Positions

Overview

  • Our lab is interested in understanding how our brain ages, and in particular, how it ages as an integrated part of a physiological system. We take a cutting edge approach to understanding brain plasticity and brain aging, examining how distant tissues such as skeletal muscle may be fundamentally influencing the rate at which our brain ages. Importantly, as these conversations may be disrupted in age-associated neurodegenerative diseases such as Alzheimer’s disease, we aim to uncover and develop novel diagnostics and therapeutics for these disorders
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease.Journal of Visualized Experiments2019
    2019 Challenges in IBD Research: Preclinical Human IBD Mechanisms.Inflammatory Bowel Diseases.  25:S5-S12. 2019
    2019 TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities.Neurobiology of Disease.  122:83-93. 2019
    2018 X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity.Advances in Experimental Medicine and Biology.  1049:103-133. 2018
    2017 Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.Autophagy.  13:506-521. 2017
    2015 Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.eLife.  4:e08493. 2015
    2015 Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Molecular and Cellular Neuroscience.  66:53-61. 2015
    2014 Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.Nature Neuroscience.  17:1180-1189. 2014
    2014 The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy.Drug Discovery Today.  19:963-971. 2014
    2014 Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.Cell Reports.  7:774-784. 2014
    2014 Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.Neuron.  82:295-307. 2014
    2014 Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases.Rare Diseases.  2:e962402. 2014
    2013 Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy.International Journal of Cell Biology.  2013:560421. 2013
    2012 Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease. 2012
    2008 A novel PRNP-P105S mutation associated with atypical prion disease and a rare PrPSc conformation.Neurology.  71:1431-1438. 2008
    2006 Proacrosin/acrosin quantification as an indicator of acrosomal integrity in fresh and frozen dog spermatozoa.Animal Reproduction Science.  93:165-175. 2006
    2006 S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. 2006
    2005 Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa.Biochemical and Biophysical Research Communications.  337:1337-1344. 2005

    Research Overview

  • aging, Alzheimer's disease, brain aging, synaptic plasticity, skeletal muscle, metabolism, exercise, autophagy, proteostasis
  • Education And Training

  • Doctor of Philosophy in Cell Physiology, University of Illinois at Chicago 2010
  • Full Name

  • Constanza Cortes Rodriguez