesis.Journal of Cellular Physiology.  67:Suppl 1:207-16. 1966
    1966 Concluding remarks: The regulation of hemoglobin and immunoglobulin synthesisJournal of Cellular Physiology.  67:207-215. 1966
    1965 The molecular basis of antibody formation: a paradox.Proceedings of the National Academy of Sciences.  54:864-869. 1965
    1965 EVIDENCE FOR AMINO ACID SEQUENCE DIFFERENCES AMONG PROTEINS RESEMBLING THE L-CHAIN SUBUNITS OF IMMUNOGLOBULINS.Journal of Molecular Biology.  12:81-87. 1965
    1964 THE RELATIONSHIP OF THE THREE DIMENSIONAL CONFORMATION OF PROTEINS TO THEIR ANTIGENIC SPECIFICITY.Medicine.  43:305-314. 1964
    1963 Studies on antigen conformation during antibody purification.Journal of Biological Chemistry.  238:1362-1366. 1963
    1962 Polarization of fluorescence as a measure of antigen-antibody interaction.Proceedings of the National Academy of Sciences.  48:1935-1942. 1962

    Education And Training

  • Doctor of Medicine, Harvard University
  • Full Name

  • J Bennett